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WO/2003/106031A1 |
A method and a device for determining the presence or the amount of an analyte in a test sample. The method comprises: (a) introducing a test sample in a chamber (12), (b) performing the following steps in that chamber (12): (b.l) captur...
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WO/2003/104783A1 |
An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber (12) without direct physical contact between a heating device (10) and the reaction chamber (12), or between a temperature senso...
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WO/2003/103828A1 |
The invention relates to automatic synthesis equipment for carrying out chemical reactions with the aid of reflux condensation. Said equipment consists of one or more reactor modules (2), each comprising a reactor (3), one or more feed c...
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WO/2003/102226A1 |
The invention relates to a method for the amplification of DNA and apparatus for such amplification. The method comprises steps typically found in amplification methods but utilises an optical procedure to detect denaturation of DNA or a...
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WO/2003/102585A2 |
The present invention relates to methods for monitoring interactions between target-molecules and at least one analyte comprising: (a) contacting a plurality of target-molecules, said target-molecules being immobilized on a porous substr...
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WO/2003/102241A1 |
Various methods are provided for an integrated micro array system (100) that allows fully automated sample processing and detection/quantification of nucleic acid and protein samples in a single analytical device, which may be configured...
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WO/2003/102238A2 |
A process to monitor the production of coherent nucleic acid molecules from an inherent PCR mixture, the process comprising collating PCR starting materials in a chamber, and carrying out the PCR steps of denaturation, annealing and exte...
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WO/2003/100382A1 |
This invention is directed to a method and apparatus using polymerase chain reaction (PCR) technology for automatically collecting air samples and identifying biological agents in the air sample. A fully automated system is provided that...
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WO/2003/098282A1 |
The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of biological samples, and a lens having first ...
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WO/2003/098140A1 |
The invention provides a furnace suitable for treating mineral samples contained in a crucible comprising an outer wall structure enclosing an interior furnace space preferably an annular space which is adapted to be heated by heating me...
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WO/2003/092846A2 |
One embodiment (Figure 10) of the invention relates to a microfiuidc apparatus for performing two dimensional biomolecular separations. According to one aspect of the invention, after a first dimension separation in a first microchannel,...
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WO/2003/093407A1 |
The invention relates to a device for the amplification of DNA in a reaction mixture, the device (1) comprising a heated chamber (2) including a rotor (3) for holding a plurality of reaction vessels for reaction mixtures, a drive means f...
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WO/2003/089136A1 |
A substrate plate comprises a microplate (1) made of a plastic material, having an array of wells (2) arranged in rows and columns, the bottom of at least one well (2) being provided by a porous substrate (3). Each porous substrate (3) i...
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WO/2003/089137A1 |
A system for conducting bioassays comprises a substrate plate with wells, and an incubation device for holding the plate. The substrate plate comprises a microplate with an array of wells arranged in rows and columns, wherein the bottom ...
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WO/2003/087410A1 |
Apparatus and methods for carrying out biochemical processes directly on a substrate (115) are provided. A substrate assembly (110) includes a cartridge (130) that removably supports a substrate (115) in a fixed position, and a reaction ...
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WO/2003/080247A1 |
The invention relates to a device for cooling a sampler (1), which comprises a recipient (2) for receiving at least one sample flask (3) or a sample container which can be placed in the sample (1), a cooling unit and a condenser (4). The...
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WO/2003/080862A1 |
The invention outlines a method for the methylation pattern retaining amplification of nucleic acid molecules. Furthermore the invention describes several devices for use in the methylation pattern retaining amplification of nucleic acid...
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WO/2003/076661A1 |
The present invention provides an apparatus for amplifying a polynucleotide, comprising a substrate, a microflow channel system disposed in the substrate and comprising a sample inlet port, a sample flow channel extending from the sample...
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WO/2003/075111A1 |
Provided are a temperature control method and apparatus for driving a polymerize chain reaction (PCR) chip. In the temperature control apparatus, which is for a polymerize chain reaction chip, PCR chips receive electric power from the ou...
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WO/2003/072817A2 |
The invention relates to a method of increasing the sensitivity and specificity of nucleic acid chip hybridization tests and to devices suitable for carrying out the inventive method.
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WO2002024322A9 |
A microfluidic device having integrated components for conducting chemical operations. Depending upon the desired application, the components for manipulating charged entities, heaters, electrochemical detectors, sensors for temperature,...
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WO/2003/069322A2 |
The invention relates to a device for simultaneously testing the action of liquids on one or more surface structures (5). Said device comprises at least one continuous element (2) with a plurality of chambers, a cover (1) for closing sai...
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WO/2003/066667A2 |
Methods for preparing nanoscale reactions using nucleic acids or proteins are presented, Nucleic acids are captured saturably, yet reversibly, on the internal surface of the reaction chamber, typically a capillary. Excess nucleic acid is...
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WO/2003/064697A1 |
A thermal cycling device (10) for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray (14). The thermal cycling device (10) includes a sample block assembly (50), an optical detecti...
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WO/2003/064042A1 |
The base (A) of the modular reactor includes a frame (10) defining an opening (9) in which one of a plurality of interchangeable reaction vessel carrying inserts (12) can be received. Each insert (12) has an array of recesses (14) adapte...
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WO/2003/062797A1 |
The invention relates to a method for preparing biological samples for analysis, comprising the following steps: (a) the biological sample is placed on a two-dimensional support; (b) application of a first protein-precipitating or denatu...
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WO/2003/060157A2 |
The present invention relates to a microfabricated reaction chamber system and a method of fluid transport. The system may be used, for example, in a method of carrying out a nucleic acid sequence amplification and detection process on a...
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WO/2003/059516A1 |
The invention relates to a reaction vessel, a device and a method for the determination of specific interactions between molecular targets and probe molecules. The invention particularly relates to a reaction vessel which comprises a sca...
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WO/2003/058253A1 |
Sample processing systems and methods of using those systems for processing sample materials located in devices that are separate from the system are disclosed. The sample processing systems include a rotating base (10) on which the samp...
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WO/2003/057310A2 |
A lid (10) for a well plate (2) is provided. Pins (14) penetrate the lid (10) and project downwardly into the wells (6) of the well plate (2). Thermal energy is applied to the upper end of the pins (14) to regulate the temperature of liq...
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WO/2003/056919A2 |
Disclosed is a method for changing the temperature of a sample from an initial temperature via an intermediate temperature to a final temperature, one of the initial and final temperatures being above the freezing point of said sample an...
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WO/2003/057875A1 |
It is intended to provide a PCR method by electrostatic transportation wherein DNA−containing droplets can be accurately transported, the temperature of the droplets can be appropriately controlled and individual droplets can be separa...
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WO/2003/055606A1 |
The invention is a method to construct and to use portable or transferable microbe enrichment euiqpment in order to be able to handle and treat a microbiological or biochemical sample in a desirable way after the taking of the sample. Th...
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WO/2003/055973A1 |
A reaction container (100) used for gene inspection, comprising at least one reaction liquid storage part for storing reaction liquid having upper side wells (152) opened in the upper surface of the reaction container (100), lower side w...
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WO/2003/052421A1 |
An electro-chemical analysis device (10) and method for analyzing biomolecular samples, including a means for holding a sample (24) on a substrate platform (12), a thermal sensor (18), a biosensor (14) formed having a specific spatial re...
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WO/2003/047755A1 |
A system for analyzing a blood sample comprises an element for nucleic acid (NA) isolation, an element for NA amplification, an incubator and a detector for detecting a parameter of the blood sample. The system comprises a single disposa...
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WO/2003/042677A1 |
Methods and systems for effecting a parameter and detecting a parameter using two electric signals are described.
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WO/2003/042410A1 |
Provided are an apparatus for circulating a carrier fluid having two or more chambers or sections, an apparatus for amplifying a nucleic acid using the same, and a chip containing the same. The apparatus for circulating a carrier fluid i...
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WO/2003/038127A1 |
The present invention generally relates to methods and apparatuses for amplifying nucleic acid sequences using immobilized DNA polymerase. More particularly, it relates to methods and apparatuses useful for amplifying target nucleic acid...
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WO/2003/038445A1 |
The invention involves an apparatus proteins and cells. The apparatus includes a plate (16) having wells (14) in which cells are disposed. The apparatus includes means for analyzing the effect of proteins and other biological and chemica...
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WO/2003/037514A2 |
The present invention is an apparatus for providing a linear temperature gradient to an architecture suitable for massively parallel chemical or biochemical processing. The architecture is disposed on a substrate. The apparatus uses two ...
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WO/2003/035239A2 |
A particle dispensing device including a hollow tube (1802) and a plunger (1804) inserted through the tube is used to transport and dispense solid reagents such as resin. The particle dispensing device can be coupled to a dispenser assem...
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WO/2003/035260A1 |
Disclosed is a process line system (100) for handling biological samples. The system includes a control computer (101) that controls the movement of a sample material plate along the process line. The control computer accepts user inputs...
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WO/2003/036263A2 |
A sample preparation system(100) provides an automated process that dispenses appropriate amounts of solid material into wells of a microtiter plate for mixing into a suspension. The system utilizes an array of hollow tubes(1802) that ar...
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WO/2003/035229A2 |
The present invention relates to an apparatus comprising a substrate having at least one assay station. The at least one assay station has at least a first assay station channel and at least a second assay station channel and the first a...
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WO/2003/035909A2 |
The present invention relates to diagnostic methods utilizing an apparatus comprising a substrate having at least one assay station. The at least one assay station has at least a first assay station channel and at least a second assay st...
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WO/2003/031063A2 |
The invention relates to a modularly structured device for holding substance library carriers and the use of said device for qualitative and quantitative detection of given molecular target molecules. The invention more particularly rela...
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WO/2003/027325A2 |
A nucleic acid assay system includes a holding means that receives a sample an a reagent. A PCR reactor means amplifies the sample and produces an amplified sample. A detection means detects PCR amplicon. A transport means selectively tr...
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WO/2003/026788A1 |
The invention relates to a microcomponent (1) for carrying out chemical reactions. Said microcomponent has an electric heating element, which is located directly on the surface of the microcomponent (1). The electric heating element can ...
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WO/2003/025226A1 |
The present invention provides a nucleic acid sequence amplification method and apparatuses thereof that are simple in the design and easy to miniaturize and integrate into complex apparatuses, with capability of using DNA polymerases th...
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