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WO/2005/065827A1 |
A heating arrangement for heating one or more liquid-containing microcavities (102) that are present on a microdevice (101) in which there is a contact surface (Sae,,) (108). The arrangement comprises a heating support (104,204) that has...
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WO/2005/066559A2 |
Disclosed is a transport container for shipping frozen material, particularly biological tissue samples. Said transport container comprises a jacket-shaped insulation (superinsulation) and a removable inner container (44) which is provid...
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WO/2005/066327A1 |
An apparatus for processing biological samples comprising means for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber, characterised in that at least one reservoir (18) able to accomm...
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WO/2005/064348A1 |
An analyzing device (1) constructed such that a sample is analyzed by using a container (2) where reagents are received in a tightly closed state and that the reagents can be raised to a set temperature. The analyzing device (1) has firs...
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WO/2005/060432A2 |
A cartridge is disclosed. The cartridge includes an independent storage component and transport component. The storage component can be coupled with the transport component. The storage component includes one or more pockets that each co...
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WO/2005/058501A1 |
A heating apparatus which uses resistive heating to heat samples carried in a metallic sheet carrier. Gradient heating effects and other heating patterns are produced by applying offsets to the outputs of temperature sensors, sensing the...
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WO2004108269B1 |
This disclosure generally relates to systems and methods for manipulating chambers and other substrates for chemical, biological, or biochemical samples, such as cell culture and other chambers, within units such as incubators. In certai...
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WO/2005/054458A1 |
A convenient, inexpensive and highly accurate method for analyzing expression of a gene in which amplification and individual inspection are performed simultaneously for a plurality of kinds of target in a single sample. A plurality of s...
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WO/2005/054813A1 |
An object of he invention is to provide a decomposition reaction vessel adapted for microwave decomposition method and allowing visual observation of a sample in the process of reaction from outside and being capable of being used for ev...
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WO/2005/047855A2 |
A method and apparatus are provided for preparing a test sample for detecting a predetermined target nucleic acid. The method includes the steps of providing a test probe comprising an oligonucleotide attached to a nanoparticle and provi...
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WO/2005/037433A1 |
The invention relates to a device for carrying out a reaction, which device comprises a wafer provided with a group of at least two wells. In the device according to the invention the wells are thermally separate from each other by means...
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WO/2005/036136A1 |
The invention relates to a cooling apparatus, especially for cryogenically preserving biological samples, comprising a duct (5) for delivering a coolant (3) to a cooling chamber (1), a heater (6) that has an adjustable first heating perf...
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WO/2005/029074A1 |
A system for reacting a biological material comprises an incubator (200) for housing and holding a reaction container (100), a pump (600) for driving a reaction liquid containing a biological material in the reaction container (100), a r...
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WO/2005/023427A1 |
A microfluidic analysis system (1) performs polymerase chain reaction (PCR) analysis on a bio sample. In a centrifuge (6) the sample is separated into DNA and RNA constituents. The vortex is created by opposing flow of a silicon oil prim...
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WO/2005/019835A1 |
The invention relates to a quality control device for a blood analyser using whole blood. More specifically, the invention relates to a device which can be used to check the correct operation of a blood analyser (9). The inventive device...
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WO/2005/011865A2 |
Improved valve and methods for analytical techniques and systems. The valve includes a main housing, together with a rotor and stator. The stator has openings therethrough which allow for fluid communication between tubing when connected...
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WO/2005/012916A1 |
A sample analyzer capable of efficiently heating only a specified portion on the surface of a disk by a simple external heating means and a disk-like sample analyzing medium. An analyzing area (3) and an optical recording area (7) are fo...
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WO/2005/009617A1 |
A detection device includes a housing containing a chamber configured to receive a specimen, a heating element disposed in the chamber, and an optical window to permit observation of the chamber. The housing includes a passage configured...
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WO/2005/005046A2 |
A fluidic micro electro-mechanical system (MEMS) device (200) is described. At least one at least partially covered fluidic channel (124) is formed on a polymer layer (42) deposited on a substrate (120). In one aspect, the partially cove...
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WO/2005/005594A1 |
A nucleic acid amplifier capable of efficiently performing PCR even with the use of nucleic acid synthetase lacking heat resistance, which nucleic acid amplifier can realize nucleic acid synthetase reutilization, scaleup, etc. and facili...
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WO/2005/003395A1 |
Methods and systems for performing continuous amplification of RNA and other nucleic acids are provided. Expression profiling using the continuous flow RNA amplification systems are also provided.
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WO/2005/002730A1 |
A microfluidic device and method for the monitoring, manipulation and/or detection of chemical and biological samples wherein an aqueous reaction mixture comprising a sample is introduced into a volume of a carrier fluid immiscible with ...
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WO/2005/001437A1 |
The invention relates to the processing of a biological sample for histological analysis. In particular, it relates to a rapid automated processing system that can be operated with continuous throughput and that eliminates the use of tox...
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WO/2004/108288A1 |
An apparatus and method for rapid thermal cycling including a thermal diffusivity plate. The thermal diffusivity plate can provide substantial temperature uniformity throughout the thermal block assembly during thermal cycling by a therm...
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WO/2004/108287A1 |
An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The micr...
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WO/2004/105934A1 |
In a multi-station reaction apparatus (1) comprising an annular heat transfer block (30) formed with a plurality of cavities (31) for receiving respective reaction vessels (36), the upper surface of the heat transfer block (30) has a cen...
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WO/2004/105947A2 |
Individual temperature control in multiple reactions performed simultaneously in a spatial array such as a multi-well plate is achieved by thermoelectric modules with individual control, with each module supplying heat to or drawing heat...
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WO/2004/106546A1 |
The single nucleotide polymorphism (SNP) analysis involves the utilization of a DNA hybridization as well as the use of a DNA chip. A liquid DNA sample to be analyzed is guided over a DNA chip in a defined time course. After successful h...
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WO/2004/104547A2 |
A fluorescence detection apparatus for analyzing samples located in a plurality of wells in a thermal cycler and methods of use are provided. In one embodiment, the apparatus includes a support structure attachable to the thermal cycler ...
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WO/2004/104228A1 |
The use of microfluidic structures enables high throughput screening of protein crystallization. In one embodiment, an integrated combinatoric mixing chip allows for precise metering of reagents to rapidly create a large number of potent...
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WO/2004/102088A1 |
The present invention relates to a method and apparatus for the batch or semi-batch freezing of a large volume of liquid and particularly, but not exclusively, to a method and apparatus for the batch or semi-batch freezing of a large v...
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WO/2004/097370A2 |
A system operable to monitoring bio/chemical activities includes a first measurement probe, a second measurement probe and a comparator. The first measurement probe is operable to interrogate one or more physical properties of a sample a...
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WO/2004/094059A1 |
Disclosed is a biochip for analyzing nucleic acid samples, comprising a support that is provided with a top face, a bottom face, and a support member. Reaction zones for synthesizing or fixing oligonucleotide probes are configured on the...
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WO/2004/089545A1 |
A DNA analysis system 10 includes a thermal cycler 12 operable as an extraction stage for extracting DNA from a sample to be tested and an as amplification stage for replicating identically a region of interest in DNA strands extracted f...
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WO/2004/089810A2 |
A variety of elastomeric-based microfluidic devices and methods for using and manufacturing such devices are provided. Certain of the devices have arrays of reaction sites to facilitate high throughput analyses. Some devices also include...
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WO/2004/089534A2 |
Refluxing means (30) of a refluxing head (3) for use with a multi-station reaction apparatus (1) comprise an array of frusto-conical cooled members (31) each having a slanted end face (33). The refluxing head may include a device (306) f...
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WO/2004/087323A1 |
Multi-array systems useful for performing assays on multiple biomolecule arrays simultaneously while minimizing sample volume are provided. Apparatuses and kits comprising the multi-array systems also provided. Methods of using the multi...
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WO/2004/087951A2 |
The invention relates to a device for the multiplication and detection of nucleic acids, comprising a temperature controller and/or regulation unit, a reaction chamber, containing a substrate with a detection surface on which a substance...
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WO/2004/088291A1 |
The present invention relates to an apparatus for real-time monitoring chemical reaction between various biomaterials. More particularly, the present invention directed to a real-time monitoring apparatus for biochemical reaction, which ...
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WO/2004/086000A1 |
An incubator provided with incubator sections (12) adapted to thermally insulate samples at an arbitrary processing temperature by thermally insulating well racks (14) containing samples therein at the mentioned temperature, cooling sect...
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WO/2004/085134A1 |
Disposable units in current use for performing PCR are limited by their heat block rates and by the thermal diffusion delay time through the plastic wall as well as by the sample itself. This limition has been overcome by forming a dispo...
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WO/2004/085065A1 |
A method and apparatus for conducting a polymerase chain reaction process on a reaction mix to amplify a target template of DNA in the reaction mix, the method including at least one cycle having an denaturing phase, an annealing phase a...
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WO/2004/083824A1 |
The invention provides a manually operated or automated clamping means to seal a solid support substrate to a solid support cover creating a uniform environmental chamber above a specimen mounted to the support substrate. The clamping me...
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WO/2004/083443A1 |
Methods and systems for performing single molecule amplification for detection, quantification and statistical analysis of rare nucleic acids are provided.
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WO/2004/079002A1 |
This invention relates generally to the field of nucleic acid detection. In particular, the invention provides a lab-on-chip system for analyzing a nucleic acid, which system comprises, inter alia, controllably closed space, and a target...
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WO/2004/074818A2 |
A system for holding at least one of sample and reagent for analysis. The system includes a pair of parallel covers (22, 23), at least one of which is light transmissive, of which pair a light transmissive cover forms a top (22), and of ...
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WO/2004/073863A2 |
Method and apparatus for performing controlled performance of reactions, the apparatus comprising at least one channel for receiving a substance, the channel having a first end and a second end, and at least one treatment zone intermedia...
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WO/2004/071665A1 |
A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the ...
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WO/2004/069412A1 |
A microfluidic device (90) for analysis of a sample. The microfluidic device includes a substrate portion (94) that at least partially defines a chamber (102) for receiving the sample. The substrate portion (94) includes a substrate (98)...
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WO/2004/067444A1 |
A microfluidic device comprising one, two, three or more enclosed microchannel structures, each of which comprises a) an inlet arrangement with an inlet opening for liquid, b) a reaction microcavity (RM1) downstream to the inlet opening,...
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