| Document |
Document Title |
|
JP5426556B2 |
|
|
JP5427167B2 |
The present invention relates to titanium catalysts for asymmetric synthesis reactions produced by bringing a reaction mixture obtained by contacting water and a titanium alkoxide into contact with an optically active ligand represented ...
|
|
JP5420549B2 |
The present invention describes a new process for the preparation of (poly)aminoalkylaminoacetamide compounds of epipodophyllotoxin useful for their applications in therapeutics as anticancer agents. This process comprises a step of cond...
|
|
JP5420658B2 |
The present invention relates to cinchona-based bifunctional organocatalysts and methods for preparing chiral hemiesters using the same. More specifically, the present invention relates to methods for preparing chiral hemiesters from pro...
|
|
JP5417560B2 |
|
|
JP5415448B2 |
Diastereoselective conversion of chiral imines of the formula I to amines of the formula II where the R1 to R4 radicals are each as defined in the description and R1 and R2 are different than one another, by converting the imine of the f...
|
|
JP5411850B2 |
The present invention relates to methods of making compounds that inhibit 11-hydroxysteroid dehydrogenase type 1 enzyme (11-HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the pres...
|
|
JP5408662B2 |
Hexamethylphosphoramide (HMPA) was added to a reaction vessel containing (R)-1,1'-binaphthyl-2,2'-dithiol and potassium hydroxide. The vessel was purged with oxygen and stirred at 80°C for 5 days under 7 atmospheres of oxygen. After bei...
|
|
JP5406524B2 |
A compound of the formula I or I′, where the radicals R1 are each, independently of one another, a hydrogen atom or C1-C4-alkyl and R′1 is C1-C4-alkyl; X1 and X2 are each, independently of one another, a sec-phosphino group; R2 is (1...
|
|
JP5410677B2 |
There are provided a process for preparing an optically active aminopentane derivative that is promising as a psychotropic agent, an antidepressant agent, an antiparkinsonian agent, an anti-Alzheimer's agent, an apoptosis inhibitor, or t...
|
|
JP5400030B2 |
The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase I...
|
|
JP5398983B2 |
The purpose of this invention is: new selenohydroxy acid compounds and their derivatives; their process for the preparation; use of the new compounds as precursors of L(+)-selenomethionine and/or source of selenium in human or animal nut...
|
|
JP5399902B2 |
The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthes...
|
|
JP5399711B2 |
The invention relates to a new process for the synthesis of high purity 17α-cyanomethyl-17β-hydroxy-estra-4,9-diene-3-one (further on dienogest) of formula (I) from 3-methoxy-17-hydroxy-estra-2,5(10)-diene of formula (V). The invention...
|
|
JP5403762B2 |
The invention provides 3-carboxypropyl-aminotetralin compounds of formula (I): wherein R1, R2, R3, R4, R5, and R6 are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are antagonists at the mu opioid rece...
|
|
JP5396578B2 |
A chiral tetraaminophosphonium salt represented by formula (1) and a method for producing chiral β-nitroalcohol comprising reacting an aldehyde or a ketone and a nitroalkane in the presence of the chiral tetraaminophosphonium salt repre...
|
|
JP5392217B2 |
|
|
JP5397907B2 |
|
|
JP5396841B2 |
±-trifluoromethyl-²-substituted-²-amino acids can be produced by allowing ±-trifluoromethyl-²-substituted-±,²-unsaturated esters to react with hydroxylamine to convert ±-trifluoromethyl-²-substituted-±,²-unsaturated esters int...
|
|
JP2014005257A |
To provide an enzyme enantioselective method for producing a monofluoromethyl substituted indole compound.A high enantioselective conjugate addition reaction from a carbanion of a fluorobis(phenylsulfonyl)methane to a 3-(arenesulfonylmet...
|
|
JP5388294B2 |
|
|
JP5389164B2 |
The invention relates to a novel class of ruthenium complexes containing phosphine and hybrid amine ligands, their preparation and use as catalysts in the reduction of simple ketones to alcohols by molecular hydrogenation. The reactivity...
|
|
JP2014001177A |
To provide a catalytic enantioselective production method of a trifluoromethyl-substituted pyrroline having an asymmetric tetrasubstituted carbon.A highly enantioselective conjugate addition reaction of a cyano anion from a cyanohydrin t...
|
|
JP5382350B2 |
There is provided a novel optically active dinickel complex and/or a production method of an optically active amine by an asymmetric Mannich reaction using the dinickel complex as a catalyst. An optically active dinickel complex of Formu...
|
|
JP5383203B2 |
Preparation of L- and/or D-methionine from homoserine involves chemically converting L- and/or D-homoserine to methionine without an N-carbamoylserine, 4-(2-bromomethyl)-hydantoin and 4-(2-methylthioethyl)-hydantoin intermediate stage. P...
|
|
JP5377285B2 |
This invention provides amines that include the 1,2,3,4-tetrahydro-1-naphthalenamine substructure.
|
|
JP5378837B2 |
To provide a method for easily and economically manufacturing an optically active bis(alkylphosphino)methane. The manufacturing method comprises a step A of oxidizing a dialkylhydroxymethylphosphineborane (2) to obtain a dialkylphosphine...
|
|
JP5379523B2 |
To provide a method for producing a cyclohexyl alkanol which can impart the floral fragrance having creamy sweetness possessed by natural flowers and much includes a cis-form isomer and a perfume composition containing the cyclohexyl alk...
|
|
JP5371239B2 |
To provide a new iodide, and an oxidative method for forming an asymmetric spiro-ring using the same. The iodide represented by formula (I) or its salt, and the iodide represented by formula (II) or its salt are disclosed. The oxidative ...
|
|
JP5369853B2 |
By reacting a ²-hydroxy-±-amino acid with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base, it is possible to produce an ±-fluoro-²-amino acid of the formula [2]. By using a C8-12 tertiary amine having two or more alk...
|
|
JP2013245215A |
To provide a method for optically actively producing bicyclic γ-amino acid derivatives and pharmaceutically acceptable salts thereof, in particular compounds and intermediates thereof having activity as an α2δ ligand.Optically active ...
|
|
JP5360801B2 |
To provide a method for producing a derivative from a cyclic olefin compound in a high yield with high optical selectivity by a simple operation with low-cost, low-risk, and mild conditions. The method for producing an optically active c...
|
|
JP5361904B2 |
The invention relates to a process for the preparation of (S)-2-amino-1-propanol (L-alaninol) from (S)-1-methoxy-2-propylamine via the hydrochloride of (S)-2-amino-1-propanol and subsequent work-up.
|
|
JP5359252B2 |
Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO 2 F 2 ) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active ±-h...
|
|
JP5357756B2 |
The present invention relates to an improved process for the preparation of 3-[(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
|
|
JP2013237674A |
To provide a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives which are useful in the asymmetric synthesis of biologically active molecules.A process comprises an enantioselective hydrogenati...
|
|
JP5350767B2 |
An object of the present invention is to provide an optically active phosphine-borane compound and a method for producing the same which are useful for the production of an optically active phosphine ligand and allow easy production of a...
|
|
JP5352086B2 |
Optically active cyclic amines of the formula (I) or salts thereof in which A, R0, R are each as defined in claim 1, and R0 and A, or R and A, or R0 and R may also form rings, where R and the NH—R0 group on the two ring carbon atoms ma...
|
|
JP5352478B2 |
A process for the enantioselective preparation of (2 R ,3 S )-3-phenylisoserine methyl ester acetate salt of formula (I) which is an useful building block for the synthesis of taxane derivatives. The process involves the resolution of ra...
|
|
JP5351157B2 |
A process for preparing a compound of formula 1 , having the chemical name 3- endo -(8-azabicyclo[3.2.1]oct-3-yl)benzamide, or a salt thereof: the process comprising hydrogenating a compound of formula 2, having the chemical name 3-(8-az...
|
|
JP5353046B2 |
A method of producing an optically active cyanohydrin compound represented by formula (3) (wherein, Q 1 and Q 2 are as defined below, and * represents that the indicated carbon atom is the optically active center) comprising reacting an ...
|
|
JP5344523B2 |
According to the invention, a catalyst for a strecker reaction comprising a quaternary ammonium salt and a method for stereoselectively producing an a-aminonitrile derivative using the same are provided. By using the a-aminonitrile deriv...
|
|
JP5345932B2 |
The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruth...
|
|
JP5344176B2 |
An optically active sulfoxide compound that is useful as an intermediate for synthesis or an active ingredient of a physiologically active substance such as a pharmaceutical agent is produced at a high optical purity. A process for produ...
|
|
JP5346434B2 |
To provide a method for commercially advantageously preparing a β,β-bishetero-substituted optically active alcohol from the corresponding α,α-bishetero-substituted carbonyl compound by using an easily available ruthenium compound as ...
|
|
JP5343925B2 |
A process for the preparation of (2R)-2-propyloctanoic acid which is characterized by subjecting (2S)-2-(2-propynyl)octanoic acid or (2S)-2-(2-propenyl)octanoic acid to reduction using platinum on carbon. This process gives (2R)-2-propyl...
|
|
JP5334435B2 |
To produce an optically active amino acid ester derivative using an aldehyde group-having amino aldehyde derivative as a raw material for a kinetic optical resolution method. Provided is a method for producing an optically active amino a...
|
|
JP5329462B2 |
To provide a method for synthesizing an optically active dicarboxylic acid derivative. The method for synthesizing an optically active dicarboxylic acid derivative comprises allowing an α, β-unsaturated carbonyl compound and a compound...
|
|
JP5320283B2 |
Compounds of the formula I in the form of enantiomerically pure diastereomers or a mixture of diastereomers, (I), where the radicals R1 are identical or different and are each C1-C4-alkyl; m is 0 or an integer from 1 to 3; n is 0 or an i...
|
|
JP5315496B2 |
To provide 1,2,4,5-cyclohexane tetracarboxylic acid dianhydride having high polymerization capability as a raw material of a polyimide. The compound 1,2,4,5-cyclohexane tetracarboxylic acid dianhydride is subjected to selective isomeriza...
|
