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JP2014514273A |
Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X1, X2, R3 and R4 are as defined herein. Compounds made by the process of the ...
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JP5523833B2 |
Solid forms comprising 4-[9-(tetrahydro-furan-3-yl)-8-(2,4,6-trifluoro- phenylamino)-9 H- purin-2-ylamino]-cyclohexan-1-ol, compositions comprising the solid forms, methods of making the solid forms and methods of their use for the treat...
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JP5514942B1 |
A method for producing a compound represented by General Formula (1), the method including: reacting a compound represented by General Formula (3) and a compound represented by General Formula (4): where R 1 and R 2 each represent alipha...
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JP5505648B2 |
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JP5502750B2 |
A process for preparing amines of the formula I, by reacting a carbonyl compound of the formula II with an amine of the formula III where R1 and R2 are different and are each an organic radical which has from 1 to 20 carbon atoms and may...
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JP5501701B2 |
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JP5507499B2 |
Provided are a novel 1,2-bis(dialkylphosphino)-4,5-(methylenedioxy)benzene derivative that forms a metal complex having particularly high asymmetry induction capacity and catalytic activity on β-dehydroamino acids, a method for manufact...
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JP5503670B2 |
A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]p
ropan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride o...
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JP5507081B2 |
A method for preparing an enantiomeric chromane, by asymmetrically hydrogenating a chromene compound in the presence of an Ir catalyst having a chiral ligand. The method includes the enantioselective preparation of enantiomeric equol. A ...
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JP5507285B2 |
Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated ±-keto ester with an acyl alkenyl ether in the presence of a...
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JP5500343B2 |
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JP5495618B2 |
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JP5491854B2 |
Disclosed is a method for producing an alcohol from a lactone or a carboxylic acid ester, which enables to produce an alcohol from a lactone or a carboxylic acid ester under relatively mild conditions with high yield and high catalytic e...
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JP5490155B2 |
The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity...
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JP5487425B2 |
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JP5487692B2 |
The present invention provides a compound having a heterocyclic skeleton, which is represented by of the formula (I) : wherein R 1 and R 2 are the same or different and each is a lower alkyl group optionally having substituent(s), an ara...
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JP5476299B2 |
The present invention relates to a process for preparing racemic or optically active menthol by catalytically hydrogenating racemic or optically active isopulegol in the presence of hydrogen and catalysts which comprise nickel-, copper-,...
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JP5479572B2 |
or a salt thereof.
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JP5479320B2 |
The present invention relates to a process for preparing optically active carbonyl compounds by asymmetrically hydrogenating α,β-unsaturated carbonyl compounds in the presence of optically active transition metal catalysts which are so...
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JP5479368B2 |
The present invention relates to a method of preparation of an optically active cyclohexenone derivative of Formula (I) OR1R2*R1 and wherein R1 and R2 are organic residues.
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JP5476895B2 |
In the present invention, a hydroxyl group substitution product is manufactured by reaction of an alcohol with sulfuryl fluoride (SO 2 F 2 ) in the presence of an organic base and a nucleophile (X - ). The present invention is thus effec...
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JP5482200B2 |
Disclosed is a method for highly efficiently obtaining an optically active alcohol from a carbonyl compound highly enantioselectively. Also disclosed is a ligand used in such a method. Specifically, an optically active alcohol is obtaine...
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JP2014509592A |
The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are...
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JP5473900B2 |
The invention relates to ruthenium complexes with a chiral ferrocenyldiphosphine ligand, wherein the ruthenium has the oxidation state (+II) and the chiral ferrocenyldiphosphine ligand has bidentate P-P coordination to the ruthenium. The...
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JP5466152B2 |
The present application is directed to i) a method for synthesizing aminophosphine (P,N) and phosphine-aminophosphine (P,N,P) ligands, ii) the use of such ligands in the preparation of metal complexes as hydrogenation catalysts, and iii)...
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JP5467260B2 |
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JP5464444B2 |
Disclosed is a process for producing carnosic acid (the major antioxidant active substance contained in a rosemary plant) with high efficiency by carrying out the ortho-position oxidation of a phenol with an oxidizing agent (e.g., 2-iodo...
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JP5465584B2 |
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JP5466725B2 |
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JP5462899B2 |
A process for the preparation of beta -amino alcohols in syn configuration as represented by the general formula (2): R>ab<)-R>c< [wherein R>a< and R>c< are each optionally substituted alkyl or the like; R>b< is a group se...
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JP5460947B2 |
The present invention provides a novel process for preparing pleuromutilin derivatives, novel salts of mutilin 14-(exo-8-methyl-8-azabicyclo[3.2.1]oct-3-ylsulfanyl)-acetat
e or solvates thereof, novel pharmaceutical compositions or formu...
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JP5458303B2 |
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JP5458528B2 |
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JP2014055179A |
To provide processes and intermediate compounds useful for production of (+)-opiates.The invention generally provides processes and intermediate compounds useful for production of (+) nal morphinan compounds. In particular, the process e...
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JP5451404B2 |
This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-ph
enyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmace...
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JP5453003B2 |
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JP5455627B2 |
The invention relates to a process for producing a compound according to formula (i) wherein R1 and R1' are independently hydrogen or an amine protecting group and R2 is a carboxylic group or derivative thereof, comprising reacting a com...
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JP5451209B2 |
Esters and lactones can be respectively reduced to alcohols and diols in the presence of the Group 8 (VIII) transition metal complex, base and hydrogen gas (H 2 ). An extremely practical reduction method can be provided by preferable com...
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JP5454756B2 |
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JP5450056B2 |
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JP2014051492A |
To provide a process for industrially producing compounds (1a) which are useful as inhibitors of activated blood coagulation factor X.Hydrazide derivative compounds (4) are obtained by condensing carboxylic acid derivatives, which are ob...
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JP5439384B2 |
The present invention relates to a new process for the preparation of macrocyclic HCV protease inhibitor compounds of the formula wherein R1 is an amino protecting group and X is halogen by way of a ring closing metathesis approach.
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JP5438976B2 |
The objective of the present invention is to produce an optically active 2-arylpiperazine derivative useful as a synthetic intermediate for pharmaceutical products and agricultural chemicals from inexpensive and readily available startin...
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JP2014040457A |
To provide a method of high efficiency and high enantioselectivity for manufacturing an optically active alcohol from a carbonyl compound, and to provide a ligand used therefor.An optically active alcohol is obtained by reacting a carbon...
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JP2014040476A |
To provide a method of manufacturing a chiral organic compound by an asymmetric contact with using an ionic catalyst containing a chiral catalytic anion.The method is suitable for performing reactions progressing through a cationic inter...
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JP5432895B2 |
Provided is a process in which cyclization of a compound having, in a molecule, a formyl group and a double bond which allow carbonyl-ene cyclization, the compound existing as a mixture of optical isomers thereof, increases the ratio of ...
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JP5431496B2 |
Methods for producing a compound of formula k1 or k2 by reducing a dihydronapthalene amide compound of formula i with hydrogen gas in the presence of a ruthenium catalyst of formula j1 or j2 Ru(Z)2(L) j1; Ru(E)(E′)(L)(D) j2; ...
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JP2014037369A |
To provide a method of manufacturing a cyclized addition product by Diels-Alder reaction using catalyst applicable to various substrates and having high activity.Diels-Alder reaction of conjugated diene and dienophile is performed in the...
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JP5425402B2 |
Improved processes for the preparation and purification of maytansinoid esters, especially thiol and disulfide-containing maytansinoids are described. In one aspect the process comprises a process of making a maytansinoid ester comprisin...
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JP5426556B2 |
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