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JP5119149B2 |
The present invention relates to a cyclohexanone derivative of formula in the form of any one of its isomers or mixture thereof. The invention concerns also the preparation and the use of this derivative. The compounds of the invention a...
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JP5121346B2 |
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JP5122956B2 |
This invention relates to asymmetric hydroformylation processes in which a prochiral or chiral olefin is reacted with carbon monoxide and hydrogen in the presence of an optically active metal-ligand complex catalyst to produce an optical...
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JP5120962B2 |
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JP2013500949A |
The present invention relates to an imidazole-containing phosphinobolan compound, an optically active ligand produced using the imidazole compound, a transition metal complex containing such a ligand, and a catalyst containing such a tra...
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JP2013500971A |
Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
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JP5112881B2 |
The present invention concerns a metallocene-based phosphine ligand for use in enantioselective catalysis, the ligand having the Formula (I): Wherein M is a metal; Z is P or As; L is a suitable linker; R1 is selected from alkyl, alkoxy, ...
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JP5112583B2 |
Methods of synthesizing pure enantiomers of acylanalides such as Casodex(R) (bicalutamide) and its derivatives utilizing a compound having a ring structure that, when opened, provides a substituent having the structure of Formula I: wher...
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JP5116694B2 |
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JP5115884B2 |
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JP5112670B2 |
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JP2012533618A |
A process for making a capecitabine or its derivative comprising (a) reacting a compound of the formula (II): wherein each of R1 and R2 independently represents a hydroxyl protecting group, with an acylating agent of formula (III): X—C...
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JP5107286B2 |
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JP5108777B2 |
The present invention discloses an optically active quarternary ammonium salt having axial asymmetry and a method for producing an α-amino acid and a derivative thereof using the same. The optically active quarternary ammonium salt havi...
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JP5107382B2 |
Preparing tetrahydro-benzo[d]azepin-2-one compounds (A) comprises: reacting 3-(7,8-dimethoxy-2-oxo-1,2,4,5-tetrahydro-benzo[d]azepin-3-y
l)-propionitrile (VIII) with (3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylmethyl)
-methyl-am...
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JP5109116B2 |
To provide an optically active macrocyclic compound having high discrimination potency and excellent versatility function, a method for producing the compound and uses of the compound. The invention provides an optically macrocyclic comp...
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JP5108383B2 |
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JP5108017B2 |
The present invention relates to a process for the preparation of Nebivolol and, more particularly, to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.
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JP5108888B2 |
The present invention provides a method for producing an optically active N-(halopropyl)amino acid derivative, wherein the method comprises the steps of obtaining a compound represented by formula (III) by reacting an optically active al...
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JP5107381B2 |
Preparing 3-{3-[(3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-trien-7-ylm
ethyl)-methyl-amino]-propyl}-7,8-dimethoxy-1,3,4,5-tetrahydr
o-benzo[d]azepin-2-one (VIII) comprises: reacting 3,4-dimethoxy-bicyclo[4.2.0]octa-1(6),2,4-triene-7-carb...
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JP5099932B2 |
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JP5100588B2 |
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JP5094397B2 |
A process for producing an optically active 2-hydroxybutyric ester (1), characterized by including reacting an optically active 2,3-epoxybutyric ester (2) with a thiol in the presence of scandium trifluoromethanesulfonate or ytterbium tr...
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JP5097607B2 |
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JP5094392B2 |
To provide a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity. The process for producing an optically active 2-hydroxybutyric ester (1), characterized in that the process includes rea...
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JP2012240959A |
To create a simple and highly enantioselective synthetic method for a precursor capable of easily being converted to an optically active β-aminothiol and β-aminosulfonic acid.This method for synthesizing an optically active β-aminothi...
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JP2012236798A |
To provide a method for economically producing 1-menthyl (3R)-3-hydroxybutanoate in high enantiomeric excess at a low cost.The 1-menthyl (3R)-3-hydroxybutanoate can economically be produced in higher enantiomeric excess at a low cost by ...
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JP2012236799A |
To provide a method for economically producing 1-menthyl (3R)-3-hydroxybutanoate in higher enantiomeric excess at a lower cost.The 1-menthyl (3R)-3-hydroxybutanoate can economically be produced in the higher enantiomeric excess at a lowe...
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JP2012236818A |
To provide a new method for producing amine compounds regardless of the presence of inorganic salts.The method for producing an amine compounds (5) includes the following steps. Step (1), a step in which R-Mg-X1 is reacted with X2-Zn-X2;...
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JP5091680B2 |
To provide a process and an apparatus by means of which a composition that contains episesamin in a concentration greater than 50 wt% on the basis of the sum weight of sesamin and episesamin can be produced conveniently and at high yield...
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JP5091485B2 |
A tert-alkyl ketone, pinacolone was hydrogenated under pressurized hydrogen in the presence of a ruthenium complex (S)-1 and a base, and corresponding (S)-3,3,-dimethyl-2-butanol was thereby obtained in 100% yield and 97% ee.
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JP5087395B2 |
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JP5090926B2 |
The invention relates to the (stereoselective) hydrogenation of carbon-carbon double bonds in compounds having at least one such bond, e.g., isoprenoids, non-cyclic sesquiterpenes, tocomonoenols, tocodienols, tocotrienols or derivatives ...
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JP5090773B2 |
An optically active, fluorine-containing carbonyl-ene product is produced by reacting a fluorine-containing ±-ketoester with an alkene in the presence of a transition metal complex having an optically active ligand. There are Mode 1 of ...
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JP2012530116A |
A process for producing bortezomib N-(pyrazin-2-yl)carbonyl-L-phenylalanine-L-leucine boronic acid) comprising the step of deprotecting the compound of formula XII: to yield bortezomib.
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JP2012530115A |
The present invention is generally related to the field of organic chemistry, especially to the preparation of α-aminoboronic acid derivatives.
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JP5083868B2 |
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JP5082382B2 |
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JP5086081B2 |
A stereoselective method for preparing a chiral fluorinated molecule by converting a compound having a -OSOF group, a fluorosulfite, attached to a chiral carbon atom into a fluorinated compound by replacing the -OSOF group attached the c...
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JP5084717B2 |
The present invention describes a heterogeneous chiral catalyst comprising a heterogeneous chiral catalyst precursor complexed with a metal species. The precursor comprises a chiral bisoxazoline group coupled to an inorganic substrate. T...
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JP2012229223A |
To provide an ecological and economical method for preparing enantiomerically pure 1-substituted-3-aminoalcohols represented by the formulae, particularly (S)-(-)- and (R)-(+)-3-N-methylamino-1-(2-thienyl)-1-propanol.The method comprises...
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JP5078244B2 |
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JP5077797B2 |
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JP5081163B2 |
This invention relates to processes and intermediates for the stereoselective alkylation of carbonyl groups. The invention in particular allows the stereoselective preparation of the antidepressant drug escitalopram. It has been found th...
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JP5078612B2 |
The present invention provides a method to prepare anti-HCV nucleosides containing the 2-deoxy-2-fluoro-2-C-methyl-²-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
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JP5080050B2 |
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JP2012528851A |
The present invention relates to novel intermediate compounds used in preparing Rosuvastatin or the pharmaceutically acceptable salts thereof, to a method for preparing same, and to a method for preparing Rosuvastatin or the pharmaceutic...
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JP2012217375A |
To provide a method for producing amino alcohols having high chemical purity and optical purity.The method for producing an amino alcohol includes reducing a cyanohydrin compound represented by general formula (1) (wherein Py is 2-pyridy...
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JP2012527409A |
Disclosed are a pyrethroid compound, a preparation process and the use thereof, wherein the compound is a stereoisomer of 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl-3-(3,3,3-trifluoro
-1-propenyl)-2,2-dimethylcyclopropanecarboxylate. The ...
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JP5068960B2 |
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