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JP5639895B2 |
The invention is directed to a method to reduce a C-C double bond of an enone of a steroidal compound to produce a mixture of beta ketone product and alpha ketone product, comprising treating a solution or suspension of the steroidal com...
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JP5636054B2 |
A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represent...
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JP5607102B2 |
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JP5605008B2 |
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JP5605716B2 |
Disclosed is a method for producing an optically active 2-hydroxy ester, comprising selectively esterifying one enantiomer of a racemic 2-hydroxy ester in a solvent containing a catalyst such as tetramisole or benzotetramisole, and a car...
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JP5608636B2 |
Disclosed is a method for producing an optically active alcohol including reacting a titanium compound, an aromatic magnesium compound and a carbonyl compound in the presence of an optically active biphenol compound having a predetermine...
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JP5607103B2 |
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JP5603998B2 |
The present invention is a process comprising contacting a compound of formula 6: or a pharmaceutically acceptable salt thereof; with a deprotecting reagent to form a compound of formula A: or a pharmaceutically acceptable salt thereof; ...
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JP5597687B2 |
Provide that a useful catalyst for homogeneous hydrogenation, particularly a catalyst for homogeneous asymmetric hydrogenation for hydrogenation, particularly asymmetric hydrogenation, which is obtainable with comparative case and is exc...
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JP5599664B2 |
An industrially advantageous method for producing an optically active 1,2-bis(dialkylphosphino)benzene derivative of the present invention is provided. The method is characterized in that a phosphine-borane compound represented by the fo...
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JP5593342B2 |
The invention relates to a process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel ( I ) a synthon useful for the preparation of taxanes with antitumour activity, and intermediates for the preparation thereof. The invention als...
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JP2014169252A |
To provide a new method of producing optically active β-formyl-β-hydroxy-α-substituted aldehyde compounds.A method of producing an optically active β-formyl-β-hydroxy-α-substituted aldehyde compound (2) includes the step of making ...
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JP2014523911A |
Disclosed are compounds based on ibuprofen, their preparation methods, uses and pharmaceutical preparation. The compounds have structures shown as formula (1), wherein, m, n are integers and fulfill the requirements of 0≰n≰6, 0≰mâ‰...
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JP5592893B2 |
The present invention is directed to a novel process for the preparation of protected L-alanine derivatives, useful as intermediates in the synthesis of compounds useful as mu/delta opioid modulators.
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JP5585979B2 |
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JP2014162747A |
To provide a new asymmetric organic catalyst that can achieve a high optical activity yield and is easily available.A compound called as an aminomethylene malononitrile derivative is provided, which is expressed by general formula (IA) o...
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JP5584233B2 |
Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
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JP2014151285A |
To create a simple and highly enantioselective synthetic method for a precursor capable of easily being converted to an optically active β-aminothiol and β-aminosulfonic acid.There is provided a method for synthesizing an optically act...
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JP5576791B2 |
The present application relates to a method for producing an optically active ±-amino acid derivative, comprising steps of reacting an ±-haloester derivative represented by the general formula (1): of which alcohol part of the ester gr...
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JP5573030B2 |
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JP5566103B2 |
The invention relates to a method for producing optically active 3-aminocarboxylic acid ester compounds. According to said method, an enantiomer mixture of a mono-N-acylated 3-aminocarboxylic acid ester, which mixture was previously enri...
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JP5568299B2 |
A novel process for preparing a compound of formula (I) which comprises converting a compound of formula (II) to a compound of formula (I) via a compound of formula (III), or a salt thereof, without isolating any intermediates.
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JP5566372B2 |
The present invention belongs to a spiro phosphine-oxazoline and preparation method and application thereof, particularly, publishes a novel spiro phosphine-oxazoline and the preparation method of its iridium complex. The substituted 7-d...
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JP5560464B2 |
The present invention provides a catalyst used for manufacturing an optically active carbonyl compound by selective asymmetric hydrogenation of an ±, ²-unsaturated carbonyl compound, which is insoluble in a reaction mixture, and a meth...
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JP5563324B2 |
To provide a maxacalcitol intermediate and a process for producing the same. There are provided a chiral compound of formula (I) and a chiral compound of formula (II) in which the C-20 position is an R-form or S-form, and a process for p...
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JP5564506B2 |
To provide a process for increasing the proportion of an optical isomer of not only a compound having a closed ring but also a compound not having a closed ring when an optical isomer mixture of a compound having both a formyl group and ...
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JP5561564B2 |
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JP5561577B2 |
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JP5557460B2 |
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JP5554887B2 |
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JP5557183B2 |
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JP5559767B2 |
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JP5554698B2 |
The invention relates to a process for the preparation of N-protected alpha-aminoaldehydes by deacetalization of the acetal functional group of corresponding N-protected alpha-aminoacetals using formic acid.
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JP5557278B2 |
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JP5554888B2 |
A method for preparing cyclopentanones or lactones is provided to be useful for preparation of prostagladins, to remove problems such as the long synthesis route and the removal of undesired isomers, and thus achieves a simple and econom...
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JP2014131971A |
To provide an asymmetric catalytic production method of δ-amino-γ-butenolide having an optically-active asymmetric tetrasubstituted carbon using proper asymmetric catalyst.A δ-amino-γ-butenolide having an optically-active asymmetric ...
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JP5548129B2 |
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JP5552716B2 |
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JP5550639B2 |
The invention relates to a novel process for the preparation of C-4 coupled flavonoids, proanthocyanidins and analogues thereof. According to a specific application of the invention, there is provided a method for the preparation of proa...
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JP5547271B2 |
The present invention relates to compounds of formula I wherein R1a to R1e, R2, R3 and R5 are as defined in the description and claims and R4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically accep...
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JP5542868B2 |
To provide a bisoxazoline catalyst that provides for easy separation of the catalyst from products and provides good enantioselectivity and reactivity.There is provided a heterogeneous chiral catalyst containing a heterogeneous chiral ca...
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JP5546294B2 |
To provide an axially asymmetric optically active biarylphosphorus compound that can easily produced without the step of optical resolution which was almost indispensable in conventional methods. [Means for solving the problems] A method...
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JP5546788B2 |
The present invention provides a cooling component or sensate component which does not have undesirable stimulus feeling, bitterness and the like and is excellent in the persistence of refresh-feeling and cool-feeling, a sensate composit...
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JP2014122169A |
To provide an asymmetric conjugate addition reaction of nitromethane to a β-aryl-β-trifluoromethyl enone, and a catalytic enantioselective production method of a trifluoromethyl substituted diarylpyrroline or an N-oxide thereof.A high-...
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JP5538224B2 |
Disclosed is the method for producing an optically active BSH amino acid, which comprises a step of reacting an optically active ±-amino acid derivative having a halogen in a side chain with a cyanoethyl BSH compound represented by form...
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JP5536541B2 |
There are provided a novel ruthenium-diamine complex, and methods for selectively producing an optically active alcohol and an optically active amine, which are important as precursors for the synthesis of medicinal drugs and functional ...
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JP5538542B2 |
The present invention relates to the use of a compound of formula I wherein R1, R2, R3, R4, X and n are as defined herein or to a pharmaceutically acceptable acid addition salt, to a racemic mixture, or to its corresponding enantiomers a...
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JP2014114284A |
To provide a method of producing a C-3 substituted chiral succinimide which has mild conditions and simple operations, can achieve a good yield and efficiency, and exhibits better application effect.A 3-alkenylene group substituted succi...
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JP5530423B2 |
Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation ...
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JP5534131B2 |
A 2-fluoro-1,3-benzodithiol 1,1,3,3-tetraoxide derivative as a monofluoromethyl group introduction agent that is effective as an intermediate in pharmaceutical and agrochemical synthesis, a production method thereof, and a production met...
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