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JP4924814B2 |
There is provided a process for efficiently producing an anti form of an optically active ²-hydroxy-±-aminocarboxylic acid derivative that is useful as an intermediate for pharmaceuticals and agrochemicals. The process for producing op...
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JP4925410B2 |
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JP4922521B2 |
From compounds of formula II wherein R1 and R2 are independently of one another H, C1-C6alkyl, C1-C6halogenalkyl, C1-C6alkoxy, C1-C6alkoxy-C1-C6alkyl, or C1-C6alkoxy-C1-C6alkyloxy, R3 is C1-C6alkyl, R4 is C1-C6alkyl, and R5 is C1-C6alkyl...
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JP4919562B2 |
trans-RuH(eta<1>-BH4)[(S)-xylbinap][(S,S)-dpen] (0.00125 mmol), acetophenone (5.0 mmol), and 2-propanol (2.5 mL) were placed in an autoclave, and the resulting solution was repeatedly subject 5 times to a procedure of performing pressure...
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JP4918736B2 |
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JP4918257B2 |
The present invention is to provide a novel method for producing (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcar bonyl)propionic acid which is useful as a therapeutic agent for diabetes. The present invention relates to a method for pro...
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JP2012072171A |
To provide a method of producing rivastigmine, and the salts thereof which can be pharmaceutically permitted useful for treating diseases of Alzheimer's disease, Down syndrome, Huntington's chorea, Friedrich ataxia or the like.The method...
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JP2012508780A |
Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, VII and VIII:
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JP4913296B2 |
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JP4914827B2 |
The present invention provides a production intermediate for compound (A-1) and a method for producing the intermediate at high yield and high optical yield. The present invention provides a method for producing compound (3) characterize...
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JP4913077B2 |
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JP4915955B2 |
The present invention relates to marine ostracod crustacean luciferin stabilization composition comprising marine ostracod crustacean luciferin or an analog thereof and an ascorbic acid or salts thereof.
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JP4910186B2 |
A cyclopentadienyl ruthenium (II) complex or (iv) complex having an ±-imino acid type ligand or an ±-amino acid type ligand.
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JP4910150B2 |
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JP4909084B2 |
The present invention relates to the synthesis of chiral epoxides via a catalytic asymmetric oxidation of olefins. Additionally, the methodology provides a method of asymmetrically oxidizing sulfides and phosphines. This asymmetric oxida...
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JP4910148B2 |
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JP4911528B2 |
A silicon enolate represented by the following formula (Formula 1) (in the formula, R 5 to R 7 represent hydrogen atoms, aliphatic hydrocarbon groups, monocyclic or polycyclic alicyclic hydrocarbon groups, monocyclic or polycyclic aromat...
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JP2012507525A |
7-Hydroxy-benzoimidazole-4-yl-methanone Derivatives, which are useful for PBK inhibitors, are provided.
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JP4904945B2 |
There is provided a method for producing an optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative, which includes the steps of conducting reductive alkylation of an optical...
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JP4902952B2 |
Symmetric and asymmetric 6-alkoxy-6'-alkoxycarbonyl-alkoxy- and 6,6'-bis(alkoxycarbonyl-alkoxy)-biaryl-2,2'-diyl-bis(dialkyl
, diaryl and alkyl-aryl)phosphines (I), including their 5,5'-dichloro-analogs, are new. Symmetric and asymmetric...
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JP4900755B2 |
Compounds of formula (II) are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is converted into a hydroxylactone and then the hydroxy group into a leaving group, the le...
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JP4896350B2 |
The invention concerns diamines of general formula (I), wherein: A represents a group A1 or A2 of general formula (II); B represents a group B1 or B2 of general formula (III); X represents a SO2, CH2, C-O or COO; YZ represents a group of...
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JP4898062B2 |
The invention provides compounds of formula (I) wherein n, A, R1, R2 and R3 are as defined in the description, and the preparation thereof. The compounds of formula (I) are useful as pharmaceuticals.
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JP4893308B2 |
The present invention relates to a process for preparing an optically active (S or R)-²-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group, cycloalkyl group, aralkyl group, aryl...
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JP4889501B2 |
A novel production method for a phenylethanolamine compound of the following general formula (III): (wherein R 1 represents a hydrogen atom or a halogen atom; R 2 represents an alkyl group optionally substituted with an alkoxycarbonyl gr...
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JP4892674B2 |
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JP2012505258A |
To increase the purity of L-carnitine by detecting and controlling the content of chiral material and chiral intermediate in all steps of synthesizing L-carnitine starting from S-epichlorohydrin. To provide a method for preparing high-pu...
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JP4884656B2 |
Pyran compounds having exocyclic double bonds are new. Pyran compounds of formula (I) having exocyclic double bonds are new. [Image] a-e : 0 or 1; W : -CH 2- or -C(=O)-; R 11>H, 1-15 C alkyl optionally substituted by halo or CN and optio...
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JP4886753B2 |
This invention provides a method of making (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid (pregabalin) or a salt thereof via an asymmetric hydrogenation synthesis. Pregabalin is useful for the treatment and prevention of seizure disorders...
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JP4886967B2 |
One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acid group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronst...
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JP2012036161A |
To provide a method for producing an optically active trifluoromethylcyclopropane compound without using isolated trifluoromethyldiazomethane the handling of which is required to be cautious.This method for producing the optically active...
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JP4879896B2 |
The present invention provides a method for producing asymmetrical mono-substituted alkylated compounds of ±-amino acids that are represented by a specific formula, using an aldimine-type Schiff base. In the method of the present invent...
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JP4882050B2 |
Indene derivatives that are utilizable as intermediates in the synthesis of the vitamin D 2 derivative paricalcitol, which is useful as pharmaceutical are efficiently prepared by subjecting a vitamin D 2 derivative such as 25-hydroxyvita...
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JP4879740B2 |
This invention relates to intermediates useful in the preparation of opiate alkaloids, particularly morphinane compounds. The invention also relates to processes for preparing such intermediates and to processes which utilise such interm...
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JP2012021019A |
To provide small-molecule nonpeptide caspase inhibitors that are potent, stable, and penetrate membranes to generate effective inhibition of apoptosis in vivo.There is provided a compound of formula (I), wherein: R1 is R6C(O)-, HC(O)-, R...
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JP4859461B2 |
The present invention provides an industrially safe, easily operable process for producing an optically active epoxy alcohol derivative useful as an intermediate for pharmaceuticals from inexpensively available materials, and also provid...
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JP4860510B2 |
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JP4860509B2 |
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JP4861317B2 |
The invention relates to a method for producing enantiomers form of 2,3-diaminopropionic acid derivatives of formula (I) by asymmetric hydrogenation from compounds of formula (II).
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JP4861340B2 |
The present invention provides a process for the manufacture of the compound of formula (1): which is a key intermediate in the manufacture of camptothecin (CPT). This compound continues to serve as an attractive and promising lead struc...
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JP4860481B2 |
A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentrat...
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JP4856408B2 |
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JP4854941B2 |
Production of 1,4-disubstituted cyclohexane or 2,5-disubstituted tetrahydropyran derivatives (I) involves hydrogenating a corresponding cyclohexene or dihydropyran derivative (II) in presence of a transition metal complex (III) stabilize...
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JP4855196B2 |
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JP4854970B2 |
The present invention provides compounds of the formula: wherein R 1 is C 3-6 cycloalkyl optionally substituted by one or more fluorine atoms, or C 1-6 alkyl optionally substituted by one or more fluorine atoms, or C 3-6 cycloalkylmethyl...
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JP4849732B2 |
To obtain a polymerizable optically active compound having low viscosity and high spiral induction power, a liquid crystal composition using the optically active compound, a polymeric substance and a liquid crystal element. This opticall...
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JP4852697B2 |
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JP4853888B2 |
Compounds of formula (XII), are simultaneously halogenated in the 5 position and hydroxylated in the 4 position under lactonization, the halolactone is reacted with an amine to form a carboxamide, the halogen is replaced with azide, if n...
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JP4852607B2 |
Piperidine compounds (I), are new. Piperidine compound of formula (I), their tautomers, diastereomers, enantiomer, hydrates and/or salts, preferably salt with inorganic or organic acids or base, are new. R 1> = a group of formula (i)-(ii...
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JP4852747B2 |
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