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JP2021535145A |
The present invention relates to a composition of Pibrentasvir, a pharmaceutical product thereof, a method for producing the same, and a production intermediate thereof. The present invention relates to a pharmaceutical product of Pibren...
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JP6980269B2 |
To provide a chiral complex which, when used as a catalyst, can make an aromatic boronic acid undergo asymmetric 1,4-addition to a conjugated enone in an aqueous solvent under relatively mild conditions and can be recovered by filtration...
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JP6980315B2 |
The present invention relates to a process for preparing latanoprostene bunod and an intermediate therefor. In accordance with the preparation process of the present invention, latanoprostene bunod can be efficiently and cost-effectively...
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JP6976518B2 |
Disclosed is a method of synthesizing a (1R,2R)-nitroalcohol compound of formula (I), as shown in the following reaction scheme, including: subjecting a compound of formula (II) and a compound of formula (III) to a condensation reaction ...
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JP6968809B2 |
The present invention concerns a method of synthesizing a iodo- or astatoarene comprising the reaction of a diaryliodonium compound with a iodide or astatide salt, respectively. The invention also relates to said iodo- or astatoarene and...
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JP2021172624A |
To provide new means that uses trialkyl phosphate and a strong base reaction agent to cause an alkylation reaction with various substrates such as carboxylic acid, ketone, aldehyde, amine, amide, thiol, ester or Grignard reagent with hig...
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JP2021165246A |
To provide a method for producing a pentafluoroethyl group-containing alcohol, which is a compound useful as pharmaceutical, agricultural chemical, and polymer functional materials, and an intermediate compound for the production of orga...
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JP6948057B2 |
To provide a novel organic phosphorus compound decomposition catalyst that can decompose an organic phosphorus compound.An organic phosphorus compound decomposition catalyst is represented by a general formula (1). M[M(CN)](1) [where, Mi...
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JP2021134205A |
To provide a method for efficient hydro-perfluoroalkylation of olefins.The present disclosure provides a method for producing a fluorine-containing compound represented by general formula (6), the method including the step of causing a r...
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JP6932685B2 |
A macromolecules containing metal and a use thereof as a catalyst, said macromolecules containing metal being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is ...
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JP2021522401A |
The present invention relates to the field of decomposition of contaminated plastic waste. More specifically, the present invention includes methods and systems for decomposing contaminated plastic waste and converting it into value-adde...
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JP2021521208A |
The present invention relates to a method for producing a pyroloaminopyridazinone compound and an intermediate thereof. Specifically, with respect to the method for producing the compound of formula (I), the desired product is produced b...
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JP6923559B2 |
Disclosed is a fluorination method comprising providing an aryl fluorosulfonate and a fluorinating reagent to a reaction mixture; and reacting the aryl fluorosulfonate and the fluorinating reagent to provide a fluorinated aryl species.Al...
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JP6916489B2 |
A method for producing a specific enantiomer in a larger amount than the other enantiomer, said method comprising reacting a reaction substrate in the presence of cellulose nanofiber or a derivative thereof and a catalyst so as to improv...
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JP6918577B2 |
To provide a method for manufacturing an aromatic compound with good selectivity by dehydrogenation of a compound having a cycloalkadiene structure.There is provided a manufacturing method of an aromatic compound by dehydrogenation of a ...
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JP6893932B2 |
The disclosure relates to dicarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The disclosure relates to methods for preparing these complexes and the use of these complexes, isolated or pr...
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JP2021513526A |
[Task] The present invention discloses a bioactive polysubstituted benzene compound and a method and application thereof. The compound of the present invention has good biological activity and activity for suppressing the growth of tumor...
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JP6871802B2 |
To provide a technology for solving a problem with a catalyst or a carbon monoxide source in a method for obtaining a carbonyl compound by a carbonylation reaction of a halogen compound in the presence of the catalyst and the carbon mono...
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JP6841453B2 |
The present invention relates to a process for preparing 3-pyrrolidine carboxylic acid derivatives, and particularly a simple process for preparing 5-substituted 3-pyrrolidine carboxylic acid derivatives. In addition, the present inventi...
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JP6799531B2 |
The present invention provides novel transition-metal precatalysts that are useful in preparing active coupling catalysts. In certain embodiments, the precatalysts of the invention are air-stable and moisture-stable. The present inventio...
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JP2020535148A |
Synthesize halogenated organic compounds such as halogenated alkenyl group-containing compounds and halogenated alkyl group-containing compounds having heteroatoms (eg, O, N, S) bonded to carbon atoms of halogenated alkenyl groups or hal...
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JP6792936B2 |
To provide an electrochromic element excellent in film formability and excellent in transparency and light transmittance during decoloration and in resistance to repeated coloration/decoloration, to provide an electrochromic material tha...
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JP6789526B2 |
The purpose of the present invention to provide a method for producing a nitrobenzene compound represented by general formula (1), which is economically preferable, and suitable for industrialization. The present invention pertains to a ...
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JP6763747B2 |
To provide a method for producing trifluoromethyl group-containing alcohols useful as synthetic intermediates for medicines and agrochemicals.This invention relates to a method for producing trifluoromethyl group-containing alcohols expr...
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JP6764158B2 |
To provide a method for producing a carbonyl compound, allowing for improvement of ease of production and furthermore allowing for reduction of production cost, by positively utilizing inexpensive iodine.A carbonyl compound is produced b...
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JP6737967B1 |
In the present invention, 5-fluoro-2-methyl-3-nitrobenzoic acid and its methyl ester are subjected to conversion of 5-fluoro-2-methylbenzoic acid using fuming nitric acid and fuming nitric acid, and subsequent conversion using methanol. ...
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JP6733552B2 |
To provide a novel method for producing a nitro compound which is a precursor compound for a diamine compound which is a starting material for a polyamic acid and/or a polyimide to be used as a liquid crystal aligning agent, etc. A metho...
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JP6736547B2 |
The invention relates to a method for producing dinitrotoluene, comprising the following steps: a) nitrating toluene with a mixture of nitric acid and sulfuric acid and subsequently separating a sulfuric-acid-containing aqueous phase tha...
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JP6725663B2 |
This invention discloses a fluorene polyfunctional photoinitiator as represented by general formula (I), a photosensitive resin composition containing the same, the preparation of the same, and uses of the two. This compound has the adva...
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JP6724283B2 |
To provide a process for producing optically active pregabalin with low number of reaction steps and low cost, as well as to provide a process for producing optically active 4-nitro-butanoic acid ester for use in said process.Provided is...
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JP6686012B2 |
The invention relates to a process for the preparation of a compound of formula I (I), wherein R1 is hydrogen, fluoro or chloro; which process comprises a) reacting a compound of formula II (II), wherein R1 is hydrogen, fluoro or chloro;...
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JP6668508B2 |
The present invention discloses a terpinenol compound as well as its preparation method and use; structure of such terpinenol compound is as shown in Formula (I) or (II); in Formula (I), R is independently selected from C 12 ¼C 16 alk...
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JP6665193B2 |
The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new c...
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JP6661555B2 |
The present invention relates to a process for the continuous production of nitrobenzene by the nitration of benzene with nitric acid and sulphuric acid under adiabatic conditions, not the entire production plant being shut down during a...
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JP6659828B2 |
Disclosed area hydroquinone compound, a preparation method therefor, and use thereof in anti-tumor or immunomodulation. The structural formula of the hydroquinone compound is as shown by formula I, wherein X is C=O or CH 2 ; Y is NH, O o...
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JP6659397B2 |
1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such a...
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JP2020506188A |
To provide an optimum method and manufacturing plant for carrying out a method (plant) for nitration of an aromatic organic compound (aromatic compound) which can be nitrated, particularly adiabatic nitration. It is to be. In the method ...
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JPWO2018179808A1 |
In a method for producing alkyl nitrite, in which an aqueous solution containing nitric acid and alkanol is brought into contact with a gas containing nitric oxide to produce alkyl nitrite, the reaction temperature is 60 ° C to 100 ° C...
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JP6640125B2 |
This invention relates to methods for producing chemical products, wherein the one or more feed materials are reacted to form a chemical product or a chemical composition. The invention further relates to plants for performing such metho...
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JP6623042B2 |
A catalyst including: neodymium; sodium; and a ligand, which is a compound expressed by Structural Formula (1) below, wherein the neodymium and the ligand form a complex at a molar ratio of 1 : 2 (neodymium : ligand):
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JP6616244B2 |
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JP6611735B2 |
wherein R1 is C1-C7 alkyl, C3-C6 cycloalkyl or C4-C7 alkylcycloalkyl.
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JP2019156773A |
To provide a method for easily manufacturing a difluoromethyl substituted compound using inexpensive agents.There is provided a manufacturing method of a difluoromethyl substituted compound using difluoro iodomethane and a catalyst, in w...
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JP6578116B2 |
To provide a method of efficiently producing monosubstituted(fluoroalkyl)ethylenes.The method comprises reacting a 1-chloro-2-(fluoroalkyl)ethylene with an organoboron compound under coexistence of an alkylphosphine coordinated palladium...
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JP2019151602A |
To provide a metal imide complexe that can efficiently oxidize a variety of substrates, can be synthesized easily, and have a stable structure.Provided is a metal imide complexe containing a metal and an imide as ligand, and in which, ch...
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JP2019142842A |
To provide a method in which a compound having a hydroxymethyl group is efficiently oxidized to obtain a corresponding carbonyl compound in high yields.The present invention provides a method for producing a carbonyl compound in which: i...
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JP6556476B2 |
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JP6556711B2 |
ii) in a second scrubbing step (WS-II), the prescrubbed crude mixture comprising dinitrotoluene is extracted with a scrubbing acid II in a scrub comprising at least one, preferably at least 2, extraction stage(s), where the scrubbing aci...
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JP6553490B2 |
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JP6540690B2 |
A compound represented by formula (1) (wherein X represents a chlorine atom, a bromine atom or an iodine atom) can be produced by: a step wherein a compound represented by formula (2) (wherein R1a represents an alkyl group having 1-6 car...
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