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WO/2006/090210A1 |
The object of the invention is the preparation of 2-chloro-4-fluoro-5-nitrobenzoic acid and derivatives thereof, by nitration of 2-chloro-4-fuorobenzotrichloride and the conversion of the novel synthetic intermediate thus obtained into i...
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WO/2006/087222A1 |
The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1 , by a) reaction of a compound of formula (II) wherein the substituents are as defined in claim...
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WO/2006/087221A1 |
The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1, by reaction of a compound of formula (II) wherein the substituents are as defined in claim 1, ...
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WO/2006/063728A1 |
The invention relates to nitroalkanes that are substituted by monoheteroatoms and that are devoid of enantiomers or are rich in enantiomers and to a method for producing said substances. According to said method, nitroalkanes, which are ...
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WO/2006/056535A1 |
A process for preparing a compound of formula (I) X-(CH2)n-ONO2 (I) wherein: X is a halogen atom selected from Cl, Br, I; n is an integer from 3 to 6; said process comprising the slow addition of a compound of formula (II) X-(CH2)n-OH (I...
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WO/2006/040652A2 |
The present invention relates to a method of preparing N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-8-methanesulfon
amido-dibenzo[b,d]furan-1-carboxamide and pharmaeutically acceptable salts thereof, such as its sodium salt, and novel in...
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WO/2005/123636A1 |
The invention relates to alkyl benzoles comprising branched, poly or perhalogenated alkyl groups. Said alkyl benzoles can be produced from the corresponding alkyl compounds by chlororination and subsequently fluorination. Optionally it i...
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WO/2005/107941A1 |
The invention relates to a solid basic catalyst comprising $g(a)-alumina-supported cesium fluoride CsF. The invention also relates to a method of preparing said catalyst and to the use thereof for the heterogeneous basic catalysis of che...
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WO/2005/105719A1 |
A method for synthesizing a compound, wherein a perovskite-type composite oxide containing palladium is used as a synthesis reaction catalyst, in Sonogashira reaction represented by the following reaction formula (1); R1-X + HC≡CR2 →...
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WO/2005/077908A1 |
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...
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WO/2005/077921A1 |
A guanidine compound which has a bi-aryl skeleton represented by the following general formula (1): [wherein R1, R2 and R3 each independently represents a hydrogen atom, a hydrocarbon group optionally having a substituent or a heterocycl...
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WO/2005/077866A1 |
A process for alkylation of a hydrocarbon compound includes providing a catalyst including a zeolite Y having a crystal size of no more than 100 nm, and reacting an alkylatable hydrocarbon with an alkylating agent in the presence of the ...
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WO/2005/077883A1 |
The invention relates to a method for the production of liquid nitrate esters, e.g. nitro-glycerine, wherein an alcohol is esterified by means of nitrating acid and the reaction takes place in one or several microreactors.
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WO/2005/075407A1 |
The invention relates to a method for producing dinitrotoluene, comprising the steps of a) reacting toluene with nitric acid in the presence of sulphuric acid to give mononitrotoluene, b) separating the reaction product of step a) into a...
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WO/2005/051890A1 |
The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.
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WO/2005/037766A1 |
The invention relates to a method for extracting nitrocresols from the waste water produced in the manufacture of mononitrotoluene. Said method is characterised in that the alkaline waste water produced in the manufacture of mononitrotol...
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WO/2005/023745A1 |
An aromatic aldehyde of the general formula: (3) (wherein R’ and n are as defined below) is produced by a process characterized in that a benzyl compound of the general formula: (1) (wherein R represents a hydrogen atom, etc.; n is an ...
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WO/2005/000803A2 |
A process for producing an asymmetric compound (IV), characterized by causing a compound (II) to add a nucleophilic reagent (III) through conjugate addition in the presence of an asymmetric urea compound (I). Also provided is a nonmetall...
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WO/2004/103550A1 |
This invention relates to an apparatus, comprising: at least one process microchannel having a height, width and length, the height being up to about 10 mm, the process microchannel having a base wall extending in one direction along the...
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WO/2004/103951A1 |
An optically active nitro compound having two hydrogen atoms on its &agr -cabon atom and having β-asymmetric carbon atom can be produced by making &agr , β-unsaturated nitroolefin having a hydrogen atom on its &agr -cabon atom react wi...
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WO/2004/096750A1 |
A process for producing a 3-nitro-4-alkoxybenzoic acid which comprises the step of reacting at a temperature of 30 to 100°C a mixture comprising a 4-alkoxybenzoic acid and nitric acid having a concentration of 40 to 80%, the nitric acid...
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WO/2004/055066A1 |
Polymer-immobilized formamides characterized by being represented by the general formula: (wherein R1 is an optionally substituted hydrocarbon chain which may have a cyclic moiety or a heteroatom; R2 is an optionally substituted hydrocar...
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WO/2004/043897A1 |
A process for the purification of 1,4-butanediol mononitrate from 1,4-butanediol dinitrate and 1,4-butanediol, by selective extraction with solvents is herein disclosed.
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WO/2004/043898A1 |
A process for the preparation of compounds of formula: HO-A-ONO2 (I) wherein A is a C2-C6 alkylene chain by nitration of the corresponding alkanediols with 'stabilised' nitric acid is herein disclosed. The process is safer to operators a...
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WO/2004/035520A1 |
An industrial and economical process for producing an acetylenic compound useful as an intermediate of drugs from 4-nitrofluorobenzene, specifically, a process for the production of the acetylenic compound (3): (3) characterized by react...
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WO2003018514A9 |
A method of preparing nitroform (trinitromethane) by nitrating a starting material which is dissolved or suspended in sulphuric acid. A nitrating agent consisting of nitric acid, nitrate salts or nitrogen pentoxide is added to the sulphu...
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WO/2004/026808A1 |
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donatin...
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WO/2004/020384A1 |
The present invention refers to a process for preparing a compound of general formula (A), wherein R is a radical of naproxen or bromonaproxen and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independently an integer...
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WO/2004/020385A1 |
The present invention refers to a process for preparing a compound of general formula (A), as reported in the description, wherein R is a radical of a drug and R1-R12 are hydrogen or alkyl groups, m, n, o, q, r and s are each independent...
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WO/2004/014550A2 |
The invention relates to novel monocarbene complexes of nickel, palladium or platinum containing electron-deficient olefin ligands, to their production and to the use thereof in the homogeneous catalysis of organic reactions (Formula II ...
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WO/2004/013094A2 |
One aspect of the present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-sulfur bond b...
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WO/2004/007424A1 |
The invention relates to a method of preparing a high-purity nitrophenol and, more specifically, p-nitrophenol from a nitrohalobenzene. The inventive method comprises the following steps: (a) hydrolysis of a nitrohalobenzene compound by ...
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WO/2004/000730A2 |
A method for making a zeolite includes impregnating a porous inorganic oxide with a liquid solution containing an inorganic micropore-forming directing agent. The amount of liquid solution is no more than about 100% of the pore volume of...
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WO/2003/101926A1 |
The invention relates to a method for producing compounds containing fluorine by reacting a compound, which contains hydrogen that can be exchanged for fluorine, with a fluoride or with a mixture of fluorides of general formula (I): MeF,...
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WO/2003/090926A1 |
A method for preparing a ruthenium-carrying alumina which comprises suspending alumina in a solution containing a tri-valent ruthenium, and then adding a base to the resultant suspension. A ruthenium-carrying alumina is useful as a catal...
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WO/2003/087032A1 |
Compounds are described, having general formula (I) and their use as acaricides, insecticides and/or fungicides.
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WO/2003/086605A2 |
One aspect of the present invention relates to ionic liquids comprising a pendant Bronsted-acid group, e.g., a sulfonic acid group. Another aspect of the present invention relates to the use of an ionic liquid comprising a pendant Bronst...
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WO/2003/066546A1 |
A process for producing a biaryl compound, characterized by reacting an arylhydrazine compound, hydrogen peroxide, and an aryl compound. When the reaction is conducted in the presence of a given metal or a compound of the metal or in the...
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WO/2003/064399A1 |
A process for producing a quinazolin−4−one derivative represented by the following formula (2): (2) (wherein R1, R2, R3, and R4 each represents a group not participating in the reaction and R1, R2, R3, and R4 may be bonded to each ot...
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WO/2003/062187A1 |
A process by which 2,5-bis(trifluoromethyl)nitrobenzene can be produced from an industrially easily available material in high yield through a small number of steps under mild reaction conditions using an easily handleable substance with...
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WO/2003/048090A1 |
There is provided processes for metal mediated reactions, particularly cross coupling and carbometallation reactions, wherein the metal is present as a catalyst system comprising a catalyst microencapsulated within a permeable polymer mi...
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WO/2003/045896A1 |
The present invention relates to a new process for the preparation of the ($i(S))-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for th...
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WO/2003/020684A1 |
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.
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WO/2003/020683A1 |
Aromatic compounds are mononitrated by reaction with a nitrating agent, preferably nitric acid, in a phosphonium salt ionic liquid.
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WO/2003/018552A2 |
The present invention is directed to protected amino acid halide monomers and oligomers, and to their use in the efficient sythesis of polyamides. The present invention is further directed to the use of -haloenamine reagents, which may o...
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WO/2003/014059A1 |
The invention relates to a continuous method for producing alkyl nitrites and alkyl dinitrites. According to said method, (i) an alkanol or dialkanol is mixed with an aqueous solution of a mineral acid, whereby on average no more than 1....
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WO/2003/011811A1 |
The invention relates to a method for the continuous production of 2-bromo-2-nitro-1, 3-propanediol, according to which: I) nitromethane and one or two aqueous solutions containing formaldehyde and alkali hydroxide are intermixed, with m...
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WO/2003/011810A1 |
A method for the regioselective ortho-directed nitration of phenolic compounds useful for the preparation of ortho-nitro-phenols according to formula (I) is described.
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WO/2003/006151A1 |
A microencapsulated catalyst is prepared by dissolving or dispersing a catalyst in a first phase (for example an organic phase), dispersing the first phase in a second, continuous phase (for example an aqueous phase) to form an emulsion,...
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WO/2002/100824A1 |
The present invention is to provide a novel colchicine derivative represented by the formula (I) with halogen or nitric ester group, or pharmaceutically acceptable salts thereof, pharmaceutical compositions containing the same as effecti...
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