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WO/2008/022038A1 |
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutic...
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WO/2008/020452A1 |
The present invention relates to an improved process for preparation of Rivastigmine of formula (I) or pharmaceutically acceptable salts thereof comprising a step of N-methylation of compound of formula (III), wherein R1 = R2 = H or R1 =...
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WO/2008/019690A1 |
The invention relates to novel compounds according to formula Ia and Ib; (Formula Ia and Ib) wherein A represents substituted or unsubstituted C1-10heteroaryl, C6-14aryl or C6- 10heterocycloalkylaryl; R1 is C1-6alkyl, C2-6alkenyl, C2-6al...
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WO/2008/018148A1 |
It relates to a process for producing an amino compound in which by reacting a polyhydric alcohol or an amino alcohol with ammonia or a primary amine or a secondary amine, a corresponding tertiary amine, amino alcohol or the like is prod...
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WO/2008/017886A1 |
The present invention relates to a novel hydrate form of O-desmethyl venlafaxine succinate. The present invention further relates to processes for the preparation of the novel hydrate form, pharmaceutical compositions comprising it, seco...
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WO/2008/015689A1 |
A process for the preparation of optically pure R (-) salbutamol of formula (6) and its pharmaceutically acceptable salts by using a (+) 4-nitro tartranilic acid as the resolving agent and a binary solvent system comprising alkyl acetate...
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WO/2008/012747A2 |
The present invention relates to new fluorinated quaternary ammonium compounds of formula (1) and (5), to new fluorinated proteic hydrolisates, to processes for their preparation and to fire-fighting compositions that contain said compou...
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WO/2008/011791A1 |
The present invention provides crystalline tetrabenzyl voglibose with the following physical properties: there are peaks at 2θ=16.84±0.20°C, 18.99±0.20°and 24.11±0.20°of its Cu X-ray powder diffraction spectrum, and its melting po...
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WO/2008/012046A1 |
The present invention relates to an improved process for the preparation of 3- [(1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol monohydrochloride.
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WO/2008/012602A1 |
The novel positively charged pro-drugs of diclofenac in the general formula(1) 'Structure 1' were designed and synthesized. The compounds of the general formula(1) 'Structure 1' indicated above can be prepared from functional derivatives...
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WO/2008/012603A1 |
The novel positively charged pro-drugs of diflunisal, salicylsalicylic acid, and salicylic acid in the general formula(1) 'Structure 1' and general formula(2) 'Structure 2' were designed and synthesized. The compounds of the general form...
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WO/2008/013994A2 |
Provides are intermediates and processes for preparation of o- desmethylvenlafaxine.
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WO/2008/013995A2 |
The present invention describes processes for the preparation of O-desmethylvenlafaxine and tridesmethylvenlafaxine, which may be used as an intermediate in preparing O-desmethylvenlafaxine.
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WO/2008/012047A1 |
The present invention relates to a process for the preparation of (1 R,2R)-3- dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
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WO/2008/012605A1 |
The novel positively charged pro-drugs of ketoprofen and fenoprofen in the general formula(1) 'Structure 1' were designed and synthesized. The compounds of the general formula(1) 'Structure 1' indicated above can be prepared from functio...
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WO/2008/010481A1 |
[PROBLEMS] To provide a compound which can act as an NMDA antagonist having a wide safe range and is useful as a therapeutic agent or a prophylactic agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic s...
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WO/2008/006864A1 |
The invention relates to a method for producing optically active amines, which comprise an amino group at the chiral center and at least one further amino group, and/or at least one hydroxyl group, by means of optical cleavage of the res...
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WO/2008/006749A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006754A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006750A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006752A1 |
The invention relates to a method for producing an amine by reacting a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound, selected from the group comprising ammonia, primary and secondary amines, ...
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WO/2008/006627A1 |
The present invention relates to the compounds of formula (I), processes for their production and their use as anti-inflammatory agents.
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WO/2008/000696A1 |
The invention relates to amino(meth)acrylates obtained from the reaction of amines with a mixture of epoxy(meth)acrylates and (meth)acrylated diluent and there use for making flexible varnishes, coatings, adhesives and inks.
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WO/2007/147866A1 |
The present invention generally relates to a process for preparing alkoxylated alkylamines and/or alkyl ether amines. The process consists of two stages and utilizes a catalyst with a multiple-charge counterion. The alkoxylated alkylamin...
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WO/2007/147547A1 |
A new process for preparation of 3-(2-hydroxy-5-substituted phenyl)-N,alkyl-3- phenylpropylamiηes from cinamoyl chloride via N-alky-3-phenylprop-2-en-1 -amine has been developed.
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WO/2007/145203A1 |
It is intended to provide a method for producing a compound useful as a production intermediate of a pharmaceutical represented by the following general formula (I): (I) ((R)n represents the same or different halogen atoms in number of (...
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WO/2007/146145A1 |
Industrial processes for the alternating conversion of glycerol to either an amino alcohol product or propylene glycol are disclosed. Glycerol is converted to hydroxyacetone which may then be directly reduced to obtain propylene glycol o...
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WO/2007/144091A1 |
The present disclosure relates to a process for the preparation of a compound of formula (I) wherein R is hydrogen, a formyl group, a straight, branched or cyclic C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof, ch...
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WO/2007/146143A2 |
Processes for converting glycerol to an amino alcohol product involving reacting glycerol with a metal catalyst to obtain hydroxyacetone, and reacting the hydroxyacetone with an amine compound to obtain an adduct that is then reduced usi...
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WO/2007/146144A1 |
Processes for the conversion of glycerol to a product mixture of an amino alcohol product and propylene glycol are disclosed. Glycerol is converted to hydroxyacetone and the hydroxyacetone is reduced with a reducing agent or reacted with...
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WO/2007/143356A2 |
Substrate or starting compounds having at least one active hydrogen may be reacted with one or more alkylene oxide in a ketone solvent at reduced temperatures compared with conventional, molten methods to give an adduct product having re...
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WO/2007/140965A1 |
This disclosure relates to process for the preparation of a compound of formula (I) wherein R is hydrogen, a straight or branched C1-C6 alkylcarbonyl group or a phenylcarbonyl group, or a salt thereof , comprising the following steps: a)...
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WO/2007/138440A1 |
The invention provides a process for the production of a compound of formula (I), wherein Y is selected from CH3, CH2OH, CH2CH2OH, CH2Br and Br; comprising the steps of: (i) reacting a compound of formula (II), wherein OX is hydroxy or O...
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WO2007104679B1 |
The present invention relates to the field of single site catalyst systems based on phosphino-iminophenol complexes that are suitable for oligomerising or polymerising ethylene and alpha-olefins.
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WO/2007/137799A1 |
The present disclosure relates to a process for the preparation of 2-(3-diisopropylamino-l-phenylpropyl)-4-(hydroxymethyl) phenol or its phenolic monoesters or salts thereof, characterized by the steps of a) reacting a compound of formul...
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WO/2007/136323A1 |
The present invention relates to a process for the production of a compound of formula (I) comprising a reduction of the carboxyl and cyanide groups of a compound of formula (III), followed by resolvation of the racemic product into the ...
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WO/2007/128463A1 |
The present invention relates to a process for the deprotection of protected amine compounds, wherein the protected amine compound is contacted with an electrophilic oxidating agent that is optionally formed in situ, said electrophilic o...
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WO/2007/124898A1 |
This invention is directed to compounds of formula (I): to pharmaceutical compositions comprising them; to combination products comprising them; and to their use in therapy.
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WO/2007/126217A1 |
Provided is a process for preparing tolterodine or its salt, which comprises: (a) reacting 2-[3-(p-nitrobenzenesulfonyloxy)-1-phenylpropyl]-4-methyl-(p
-nitrobenzenesulfonyloxy or p-toluenesulfonyloxy)benzene with diisopropylamine to obt...
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WO/2007/127108A1 |
A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazen...
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WO/2007/127421A2 |
The present invention is concerned with novel processes for the preparation of (+)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof, and (-)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable ...
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WO/2007/121818A1 |
The invention relates to the use of compounds of formula (X-Ar-Y), in which X and Y respectively are selected independently of one another from the groups H, C-1-8 alkyl and groups as per formulae (Ia), (Ib) or (Ic), together with other ...
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WO/2007/122488A2 |
The present invention provides a process for [18F]-fluorination of biomolecules containing a primary amino group such as proteins and peptides and in particular of peptides. The invention further provides reagents for this process, in pa...
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WO/2007/120925A2 |
Methods for preparing crystalline forms of O-desmethylvenlafaxine a described.
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WO/2007/120923A1 |
Methods for preparing substantially pure O-desmethylvenlafaxine are described.
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WO/2007/118818A1 |
The present invention refers to compounds of the formula (I) wherein X and R1 to R5 are defined as given in claim 1, as well as hair dye compositions containing them.
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WO/2007/120528A2 |
Compositions and methods of using compositions for treatment of inflammatory diseases and immune disorders are provided. Allylamino compounds are disclosed which are inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and/or vascu...
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WO/2007/118964A1 |
The invention concerns polysubstituted N-(phenethyl)benzamide derivatives, pharmaceutical compositions containing same, as well as their therapeutic uses, in particular in the field of human and animal health. The invention also concerns...
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WO/2007/118041A1 |
Compounds are provided which bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, the compounds having the general formula (I) wherein R1, R2, R3, X and Ar have the meanings given in the specification, and the p...
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WO/2007/110548A1 |
The invention relates to a process of diastereoselective synthesis. This process carries out the diastereoselective alkylation of optically active nopinone to form the compound of formula (I) according to scheme A below, in which: R repr...
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