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WO/2005/113483A2 |
The invention is directed to processes for making levalbuterol HC1 Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HC1 to the suspension or slurry of the solid (R)-S...
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WO/2005/111002A2 |
The invention relates to the compounds of formula (1), wherein the groups R1, R2, R3, R4, R5, R6, R7, R8, n, m and X are defined as in the claims and in the description. The invention also relates to the use of these compounds as drugs, ...
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WO/2005/108381A1 |
The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to pr...
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WO/2005/103280A1 |
A process for producing either a 3-benzamido-2-hydroxycarboxylic acid represented by 3-benzamido-2-hydroxy-3-phenylpropionic acid or a salt thereof. The process is safe and suitable for industrial production, and the target compound havi...
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WO/2005/100299A1 |
An efficient cost-effective process for preparation of l-erythro-2-amino-1-phenyl-1-propanol from l-1-phenyl-1-hydroxy-2-propanone, which comprises converting l-1-phenyl-1-hydroxy-2-propanone to l-1-phenyl-1-hydroxy-2-propanone oxime and...
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WO/2005/097731A2 |
The present invention relates to ionic liquid comprising an anion and a cation wherein the cation is a primary, secondary or tertiary ammonium ion containing a protonated nitrogen atom.
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WO/2005/092011A2 |
The present invention relates to N-substituted benzylic aniline derivatives that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The in...
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WO/2005/092834A1 |
Processes for the purification of voglibose are provided. Also provided are processes for the purification of substituted or unsubstituted 5-oxo-1,2,3,4-cyclohexanetetrol and substituted 5-amino-1,2,3,4-cyclohexanetetrol, which compounds...
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WO/2005/092832A1 |
The present invention provides an industrially advantageous method of producing aminophenol compounds represented by the formula (1) by a simple and easy procedure at a high yield and a high purity. The present invention provides a metho...
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WO/2005/087707A1 |
The invention relates to the compounds of formula: (I) which are as defined in the specification. Their use as chiral ligands in catalytic aryl transfer reactions to aromatic aldehydes is also described.
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WO/2005/087215A1 |
The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of d...
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WO/2005/087752A2 |
The invention relates to novel aminoalkanol derivatives and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disord...
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WO/2005/085175A1 |
An alkoxide compound that is represented by the following general formula (I) and is suitable to a raw material for thin film formation for use in a process of thin film formation though compound evaporation, such as CVD process. Further...
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WO/2005/085189A2 |
The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein X is selected from (II) and (III), Y is selected from SO2NH, CONH, CH=N, CH2NH and CH=CH; R1-5 are each independently select...
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WO/2005/082836A1 |
Severely sterically hindered secondary aminoether alcohols are prepared by a process comprising reacting a ketene with sulfuric acid to produce an anhydride which is then reacted with, to cleave the ring of, a dioxane to yield a cleavage...
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WO/2005/077870A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/077871A1 |
The invention concerns a method for producing optically active hydroxy-, alkoxy-, amino-, alkyl-, aryl- or chlorine-substituted alcohols or hydroxycarboxylic acids having 3 to 25 carbon atoms or their acid derivatives or cyclization prod...
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WO/2005/073277A1 |
Subject of the invention are substituted polyethylene polyamines having general formula (I), method of their preparation and their use as additives inhibiting, or limiting the formation of deposits in the process of cracking of hydrocarb...
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WO/2005/070873A2 |
A composition that can be used as a component in auto clear coat and primer is disclosed. The composition comprises or is an alkoxylated amine having the formula of (A)[N(R1H)2]p including an isomer or mixture of isomers thereof. Also di...
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WO/2005/070871A2 |
The application relates to novel amino alcohols of general formula (I) where R, R1, R2, R3, R4, R5, X1 and X2 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these ...
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WO/2005/070872A1 |
The invention provides novel β2-adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with β2-adrenergic r...
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WO/2005/070870A2 |
The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these ...
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WO/2005/066190A1 |
New risedronate salts selected among disodium risedronate, monopotassium risedronate, dipotassium risedronate, monoammonium risedronate, diammonium risedronate, hemipiperazine risedronate, ethanolamine risedronate and morpholinoethanolam...
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WO/2005/063707A1 |
A novel, improved, and enantiospecific process for the preparation of (-)-trans-4-(4-fluorophenyl)-3-hydroxymethyl-1-methylpiperid
ine of formula-(I), an advanced intermediate in the manufacture of antidepressant drug paroxetine is discl...
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WO/2005/063682A1 |
The invention relates to an improved method for producing chiral or enantiomer-enriched beta amino acids, -aldehydes, -ketones and gamma-amino alcohols, during which an allyl amine of formula (I), in which: R1 represents an alkyl radical...
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WO/2005/063222A1 |
An Hsp90 family protein inhibitor which contains as an active ingredient a benzene derivative represented by the following general formula (I), a prodrug thereof, or a pharmacologically acceptable salt of either.
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WO/2005/061432A1 |
Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.
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WO/2005/058794A1 |
This application discloses an improved process for the preparation of N-methyl-N-(1-naphthylmethyl)-6,6-dimethyl-2-hydroxyheptan-4
-ynyl-1-amine, a key intermediate used in the synthesis of terbinafine ((E)-N-(6,6-dimethyl-2-hepten-4-yny...
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WO/2005/058795A1 |
The invention relates to a process for the treatment of an alkanolamine, e.g. triethanolamine, having an improved colour stability over time. The process comprises contacting the alkanolamine with hydrogen in the presence of a supported ...
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WO/2005/057207A1 |
The present invention provides a method of forming an ion of formula (I) comprising the steps of: (i) reacting a compound of the formula (IIa); with a biopolymer, BP, having at least one group capable of reacting with M to form a covalen...
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WO/2005/056515A2 |
The use of bis-amines to enhance the antimicrobial activity of pharmaceutical compositions is described. The bis-amines are particularly useful for enhancing the antimicrobial activity of aqueous ophthalmic compositions, such as artifici...
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WO/2005/056514A2 |
There is provided a process for the preparation of substituted amino alcohols HO-(CH2)n-NR1R2 from haloalcohols HO-(CH2)n-X, where X is Cl, Br or I, bz reaction with an amine HNR1R2, in water as solvent at a temperature range of about 20...
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WO/2005/051889A1 |
The invention relates to novel m-diaminobenzoles of formula (I), to the use thereof in colouring agents, and to oxidation hair dyes containing said m-diaminobenzoles.
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WO/2005/051888A2 |
The invention relates to compounds of the formula (I) in which: i and j=1; R1 is in position 3 or 4 on the phenyl ring and represents a cyano group, an alkoxy group substituted by halogen, a thioalkyl group, an alkylcarbonyl group or an ...
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WO/2005/049549A1 |
A process for the synthesis of lipid cations having general formula (6) in which: R1 represents a lipophilic chain; R2, R3, R4, which are identical or different from one another, represent C1-C10 alkyl, C1-C10 alkenyl, or C1-C10 alkynyl ...
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WO/2005/049547A1 |
Provided herein are processes for the preparation of 1,2,3,4-cyclohexanetetrol derivatives, which are useful intermediates for the synthesis of voglibose; processes for the preparation of substituted 2,3,4,5-tetrahydroxycyclohexanone; an...
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WO/2005/047225A1 |
The invention relates to a method for the detection of nucleophilic species with excess electronic charge, particularly thiol groups. The invention also relates to a series of squaraine-derived compounds. The inventive method is advantag...
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WO/2005/042473A1 |
The present invention describes an improved process for the preparation of extremely pure 1-(4'-Fluorophenyl)-1-(3-dimethylaminopropyl)-5-phthalanecar
bonitrile and its bromide salt (citalopram hydrobromide), which is a well known antide...
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WO/2005/042464A1 |
Treatment of Diseases caused by Disturbances of the Activity of the Androgen Receptor uses of compounds of Formula (I): (as defined herein), for the treatment of diseases caused by disturbances of the activity of androgen receptor are pr...
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WO/2005/040091A1 |
Disclosed are compounds of formula (I) wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
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WO/2005/037769A1 |
Disclosed is a method for the distillative separation of mixtures containing ethyleneamines, the separation process being carried out in one or several fractionation columns. The ethyleneamines particularly represent ethylenediamine (EDA...
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WO/2005/035481A2 |
The invention relates to a method for distillative separation of triethanolamin from a substance mixture consisting of mono- di-, and triethanolamin, ethanolamin-ether and water obtainable by an ammonia and ethylene oxide reaction in a l...
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WO2004110364A9 |
The current invention provides novel thiotungstate derivatives, methods of making novel thiotungstate derivatives, pharmaceutical compositions of novel thiotungstate derivatives, methods of using novel thiotungstate derivatives to treat ...
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WO/2005/030698A1 |
The invention relates to processes for the preparation of pure voglibose. The invention also relates to the preparation of acid addition salts of voglibose. More particularly, it relates to the preparation of crystalline hydrochloride sa...
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WO/2005/025555A2 |
The invention provides novel β2 adrenergic receptor agonist compounds of formula (I): wherein R1 - R13 and w have any of the values described in the specification. The invention also provides combinations of such compounds and other the...
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WO/2005/022213A1 |
An optical filter which is excellent in light resistance, heat resistance, etc., does not show high absorption in the visible region, and has the ability to absorb near infrared rays. The optical filter is characterized by containing a c...
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WO/2005/019164A2 |
The present invention relates to a novel process for the preparation of phenethanolamine derivatives, which process comprises the step of reacting a compound of formula RO(CH2)nBRaRb with a compound of formula (II).
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WO/2005/014524A2 |
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protectio...
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WO/2005/014525A2 |
The invention is directed to a bi-aryl compound having a unique immunomodulating activity, a process for a preparation thereof, a pharmaceutical composition containing the same, and a method of preventing or treating disorders or disease...
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WO/2005/012227A2 |
The present invention relates to processes for preparation of 2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethyl-phenol
of Formula I, which is a metabolite of tolterodine.
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