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WO/2000/034230A1 |
4-Substituted-3-substituted-amino-cyclobut-3-ene-1,2-diones having Formula (I): wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, A and W are as defined in the specification which compounds relaxes smooth muscles.
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WO/2000/027946A1 |
An organic EL element comprising an anode, a cathode, and one or more organic compound layers sandwiched therebetween, wherein at least one of the organic compound layers comprises an organic compound represented by chemical formula (1),...
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WO/2000/020378A1 |
The present invention discloses compounds having formula (1) or a pharmaceutically acceptable salt thereof, wherein X represents (2), Y represents O or S. The meaning of R', R'', R''', R?2¿, R?3¿, R?4¿, R?5¿, and R?6¿ are specified ...
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WO/2000/018390A1 |
A heat shock protein expression inducer containing as the active ingredient a chalcone derivative; another heat shock protein expression inducer which can be selected by a screening method involving the step of using a cell line which ha...
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WO/2000/018724A1 |
The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, ...
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WO/2000/018721A1 |
The invention relates to substituted polycyclic aryl and heteroaryl $i(tertiary)-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions an...
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WO/2000/015183A1 |
The invention relates to agents for dyeing fibres containing keratin, especially human hair, containing 5-arylpenta-2,4-dienylcarbonyl compounds of formula (I) wherein R?1¿ represents a hydrogen atom or a C¿1?-C¿4?-alkyl group and R?2...
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WO/2000/009475A1 |
Amine derivatives represented by general formula (1) or their salts, wherein R?1¿ represents C¿1-4? alkyl; R?2¿ represents (i), or (ii), (iii); R?3¿ represents C¿1-3? alkyl, hydroxylated C¿1-5? alkyl, C¿1-5? acyl, C¿2-5? alkenyl ...
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WO/2000/005194A1 |
A process for the preparation of the compound AQ4 of formula (3) or a salt or $i(N)-oxide thereof, includes the step (21-9).
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WO/2000/005195A1 |
An arylsulfonamide represented by formula [1] is heated in the presence of aluminum chloride to obtain a 2-aminobenzophenone compound represented by formula [2].
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WO/2000/000469A2 |
Novel alkyl ketone compounds having potent cytotoxic activity are described as antitumor agents and are particularly effective against leukemia and breast tumor cells. The compounds of the invention have formula (I), wherein R¿1?-R¿4?,...
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WO/1999/065992A1 |
There is disclosed a compound of formula (I) wherein each of X¿1? and X¿2? are independently NH-A-NR?1¿R?2¿, and wherein A is A C¿2-8? alkylene group and R?1¿ and R?2¿ are independently selected from hydrogen, C¿1-4? alkyl, C¿2-...
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WO/1999/065866A1 |
A compound is provided having formula (I) wherein: R?1¿ and R?2¿ are independently hydrogen, hydroxy, alkoxy or acyloxy; R?3¿ and R?4¿ are independently oxo, hydroxy or hydrogen; one of R?5¿ or R?6¿ is A-B and the other is hydrogen...
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WO/1999/061410A1 |
This invention provides compounds of Formula (I) having structure (I) wherein: B and D are each, independently, hydrogen, halogen, alkyl of 1-6 carbon atoms, cycloalkyl of 3-8 carbon atoms, aryl, heteroaryl, aralkyl of 6-12 carbon atoms,...
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WO/1999/059527A2 |
The invention relates to oxidizing agents for coloration of keratin fibers, especially hair, based on a combination of developer-coupler substances, characterized in that they contain at least one 2,5-diamino-1-phenylbenzene derivative o...
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WO/1999/053242A1 |
Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be ...
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WO/1999/050223A2 |
ghis invention relates to a novel advantageous process for the stereoselective preparation of 2-hydroxy-4-phenylbutyrates (HPB esters) and of their precursors. This is done by starting from readily accessible $g(a)-unsaturated $g(a)-hydr...
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WO/1999/047474A1 |
This invention relates to a novel, inventive process for the preparation of biphenyls or aromatic olefins by coupling reactions of the Suzuki coupling and Heck coupling type, using allylpalladium catalysts of the $g(m)-halo(triisopropylp...
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WO/1999/043636A2 |
Disubstituted lavendustin A analogs that are PTK inhibitors having antiproliferative activity are described. Preferred compounds of the present invention, without limitation, satisfy either Formula (1) or Formula (2). Currently preferred...
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WO/1999/041259A1 |
A microencapsulated Lewis acid characterized in that the Lewis acid has been supported through coordinate bonds on microcapsules of an organic polymer. The acid is a novel polymer-supported Lewis acid which exceeds the technical limit to...
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WO/1999/035115A1 |
A benzyl or benzylidene tetralin or a pharmaceutically acceptable salt of benzyl or benzylidene tetralin represented by general formula (I) in which: a) R?1¿ completes a carbon-carbon double bond with the carbon at position 2, when x is...
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WO/1999/027783A1 |
Fungicidal compositions and methods comprising acylated aminosalicylamides (AASA) described herein. Novel cyclic amines and 3-nitrosalicylamides, and their use as pesticides and in the preparation of the antifungal AASA compounds are als...
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WO/1999/026928A1 |
Disclosed in a three step synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines from a 2-aminobenzophenone represented by structural formula (II) and a starting material represented by structural formula (III). Phenyl Ring A, Phenyl R...
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WO/1999/026927A2 |
The present invention provides compounds, and pharmaceutical compositions containing those compounds, that act as antagonists at metabotropic glutamate receptors. The compounds are useful for treating neurological diseases and disorders....
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WO/1999/025335A1 |
A new family of inadone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apopto...
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WO/1999/021823A1 |
Intermediates having formulas (A) and (B) wherein B?I¿ is -CH¿2?OH or -CH¿2?OR?P¿, and R?P¿ is an alcohol protecting group; a is 1, 2, or 3; T?I¿ is -OH or (C); Q?I¿ is phenyl, naphthyl or heteroaryl having 1-3 substituents; R?a¿...
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WO/1999/015494A1 |
2-Aminotetralines, a process for their preparation, and pharmaceutical compositions, for the prevention and therapeutic treatment of inflammatory pathologies (particularly septic shock) and/or autoimmune pathologies in which the aetiopat...
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WO/1999/011601A1 |
Iodopropagylamine compounds represented by general formula (1) (wherein R?1¿ and R?2¿ each independently represent a hydrogen atom or a 1-3 C alkyl group, or R?1¿ and R?2¿ combine with each other to form a tetramethylene or pentameth...
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WO/1999/007666A1 |
Novel amine derivatives represented by general formula (1) which are excellent in antifungal effect and salts thereof, wherein R?1¿ represents optionally halogenated C¿1-5? alkyl; R?2¿ represents 4-(1,1-dimethylalkyl)benzyl, 4-(1-meth...
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WO/1999/006351A1 |
This invention concerns the use of a hydroxylic solvent in the preparation of enaminones from the corresponding amine N-oxides or propargylic amines via the general process outlined above (A).
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WO/1999/002124A2 |
The invention provides compositions and methods for the direct dyeing of keratinous fibers, with particular regard to human hair on the head. The compositions of the invention contain novel anthraquinone mixtures in which each of the com...
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WO/1999/001418A1 |
The invention relates to a novel method for aminating mononuclear aromatic compounds and polynuclear compounds containing at least one aromatic ring. The inventive method enables simple separation of the aminated mononuclear aromatic com...
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WO/1999/000114A2 |
The invention relates to the use of 1,3-bis-aromatic-prop-2-en-1-ones (chalcones), 1,3-bis-aromatic-propan-1-ones (dihydrochalcones), and 1,3-bis-aromatic-prop-2-yn-1-ones for the preparation of pharmaceutical compositions for the treatm...
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WO/1998/058913A1 |
Disclosed are compounds having general formula (A) wherein Ar représents phenyl, which may be unsubstituted or substituted by one, two or three substituents independently selected from Cl, Br, F, -OMe, NO¿2?, CF¿3?, C¿1-4? lower alky...
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WO/1998/058901A1 |
3-anilino-2-cycloalkenone derivatives represented by general formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, or hydrates or solvates of these: wherein R¿1? represents optionally substituted C¿1-8? alkyl...
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WO/1998/054159A1 |
The invention relates to non-steroidal gestagens of general formula (I), wherein R?1� and R?2� are the same or different and stand for a hydrogen atom, a C�1?-C�5? alkyl group or a halogen atom, or together with the C atom of the...
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WO/1998/054122A1 |
The present invention discloses a process for the preparation of a substantially pure compound having formula (4). The process comprises the step of reacting an enolate having formula (A) with a Grignard reagent. The enolate salt is form...
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WO/1998/052906A1 |
The compounds of formula (I) in which: A represents C�6?-C�10? aryl or an optionally aromatic three- to ten-membered heterocycle; X represents halogen, cyano, C�1?-C�7? alkyl, trifluoromethyl, C�2?-C�7? alkoxy or trifluoromet...
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WO/1998/045249A1 |
Compounds represented by general formula (I), pharmaceutically acceptable acid addition salts thereof, or hydrates of the same; drugs containing these compounds; medicinal compositions containing these compounds together with pharmaceuti...
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WO/1998/045278A1 |
The present invention provides novel methods for the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihy
dro-2H-3,1-benzoxazin-2-one of formula (VI-i) which is useful as a human immunodeficiency virus (HI...
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WO/1998/043942A1 |
The invention relates to novel compounds of Formula (I) wherein R?1�, R?2�, R?3�, R?4�, R?5�, R?6�, R?7� and Ar are as defined in claim 1, their salts with physiologically acceptable acids and, when the compounds can be in ...
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WO/1998/043943A1 |
2-Phenoxyaniline derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein R?1� represents a hydrogen atom, an amino group, or an NHCOR?3� group; and R?2� represents a halogen atom, an ami...
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WO/1998/040331A1 |
A process for the preparation of indanones of formula (II) from indanones of formula (I) or of indanones of formula (IIa) from indanones of formula (Ia) comprises reacting an indanone of formula (I) or (Ia) with a coupling component.
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WO/1998/040416A1 |
The invention relates to a catalyst system obtained by mixing at least one metallocene, at least one co-catalyst and at least one support which is rendered inert. The invention further relates to a method for producing a free flowing sup...
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WO/1998/038195A1 |
This invention relates to $g(a)-ammonium ketones, iminium ketones or amidinium ketones in the form of their tetraaryl- or triarylalkylborate salts which can be photochemically converted into amines, imines or amidines as well as to a pro...
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WO/1998/033763A1 |
The compound of formula (I), wherein R?1� is straight chain alkyl, branched chain alkyl, cycloalkyl, hydroxyalkyl, fluoroalkyl, or polyfluoroalkyl; and one of R?2�, R?3� and R?4� is hydroxyl and the other two are, independently, ...
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WO/1998/033764A1 |
Novel benzophenone derivatives and methods of making and using the same are disclosed. The novel compounds can display highly active photoinitiation and photopolymerization properties.
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WO/1998/033758A1 |
A compound of formula (I), wherein R?1� and R?2� each represents a lower alkyl, or R?1� and R?2� may be bonded together to form a ring; X represents a spacer of which the number of atoms constituting the principal chain is 1 to 1...
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WO/1998/032724A1 |
Novel tetralone or benzopyranone derivatives useful as a preventive and/or remedy for various diseases dependent on male and female hormones. The derivatives are represented by general formula (I), wherein R�1? and R�2? each represen...
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WO/1998/032756A1 |
The invention relates to novel substituted aminoalkylidenamino triazines of formula (I), wherein R?1� represents the grouping A-Z, wherein A represents optionally substituted straight-chain or branched alkane diyl, which contains oxyge...
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