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WO/1992/014726A1 |
Substituted pyridylpyrimidines have formula (I), in which A and Ar have the meaning given in the test of the description. Also disclosed are their preparation, their use and new initial products. The compounds having formula (I) may be p...
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WO/1992/013833A1 |
A herbicide compound of formula (I) wherein R is halogen, C1-C2 alkyl, C1-C2 alkoxy, nitro; cyano; C1-C2 haloalkyl, or RaSOn- wherein n is 0 or 2 and Ra is C1-C2 alkyl; R1 is hydrogen or C1-C4 alkyl; R2 is hydrogen or C1-C4 alkyl; or R1 ...
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WO/1992/013827A1 |
A process for producing compounds represented by general formulae (III) and (IV), which are useful as intermediates for the production of amino acid derivatives which have a renin inhibitory activity and are useful as a hypotensive, ster...
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WO/1992/010466A1 |
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes. They have general formula (I), w...
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WO/1992/007558A1 |
The present invention provides novel substituted anthraquinones having formula (I), wherein R¿1? and R¿2? are independently H, alkyl, aryl, or arylalkyl; m and n are independently 1, 2, or 3; X is H, OH, NR¿3?R¿4?, Cl, Br, I, F, alky...
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WO/1992/007557A1 |
The present invention provides novel substituted anthraquinones having formula ($g(a)), wherein R¿1? and R¿2? are independently H, C¿1?-C¿10? alkyl, aryl, arylalkyl, alkylaryl, or R¿1? and R¿2? taken together with the adjacent nitr...
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WO/1992/006670A1 |
The object of the present invention are hair colorants containing at least one 1,4-bis-[(dihydroxyalkyl)amino]-anthrachinone of the general formula (I) in which R?1¿ and R?2¿ may be the same or different and mutually independently be a...
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WO/1992/005143A1 |
The present invention is concerned with compounds of formula (I), wherein R1 is hydrogen, hydroxy, C1-4 alkyl, halo (e.g., chloro), carbamoyl, aminosulfonyl, C1-4 alkylsulfonylamino or C1-4 alkyl(C1-4 alkylsulfonyl)amino; R2 is hydrogen,...
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WO/1992/004328A1 |
Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by compounds of formula (1.0) and their pharmaceutically acceptable salts and solvates. Pharm...
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WO/1992/004309A1 |
15,16-Seco-19-nor progestins are provided which display elevated progestational activity with a minimum of ancillary hormonal activity. Processes for the preparation of the novel progestins are provided as are methods of use. A preferred...
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WO/1992/003488A1 |
The fluorinated quinoline polymers comprising repeating units of one or more quinoline groups wherein at least a portion of the repeating units include a group selected from hexafluoroisopropylidene (6F) and 1-aryl-2,2,2-trifluoroethylid...
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WO/1992/002484A1 |
Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from diterpenes, aromatic heterocyclic compounds of the indole, indene, benzofuran and benzothiophene class and from polyacetates, diaminobe...
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WO/1992/002480A1 |
5-Hydroxy-benzo-(1',2')-cyclodeca-2,7-diyne-1-one and derivatives thereof and related fused ring diyneone macrocyclic compounds are disclosed. The compounds possess DNA-cleaving, antibiotic and tumor growth-inhibiting properties. Methods...
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WO/1991/018866A2 |
There are provided novel 1,4-diamine-2,3-dihydroxybutanes useful as antiviral agents, pharmaceutical compositions containing them and processes for preparing such compounds.
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WO/1991/016320A1 |
Derivatives and analogues of 2-deoxy-2,3-didehydro-N-acetyl neuraminic acid, pharmaceutical formulations thereof, methods for their preparation and their use in the treatment of viral infections, in particular influenza, are described.
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WO/1991/013080A1 |
Pseudonucleosides and pseudonucleotides are useful in the synthesis of oligomers which contain these components as a means to derivatize the resulting oligonucleotide. In general, these pseudonucleotide components are of formula (1), whe...
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WO/1991/009594A1 |
The invention relates to methods for the treatment of schizophrenia or other psychoses by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment....
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WO/1991/008198A1 |
This invention relates to optical elements capable of second harmonic generation and novel compositions for use in such optical elements comprising polar molecules placed in noncentrosymmetric configuration wherein such optical element h...
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WO/1991/007501A1 |
Process for the pancreatic lipase mediated transesterification method for the optical resolution of endo-norborneol; derived optically active 5-(3-(exo-bicyclo[2.2.1]hept-2-yloxy)-4-methoxyphenyl)-3,4,5
,6-tetrahydropyrimidin-2(1H)-ones;...
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WO/1991/007371A1 |
The present invention relates to a method for the preparation of alpha,beta-unsaturated ketones represented by general formula (II) (where R is a heterocyclic group with nitrogen atom in the ring or a phenyl group with electron donative ...
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WO/1991/005824A1 |
Compounds of formula (I) in which R1, R2, R3 and R4 are each separately selected from hydrogen, X, NH-A-NHR and NH-A-N(O)R'R'' wherein X is hydroxy, halogeno, amino, C1-4 alkoxy or C2-8 alkanoyloxy, A is a C2-4 alkylene group with a chai...
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WO/1990/014330A1 |
A compound of formula (I), where Z is hydrogen or halogen, Q is COR1 or 5- or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, O or S and may be substituted or fused wherein R is hydrogen or C1-methyl (cis-configurat...
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WO/1990/009368A1 |
A method for producing amines, comprising contacting at reactive conditions at least one alcohol, aldehyde or ketone, or a mixture thereof, with an aminating agent in the presence of a catalyst, is improved by employing as the catalyst a...
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WO/1990/008759A1 |
The present invention concerns compounds of formula (I) wherein R1 is hydrogen, a hydroxy group or a methoxy group; R2 is hydrogen or a methyl group; R3 is hydrogen or a methyl group; Y is a secondary amino group (NHalkyl) or a tertiary ...
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WO/1990/006299A1 |
New phenylethanolamines of general formula (I), in which A is a straight-chain or branched alkylene group, B is a bond, an alkylene group, a carbonyl or hydroxymethylene group, R1 is a hydrogen atom, a halogen atom or a trifluormethyle g...
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WO/1990/004583A1 |
A muscarinic receptor antagonist, useful in treating irritable bowel syndrome, of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1 is a group of formula (alpha) or (beta), where Z and Z1 are each independently hydro...
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WO/1989/012443A1 |
A compound of formula (I) and pharmaceutically acceptable acid addition salts thereof having antihistaminic activity wherein the various substituents are defined in the specification.
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WO/1989/003681A1 |
A racemic or optically active compound having the structural formula (I), wherein n is 0 or 1; X is CH2, O, S, SO, SO2, NH or N(C1-C4)alkyl; X1 is CH2, O, S, SO or SO2; Y and Y1 are taken together and form a carbonyl group, or Y and Y1 a...
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WO/1989/003819A1 |
Phenylcarboxylic acid derivatives represented by formula (I), and their salts, wherein R1 and R2 each represents H, halogen, alkyl, haloalkyl, alkanoyl, cycloalkyl, nitro, amino, -O-D-R5 (wherein D represents alkylene, and R5 represents ...
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WO/1989/003382A1 |
The invention comprises cyclobutarene ketoaniline monomers and the process for preparing them. The monomers can be used to graft and/or endcap a monomer or polymer having at least 1 amino-reactive functionality. The grafted and/or endcap...
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WO/1988/007036A1 |
Compound having beta-adrenergic blocking properties having formula (I), wherein X is -O-, -CH2- or -----; Y is =O or a derivatized keto group, each of which is hydrolyzable or enzymatically convertible to a ketonic group; R is alkyl havi...
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WO/1988/006580A1 |
Aryl-substituted tert.-alkylenamines, have the formula (I), where R is an alkyl group with 1-6 C-atoms, or the total residue (a) represents the heterocyclic residues (b), (c), (d), (e), or (f), where R5 is hydrogen, methyl, phenyl, 4-chl...
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WO/1987/007599A2 |
Compounds having anti-inflammatory and other activities. The compounds are derived from diterpenes, indol alkaloids, polyacetates, diaminobenzyl alcohols, diacylglycerol and bryostatins.
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WO/1987/006576A1 |
Antidepressant agents having formula (I), wherein R1 is a polycycloalkyl group; R2 is methyl or ethyl, X is O or NH; and Y comprises a 5- or 6-membered heterocyclic ring having one or two nitrogens; or fused bicyclic heterocyclic rings h...
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WO/1987/004153A1 |
2,3-Dihydro-1H-phenalene-2-amino compounds of formula (I), some of which are new, e.g., 2,3-dihydro-2-(N,N-di-n-propylamino)-1H-phenalen-5-ol, and pharmaceutically acceptable salts of such compounds have been found to be useful anti-psyc...
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WO/1987/003283A1 |
Carbacycline derivatives of general formula (I), in which Y1 is the residue of Formula (II), R9 is the residue -(CH2)m-R6 or the residue -(CH2)m-o- ADZ1-(CH2)m-p BDx- ADZ2-(CH2)m-q BDy-R6, m = 2-20; o, p and q <= 19; x, y = 0, 1 or 2; Z1...
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WO/1987/002980A1 |
The invention relates to the field of organic chemistry and particularly to a process for the synthesis of alpha-amino nitriles which comprises subjecting an RCN nitrile to the action of a metal reducing agent to form a metal imine, and ...
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WO/1986/005777A1 |
Compounds of the general formula (I) in which Z represents CR1R2(OR3) or phenyl with R1 H, C1-6 alkyl or phenyl, R2 H, C1-6 alkyl or C1-6 alkoxy, R3 H, C1-6 alkyl or C1-6 alkanoyl and Z' represents Y AD(CH2)m-X BD- with X CH2 or O, Y OH;...
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WO/1986/005778A1 |
Compounds of the general formula (I) in which Z represents CH1R2(OR3) or phenyl; R1 represents H, C1-6-alkyl or phenyl; R2 represents H, C1-6-alkyl or C1-6-alkoxy; R3 represents H, C1-6-alkyl or C1-6-alkanoyl and Z' represents Y- AD(CH2)...
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WO/1986/002350A1 |
A new and useful class of ultra light absorbing compounds and their use in sunscreen compositions and the protection of paint films and plastics materials from solar degradation. In particular the compounds possess a novel UV absorbing c...
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WO/1986/001502A1 |
A process for the production of amino compounds from hydroxyl compounds (Voelter reaction), according to which a hydroxyl compound is converted with trifluormethanesulphonic acid anhydride in water-free conditions, the corresponding trif...
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WO/1986/000895A1 |
Carbacycline derivatives of formula (I) are disclosed, wherein: n is 1 or 3, R1 is the rest having the formula (II), the rest having the formula (III), -COCH3, the rest COOR2 wherein R2 is hydrogen or alkyl with 1 to 10 atoms of carbon o...
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WO/1981/001407A1 |
Compounds of the formula (FORMULA) wherein R is H or CH3, n is 1 or 2 and X is F, Cl, Br, I bound in an optional position to the phenyl group, provided that when X is Br it is bound in a position other than the 4 position, processes for ...
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JP2024514316A |
Enantiopure (S)-methadone, (R)-methadone, (R,S) with preservation of stereochemical configuration starting from optically active or racemic N-substituted cyclic sulfamidates or N-substituted aziridines -Methods for the synthesis of metha...
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JP7451538B2 |
Provided are pamoate salts of ketamine having a stoichiometry of 2:1 of ketamine to pamoate, including R, S-ketamine pamoate, S-ketamine pamoate, or R-ketamine pamoate, and crystalline or amorphous forms of the pamoate salts, and having ...
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JP2024506398A |
The invention features compounds and methods of treating injuries or diseases (eg, stroke, congenital hypogonadotropic hypogonadism, viral infections) using the compounds. The invention also features pharmaceutical compositions that incl...
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JP2024015334A |
[Problem] The present disclosure provides (2R,6R)-hydroxynorketamine (HNK) and (2S, A method for synthesizing the free base form of 6S)-hydroxynorketamine is provided. In one embodiment, (2R,6R)-hydroxynorketamine (HNK ) was synthesized ...
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JP7413281B2 |
Described are polymerizable high energy light absorbing compounds of formula I:wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible ...
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JP7404795B2 |
To provide a metal catalyst that can be used as a catalyst capable of efficiently and selectively promoting a chemical reaction while using polysaccharide such as an environmentally friendly cellulose as a catalyst carrier.There is provi...
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JP7379567B2 |
The disclosure provides a method for synthesizing free base forms of (2R,6R)-hydroxynorketamine (HNK) and (2S,6S)-hydroxynorketamine. In an embodiment synthesis of (2R,6R)-hydroxynorketam-ine (HNK) includes preparation of (R)-norket-amin...
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