| Document |
Document Title |
|
WO/2024/153225A1 |
The disclosure is directed to novel ALPK1 inhibitors having the Formula (I), or a pharmaceutical acceptable salt, a stereoisomer, a tautomer, a stable isotopic variant, a prodrug, or a crystal form thereof. The disclosure is also directe...
|
|
WO/2024/155931A1 |
Compositions comprising lipidoid compounds, methods of preparing such compositions, and the use of these compositions in gene delivery applications are disclosed.
|
|
WO/2024/151666A1 |
The present disclosure provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, spec...
|
|
WO/2024/054843A3 |
Compounds are provided having the following Structure (I): or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1a, R1b, R2, R3, L1a, L1b, n1, and X are as defined herein. Use of the compounds as a component...
|
|
WO/2024/064923A9 |
Disclosed herein are, inter alia, activators of K2P potassium channels and pharmaceutical compositions thereof, and methods comprising their use for the treatment of diseases or adverse conditions related to low TREK family protein activ...
|
|
WO/2024/145726A1 |
The present invention comprises: first recovering trichloroethane and then recovering DMF, so as to remarkably reduce the impurity content of an obtained concentrated dry liquid, such that the yield and purity of an obtained sucralose-6-...
|
|
WO/2024/147009A1 |
One aspect of the invention relates to a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof, X is NH and Y is CO ring C is a 6-membered heteroaryl or aryl group, or a partially or fully unsaturated 6-member...
|
|
WO/2024/144829A1 |
A variety of methods and well treatment fluids are disclosed, including, in one embodiment, a method of treating a subterranean formation, comprising contacting the subterranean formation with a well treatment additive, wherein the well ...
|
|
WO/2024/139061A1 |
A method for synthesizing amide and/or a polypeptide with an unprotected amino acid as an amine component. The method for preparing the polypeptide comprises using an amino acid or a peptide fragment, which has unprotected amino and carb...
|
|
WO/2024/145585A1 |
Disclosed herein are compounds, compositions, and methods for treating cancer and/or the repair of DNA.
|
|
WO/2024/133860A1 |
The disclosure concerns a process for synthesizing a compound of formula (FI) wherein: R1 is phenyl substituted with halogen or trifluoromethyl, and further optionally substituted with one or two substituents selected from the group cons...
|
|
WO/2024/130897A1 |
The present invention relates to the field of fine chemicals. Disclosed is a preparation method for crotononitrile. Cheap and easily available crotonic acid is used as a starting raw material to prepare single-configuration trans-crotono...
|
|
WO/2024/138228A1 |
Biocatalysts and methods for performing stereocontrolled radical cyclisation to arenes and stereocontrolled radical dearomatization of aromatics are described. Generally, modified enzymes are utilized to perform enantioselective and/or d...
|
|
WO/2024/124354A1 |
In some example embodiments the invention relates to compositions comprising at least one N-acylethanolamine (NAE) and at least one of a cannabinoid, terpene, antioxidant or herbal extract. In other example embodiments the invention rela...
|
|
WO/2024/129873A1 |
Mechanochromic impact sensors, which can further include some temperature sensing capability, are disclosed. The sensors are based on core-shell vesicles having a core and a shell material layer at least party surrounding the core. The c...
|
|
WO/2024/121084A1 |
The present invention describes a process for the preparation of aromatic or heteroaromatic nitriles.
|
|
WO/2024/123607A1 |
The present invention relates to 2-methyl-2-(l-methylcyclohexyl) propanamide derivatives of formula A and l-(tert-butyl)-cyclohexane-l-carboxamide derivatives of formula B for use in umami flavor compositions.
|
|
WO/2024/123978A1 |
The present disclosure provides new ionizable lipids, lipid nanoparticle (LNP) compositions comprising the same, and methods of delivering therapeutic and/or prophylactic agents (e.g., mRNA) with the LNPs described herein. The ionizable ...
|
|
WO/2024/122569A1 |
This fluorine-containing ether compound is represented by a formula. R1-CH2-R2-(CH2-OCH2-CR3R4-CH2O-CH2-R2)z-CH2-R5 (where z is 1 or 2; R2 is a perfluoropolyether chain; R1 and R5 are each a C1-50 terminal group having at least one polar...
|
|
WO/2024/114710A1 |
Provided are a method for preparing cabozantinib and an intermediate thereof. The preparation method provided by the invention has simple operations, better facilitates industrial production, there is high yield in each step of a route a...
|
|
WO/2024/114723A1 |
The present invention relates to the technical field of pharmaceutical cocrystals. More specifically, the present invention relates to a cocrystal of an enkephalinase inhibitor and an angiotensin II receptor antagonist, and a preparation...
|
|
WO/2024/118602A1 |
Provided herein are formulations comprising a plurality of lipid particles in a liquid mixture, wherein each lipid particle comprises one or more phospholipids, or a pharmaceutically acceptable salt thereof, and a first T-cell immunoglob...
|
|
WO/2024/119098A1 |
The present disclosure describes compositions, nanoparticles (such as lipid nanoparticles), and/or lipid nanoparticle compositions and methods of their use.
|
|
WO/2024/109794A1 |
Provided are cationic lipid compounds represented by formula (I), which can be applied to lipid nanoparticles such that the lipid nanoparticles can target different tissue organs for drug delivery. The cationic lipid compounds or a lipid...
|
|
WO/2024/109867A1 |
The present invention belongs to the technical field of biological medicines. Disclosed are vegetable oil ceramides. The vegetable oil ceramides are obtained by reacting vegetable oil fatty acids with sphingosine compounds, the sphingosi...
|
|
WO/2024/103458A1 |
Disclosed are a ligand and a metal iridium complex having proton response function, a preparation method therefor, and use thereof. The ligand having proton response function has a structure represented by formula L below. The metal irid...
|
|
WO/2024/105187A1 |
The disclosed method makes it possible to obtain an n-acetylated aromatic primary amine affording good purity and a good yield.
|
|
WO/2024/105071A1 |
The present invention refers to novel polyoxyalkylene based compounds and their manufacturing method as well as compositions comprising at least one novel polyoxyalkylene based compound and at least one active agent. Furthermore, the pre...
|
|
WO/2024/105700A1 |
The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an a...
|
|
WO/2024/102078A1 |
This invention provides compounds according to formula (I): wherein A and Za are as defined in the specification. The compounds of formula (I) find use as heterobifunctional linkers. The present invention also provides compounds of formu...
|
|
WO/2024/099269A1 |
Provided are following compound (I) or a pharmaceutically acceptable salt, ester, optical isomer, tautomer, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound, metabolite, chelate, complex, inclusion compound or prodrug ...
|
|
WO/2024/099975A1 |
The invention relates to nanoparticles for Cas protein/gRNA ribonucleoprotein (RNP) complex, siRNA or PMO delivery comprising one or more Cas protein/gRNA RNP complex(es), siRNA(s) or PMO(s) as cargo; and a carrier comprising a sequence-...
|
|
WO/2024/102890A2 |
In one aspect, the disclosure relates to oligomers of benzoic acid derivatives and amino acids as well as pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions including the disclosed oligomers and met...
|
|
WO/2024/099888A1 |
The present invention relates to a process for converting an N-formyl-protected aminonitrile compound to the corresponding N-formyl-protected amino alcohol or amino alcohol compound or mixtures thereof by reductive hydrolysis in the pres...
|
|
WO/2024/098531A1 |
An intermediate and a use and method of the intermediate in preparation of pyrroloquinoline quinone. The intermediate compound has a structure as shown in formula I or formula II. In the structure, R1 is C1-C3 straight-chain or branched-...
|
|
WO/2024/102475A1 |
The present disclosure features particle compositions, such as liposomes and lipid nanoparticles, comprising a polysarcosine-lipid conjugate, as well as methods of making and using the same.
|
|
WO/2024/092593A1 |
Imidazoline additives, and methods of making and using the additives are described. The additives may be provided as concentrates for addition to process compositions comprising acrylic acid, methacrylic acid, salts of acrylic acid, salt...
|
|
WO/2024/093625A1 |
The present invention relates to the technical field of biomedicine. Disclosed is a linolenic acid-derived ceramide, which has a structure of general formula I or an isomer of general formula I: (I), wherein R1 is selected from (II) or (...
|
|
WO/2024/091450A1 |
The present disclosure relates to compounds for treating cancer. The compounds may prevent conversion of non-stem cancer cells into cancer-initiating cells caused by radiation treatment.
|
|
WO/2024/089565A1 |
Antifouling compositions are provided. The antifouling compositions include a dispersing agent including an imidazoline, a solvator including a phthalate, and a promoter agent including an acylamide. Methods of mitigating fouling caused ...
|
|
WO/2024/090041A1 |
Provided are a radioactive-ray-sensitive resin composition and a pattern formation method that make it possible to form a resist film that has satisfactory storage stability, and also has excellent sensitivity and LWR performance when ne...
|
|
WO/2024/090485A1 |
The present invention provides a method for producing a fluorine-containing compound under relatively mild conditions by introducing a fluorine atom into a wide variety of oxygen-containing compounds having a ketone group, an aldehyde gr...
|
|
WO/2024/083172A1 |
The present invention relates to a lipid compound and a lipid nanoparticle composition. The present invention specifically relates to a lipid compound, which can be used in combination with other lipid components such as neutral lipids, ...
|
|
WO/2024/082523A1 |
The present invention relates to a discoid liquid crystal molecule functional modifier, and a preparation method therefor and the use thereof. In the invention, a discoid liquid crystal molecule functional modifier is first synthesized b...
|
|
WO/2024/086259A1 |
Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3- dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecti...
|
|
WO/2024/083171A1 |
The present invention relates to a lipid compound and a lipid nanoparticle composition. The present invention specifically relates to a lipid compound, which can be used in combination with other lipid components such as neutral lipids, ...
|
|
WO/2024/081739A2 |
The present document relates to covalent compounds and uses thereof, including methods of targeting or engaging one or more targets with a covalent compound. Also provided herein are methods of treating a disease using such a compound an...
|
|
WO/2023/240156A9 |
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.
|
|
WO/2024/074641A1 |
The present invention relates to a method for preparing of an amide of the formula (I-1) or a diamide of the formula (I-2) where the variables areas defined in the claims and the description, by reacting an ester with an aromatic or hete...
|
|
WO/2024/075535A1 |
In the present invention, there is employed a resist composition having, as a base resin, a polymer compound that has constituent units derived from a compound expressed by general formula (a0−m). In the formula, W is a polymerizable-g...
|
