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Matches 1 - 50 out of 15,340

Document Document Title
WO/2024/103458A1
Disclosed are a ligand and a metal iridium complex having proton response function, a preparation method therefor, and use thereof. The ligand having proton response function has a structure represented by formula L below. The metal irid...  
WO/2024/105187A1
The disclosed method makes it possible to obtain an n-acetylated aromatic primary amine affording good purity and a good yield.  
WO/2024/105071A1
The present invention refers to novel polyoxyalkylene based compounds and their manufacturing method as well as compositions comprising at least one novel polyoxyalkylene based compound and at least one active agent. Furthermore, the pre...  
WO/2024/105700A1
The present invention discloses a method for the synthesis of a compound of formula (V) or a salt thereof, wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The method further comprises the synthesis of an a...  
WO/2024/102078A1
This invention provides compounds according to formula (I): wherein A and Za are as defined in the specification. The compounds of formula (I) find use as heterobifunctional linkers. The present invention also provides compounds of formu...  
WO/2024/099269A1
Provided are following compound (I) or a pharmaceutically acceptable salt, ester, optical isomer, tautomer, stereoisomer, polymorph, solvate, N-oxide, isotope-labeled compound, metabolite, chelate, complex, inclusion compound or prodrug ...  
WO/2024/099975A1
The invention relates to nanoparticles for Cas protein/gRNA ribonucleoprotein (RNP) complex, siRNA or PMO delivery comprising one or more Cas protein/gRNA RNP complex(es), siRNA(s) or PMO(s) as cargo; and a carrier comprising a sequence-...  
WO/2024/102890A2
In one aspect, the disclosure relates to oligomers of benzoic acid derivatives and amino acids as well as pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions including the disclosed oligomers and met...  
WO/2024/099888A1
The present invention relates to a process for converting an N-formyl-protected aminonitrile compound to the corresponding N-formyl-protected amino alcohol or amino alcohol compound or mixtures thereof by reductive hydrolysis in the pres...  
WO/2024/098531A1
An intermediate and a use and method of the intermediate in preparation of pyrroloquinoline quinone. The intermediate compound has a structure as shown in formula I or formula II. In the structure, R1 is C1-C3 straight-chain or branched-...  
WO/2024/102475A1
The present disclosure features particle compositions, such as liposomes and lipid nanoparticles, comprising a polysarcosine-lipid conjugate, as well as methods of making and using the same.  
WO/2024/092593A1
Imidazoline additives, and methods of making and using the additives are described. The additives may be provided as concentrates for addition to process compositions comprising acrylic acid, methacrylic acid, salts of acrylic acid, salt...  
WO/2024/093625A1
The present invention relates to the technical field of biomedicine. Disclosed is a linolenic acid-derived ceramide, which has a structure of general formula I or an isomer of general formula I: (I), wherein R1 is selected from (II) or (...  
WO/2024/091450A1
The present disclosure relates to compounds for treating cancer. The compounds may prevent conversion of non-stem cancer cells into cancer-initiating cells caused by radiation treatment.  
WO/2024/089565A1
Antifouling compositions are provided. The antifouling compositions include a dispersing agent including an imidazoline, a solvator including a phthalate, and a promoter agent including an acylamide. Methods of mitigating fouling caused ...  
WO/2024/090041A1
Provided are a radioactive-ray-sensitive resin composition and a pattern formation method that make it possible to form a resist film that has satisfactory storage stability, and also has excellent sensitivity and LWR performance when ne...  
WO/2024/090485A1
The present invention provides a method for producing a fluorine-containing compound under relatively mild conditions by introducing a fluorine atom into a wide variety of oxygen-containing compounds having a ketone group, an aldehyde gr...  
WO/2024/083172A1
The present invention relates to a lipid compound and a lipid nanoparticle composition. The present invention specifically relates to a lipid compound, which can be used in combination with other lipid components such as neutral lipids, ...  
WO/2024/082523A1
The present invention relates to a discoid liquid crystal molecule functional modifier, and a preparation method therefor and the use thereof. In the invention, a discoid liquid crystal molecule functional modifier is first synthesized b...  
WO/2024/086259A1
Described herein are novel methods of synthesizing 2-amino-5-chloro-N,3- dimethylbenzamide. Compounds prepared by the methods disclosed herein are useful for preparation of certain anthranilamide compounds that are of interest as insecti...  
WO/2024/083171A1
The present invention relates to a lipid compound and a lipid nanoparticle composition. The present invention specifically relates to a lipid compound, which can be used in combination with other lipid components such as neutral lipids, ...  
WO/2024/081739A2
The present document relates to covalent compounds and uses thereof, including methods of targeting or engaging one or more targets with a covalent compound. Also provided herein are methods of treating a disease using such a compound an...  
WO/2023/240156A9
Provided are ionizable cationic lipids and lipid nanoparticles for the delivery of nucleic acids to cells (e.g., immune cells), and methods of making and using such lipids and targeted lipid nanoparticles.  
WO/2024/074641A1
The present invention relates to a method for preparing of an amide of the formula (I-1) or a diamide of the formula (I-2) where the variables areas defined in the claims and the description, by reacting an ester with an aromatic or hete...  
WO/2024/075535A1
In the present invention, there is employed a resist composition having, as a base resin, a polymer compound that has constituent units derived from a compound expressed by general formula (a0−m). In the formula, W is a polymerizable-g...  
WO/2024/071392A1
This fluorine-containing ether compound is represented by the following formula. R1-CH2-R2(-CH2-R3-CH2-R2)x-CH2-R4 (In the formula, x represents an integer of 1 or 2; R2 represents a perfluoropolyether chain; R3 is represented by formula...  
WO/2024/071399A1
This fluorine-containing ether compound is represented by the following formula. R1-CH2-R2[-CH2-R3-CH2-R2]x-CH2-R4 (x is 1 or 2. R2 is a perfluoropolyether chain. R3 is represented by formula (2). R1 and R4 are terminal groups having 1-5...  
WO/2024/069507A1
This invention relates to novel processes for synthesizing N-(3-(6-Amino-5-(2-(N- methylacrylamido)ethoxy)pyrimidin-4-yl)-5-fluoro-2-methylphe nyl)-4-cyclopropyl-2-fluorobenzamide and to intermediates which are used in such processes.  
WO/2024/065043A1
Provided are lipids and nanoparticles containing such lipids and a cargo molecule, such as nucleic acid, methods to formulate said lipids with nucleic acids to produce lipid nanoparticles and chemical routes for making the lipids. The li...  
WO/2024/059951A1
This invention provides compound having a structure of Formulas I-VI. Uses of such compounds for treatment of various indications that would benefit from modulation of the androgen receptor, including prostate cancer. Also provided are m...  
WO/2024/059661A1
Provided herein are compounds of formula (I) or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein m, n, R1, R2, R3, R4, Y1, Y2, X1, X2, L, and Q1 are as defined elsewhere herein. A...  
WO/2024/050715A1
Provided in the present application are amide compounds having amino groups on both ends, having general formula (I), in which A and B are independently selected from substituted or unsubstituted C1-C18 alkylene groups, C2-C18 alkenylene...  
WO/2024/054321A1
Non-triazole compounds are provided that can be effective to inhibit corrosion of a corrodible metal surface in an aqueous system. The non-triazole compounds show comparable or better corrosion inhibition as compared to conventional tria...  
WO/2024/050108A2
Aspects of the disclosure relate to compositions and methods for modulating the immune response of a subject. The disclosure is based, in part, on compositions comprising one or more compounds that promotes interferon, e.g., interferon g...  
WO/2024/048438A1
The present invention addresses the problem of providing: a diastereomer preparation method whereby it becomes possible to produce a desired diastereomer from a diastereomer mixture with high efficiency; and a solid-phase photosensitizer...  
WO/2024/040745A1
The present application provides an amide compound containing iodo aryl or iodo heteroaryl, and a preparation method therefor and a use thereof. The amide compound containing iodo aryl or iodo heteroaryl can be used for preparing an X-ra...  
WO/2024/044728A1
The present disclosure relates to PEGylated lipid compounds and pharmaceutically acceptable salts thereof. Such compounds are useful, for example, as constituent parts of lipid nanoparticle (LNP) formulations for delivery of various acti...  
WO/2024/040091A1
Embodiments of the present disclosure relate to lipid-PEGylated solid support and phosphoramidites derivatives, methods for preparing the same, and their uses in the delivery of oligonucleotide drugs to the cellular targets.  
WO/2024/040182A1
Disclosed herein is the use of purified 2-S rimantadine or purified 2-R rimantadine or a pharmaceutically acceptable thereof to treat cancers and precancer lesions, including cancers and precancer lesions associated with papilloma virus ...  
WO/2024/032774A1
Provided are a compound as a voltage-gated sodium channel inhibitor, a preparation method therefor, a pharmaceutical composition thereof, and use thereof. The compound has the structural characteristics of formula (I).  
WO/2024/031970A1
The present invention relates to a compound having a chemical formula (I), and further relates to a preparation method therefor and use thereof. Pharmacological experiment results show that the compound of the present invention has excel...  
WO/2024/033479A1
The application relates to compounds of formula (B1A), (B1B), (B1C) or a salt, a solvate, a hydrate, a polymorph, a tautomer, a racemate or a stereoisomer thereof, to pharmaceutical compositions comprising such a compound, and to the com...  
WO/2024/030627A1
Provided herein are compounds having a structure of formula (A), or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rd, and n are described herein. Also provided herein are compositions comprising compounds of Formula ...  
WO/2024/028808A1
The present disclosure relates to compounds of Formula (I) which modulate the activity of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, au...  
WO/2024/026359A1
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that are inhibitors for thioredoxin glutathione reductase (TGR), which is key for ...  
WO/2024/024781A1
This fluorine-containing ether compound is represented by the following formula. R1-CH2-R2[-CH2-R3-CH2-R2]x-CH2-R4 (x represents an integer of 1 or 2, R2 represents a perfluoropolyether chain, at least one of the x-number of R3 is repres...  
WO/2024/011415A1
Disclosed in the present invention is a method for preparing an o-iodophenyl compound, wherein an iodobenzene compound and an amide compound as raw materials are reacted in the presence of sodium hydride or n-butyllithium and a solvent t...  
WO/2024/013445A1
The present invention relates to a compound of formula (1), wherein the variables R, X, l, R 1, R 2, A, n and R 3 are as defined in the description. The invention also relates to the use of the compound of formula (1) as a surfactant.  
WO/2024/007851A1
A catalyst for amide synthesis and preparation and use thereof are disclosed. The catalyst is a thio or seleno pyranodipyrimidine compound and has a simple and novel structure, high catalytic efficiency, and good atom economy. The cataly...  
WO/2024/007722A1
Provided is a compound of Formula (I) : Besides, provided is a pharmaceutical composition comprising the above compound and their use for preventing or treating cocaine addiction, reducing the likelihood of a relapse of cocaine addiction...  

Matches 1 - 50 out of 15,340