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WO/2021/012014A1 |
The present invention relates to methods for preparing a variety of difluorohaloallylamine derivatives. The present invention also relates to novel difluorohaloallylamine derivatives that are capable of inhibiting certain amine oxidase e...
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WO/2021/007840A1 |
Provided is a carbamate-substituted styryl sulfone compound, a preparation method, and an application thereof. The carbamate-substituted styryl sulfone compound has a structure represented by general formula I. The carbamate-substituted ...
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WO/2020/257573A1 |
The invention provides crystalline salt and cocrystal forms of bempedoic acid. Also provided are compositions and pharmaceutical materials including a crystalline salt or cocrystal form of bempedoic acid as well as methods of treating va...
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WO/2020/257571A1 |
The invention provides methods of preparing 8-hy droxy-2,2, 14,14- tetramethylpentadecanedioic acid and methods of making a pharmaceutical material comprising a purified amount of 8-hy droxy-2,2, 14, 14-tetramethylpentadecanedioic acid. ...
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WO/2020/251012A1 |
Provided is are an agricultural and horticultural agent, in particular a compound which is useful as the active ingredient of an agricultural and horticultural pest control agent, a mite control agent, a nematode control agent or a disea...
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WO/2020/238779A1 |
The present invention relates to a method for synthesizing florfenicol. The method comprises the steps of: using sulfuryl fluoride as a fluorinating reagent to fluorinate compound I to obtain a product, and then performing a ring opening...
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WO/2020/207929A1 |
The invention relates to a process for working up a composition comprising solid 4,4'- dichlorodiphenyl sulfoxide and a solvent, wherein the amount of solvent in the composition is in the range between 5 and 25 wt% based on the total mas...
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WO/2020/186632A1 |
The present application relates to a benzidine compound and an application thereof, the benzidine compound having the structure as shown in formula I below. Further provided in the present application are a pharmaceutically acceptable sa...
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WO/2020/187795A1 |
The invention relates to an anionic surfactant of general formula (I) or general formula (II) or mixtures thereof, in which R represents hydrogen or a linear or branched alkyl, alkenyl, alkyl-aryl or alkenyl-aryl group with 5 to 25 C ato...
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WO/2020/161225A1 |
The invention relates to a process for purifying 4,4'-dichlorodiphenyl sulfoxide comprising: (a) providing a suspension comprising particulate 4,4'-dichlorodiphenyl sulfoxide in monochlorobenzene, (b) solid-liquid separation of the suspe...
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WO/2020/161228A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfoxide comprising: (I) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride : chlorobenzene : aluminum chloride of 1...
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WO/2020/161232A1 |
The invention relates to a process for producing 4,4'-dichlorodiphenyl sulfoxide comprising: (a) reacting thionyl chloride, chlorobenzene and aluminum chloride in a molar ratio of thionyl chloride : chlorobenzene : aluminum chloride of 1...
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WO/2020/161100A1 |
The invention relates to a crystal (C) consisting of at least 95 % by weight of 4,4'-dichlorodiphenylsulfoxide, 0 to 2 % by weight of impurities and 0 to 3 % by weight of an organic solvent (os). Moreover, the present invention relates t...
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WO/2020/161226A1 |
The invention relates to a process for obtaining 4,4'-dichlorodiphenyl sulfoxide from a liquid mixture comprising 4,4'-dichlorodiphenyl sulfoxide and a solvent, comprising: (a) cooling the liquid mixture to a temperature below the satura...
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WO/2020/135000A1 |
Disclosed is a preparation method for 3-phenyl-L-serine or derivatives thereof, comprising the following steps: a. obtaining 3-phenyl-L-serine or derivatives thereof on the basis of the reaction formula represented by Formula I, wherein ...
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WO/2020/099285A1 |
The invention is directed to a catalyst, to a method for manufacturing a catalyst, to a method for manufacturing a bisphenol compound, and to the use of a catalyst. The catalyst of the invention comprises particles having a core and a sh...
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WO/2020/094917A1 |
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl halides is catalyzed by a cat- alyst compound comprising a transition metal. The process is scalable...
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WO/2020/084094A1 |
The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromati...
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WO/2020/006778A1 |
The invention belongs to the field of chemical synthesis and discloses a new crystal form of tembotrione, which is a herbicide, a preparation method thereof, and an application thereof as a preparation for plant protection. The present i...
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WO/2019/243179A1 |
The present invention relates to disubstituted 5(3)-pyrazole carboxylates of the formula (la) or (lb) and a process for their preparation wherein R1, R2, R3, R4 and n are defined as above.
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WO/2019/243178A1 |
The present invention relates to disubstituted 3-pyrazole carboxylates of the formula (I) and a process for their preparation (I) wherein R1, R2, R3, R4 and n are defined as above.
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WO/2019/237005A1 |
The present disclosure provides methods for preparing polyunsaturated hydrocarbons, such as E,E-farnesol, farnesyl acetate and squalene, by base catalyzed addition of a dialkylamine to a 3-methylene-1-alkene, such as farnesene. The prese...
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WO/2019/194690A1 |
Provided is an improved process of vitamin K2 derivatives preparation, represented by formula (I) wherein n is an integer from 3 to 13.
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WO/2019/192058A1 |
A biochip substrate, a preparation method therefor, and an application thereof. The surface of the biochip substrate contains an active vinyl sulfone group. The preparation method involves a one-step reaction of a compound containing vin...
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WO/2019/180627A1 |
The present invention relates to an improved asymmetric synthesis of alpha- (diarylmethyl) alkyl amines (hereafter referred to as the compound (1)) or its pharmaceutically acceptable salt and derivatives. The process comprises an unusual...
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WO/2019/175149A1 |
The present invention relates to compounds of the formula (1) which are suitable for use in electronic devices, in particular organic electroluminescent devices, and to electronic devices which comprise these compounds.
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WO/2019/088800A9 |
The present invention relates to a polyethylene glycol derivative and a preparation method thereof. A preparation process of a polyethylene glycol derivative, according to the present invention, may provide a novel polyethylene glycol de...
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WO/2019/091179A1 |
Disclosed is a method for preparing florfenicol intermediate V, which belongs to the technical field of the preparation of veterinary medicines. The method comprises an addition reaction, a ring-closing reaction, a hydrolysis reaction an...
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WO/2019/062561A1 |
Provided herein the synthesis methods of firocoxib and an intermediate thereof. The synthesis of the first intermediate is performed through methylation of p-bromopropiophenone or through Friedel-Crafts acylation of bromobenzene, avoidin...
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WO/2019/043289A1 |
The present invention relates to a process for the preparation of arylsulfonylpro- penenitriles. The reaction starting from arylsulfonyl iodides is catalyzed by light. The process is scalable, environmentally benign and provides the prod...
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WO/2019/039705A1 |
The present invention relates to a method for separating 5-hydroxymethyl-2-furfural (HMF) and dimethyl sulfoxide (DMSO), the method comprising the steps of: (a) preparing a mixture solution comprising HMF and DMSO; and (b) mixing an orga...
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WO/2019/035479A1 |
A cyclopropanation method includes reacting an alcohol, an ester, or an aldehyde with a sulfone in an organic solvent containing a base providing a counter cation to form a cyclopropane; and isolating the cyclopropane.　When using the a...
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WO/2019/030184A1 |
The invention relates to new compounds of formula (I) wherein X represents a halogen atom selected from the group consisting of fluorine, chlorine, bromine and iodine, which are useful for the preparation of 4,4'dihalodiphenylsulfones of...
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WO/2019/026479A1 |
In one or more embodiments, the present invention pertains to a method for purifying dimethyl sulfoxide, the method including a step for adding an alkaline earth metal hydroxide to a material to be distilled that contains dimethyl sulfox...
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WO/2019/026868A1 |
A method for recovering dimethyl sulfoxide, which comprises a step wherein water and a recovered resist remover that contains dimethyl sulfoxide and at least one compound selected from the group consisting of glycol ethers, glycols and t...
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WO/2018/228079A1 |
The present invention discloses a fluorescent probe for detecting a sulfenated protein, having the following structural general formula (I). The fluorescent probe has good stability and can be preserved for long-term use. The fluorescent...
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WO/2018/210633A1 |
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.
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WO/2018/189969A1 |
The present invention is a method for distilling a liquid containing dimethylsulfoxide using a distillation apparatus, wherein: (1) assuming the total of the liquid containing dimethylsulfoxide at the bottom of the distillation apparatus...
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WO/2018/114914A1 |
The present invention relates to a method for producing (functionalized) biaryls by employing a visible-light-driven, gold-catalyzed C-C cross-coupling reaction system involving boron- and silicon-containing aryl compounds and aryldiazon...
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WO/2018/096066A1 |
This invention is directed at a mechanochemical process using at least one solid catalytically active compound for simulating or capturing the transformation over time of a solid pharmaceutical composition in a shortened time span and th...
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WO/2018/067401A1 |
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a hig...
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WO/2018/061034A1 |
The present invention relates to a process for the preparation of 1-(3-ethoxy-4-methoxy-phenyl)-2-methylsulfonyl-ethanamine, an intermediate for the preparation of apremilast via a compound of Formula (V) wherein R is (C1-C4)alkyl, (C1-C...
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WO/2018/054877A1 |
The invention relates to a method for producing bistolanes which are substituted in the 1,1 '-position with halogen and to products from said compounds. The C-C-triple bonds of the bistolanes are produced by elimination reactions.
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WO/2018/012947A1 |
The present invention relates to a novel organic sulfur compound, a method for preparing the same, and a pharmaceutical composition for preventing or treating cancer or an inflammatory disease, containing the same as an active ingredient...
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WO/2018/007481A1 |
A process for preparing polyaryl ethers in which a polycondensation of the monomer building blocks is carried out using microwave irradiation leads to thermoplastic molding compositions having improved color properties.
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WO/2018/001353A1 |
Provided is a method for preparing apremilast of formula I. Method one: (S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethylamin
e N-acetyl-L-leucine salt of formula II is reacted with 3-acetylaminophthalic anhydride of formula III i...
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WO/2017/208501A1 |
Provided are: a surface-modified sodium hypochlorite pentahydrate crystal, an aqueous solution of which has a pH which can be significantly lowered safely and simply and at low cost without performing risky, high-cost pH adjustment that ...
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WO/2017/164813A1 |
D The present invention relates to ion pair catalysts (I) comprising the cationic bisguanidinium ligand (A) and diperoxomolybdate anion (B). The present invention also relates to ion pair catalysts (III) comprising the cationic bisguanid...
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WO/2017/150478A1 |
[Problem] To provide an industrially preferred method for producing a sulfoxide derivative. [Solution] A method for producing a sulfoxide derivative represented by general formula (1), the method being characterized in that a sulfide der...
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WO/2017/137147A1 |
The present invention relates to novel crystalline modifications of N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine hydrochloride, novel N-(4,5- bismethanesulfonyl-2-methylbenzoyl)guanidine salts and their crystalline modifications ...
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