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JP2002526461A |
The invention concerns LTA4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.
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JP3310301B2 |
A compound having the structure: wherein n is an integer from 1-5; each of R1 and R2 independently is optionally substituted C1-C6 alkyl; each of W and X is independently hydrogen or C1-C6 alkyl; Y is O, S or NR3 where R3 is hydrogen, C1...
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JP2002521476A |
This invention provides a process for preparing compounds of formula (1) wherein: X is phenyl optionally substituted with one or more substituents selected from the group consisting of halogen, alkyl of 1-6 carbon atoms, alkoxy of 1-6 ca...
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JP2002193922A |
To provide a compound used as a VEGF receptor antagonist for the treatment of diseases which the vascularization induced by VEGF participates in and the improvement of morbid symptoms induced by the VEGF.The compound represented by formu...
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JP3300365B2 |
Novel compounds are described. The compounds generally comprise an acidic group, a basic group, a substituted amino or N-acyl and a group having an optionally hydroxylated alkane moiety. Pharmaceutical compositions comprising the inhibit...
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JP2002519340A |
Thyroid hormone analogues are disclosed. Methods of using such analogues and pharmaceutical compositions containing them are also disclosed, as are novel procedures for their preparation.
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JP2002173465A |
To provide a method for producing high-purity, light-colored condensed dehydration product(s).This method for producing at least one condensed dehydration product selected from the group consisting of a (thio)ester, a (thio)acetal, a (th...
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JP2002517422A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517423A |
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 l...
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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002516863A |
(57) [Summary] Certain 6-membered ring aromatic and heteroaromatic dioxobutyric acid derivatives have been described as inhibitors of HIV integrase and inhibitors of HIV replication. The compound may or may not be used in combination wit...
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JP2002121182A |
To provide a method for producing a sulfide derivative, easy for purifying the objective material and in a high yield in producing the sulfide derivative by reacting olefins with mercaptans.This method for producing the sulfide by reacti...
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JP3276648B2 |
The present invention relates to perfluoroalkyl substituted sulfates and salts thereof of the formulas (Rf X CH2)xC(CH2OH)y(CH2OSO3-M+)z (I) or (RfE X CH2)xC(CH2OH)y(CH2OSO3-M+)z (II) which are prepared by sulfation of perfluoroalkyl sub...
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JP2002114759A |
To provide a resin monomer capable of forming a dielectric film suitable for electronic parts and a method for producing the above resin monomer.This bis(mercaptomethyl)benzene derivative is represented by the following chemical formula ...
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JP2002114760A |
To provide a resin monomer capable of forming a dielectric film suitable for electronic parts and a method for producing the above resin monomer.This bis(vinylbenzyl)sulfide derivative is represented by the following chemical formula (1)...
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JP2002510727A |
Sulphur product, (P), process for making (P), films, molded articles made therefrom, wherein (P) is obtained by the addition reaction of at least one polythiol (I) with at least one compound of formula (II):in which R1 represents a linea...
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JP2002087991A |
To provide a clearly defined bonding platform molecule that can be produced with high reproducibility and has an almost constant activity and/or a bonding platform molecule that has a plurality of specific bonding sites and a complex tha...
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JP2002505709A |
Composite materials particularly suitable in the dental art as a tooth filling material including a polymer matrix, a metal, metal alloy, metal oxide particulate, or combinations thereof, in the presence or absence of colloidal silica, a...
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JP2002047260A |
To provide a method for stabilizing α-amino acid amide in an aqueous solution.An aqueous solution of α-amino acid amide is stored after adding an acid to the solution so as to adjust the pH to 3-8. Otherwise, the aqueous solution of α...
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JP2002014201A |
To provide a lens made of e synthetic resin, excellent in optical characteristics, having a high refractive index and a high Abbe's number and excellent also in various physical properties such as low specific gravity, dyeability, heat a...
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JP3244271B2 |
Diaromatic compounds, characterised in that they correspond to the following general formula: in which: R1 is -CH3, -CH2OH, -COR8 or -CH2OCOR9, R8 is H, OH, -OR10, -N(rr') or alkyl, R10 is alkyl, alkenyl, aryl or aralkyl, r and r' being ...
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JP2001348351A |
To obtain a liquid crystalline charge transfering compound having a high fluidity, a low transition temperature to a liquid crystal phase and a wide liquid crystal temperature range and further high charge mobility.This liquid crystal co...
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JP2001342168A |
To provide zofimarin derivatives that have the high antifungal effect against the fungi having tolerance to azole antifungal agents, particularly against the candida.This invention provides zofimarin derivatives represented by general fo...
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JP2001523223A |
Novel arylalkylamino compounds exhibiting calcilytic properties are provided.
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JP3230024B2 |
PURPOSE: To obtain a liquid crystal compound which is useful as a component for ferroelectric liquid crystal composition having high response speed, reduced temperature dependence and increased contrast. CONSTITUTION: A compound of formu...
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JP2001316314A |
To obtain a new compound as an antiasthmatic agent which is a cyclic nucleotide phosphodiesterase(PDE) IV inhibitor.This compound comprises a compound represented by formula (I) (wherein, ring A and ring B may contain an unsaturated bond...
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JP3227498B2 |
PURPOSE: To obtain an agent for inhibiting scale deposition on the inner surface of a polymerizer for vinyl monomer polymerization by using as a major ingredient a sulfide of a hindered monohydric phenol which sulfide has a specific mol....
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JP2001302604A |
To provide a method for recemizing an N-acylamino acid which progresses under a mild condition. This method for recemizing an N-acylamino acid by a transition metal catalyst is to react a mixture brought to be rich in an enantiomer expre...
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JP2001302615A |
To provide a method for producing bis(phenylthio)benzenes at an industrially low cost and the bis(phenylthio)benzenes without having a thiophenol smell by treating the un-reacted thiophenol in a reaction liquid for no-smelling. This meth...
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JP2001520220A |
The invention relates to novel S-(4-biphenyl)-thiosulfuric acids and their salts, to a method for producing them from S-(4-biphenyl)-thiosulfinic acids and their salts, and to a method for producing 4-mercaptobiphenyls from the S-(4-biph...
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JP2001520218A |
The invention relates to a particularly advantageous method for producing aryl thiols through the catalytic hydrogenation of diaryldisulphides. According to the invention, the hydrogenation is carried out in a basic alcoholic medium.
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JP3222940B2 |
PURPOSE: To obtain the subject compound useful as a molecular weight modifier, etc., in polymerizing a monomer for plastic lenses having a high refractive index in high yield by reacting pentaerythritol tetrahalide with a trithiocarbonat...
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JP2001288162A |
To provide a trithiole compound with a low bad order, excellent in handling workability and produced by a simple process and to provide a method for producing the trithiole compound. This trithiole compound represented by general formula...
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JP2001253865A |
To provide a method for industrially and inexpensively producing 3,4-dimethoxybenzenethiol useful as an intermediate for producing various medicines, agrochemicals, functional materials, or the like.This method for producing 3,4-dimethox...
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JP2001253866A |
To provide a method for producing a polysulfide compound, capable of actualizing a reaction high in safety.This method for producing a polysulfide comprises reacting a liquid alkylmercaptan with sulfur in a molten state by mixing them in...
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JP2001515063A |
There is disclosed a structural genus of compounds, defined according to coordinates in three-dimensional space, that binds amino moieties on neighboring lysine residues in a tyrosine residue 29 pocket of the matrix protein component of ...
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JP2001515063A5 |
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JP3207200B2 |
There are provided compounds of the formula wherein R1 is a substituted or unsubstituted divalent aliphatic group of 1 to 16 carbon atoms; wherein the substituents are mono or poly and are selected from the group consisting of lower alky...
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JP2001240583A |
To provide a dehalopropenyloxybenzene derivative compound that has excellent performance as insecticide and acaricide.The compound is shown by formula 1 and a representative example is a dihalopropenyloxybenzene derivative, which has the...
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JP2001233852A |
To provide a method for producing a mercaptomethylphenol compound having a reduced, reduced discoloration and good storage stability in the presence of a lithium catalyst or an alkali medium.This improved method for producing the mercapt...
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JP3181297B2 |
The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I)as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatolog...
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JP3180832B2 |
The preparation of gold(I) mercaptides, which is known per se, by reaction of a gold(I) halide-dialkyl sulphide complex, which is obtainable from gold(III) halide or gold(III) halogen complex and a dialkyl sulphide, with a mercaptan can ...
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JP2001152363A |
To provide a method for producing a self-organizing monomolecular film having reduced columnar molecular voids and pits caused by the falling of a gold surface atomic layer.In the method in which a metallic substrate of gold or the like ...
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JP2001507332A |
Provided is a process for grafting a substituted difluoromethyl group onto a compound bearing at least one electrophilic substituent, comprising (i) contacting the compound bearing at least one electrophilic substituent with a nucleophil...
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JP3172236B2 |
PURPOSE: To effectively lessen the copper corrosiveness of sulfur-contg. substances, such as dialkyl polysulfides. CONSTITUTION: This method of lowering the copper corrosiveness of the org. sulfur-contg. substances corrosive to copper co...
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JP2001139615A |
To provide an organic peroxide composition having a good stability and giving a resin composition having an excellent stock stability when blended in a resin as a curing agent, to provide a cured-resin preparation process enabling a fast...
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JP2001064623A |
To suppress an undesirable secondary reaction to the lowest level through a simple method comprising a treatment with a specific amount of an organic hydroperoxide. The releasing of hydrogen sulfide and/or mercaptan from a sulfurized org...
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JP2001026506A |
To obtain an agricultural and horticultural microbiocide useful as a controlling agent for blast, or the like, of rice plants by including a specific safe sulfonamide derivative having microbiocidal actions, slight influences on mammals,...
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JP3126541B2 |
A benzothiazole compound represented by general formula (I) and a pharmaceutically acceptable salt thereof wherein, R<1> represents halogen; R<2> and R<3> represent each independently hydrogen or halogen; R<4> represents hydrogen, haloge...
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JP3119390B2 |
PURPOSE: To form a precious metal film for decoration on a substrate by applying a composition containing a polymer resin and a thiolate soln. of the precious metal in water and a co-solvent onto the substrate and then heating. CONSTITUT...
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