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JP3735026B2 |
To provide a method for manufacturing citalopram at a low cost, in high yield and advantageously on an industrial scale, and a new method for manufacturing a compound (compound [III]) expressed by formula [III], which is a key compound i...
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JP2001524099A5 |
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JP2002511375A5 |
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JP2005538992A |
This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula:
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JP3727334B2 |
Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to member...
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JP2005336121A |
To provide a method for stably producing 3,5-di-tert-butyl-4-hydroxabenzoic acid in high yield.This method for producing 3,5-t-butyl-4-hydroxybenzoic acid comprises the step (1) where a 2,6-di-t-butylphenol containing 0.5 % or less of 3,...
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JP2005537227A |
The invention relates to a novel process for synthesizing organic compounds of general formula (I):said process may be carried out on an industrial scale and makes it possible to obtain from a mixture of racemic alcohols of formula (II),...
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JP3723584B2 |
PURPOSE: To obtain a new compd. useful in synthesis of liquid crystalline compounds and displays. CONSTITUTION: 4-Hydroxy-2,3,5-trifluorobenzoic acid of the formula is provided. The compd. is obtained by reacting 2,3,4,5-tetrafluorobenzo...
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JP3719723B2 |
PURPOSE: To obtain the subject recording material excellent in sensitivity of color development, deepness of color development and storage stability of a recorded image, having very great practical utility and useful for an electronic co...
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JP3714978B2 |
PURPOSE: To obtain a new compound capable of inhibiting both of an intracellular phospholipase A2 and a secretion type phospholipase A2. CONSTITUTION: A compound of formula I {A is OH, NH2 or a lower alkylamino; R1 to R12 are each H, met...
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JP2005533126A |
The present invention relates to novel compounds of formula (I) and to the salts, solvates and prodrugs thereof, wherein the meanings of the various substituents are as disclosed in the description. Said compounds are useful for the trea...
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JP3701690B2 |
PURPOSE: To obtain a 3,5-di(α-methylbenzyl)salicylic acid derivative by simple operation using an inexpensive raw material by reacting salicylic acid and α-methylbenzyl halide represented by a specific formula in an org. solvent in the...
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JPWO2003101916A1 |
In the present invention, the halogen of a halide in which a group having an acidic proton is substituted and one or more halogens are substituted in the carbon of a carbon-carbon double bond is exchanged with a metal atom by a halogen-m...
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JP3697414B2 |
Granular product of 2-hydroxynaphthalene-3-carboxylic acid with well-suppressed dusting tendency, and process for preparing the same is provided. Granular product of 2-hydroxynaphthalene-3-carboxylic acid having an average particle size ...
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JP2005523944A |
A method for identifying a solid support in combinatorial synthesis or determining the structure of a compound in combinatorial synthesis. The method involves attaching, detaching and identifying at least one tag by detaching the tag fro...
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JP2005522476A |
This invention relates to novel compounds according to the general formula: which are thyroid receptor ligands, preferably antagonists, partial antagonists or partial agonists and to methods for using such compounds in the treatment of c...
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JP2005522477A |
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprisin...
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JP2005521717A |
Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds...
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JP2005187363A |
To provide a method for producing a high-purity ethynyl group-containing aromatic carboxylic acid ester having an extremely low metal ion content in a high yield by simple operation.The method for producing a low-metal, high-purity ethyn...
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JP3664653B2 |
The present invention provides crystalline 2-hydroxynaphthalene-3-carboxylic acid (BON) characterized in that the average particle size is equal to or more than 157 mu m and the proportion of the particles of which particle size is less ...
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JP3665079B2 |
The invention concerns bi-aromatic compounds of formula (I) in which Ar represents (a), Z being O or S, R1 is CH3, -CH2-O-R6, -OR6 or -COR7; R2 is -OR8, -SR8 or a polyether radical if in the latter case R4 is C1-C20alkyl and is in ortho ...
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JP2005516908A |
The present invention provides compounds that are inducers or inhibitors of apoptosis of apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals wi...
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JP2005509671A |
Composition for controlling phytopathogens comprising compound of the formula: wherein: R1 represents H, or a CO-R' acyl group; R2, the same or different when n is equal to 2, is a halogen, optionally selected from fluorine, chlorine, br...
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JP2005507381A |
This invention relates to novel compounds which are thyroid receptor ligands, preferably antagonists, and to methods for using such compounds in the treatment of cardiac and metabolic disorders, such as cardiac arrhythmias, thyrotoxicosi...
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JP2005506977A |
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.
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JP2005053780A |
To selectively oxidize an aldehyde residue of ascochlorin, its analogue and a derivative thereof into a carboxylic acid.All the phenolic hydroxy groups of the ascochlorin, its analogue and the derivative thereof are protected by alkylato...
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JP3624964B2 |
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JP2005504096A |
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...
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JP2005501898A |
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.
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JP2005008642A |
To provide an industrially advantageous method for manufacturing citalopram at a low cost and in high yield, and to provide a new method for manufacturing a compound (compound [III]) represented by formula [III], which compound is a key ...
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JP2005501126A |
A linear compound and a metal salt or boron-containing metal salt thereof contains one or more carboxyl-containing phenol units or derivatives thereof and one or more on average at least C18 hydrocarbyl-substituted hydroxyaromatic units ...
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JP2005002111A |
To provide a light-resistant additive excellent in ultraviolet absorptivity, wetting function, and colorant stabilization function; and an ink composition containing the additive.The light-resistant additive is a benzophenone derivative ...
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JP2004359553A |
To provide a method for preparing a catechol derivative useful as a chemical such as a drug, an agricultural chemical, and an electronic material and its intermediate from the corresponding methylenedioxybenene derivative in a high yield...
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JPWO2003024913A1 |
A substituted benzoic acid derivative represented by the following formula (I) and having an NF-κB inhibitory action (in the formula, R3, R4 and R5 are independently hydrogen atoms, alkyl groups having 1 to 6 carbon atoms or carbon atom...
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JP2004346050A |
To provide a pigment-including organic material that retains the orientation properties even under high temperature conditions and has an extremely high density of the second-order nonlinear group and high second-order nonlinear coeffici...
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JP2004346009A |
To provide a method for producing a p-hydroxybenzoic acid compound or a salt thereof.The method for producing the p-hydroxybenzoic acid compound of formula(2)( wherein, R1 to R4 are each the same as mentioned below ) comprises carrying o...
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JP2004534901A5 |
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JP2004323358A |
To provide a method with which 6-hydroxy-2-naphthoic acid can be purified in high purity with excellent operating efficiency.The method for purifying the 6-hydroxy-2-naphthoic acid is characterized as follows. (1) A crude purified substa...
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JP3587554B2 |
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JP3581714B2 |
Compounds of general formula (1) (1) are described wherein Y is a halogen atom or a group -OR1, wherein R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R6)-, where R6 is a hydrogen atom or an alkyl group; R2 is an option...
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JP3581713B2 |
Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR<1>, where R<1> is an optionally substituted alkyl group; X is -O-, -S- or -N(R<8>)-, where R<8> is a hydrogen atom or an alkyl group; R<2> is an op...
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JP2004292374A |
To provide a method for producing a high-purity and high-quality organic carboxylic acid halide in high yield by using a halogenation agent.This method for producing the carboxylic acid halide involves carrying out the reaction by adding...
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JP2004532297A |
The invention disclosed herein relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicylic acid units. These compounds are useful as add...
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JP2004530714A |
The invention relates to chainlike polycyclic bisanhydrides, containing between 2 and 12 permanent-chain cyclenes, selected from 1,3-phenylene, 1,4-phenylene, 2,6-naphthylene, 2,7-naphthylene, 1,4-cyclohexylene, bicyclopentylene, bicyclo...
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JP2004256434A |
To provide a method for purifying 2,5-dihydroxybenzoic acid, by which the inorganic salt content of the crude 2,5-dihydroxybenzoic acid containing an inorganic salt as an impurity can efficiently be reduced in an economical and simple op...
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JP2004256448A |
To provide a method for effectively decoloring 6-hydroxy-2-naphthoic acid.The method for decoloring 6-hydroxy-2-naphthoic acid is a method for decoloring 6-hydroxy-2-naphthoic acid by decoloring treatment and comprises carrying out the d...
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JPWO2002098840A1 |
The present invention provides a novel carboxylic acid derivative represented by the following general formula, which is useful as an insulin sensitizer. In the formula, L, M, T, X represent a single bond or the like; W represents a carb...
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JP2004528383A |
The present invention concerns a process for oxidising an aromatic aldehyde to the corresponding carboxylic acid. The process of the invention for preparing an aromatic acid by oxidising an aromatic aldehyde consists of carrying out the ...
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JP2004256449A |
To provide a method for effectively preventing discoloration of 6-hydroxy-2-naphthoic acid.The method for preventing discoloration of 6-hydroxy-2-naphthoic acid is a method for preventing discoloration of 6-hydroxy-2-naphthoic acid durin...
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JP2004244417A |
To provide a method for producing 5-formyl-2-methoxybenzoic acid which is a raw material for an N-benzyldioxothiazolidylbenzamide derivative useful for treating diabetes and hyperlipemia, highly safe and useful for industrially obtaining...
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