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JP2007536238A |
Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
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JP4021478B2 |
PCT No. PCT/FR96/00779 Sec. 371 Date Jan. 24, 1997 Sec. 102(e) Date Jan. 24, 1997 PCT Filed May 24, 1996 PCT Pub. No. WO96/37454 PCT Pub. Date Nov. 28, 1996The present invention concerns a process for the preparation of 3-carboxy-4-hydro...
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JP2007525494T6 |
The present invention provides ヘパラナーゼ inhibitor suitable for medical treatment of diseases which originate or relate to the catalyst activity of ヘパラナーゼ, such as cancer, an inflammatory obstacle, and an autoimmune ...
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JP4018066B2 |
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JP2007534658A |
A process for preparing an organometallic framework material comprising reacting at least one metal salt with at least one at least bidentate compound capable of coordination to the metal ion of said metal salt, in the presence of an aqu...
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JP4008498B2 |
The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the productio...
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JP2007290972A |
To industrially efficiently produce an aromatic carboxylic acid in which a carboxy group is bonded to an aromatic ring and which contains a substituent group at least at one ortho position in a high yield. An aromatic aldehyde in which a...
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JP4004080B2 |
Metal compound of formula ÄIÜ which is excellent in charge control or charge - enhancing property, and toner for developing electrostatic images and powdery paint for electrostatic painting incorporating thereof: wherein R<1>, R<2>, R<...
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JP3997155B2 |
The present invention is a method of producing dry, alkali metal or ammonium carboxylic acid salt particles. In accordance with the invention, a molten carboxylic acid is mixed with a solution of an alkali metal-containing or ammonium-co...
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JP2007528878A |
The present invention relates to novel compounds 2-(±-n-pentanonyl)benzoates, their preparation method, the pharmaceutical composition containing the same, and their use in preparing the medicament for preventing and treating cardio-cer...
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JP2007260535A |
To provide a means capable of rapidly and efficiently deciding an optimum crystallizing condition for making a chemical or the like particulate at a crystallizing ratio as high as possible by using a supercritical fluid. An apparatus for...
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JP3987171B2 |
Nucleophilic substitution reactions on halobenzenes are carried out in the presence of catalysts. In particular the present invention provides a process leading to optionally substituted hydroxybenzoic and alkoxybenzoic acids and optiona...
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JP3981771B2 |
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JP3982872B2 |
A methyl group-containing aromatic compound having a phenolic hydroxyl group protected by a protecting group, is oxidized with oxygen in the presence of a imide compound (e.g. N-hydroxyphthalimide) to provide anaromatic hydroxycarboxylic...
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JP2007238469A |
To provide a method for preparing an aromatic hydroxycarboxylic acid at a low temperature. The method for preparing the aromatic hydroxycarboxylic acid comprises reacting an alkali metal salt of an aromatic hydroxy compound with carbon d...
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JP2007230955A |
To provide a copolymerizable rare earth metal complex which undergoes graft copolymerization with a matrix resin, particularly an EVA resin, to form a composition in which a rare earth metal complex powder is chemically uniformly dispers...
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JP2007525942A |
Methods are provided for the production and recovery of multifunctional aromatic compounds from a fermentation medium. Preferred multifunctional aromatic compounds include para-hydroxycinnamic acid (pHCA), cinnamic acid (CA), and para-hy...
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JP3973708B2 |
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JP2007525494A |
The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.
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JP3968427B2 |
To provide a method for producing a carboxylic acid, by which the carboxylic acid can safely, simply and efficiently be obtained in a high yield by the reaction of an aldehyde compound with a hydrogen peroxide aqueous solution under mild...
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JP2007519618A |
A compound of Formula (I): Formula (I) wherein: R1 is selected from hydrogen and C1-4alkyl; R2 is selected from: R4-C(R5aR5b)-, R4-C(R6)- and R7aC(R7b)-C(R6)-; R3X- is selected from methyl, methoxymethyl and; R4 is selected from (optiona...
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JPWO2005063222A1 |
Provided is an Hsp90 family protein inhibitor containing a benzene derivative represented by the general formula (I), a prodrug thereof, or a pharmacologically acceptable salt thereof as an active ingredient.
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JP2007169237A |
To provide a method for purifying 6,6'-(ethylenedioxy)di-2-naphthoic acid being a raw material of a condensation polymer.The method for purifying 6,6'-(ethylenedioxy)di-2-naphthoic acid comprises forming an amine salt or an ammonium salt...
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JP2007169238A |
To provide a method for purifying 6,6'-(ethylenedioxy)di-2-naphthoic acid being a raw material of a condensation polymer.The method for purifying 6,6'-(ethylenedioxy)di-2-naphthoic acid comprises subjecting a 6,6'-(ethylenedioxy)di-2-nap...
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JP2007516995A |
The invention relates to a method for the production of a compound according to general formula (I), wherein a) a compound (II) is reacted with a compound (III) in the presence of a base B1 and b) the compound (IV) formed in step a) as a...
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JP2007161625A |
To obtain an aromatic carboxylic acid compound and an acid chloride derivative of the same which can convert a resin to have a low relative permitivity.The aromatic carboxylic acid compound has a structure expressed by general formula (1...
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JP3935347B2 |
To provide a charge control agent which is good in heat resistance and affinity and dispersibility to a resin, is high in a rising speed of electrostatic charge, is excellent in environmental resistance and preservable stability and is u...
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JP3926392B2 |
PCT No. PCT/EP96/05519 Sec. 371 Date Jun. 18, 1998 Sec. 102(e) Date Jun. 18, 1998 PCT Filed Dec. 11, 1996 PCT Pub. No. WO97/22607 PCT Pub. Date Jun. 26, 19971,7-Disubstituted perylene-3,4,9,10-tetracarboxylic dianhydrides I and perylene-...
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JP3920939B2 |
To obtain a new crystalline cephem acid addition salt with long half- life in the blood and excellent medicinal sustainability, useful for the treatment of bacterial infectious diseases. This compound is shown by formula I [(n) is 1 or 2...
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JP3921238B2 |
The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for a...
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JP3911562B2 |
To provide a production method capable of simply and highly selectively synthesizing an aromatic carboxylic acid in a short time without using a catalyst and an organic solvent from an alkyl-substituted aromatic compound. In the method f...
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JP2007099727A |
To provide a compound suitably used for the production of a low molecular compound expected to be utilized as a resist composition, and a method for producing the composition.This compound is expressed by general formula (I) [wherein, R1...
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JP3907787B2 |
To produce the subject high-purity derivative on an industrial scale at a low cost needing no extraction operation by reacting a specific phenylalkyl halide derivative with a specific hydroxybenzoic acid ester derivative under specific c...
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JP2007509039A |
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions...
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JP3901945B2 |
The present invention provides non-steroidal compounds of formula I which are selective modulators (i.e., agonist and antagonists) of a steroid receptor, specifically, the glucocorticoid receptor. The present invention also provides phar...
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JP3897819B2 |
Alkali metal aryloxides may be speedily dried by removing water while the aryloxide is molten. Such dried alkoxides are useful as chemical intermediates. Molten alkali metal aryloxides may be contacted with carbon dioxide to quickly prod...
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JP3896557B2 |
To obtain a new derivative useful as a raw material in industrially producing intermediates highly useful for medicines an agrochemicals. This new compound is a 2'-alkyl-3'-methoxyacetophenone acetal derivative of formula I (R1, R2 and R...
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JP3895404B2 |
To obtain a new chalcone derivative useful for an antiallergic agent having an excellent cis-leukotriene receptor antagonistic action. This derivative is expressed in formula I (A is phenyl, quinolyl, etc., W is vinylene, etc.,; R1 to R5...
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JP3891501B2 |
To easily produce the subject compound useful as an intermediate for pharmaceuticals and agrochemicals and an intermediate for functional materials in high yield by decarboxylating a fluorosalicylic acid in the presence of a base. 3-Fluo...
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JP2007055994A |
To provide an industrially useful method for producing an aromatic carboxylic acid compound, solving such problems as product yield decline and the poor filterability of manganese dioxide formed by oxidation reaction using potassium perm...
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JP3887207B2 |
To manufacture a non-steroid glucocorticoid receptor modulator. In the manufacture of a compound represented by formula (I), the reaction of a compound represented by formula (II) with a amide represented by the formula in the presence o...
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JP2007502777A |
The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
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JP3882229B2 |
To obtain a new vinyl ether compound which is a bifunctional vinyl ether compound containing an aromatic ring, effective as a copolymerization component to be copolymerized as a crosslinking site monomer in a fluorine- containing elastom...
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JP3882195B2 |
A method for making a compound of Formula I which is racemic or enantiomerically enriched at chiral center* comprising hydrogenating a compound of Formula V in the presence of a compound of Formula VII wherein: R 1 is F, Cl, or C 1 -C 3 ...
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JP2007502314A |
Compounds are described, having general formula (I): A.Cu wherein A represents the bibasic ion of an organic acid which can have the meanings (A1)-(A8) and Cu represents the copper 2+ ion; and the use of compounds having formula (I), ind...
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JP3877754B2 |
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JP3878250B2 |
To simply and efficiently extract an alcohol by adding a specific compound to a solution of the alcohol in a solvent. Perfluorononeyloxyisophthalic acid of formula I is dissolved in a solution of an alcohol of the formula, ROH (R is a 1-...
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JP3875365B2 |
To obtain the subject carboxylic acid useful as a raw material for electroluminescence elements, liquid crystalline compound mesogens and the like in a stable yield by reacting a specific compound with a specific phosphorus compound. (A)...
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JP3869531B2 |
To selectively produce the subject derivative useful as an intermediate for medicines, agrochemicals, liquid crystals, heat-resistant polymers or the like from an inexpensive raw material by reacting a specific cyclohexenone derivative w...
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JP2007001982A |
To provide a method for screening a substance for the ability to exert an influence on the formation of a retinoid X receptor homodimer comprising a step for combining the substance and a solution containing retinoid X receptors and a st...
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