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JP4560609B2 |
A nucleophilic substitution reaction on optionally substituted dihalobenzenes is carried out in the presence of an optional catalyst followed by formation of and subsequent carboxylation of a Grignard reaction intermediate. In particular...
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JP4554926B2 |
A benzophenone derivative represented by the following formula: wherein R<1> represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R<2> represe...
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JP4553077B2 |
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JP4554678B2 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and...
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JP4549972B2 |
The present invention provides a process for preparing crystalline parahydroxybenzoic acid anhydride, comprising the step of precipitating and isolating parahydroxybenzoic acid in an aqueous solvent at a temperature equal to or above the...
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JP2010189418A |
To provide new 2-(α-hydroxypentyl)benzoate, its production, and pharmaceutical compositions containing its salt as an active ingredient, and to provide a use of the compound for preventing and treating cardiac ischemia, cerebral ischemi...
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JP2010184906A |
To provide a method for oxidizing an aromatic alcohol by which an aldehyde or ketone can efficiently be produced without using a metallic oxidizing agent or catalyst.The method for oxidizing the aromatic alcohol includes oxidizing the ar...
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JP4532579B2 |
The present invention relates to a novel zirconium compound which is useful as a charge control agent for an electrophotographic toner. Further, it relates to an electrophotographic toner which contains said zirconium compound as a charg...
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JP2010528010A |
The invention provides ophthalmic formulations of Amyloid-beta contrast agents. Also provided are methods of using such formulations in the diagnosis of Alzheimer's Disease or a predisposition thereto as well as methods for the prognosis...
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JP2010180202A |
To provide a metal complex having an excellent gas-separating performance.This metal complex comprises a dicarboxylic acid compound in whose structure the carboxy groups are located at an angle of 120° to each other, such as an isophtha...
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JP4519326B2 |
A novel compound represented by the general formula (1) or salts thereof. The compound is useful as a structural component of polymers such as polyesters and polyamides. The compound wherein Y1, Y2, Y3, and/or Y4 are carboxy groups is es...
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JP2010163382A |
To provide a production method by which a calixresorcinarene compound having a carboxy group can be produced by a small number of reaction steps. The method for producing the cyclic compound represented by general formula (3) includes a ...
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JP2010524932A |
The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention als...
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JP4508548B2 |
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JP2010523484A |
The invention relates to the use of non-steroidal 17beta-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment and prophylaxis of hormone-dependent, particularly estrogen-dependent, diseases. The invention further relates to s...
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JP4497581B2 |
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JP4494770B2 |
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JP2010138114A |
To provide a material for photoresist substrates. There is provided a compound represented by only one of formula (1) and formula (2) and having a purity of ≥90%.
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JP4471974B2 |
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, m, n, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/o...
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JP2010518057A |
A pharmaceutically acceptable salt of N-[2-(Diethylamino)ethyl]-N-(2-{[2-(4-hydroxy-2-oxo-2,3-dihy
dro-1,3-benzothiazol-7-yl)ethyl]amino}ethyl)-3-[2-(1-naphthy
l)ethoxy]propanamide provided it is not the dihydrobromide or dihydrochloride...
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JP2010513503A |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diamine ligand that coordinates to copper.
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JP2010513510A |
The inventions disclosed herein include processes for the preparation of an ether of an aromatic acid, processes for the preparation of products into which such an ether can be converted, the use of such processes, and the products obtai...
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JP2010513509A |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a copper (I) or copper (II) source and a diketone ligand that coordinates to copper.
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JP2010513504A |
Ethers of aromatic acids are produced from halogenated aromatic acids in a reaction mixture containing a halogenated aromatic acid such as is described by the structure of Formula II wherein each X is independently Cl, Br or I; the react...
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JP2010511042A |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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JP2010511047A |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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JP2010511048A |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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JP2010511046A |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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JP2010511049A |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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JP2010511043A |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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JP2010511044A |
2,5-dihydroxyterephthalic acid is produced in high yields and high purity from 2,5-dihaloterephthalic acid by contact with a copper source and a ligand that coordinates to copper under basic conditions.
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JP2010511045A |
Hydroxy aromatic acids are produced in high yields and high purity (>95%) from halogenated aromatic acids in a reaction mixture containing a copper source and a ligand that coordinates to copper.
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JP4447038B2 |
(2S)-(4E)-N-methyl-5-(5-isopropoxy-3-pyridinyl)-4-penten-2-a
mine p -hydroxybenzoate and a pharmaceutical composition comprising this compound.
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JP2010510177A |
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy,...
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JP4443906B2 |
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JP4437004B2 |
The invention relates to 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl-5-nitrobenzofu
ran hydrochloride, to its preparation and to its use as synthetic intermediate, in particular in preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoy...
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JP4427850B2 |
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JP2010047582A |
To provide a compound useful as a modulating agent for liver X receptors (LXRs).The compound represented by formula (II-A), a pharmaceutically acceptable salt or solvate thereof, and pharmaceutical composition including the compounds are...
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JP4424763B2 |
The present invention provides a process for producing aromatic compounds or polymers thereof from a plant material in a short period of time and by a simple procedure. Concretely, the process treats the plant material with supercritical...
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JP2010043045A |
To provide a transportation method of a cashew nutshell liquid which modifies anacardic acid into an anacardic acid metal salt so that the quality is hard to be degraded against an environmental change during transportation.A hydroxide, ...
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JP4422549B2 |
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JP2010037238A |
To provide a method for producing a biaryl compound having tyrosinase inhibitory activity, useful as a skin-lightening agent.The biaryl compound represented by formula (3) is produced by reacting a methyl 6-methoxybenzoate derivative, bo...
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JP4416851B2 |
Substituted benzophenone compounds are disclosed, having the formula: The compounds are useful as fungicides having high systemicities.
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JP2010030940A |
To provide a method for synthesizing 4-methoxysalicylic acid, by which the 4-methoxysalicylic acid can be synthesized in a microreactor in an excellent reaction yield and at excellent reaction speed.There is provided the method for synth...
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JP2010006714A |
To provide a new compound which is a charge control agent ingredient good in heat resistance and in compatibility and dispersibility with resins, high in charging speed, excellent in environmental resistance and storage stability, and us...
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JP2010006735A |
To provide an industrially practicable and safe method for producing 1,4-bis(3,4-dicarboxyphenoxy)benzene, and a dianhydride thereof in high quality by oxidizing 1,4-bis(3,4-dimethylphenoxy)benzene with molecular oxygen.The method for pr...
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JP4397550B2 |
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JP4398143B2 |
Compounds of the formula (I) and also process for preparing themwhere substituents X<1>, X<2>, Y and Z are defined as follows:X<1 >is H or FX<2 >is H or FY is CI, Br, or IZ is CHO or COOH or CNn is 0 or 1and also their use as starting ma...
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JP2009545566A |
The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson...
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JP2009292748A |
To provide a rare earth metal-based luminescent material that forms various metal ion complexes exhibiting fluorescent colors being the three primary colors of red, green and blue by using the same ligand.The rare earth metal complex is ...
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