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WO/2007/021001A1 |
A 2,3,4-trifluoro-5-substituent-benzoic acid compound represented by the general formula (1): (wherein Y represents iodine, formyl, or an electrophilic species; and M represents hydrogen or a metal); a process for producing the compound;...
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WO/2007/013471A1 |
Compounds represented by the general formula (I) or (I’) wherein R11 to R13 are each alkyl having 1 to 10 carbon atoms; s is an integer of 1 to 2; t is an integer of 1 to 3; u is an integer of 1 to 3; the sum of s, t and u is an intege...
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WO/2007/008888A2 |
A method of making an aromatic dihydroxy diacid dihalide comprises forming a solution of an aromatic dihydroxy diacid in a solvent, contacting the aromatic dihydroxy diacid solution with a halogenating agent; heating the solution under a...
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WO/2007/005531A2 |
Non-nucleoside inhibitors of HIV-I reverse transcriptase are described. Such inhibitors may be used as part of a combination therapy to treat HIV infection. Compounds described herein exhibit antiviral potency. In addition, compounds des...
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WO/2006/132442A1 |
Disclosed are a compound represented by the general formula (I): (I) or a pharmaceutically acceptable salt thereof; a pharmaceutical composition comprising the compound or the like; and others. The compound or pharmaceutically acceptable...
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WO/2006/128542A1 |
The invention relates to salts from at least one imidazole of general formula (I), wherein R1, R2, R3 and R4 are the same or different and represent hydrogen, an alkyl group with 1 to 20, preferably 1 to 10, especially 1 to 4 carbon atom...
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WO/2006/123672A1 |
Disclosed is a method for commercially producing an aminoalcohol derivative (I) having a biphenyl group. Also disclosed are a biphenyloxyacetaldehyde derivative used therefor, a method for producing such a biphenyloxyacetaldehyde derivat...
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WO/2006/121390A2 |
Compounds of formula I, wherein Y = H, -OH, halo, -OC1-6alkyl, -C1-6alkyl, the two latter optionally substituted with halo, -CN, -OH, -CF3, -NH2; Rl = -C3-6cycloaUcyl, heterocycloalkyl, aryl, alkylaryl, heteroaryl, -C3-6-alkyl, optionall...
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WO/2006/108717A2 |
The present invention relates to a novel method for preparing 6- [3- ( 1 - adamantyl ) -4-methoxyphenyl] -2- naphthoic acid.
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WO/2006/092081A1 |
The invention provides structures of active compounds isolated from medicinal herbal of Euphorbia Lunulata and the use thereof. These compounds possess insulin- or IL-10-like activity, wherein the structures of compounds (1), (2), (4), (...
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WO/2006/088716A1 |
The present invention relates to novel tetralin ER-β agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated disease such as nocturia, obstructive uropathy, benign prostatic hypertrop...
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WO/2006/085630A1 |
A process for producing an aromatic dicarboxylic acid of the formula: (1) (wherein R1 to R6 each independently is hydrogen, an alkyl or an aryl, and may be identical with or different from each other), comprising the first step of reacti...
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WO/2006/077884A1 |
[PROBLEMS] To impart an antiglare effect to a laminated glass making use of a polyvinyl butyral resin as an intermediate film without coloring the same. [MEANS FOR SOLVING PROBLEMS] There is provided an intermediate film of laminated gla...
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WO/2006/069678A1 |
The invention relates to conjugates of metal complex hydroxypyridin derivatives and biomolecules and to the production thereof. Said conjugates are suitable for use in the form of contrast agents in NMR diagnosis. The special embodiment ...
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WO/2006/069685A1 |
The invention relates to compounds of formula (I), where A1, A2, R1, R2, R3, R4, R5 and Y have the meanings given in the description, methods and intermediates for production thereof and use thereof for the prevention of pests.
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WO/2006/066975A1 |
Process for the preparation of aryl or vinyl carboxylic acids via Pd-catalysed hydroxycarbonylation of aryl and vinyl bromides, wherein the aryl or vinyl bromides are reacted with a carbon monoxide source comprising lithium formate and a...
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WO/2006/069153A2 |
The present invention relates to novel, non-secosteroidal, phenyl-naphthalene compounds of Formula (I): wherein R, R1, RP, ZP, LP1, LP2 LNP, RP3, RN, and ZNP are defined herein, their preparation, pharmaceutical compositions, and methods...
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WO/2006/058648A2 |
The present invention relates to compounds of Formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and...
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WO/2006/046593A1 |
Disclosed is an excellent LXR modulator. Specifically disclosed is a compound represented by the general formula (I) below or the like. (I) [In the formula, R1 represents a -COR9 (wherein R9 represents an alkyl, optionally substituted al...
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WO/2006/037449A2 |
This invention relates to certain iron complexes which comprise ferrous or ferric iron and mono-, bi-, tri- or hexadentate ligands containing a five- or six-membered aromatic or heterocyclic ring for use in the treatment and/or preventio...
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WO/2006/037480A1 |
The invention is concerned with hexafluoroisopropanol substituted ether derivatives of formula (I), wherein Rl to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. The...
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WO/2006/022252A1 |
Disclosed is a selective demethylation process of a 2-methoxy group. Specifically disclosed is a method for producing a compound represented by the formula (7) below through the following reactions.
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WO/2006/011469A1 |
A cyclohexane derivative having the function of reducing a blood sugar level and having preferable properties required of medicines, such as long-lasting drug activity, metabolic stability, and safety; and a medicinal composition for use...
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WO/2006/003395A2 |
A molten salt is described comprising a quinone or quinone derivative as anion or cation. A process for the production of hydrogen peroxide is also described comprising the steps of reducing the molten salt to produce a corresponding hyd...
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WO/2006/002185A1 |
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen receptor modulation.
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WO/2005/123652A1 |
A rare earth metal complex represented by the formula (1) below emits very monochromatic light which is derived from the rare earth metal ions, and provides a light-emitting material having high luminous (quantum) efficiency and excellen...
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WO/2005/123651A1 |
The present invention relates to new L-2-(&agr -hydroxypentyl) benzoates and the preparation thereof, and to the pharmaceutical compositions in which the compounds are used as active ingredients. The invention also relates to the use of ...
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WO/2005/121061A1 |
Disclosed herein is a novel process for producing Sodium dihydrate salt of Ibuprofen of Formula (Structure I) by treating a salt of long chain carboxylic acid of Formula (Structure III) with Ibuprofen of Formula (Structure II) in the pre...
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WO/2005/116010A1 |
This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressur...
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WO/2005/115075A2 |
The present invention provides L-arginine salts of 4-ammosalicylic acid and 5-ammosalicylic acid (mesalamine) Pharmaceutical compositions containing these L-argmme salts are useful for the treatment of inflammatory conditions of the gast...
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WO/2005/108337A2 |
Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.
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WO/2005/100297A1 |
The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and...
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WO/2005/097773A1 |
The present invention is related to carboxylic acids of Formula (I) and use thereof for the treatment and/or prevention of obesity and/or metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type I and...
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WO/2005/095319A1 |
A method for producing a carboxylic acid compound represented by the following formula (3) (wherein n is as defined below) is characterized in that an organic layer containing a carboxylic acid compound represented by the above formula (...
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WO/2005/095360A1 |
Neurologically-active heterocyclic compounds comprising two fused 6-membered rings with nitrogen atoms at positions 1 and 3, a carboxy group at position 4,and a hydroxy group at position 8, with one ring being aromatic. Processes for the...
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WO/2005/087701A1 |
The present invention relates to novel compounds 2-(&agr -npentanonyl)benzoates, their preparation method, the pharmaceutical composition containing the same, and their use in preparing the medicine for preventing and/or treating cardi...
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WO/2005/087700A2 |
The present invention discloses bisphenyl compounds of the formula (1): wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
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WO/2005/085168A1 |
Particles of aluminum salt hydroxide containing an organic acid anion represented by the general formula (1): Ma[Al1-xM’x]bAzBy(OH)n·mH2O (1) [wherein M represents at least one cation selected from the group consisting of Na+, K+, NH4...
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WO/2005/085189A2 |
The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein X is selected from (II) and (III), Y is selected from SO2NH, CONH, CH=N, CH2NH and CH=CH; R1-5 are each independently select...
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WO/2005/063222A1 |
An Hsp90 family protein inhibitor which contains as an active ingredient a benzene derivative represented by the following general formula (I), a prodrug thereof, or a pharmacologically acceptable salt of either.
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WO/2005/061427A2 |
The invention relates to a method for the production of a compound according to general formula (I), wherein a) a compound (II) is reacted with a compound (III) in the presence of a base B1 and b) the compound (IV) formed in step a) as a...
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WO/2005/058791A1 |
A carboxylic acid compound represented by the formula (1); [Chemical formula 1] and an epoxy compound having a structural unit derived from the carboxylic acid compound and an epoxy group.
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WO/2005/056510A2 |
The present invention relates to novel compounds corresponding to the general formula (I) below: to compounds containing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, or alternati...
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WO/2005/051893A2 |
The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon- linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1&agr ,25 dihydroxy vitamin D3. These com...
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WO/2005/049604A2 |
This application relates to a compound of formula I (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of fa...
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WO/2005/042594A1 |
A compound represented by the following general formula (1): (1)wherein A represents an alkenyl ether group which may be substituted; B represents a linear or branched alkylene group having 1 to 15 carbon atoms which may be substituted; ...
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WO/2005/037759A1 |
A compound represented by the formula (I): [wherein X represents hydrogen or halogeno; R1 represents hydrogen, etc.; R2 represents hydrogen or C1-4 alkyl; R3 represents -CHO or -COOH; and R4 represents -(CH2)r-CH3 (wherein r is an intege...
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WO/2005/037793A1 |
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions...
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WO/2005/037760A1 |
Compounds represented by the formula (I): [Chemical formula 1] (I) (wherein, for example, X represents hydrogen or halogeno; R1 represents hydrogen; R2 represents hydrogen or C1-4 alkyl; R3 represents -CHO or -COOH; and R4 represents -CH...
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WO/2005/033059A1 |
The invention relates to novel compounds which inhibit amyloidogenesis, having formula (I), wherein: R1 is (i) a -NRaRb group, Ra and Rb representing independently a hydrogen atom or a C1-C6 alkyl group, (ii) a -ORC group, RC representin...
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