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WO2003006570B1 |
New, efficient methods for making novel platform molecules and polymerizable mesogens are provided, as well as the novel mesogens and methods of using same.
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WO/2003/095412A1 |
The present invention relates to a new compound of 2-(&agr -hydroxypentyl) benzoate, its preparation and the pharmaceutical composition in which the compound is used as active ingredient; the invention also relates to the use of the comp...
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WO/2003/093823A2 |
A method for identifying a solid support in combinatorial synthesis or determining the structure of a compound in combinatorial synthesis. The method involves attaching, detaching and identifying at least one tag by detaching the tag fro...
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WO/2003/091196A1 |
The invention relates to a novel process for synthesizing organic compounds of general Formula (I). The said process may be carried out on an industrial scale and makes it possible to obtain from a mixture of racemic alcohols of formula ...
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WO/2003/084915A1 |
This invention relates to novel compounds according to the general formula : which are thyroid receptor ligands, preferably antagonists, partial antagonists or partial agonists and to methods for using such compounds in the treatment of ...
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WO/2003/084917A1 |
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions c...
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WO/2003/083063A2 |
The present invention provides common ligand mimics that act as common ligands for a receptor family. The present invention also provides bi-ligands containing these common ligand mimics. Bi-ligands of the invention provide enhanced affi...
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WO/2003/082787A1 |
Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate,or salt thereof; pharmaceutical compositions containing such compounds,...
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WO/2003/082794A1 |
The present invention provides a novel bioactive compound 12- (2'-CARBOXY- 5'-METHOXYPHENYL)-2,12-DIHYDROXY-DODECA-4-ONE 'Sporotricolone', mainly as acetylcholinesterase (AchE) inhibitor, along with a process for the isolation of said co...
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WO/2003/080542A2 |
The invention relates to a method for producing 3-hydroxy-2-methylbenzoic acid or solutions containing salts of 3-hydroxy-2-methylbenzoic acid, with naphthalene as the starting substance. Said method essentially comprises the following s...
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WO/2003/048101A1 |
The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical compositions and methods for treating mammals wi...
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WO/2003/043971A1 |
Fungicidal compositions are described, containing one or more salts of derivatives of salicylic acid having formula (I): in any molar ratio, with at least one fungicidal compound not corresponding to a salt of derivatives of salicylic ac...
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WO/2003/043624A1 |
Compounds that are dual aP2/k-FABP inhibitors are provided having the formula (I), wherein A, B, X, Y, R?1¿, R?2¿ and R?3¿ are as described herein. A method is also provided for treating diabetes and related diseases, especially Type ...
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WO/2003/042150A1 |
Because of having an anti−arthritic effect, inhibiting bone fracture induced by arthritis and having a high safety, benzophenone derivatives represented by the following general formula or salts thereof are useful as remedies for arthr...
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WO/2003/039729A1 |
A process for preparing particles of a substance comprising contacting a first formulation including a first substance with a first solvent stream and a second solvent stream, thereby causing formation of particles of the first substance...
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WO/2003/027050A2 |
A process for preparing substituted pentacene compounds comprises the step of cyclizing substituted bis(benzyl)phthalic acids using an acid composition comprising trifluoromethanesulfonic acid, the substituted bis(benzyl)phthalic acids b...
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WO/2003/024913A1 |
Substituted benzoic acid derivatives represented by the general formula (&Verbar ) and exhibiting NF−κB inhibiting activity: (&Verbar ) (&Verbar &Verbar ) (&Verbar &Verbar &Verbar ) wherein R3, R4, and R5 are each independently hydrog...
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WO/2003/020684A1 |
The present invention describes immobilized haloenamine reagents, immobilized tertiary amides, methods for their preparation, and methods of use.
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WO/2003/018728A1 |
A linear compound and a metal salt or boron-containing metal salt thereof contains one or more carboxyl-containing phenol units or derivatives thereof and one or more on average at least C¿18? hydrocarbyl-substituted hydroxyaromatic uni...
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WO/2003/018515A2 |
This invention relates to novel compounds according to the general formula (I) or a pharmaceutically acceptable salt thereof, which are thyroid receptor ligands, preferably antagonists and to methods for using such compounds in the treat...
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WO/2003/018552A2 |
The present invention is directed to protected amino acid halide monomers and oligomers, and to their use in the efficient sythesis of polyamides. The present invention is further directed to the use of -haloenamine reagents, which may o...
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WO/2003/014058A1 |
An alkylenebisnaphtol derivative represented by the general formula [I]: [I] and salts thereof. The compounds have excellent static properties and are useful as, e.g., a charge control agent for electrophotographic toners.
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WO2002072529A9 |
This invention relates to linear compounds in the form of oligomers or polymers containing unsubstituted or substituted phenol units and unsubstituted or substituted salicyclic acid units. These compounds are useful as additives for lubr...
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WO/2003/007933A1 |
Provided are napthoquinone-type compounds which can be used to modulate the aggregation of protein (e.g. tau) associated with neurodegenerative disease (e.g. Alzheimer's disease). Structure-function characteristics for oxidised and reduc...
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WO/2002/102756A2 |
The invention relates to chainlike polycyclic bisanhydrides, containing between 2 and 12 permanent-chain cyclenes, selected from 1,3-phenylene, 1,4-phenylene, 2,6-naphthylene, 2,7-naphthylene, 1,4-cyclohexylene, bicyclopentylene, bicyclo...
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WO/2002/098220A2 |
The present invention provides non-peptide organic compounds that have a structure analogous to or reminiscent of the TMOF structure and have pesticidal activity. Thus the present invention concerns pesticidal compounds that inhibit dige...
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WO/2002/097393A2 |
Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
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WO/2002/092548A1 |
The invention relates to a method for oxidising an aromatic aldehyde into the corresponding carboxylic acid. According to the invention, the method of preparing an aromatic acid by oxidation of an aromatic aldehyde consists in performing...
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WO/2002/085835A1 |
Granules of parahydroxybenzoic acid or a parahydroxybenzoic ester which are extremely inhibited from flying off or caking; and a process for producing the granules. The granules of parahydroxybenzoic acid or an ester thereof have an aver...
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WO/2002/085836A1 |
A binaphtol derivative represented by the following general formula [1]: [1] and a salt of the derivative.
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WO/2002/076918A1 |
A novel NF-$g(k)B inhibitor represented by the following formula. (I)
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WO/2002/074725A1 |
Aldehyde residues in ascochlorin, analogs thereof and derivatives of the same can be selectively oxidized into carboxylic acids. All of phenolic hydroxyl groups of ascochlorin, analogs thereof and derivatives of the same are protected by...
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WO/2002/065984A2 |
There are provided compounds represented by formula (I) or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, wherein the various substituents are as defined. Also included are methods for...
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WO/2002/057210A1 |
The invention concerns compositions containing for one o-iodoxybenzoic acid mole from 0.5 to 4 moles: of a aliphatic acid of formula CH¿3?(CH¿2?)¿n?COOH, wherein n ranges between 8 and 20; a benzenecarboxylic acid of formula (I) where...
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WO/2002/048078A1 |
The invention concerns 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzof
uran hydrochloride, its preparation and its use as synthesis intermediate in particular for preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-ni...
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WO/2002/044128A2 |
Salicycate analogs of formula, methods of making them, pharmaceutical compositions containing them, and methods for their use. The compounds are interleukin-4 antagonists, and are useful for the treatment of asthma and allergies.
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WO/2002/042248A2 |
The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
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WO/2002/042251A1 |
Novel aromatic carboxylic acids and acid halides thereof, useful as raw materials for polymers, particularly heat-resistant condensation polymers; and processes for preparing the acids or the halides. The carboxylic acids and the acid ha...
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WO/2002/032845A2 |
The present invention is a method of producing dry, alkali metal or ammonium carboxylic acid salt particles. In accordance with the invention, a molten carboxylic acid is mixed with a solution of an alkali metal-containing or ammonium-co...
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WO/2002/028810A2 |
The current invention provides novel retinoid compounds and methods for their synthesis, the use of such compounds for the preparation of medicaments for treating or preventing emphysema, cancer and dermatological disorders, methods for ...
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WO/2002/026727A2 |
Novel compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification, and certain previously known compounds have been discovered to act as inhibitors of the cytochrome P450RAI (retinoic acid...
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WO/2002/026701A2 |
Ionic compounds with a freezing point of up to 100 °C are formed by the reaction of an one amine salt of formula (I) R?1¿ R?2¿ R?3¿ R?4¿ N?+¿ X?-¿, such as choline chloride with an organic compound (II) capable of forming a hydrog...
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WO/2002/024645A1 |
2,5-bisaryl-$g(D)?1¿-pyrrolines of formula (I) are produced by reacting azides of formula (II) with a trialkylphosphine or a triarylphosphine or a trialkylphosphite or a reduction agent in the presence of a diluting agent and optionally...
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WO/2002/022551A1 |
Compounds of formula (I') wherein A, R¿1? to R¿3? and t are as defined in claims, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
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WO/2002/018361A2 |
Compounds having the Formulas 1 through 8, wherein the symbols have the meaning defined in the specification are inhibitors of the cytochrome P450RAI (retinoic acid inducible) enzyme, and are used for treating diseases responsive to trea...
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WO/2002/014250A1 |
The invention relates to a method for producing 2- and 2,5-substituted derivatives of 4-(trifluoromethyl)-phenol and 4-(2-trifluoromethyl)-phenyl)-2-tetrahydropyranyl) ether and to novel derivatives. Said method is characterised in that ...
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WO/2002/010179A1 |
The invention concerns a method for preparing a water-insoluble chromium III organic complex which consists in reacting a Cr III compound formed in situ with at least an aromatic compound bearing a carboxylic acid function or its salt. T...
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WO/2002/006201A1 |
A process for the production of an aromatic carboxylic acid comprising contacting in the presence of a catalyst, within a continuous flow reactor, one or more precursors of the aromatic carboxylic acid with an oxidant, such contact being...
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WO/2002/000603A1 |
The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medi...
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WO/2001/092273A2 |
New benzenedicarboxylic acid derivative compounds; pharmaceutical compositions, diagnostic methods, and diagnostic kits that include those compounds; and methods of using those compounds for inhibiting NAALADase enzyme activity, detectin...
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