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Matches 651 - 700 out of 4,430

Document Document Title
WO/2009/141291A1
The present invention relates to heteroarylylmethyl sulfonamides of formula (I) wherein B, E, Ra, n, R, A, Y and Cy are as defined in the claims, to the N-oxides, and salts thereof and their use for combating harmful fungi, and also to c...  
WO/2009/136191A1
The invention relates to chemical compounds of formula (I): or pharmaceutically acceptable salts thereof which possess CSF-IR kinase inhibitory activity and are accordingly useful for their anti-cancer activity and thus in methods of tre...  
WO/2009/131947A2
The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administerin...  
WO/2009/127338A1
The present invention relates to novel carboxylic acid derivates of the formula (I), having an oxo-substituted azaheterocyclic partial structure, method for the production thereof, use thereof for treating and/or preventing illnesses and...  
WO/2009/129267A2
Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.  
WO/2009/124903A1
The present invention relates to pyridazinylmethyl sulfonamides of formula (I) wherein Ra, n, R1, R2, R3, A, Y and Het are as defined in the claims, to the N-oxides, and salts thereof and their use for combating harmful fungi, and also t...  
WO/2009/079797A9
The invention relates to a compound of Formula (I) and/or a pharmaceutically-acceptable salt, hydrate, solvate, tautomer, optical isomer, E-isomer, Z-isomer, or combination thereof, wherein X is selected from S or O; R5 is selected from ...  
WO/2009/114994A1
Derivatives of 6-(3-(trifluoromethyl)phenyl)pyridazin-3(2H)-one having the following formula (I) are used for the manufacture of medicament for anti-tumour, particularly anti-liver cancer.  
WO/2009/114993A1
Pyridazinones of formula I, which have a mother nucleus of 6-[3-(trifluoromethyl)phenyl] pyridazin-3(2H)-one, the preparation and the use in manufacturing medicaments of treating tumor thereof. Particularly, the use of such compounds in ...  
WO/2009/112461A1
This invention relates to novel triaryl derivatives derivatives, formula (I), a stereoisomer thereof or a mixture of its stereoisomers, or a pharmaceutically acceptable salt thereof, wherein all of X, Y and Z represent CH; or one or two ...  
WO/2009/103478A1
The present invention relates to pyridone and pyridazinone derivatives as listed in claim 1 including their salts. Moreover the invention relates to pharmaceutical compositions containing at least one compound according to the invention....  
WO/2009/097306A1
The present invention is directed to compounds having histamine H3 antagonist activity, as well as methods of their use and preparation.  
WO/2009/086041A1
Disclosed are compounds of Formula (1), N-oxides, and salts thereof, wherein W1 is O or S, and R1, R2, R3, G and J are as defined in the disclosure. Also disclosed are compositions containing the compounds of Formula (1) and methods for ...  
WO/2009/080314A1
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: formula (I) wherein R1 is C1-C6alkyl, C1-C6haloalkyl or C3-C6cycloal...  
WO/2009/071448A1
The present invention relates to novel pyridylmethyl-sulfonamide compounds of formula (I) where: n is 0 to 4; m is 0 to 4; R1 is halogen, CN, NO2, OH, SH, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc.; and/or two rad...  
WO/2009/071449A1
The present invention relates to novel pyridylmethyl-sulfonamide compounds of formula (I): where: n is 0 to 4; m is 0 to 4; R1 is halogen, CN, NO2, OH, SH, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, etc.; and/or two ra...  
WO/2009/056692A2
The invention relates to novel products of formula (I): where ---- is a single or double bond, Ra = H, HaI, alkoxy, O-cycloalkyl, heteroaryl,.phenyl, NHCOaIk, NHCOcycloalk or NR1 R2; X = S, SO or SO2; A = NH or S; W = H, alkyl or COR wit...  
WO/2009/057827A1
Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.  
WO/2009/053799A1
The present invention relates to compounds of f formula (I) as cannabinoid receptor modulators, in particular cannabinoid 1 (CB1) or cannabinoid 2 (CB2 ) receptor modulators, and uses thereof f or treating diseases, conditions and/or dis...  
WO/2009/050469A1
4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro -benzyl]-2H-phthalazin-1-one as crystalline Form L, methods of obtaining form L, pharmaceutical compositions comprising Form L and methods of using Form L and compositions comp...  
WO/2009/048864A1
Solid forms of (S)-2-amino-3-(4-(2-amino-6-((R)-2,2,2-trifluoro-1-(3'-metho xybiphenyl-4-yl)ethoxy)pyrimidin-4-yl)phenyl)propanoic acid and salts thereof are disclosed.  
WO/2009/048101A1
Disclosed is a novel fused ring compound, which has FAAH inhibitory activity and is useful as an analgesic. Specifically disclosed is a compound represented by the formula (I) below or a salt thereof. (In the formula, the symbols are as ...  
WO/2009/040288A1
The present invention relates to compounds of formula (1), wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antag...  
WO/2009/037394A2
The invention relates to 6-cycloamino-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine derivatives of general formula (I) where R2 = an optionally substituted aryl, A = optionally substituted C1-7 alkylene, B = optionally substituted C1-7 alky...  
WO/2009/035150A2
There is provided a compound represented by the formula (I): wherein R1 is a C1-6 alkyl group or a (C1-6 alkyloxy)C1-6 alkyl group; R2 is a hydrogen atom or a C1-6 alkyl group; G is a hydrogen atom etc.; Z1 is a C1-6 alkyl group or a C1-...  
WO/2009/030715A1
The invention relates tosubstitutedarylsulphonylaminomethylphosphonic acid derivativesof general formula (I) wherein the groups Ra to Rf, A and Z are defined as mentioned in the specification and claims, which are suitable for preparinga...  
WO/2009/032277A1
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the c...  
WO/2009/027450A1
The invention relates to compounds of general formula (I), in which n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as cited in the description, to the enantiomers, diastereomers, mixtures and salts of said compounds, in particular to t...  
WO/2009/027730A1
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP- ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory di...  
WO/2009/024221A1
Compounds of the formula I in which R1, R2 and R3 have the definitions stated in claim 1 are inhibitors of tyrosine kinases, more particularly of Met kinase, and can be used for purposes including the treatment of tumours.  
WO/2009/016286A2
The invention relates to the 6-cycloamino-3-(pyridin-4-yl)imidazo[1,2-b]pyridazine derivatives corresponding to general formula (I), in which formula (I) R2 is an aryl group optionally substituted with one or more substituents chosen fro...  
WO/2009/007856A2
The present invention provides a novel polymorphic form of atorvastatin calcium, designated as form Al, process for preparation, pharmaceutical compositions, and method of treating thereof. The present invention further provides a proces...  
WO/2009/004356A1
A compound of the formula (I): wherein: R represents one or more optional substituents on the fused cyclohexene ring; X can be NRX or CRXRY; if X = NRX then n is 1 or 2 and if X = CRXRY then n is 1; if X = NRX, then RX is selected from t...  
WO/2008/156208A1
The object is to find a compound having an inhibitory activity on the production of PAI-1, an inhibitory activity on the fibrosis of a tissue and a fibrinolytic activity, and to provide a novel compound useful for the prevention and/or t...  
WO/2008/146914A1
A compound represented by the formula: (I) (wherein the ring A represents pyrimidine or the like, the ring B represents a carbocyclic ring which may be substituted, an aromatic heterocyclic ring which may be substituted or an alicyclic h...  
WO/2008/145242A1
Compounds of formula (I), where R1, R2, R3, R4, R5 and X have the meanings given in claim 1 are tyrosine kinase inhibitors, in particular of Met-kinase and amongst other things can be used for treating tumours.  
WO/2008/145243A1
Compounds of formula (I), where R1, R2 and R3 have the meanings given in claim 1 are tyrosine kinase inhibitors, in particular of Met kinase and can amongst other things be used for treating tumours.  
WO/2008/143706A2
Peripheral Benzodiazepine Receptor (PBR) is an attractive target for tumor imaging and treatment due to its upregulation in numerous cancer cell types. DAAl 106 is a selective PBR ligand with high binding affinity. Aspects of the present...  
WO/2008/135413A1
The invention relates to pyridazines of the formula (I), in which the substituents are defined according to the description, methods and intermediate products for the production of said compounds, agents containing the same and the use t...  
WO/2008/135153A1
The invention relates to a novel polymorphic form of FHMP (formula (I)), a method for production thereof, medicament comprising the same and use thereof for treating diseases.  
WO/2008/135152A1
The invention relates to a novel amorphous form FHMP, method for production thereof, medicaments comprising the same and use thereof for treating diseases.  
WO/2008/129029A1
The invention relates to novel heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicamen...  
WO/2008/125627A1
A compound of formula (I) wherein the substituents have various meanings, optionally in salt and/or solvate form, and their use as pharmaceuticals.  
WO/2008/114023A2
A compound of the formula (I) wherein: A and B together represent an optionally substituted, fused aromatic ring or an optionally substituted, fused cyclohexene ring; D is selected from: (i), where Y1 is selected from CH and N, Y2 is sel...  
WO/2008/111631A1
Disclosed is an important production intermediate for an optically active phthalazinone derivative [1], which is useful as a pharmaceutical product, or a pharmaceutically acceptable salt thereof. Also disclosed are a method for producing...  
WO/2008/111295A1
Disclosed is an agent for prevention and/or treatment of systemic lupus erythematosus which is obtained by combining 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H- pyridazin-3-one or a solvate thereof with a adrenocortical ster...  
WO/2008/110611A1
The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative di...  
WO/2008/108842A1
Analogs of a Lisofylline (LSF), and synthetic methods for the preparation of such analogs are provided. The analogs of LSF provided have the ability to protect cell viability, particularly the ability to protect pancreatic β-cells.  
WO/2008/101613A1
The present invention relates to a novel polymorphic form of FHMP, to processes for preparing it, to medicaments comprising it, and to the use thereof in the control of diseases.  
WO/2008/101614A1
The invention relates to an improved method for producing 4-(3-hydroxy-3-methylbutoxy)-5-[4-(methylsulfonyl)phenyl]-2- (4-fluorphenyl)pyridazin-3(2H)-one and closely related analogs, said method being especially suitable for production o...  

Matches 651 - 700 out of 4,430