Heterocyclic Compounds

Matches 951 - 1,000 out of 4,414	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >

Document	Document Title
WO/2003/097613A1	PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I); are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of ph...
WO/2003/097622A2	SYNTHESIS OF 2-ALKYLCYSTEINES, 2-(HYDROXYLATED PHENYL)-4-ALKYLTHIAZOLINE-4-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF The present invention provides methods of preparing 2-alkylcysteine derivatives, many of which can be performed stereoselectively. The present invention also discloses a method of preparing a class of iron chelating agents related to des...
WO/2003/097612A1	SUBSTITUTED 2-PHENYL-3(2H)-PYRIDAZINONES The invention relates to substituted 2-phenyl-3(2h)-pyridazinones, to a method for the production thereof, and to their use as medicaments used in the prophylaxis and/or treatment of diseases in humans and/or animals.
WO/2003/095433A1	HEXAHYDRO-PYRIDAZINE-3-CARBOXYLIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND PREPARATION METHODS THEREOF The invention relates to a compound having general formula (I), wherein R1, R2 and R3 have different meanings. The invention also relates to the combinatorial libraries of the aforementioned compounds, a method of preparing said compound...
WO/2003/093261A1	PHTHALAZINONE DERIVATIVES A compound of formula (I); or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is a C5-7 aryl group substituted in the meta pos...
WO/2003/093254A1	SEMICARBAZIDE DERIVATIVES FOR COMBATING THROMBOEMBOLIC DISEASES The invention relates to novel compounds of formula (I), wherein R, R1, R1', X and T have the meaning given in patent claim 1. Said novel compounds are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therap...
WO/2003/093242A2	SUBSTITUTED 5-MEMBERED POLYCYCLIC COMPOUNDS USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE The present invention relates to substituted 5-membered polycyclic compounds and prodrugs thereof, compositions and methods useful for preventing and treating thrombotic conditions in mammals. The compounds of the present invention, and ...
WO/2003/088959A2	TREATMENT OF PARKINSON'S DISEASE WITH CYCLOOXYGENASE-2 (COX 2) INHIBITOR(S) A method of treating, preventing, or inhibiting PD, in a subject in need of such treatment, inhibition or prevention. The method comprises treating the subject with one or more cyclooxygenase-2 selective inhibitor(s), ester(s), salt(s) o...
WO/2003/087067A1	ARYL-ALKYNE COMPOUNDS AS HERBICIDES Compounds of formula (I) wherein Q is a group formula (II), (III); Z is=N-, formula (IV) or =C(R2)-; n is 0, 1, 2 or 3; R3 or R4 are each independently of the other hydrogen, alogen, -CN, C1-C4alkyl or C1-C4alkoxyl; or R3 and R4 together...
WO/2003/087057A1	BENZAMIDE DERIVATIVES USEFUL AS HISTONE DEACETYLASE INHIBITORS The invention concerns a compound of the formula (I) wherein Ring A is heterocyclyl; m is 0-4 and each R1 is a group such as hydroxy, halo, trifluoromethyl and cyano; R2 is halo and n is 0-2; and each R4 is a group such as hydroxy, halo,...
WO/2003/084917A1	(2-((2-ALKOXY) -PHENYL) -CYCLOPENT-1-ENYL) AROMATIC CARBO AND HETEROCYCLIC ACID AND DERIVATIVES Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: (I) wherein A, R1 , R2 , Rx , R8 , R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions c...
WO/2003/084927A1	HALOALKENES, PROCESS FOR PRODUCTION THEREOF, AND PEST CONTROLLERS CONTAINING THE SAME Haloalkenes represented by the general formula (I) which are useful as pest controllers: (I) wherein X1 and X2 are each halogeno; Y is hydrogen or halogeno; n is 0 to 5; and Q is (1) a heterocyclic group selected from among thienyl, fury...
WO/2003/082829A1	NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS The invention provides Aryl substituted imidazoles, pyrazoles, pyridizines and related compounds of the Formula (I) where the ring system represented by Formula (A) is a 5 membered heteroaryl ring system, in which x is 0, A is chosen fro...
WO/2003/082280A1	GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5 and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds,...
WO/2003/080578A1	HETEROAROMATIC UREA DERIVATIVES AS VR-1 RECEPTOR MODULATORS FOR TREATING PAIN The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R1, R2, R3, R4, R5 and R6 are simple substituents,...
WO/2003/077847A2	SUBSTITUTED AMIDES Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds...
WO/2003/077828A2	NOVEL FLORFENICOL-TYPE ANTIBIOTICS The present invention relates to novel florfenicol compounds having the chemical structure (I) wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without lim...
WO/2003/076422A1	SULFONYL-DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE This invention comprises the novel compounds of formula (I) wherein n, m, t, R1, R2, R3, R4, L, Q, X, Y, Z and have defined meanings, having histone deacetylase inhibiting enzymatic activity; their preparation, compositions containing th...
WO/2003/075928A2	STABLE PHARMACEUTICAL COMPOSITIONS Pharmaceutical compounds having the general formula: (I) or compounds having the formula: (II) Where R1 and R2 are independently H, branched or straight chain alkyl having from 1 to about 7 carbon atoms, substituted or unsubstituted cycl...
WO/2003/074495A1	HPPARS ACTIVATORS Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseas...
WO/2003/072535A2	SUBSTITUTED HYDROXYETHYLAMINES This present invention relates to prodrug compounds of the formula (Y) and pharmaceutical salts thereof: where RN, R1, R2, R3R4 and RC are defined herein, which are useful in treating Alzheimer's disease and other similar diseases.
WO/2003/072558A2	ARYLSULFONE DERIVATIVES The invention provides compounds of the formula (I) and methods of using those compounds for treating a disease or condition in a mammal wherein a 5-HT receptor, such as a 5-HT¿6? receptor, is implicated and modulation of a 5-HT functio...
WO/2003/070247A1	FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR Compounds of formula (I), are novel VR1 antagonists that are useful in treating pain, inflammatory thermal hyperalgesia, urinary incontinence and bladder overactivity.
WO/2003/070707A1	FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT Fused pyridazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of inhibiting poly(ADP-ribose)polymerase, the...
WO/2003/068140A2	NOVEL PYRIDAZINE DERIVATIVES, USE OF THE SAME AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND METHOD FOR PRODUCING THE SAME The invention relates to the products of formula (I) wherein R1 represents a hydrogen atom or an optionally substituted alkyl, COR, COOR, aryl, or aralkyl radical; R2 represents a radical of formula (II) wherein n is equal to 0, 1, 2 or ...
WO/2003/065789A2	N-BIPHENYLMETHYL AMINOCYCLOALKANECARBOXAMIDE DERIVATIVES N-Biphenyl(substituted methyl) aminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pa...
WO/2003/066604A2	NOVEL ARYL- AND HETEROARYLPIPERAZINES Novel aryl- and heteroarylpiperazines, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of treatment employing these compounds and compositions. The compounds show ...
WO/2003/063874A1	CONDENSED HETEROCYCLIC COMPOUNDS A condensed heterocyclic compound having poly(adenosine 5'-diphospho-ribose)polymerase (PARP) inhibitory activity represented by the formula (I): wherein R1 is hydrogen, halogen, lower alkyl or lower alkoxy, A and two adjacent carbon ato...
WO/2003/064369A1	NOVEL THYROID HORMONE RECEPTOR LIGAND, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND USE THEREOF It is intended to provide compounds represented by the following general formula (I) which have a high affinity for human thyroid hormone receptors, in particular, human thyroid hormone receptor β, medicinal compositions containing the ...
WO/2003/063576A2	ARYLSULFONAMIDOBENZYLIC COMPOUNDS Arylsulfonamidobenzyl alcohols, amines and sulfonamides are provided which are useful in treating lipid disorders, metabolic diseases and cell-proliferative diseases.
WO/2003/062209A2	SUBSTITUTED QUINAZOLIN-4-YLAMINE ANALOGUES AS MODULATORS OF CAPSAICIN This invention relates generally to substituted quinazolin-4-ylamine analogues that are modulators of capsaicin receptors, and to the use of such compounds for treating conditions related to capsaicin receptor activation. The invention f...
WO/2003/062192A1	CYCLOALKYL KETOAMIDES DERIVATIVES USEFUL AS CATHEPSIN K INHIBITORS Cycloalkyl ketoamide derivatives, which are useful as cathepsin K inhibitors are described herein. The described invention also includes methods of making such cycloalkyl ketoamide derivatives as well as methods of using the same in the ...
WO/2003/059064A1	INSECTICIDES CONTAINING HYDRAZONE DERIVATIVES AS THE ACTIVE INGREDIENT AND NOVEL HYDRAZONE DERIVATIVES Insecticides containing as the active ingredient hydrazone derivatives represented by the general formula (I); and novel hydrazone derivatives: (I) wherein A and Q are each aryl or a heterocyclic group; W is oxygen, aminylene, alkylene, ...
WO/2003/059891A1	SUBSTITUTED PYRIDAZINONES AS INHIBITORS OF P38 (Formula I); Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition containing the pyridazinone com...
WO/2003/057676A1	3,4-DI-SUBSTITUTED PYRIDAZINEDIONES AS CXC CHEMOKINE RECEPTOR ANTAGONISTS Disclosed compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
WO/2003/053933A1	HETEROARYL-SUBSTITUTED AMINOCYCLOHEXANE DERIVATIVES The present invention relates to compounds of formula (I) wherein A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, U, V, m, n and o are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are u...
WO/2003/053926A1	NOVEL PHENYLALANINE DERIVATIVE A phenylalanine derivative represented by the following formula, its analog and pharmaceutically acceptable salts thereof show an &agr 4 integrin inhibitory activity. These compounds are usable as remedies or preventives for various dise...
WO/2003/051841A2	COMPOUNDS AND USES THEREOF FOR DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone ...
WO/2003/051119A1	NEW HERBICIDAL COMPOUNDS AND METHOD The invention relates to a method for the control of weeds (i.e. undesired vegetation) at a locus, which method comprises applying thereto a herbicidally effective amount of at least one compound which is a 3,5-dicyanophenoxy derivative ...
WO/2003/051842A2	COMPOSITIONS DECREASING ACTIVITY OF HORMONE-SENSITIVE LIPASE Carbamates and related compounds of formula R1R2NCO-Y or R1R2NCS-Y wherein R1 and R2 may form a ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasm...
WO/2003/049702A2	VANILLOID RECEPTOR LIGANDS AND THEIR USE IN TREATMENTS Compounds having the general structure of the Formula (I) and compositions containing them, for treatment of various diseases.
WO/2003/045923A1	PREVENTIVES OR REMEDIES FOR ALZHEIMER’S DISEASE OR AMYLOID PROTEIN FIBROSIS INHIBITORS CONTAINING NITROGEN−CONTAINING HETEROARYL COMPOUNDS Preventives or remedies for Alzheimer’s disease or amyloid protein fibrosis inhibitors containing, as the active ingredient, compounds having the following general formula (I) or pharmacologically acceptable salts thereof&semi and nitr...
WO/2003/045912A1	INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE The present invention provides compounds of Formula (I), wherein A, B, C, G, and W?1¿ have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also...
WO/2003/042168A1	NOVEL &agr -OXYGENATED OR &agr -THIOLATED CARBOXYLIC ACID PHENETHYLAMIDE DERIVATIVES The invention relates to &agr -oxygenated or &agr -thiolated carboxylic acid phenethylamide derivatives of general formula (I) including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitute...
WO/2003/042167A1	NOVEL $g(a)-OXYGENATED OR $g(a)-THIOLATED CARBOXYLIC ACID PENETHYLAMIDE DERIVATIVES The invention relates to $g(a)-oxygenated or $g(a)-thiolated carboxylic acid phenethylamide derivatives of the general formula I including the optical isomers thereof and mixtures of such isomers, wherein A stands for optionally substitu...
WO/2003/039548A1	HYDRAZONO-MALONITRILES Hydrazono-malonitrile derivatives of the formula (I) in which R?1¿, R?2¿, R?3¿, R?3'¿ and R?4¿ have the meanings given in Claim 1 act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours,...
WO/2003/039451A2	THIAZOLE PYRIDAZINONES AS ADENOSINE ANTAGONISTS A thiazole derivative of the formula (I):wherein R is 1-optiona lly substituted-6-oxo-1,6-dihydro-3-pyridazinyl, R' is an optionally substituted phenyl, and R?2¿ is hydrogen, a group of the formula (i): wherein R?4¿ is hydrogen, lower ...
WO/2003/040096A2	N, N'−SUBSTITUTED−1,3−DIAMINO−2−HYDROXYPROPANE DERIVATIVES Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
WO/2003/037349A1	TYPE 4 PHOSPHODIESTERASE INHIBITORS AND USES THEREOF The invention relates to the use of type 4 phosphodiesterase inhibitors (PDE IV inhibitors) to treat diseases and to combinations of PDE IV inhibitors with other drugs.
WO/2003/035602A1	LIPID MODULATORS Compounds represented by the following general formula (I) and which have a PPAR&gammad modulator activity: (I) wherein A represents optionally substituted aryl&semi B represents optionally substituted aryl, optionally substituted cycloa...

Matches 951 - 1,000 out of 4,414	< 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 >