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WO/2022/166990A1 |
Provided in the present invention are a 2-(substituted phenoxy)aromatic formic acid FTO inhibitor, a preparation method therefor and the use thereof, and specifically disclosed are a compound represented by formula (I), and the use of a ...
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WO/2022/167457A1 |
The present invention provides compounds of formula (I), compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.
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WO/2022/165016A1 |
The present disclosure provides conjugates, methods of making the same, and uses thereof. The conjugates of the present technology are useful in inducing anergy in insulin-binding B cells.
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WO/2022/164249A1 |
The present invention relates to a novel benzotriazole derivative compound, a tautomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a stereoisomer thereof, which are related to a compound for inhibiting ENPP...
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WO/2022/164857A1 |
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N -oxides, and salts thereof, Wherein R1, R2, R3, A, X and Q are as defined in the disclosure. Also disclosed are compositions containing the compounds of F...
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WO/2022/158713A1 |
The present application relates to a method for obtaining 3,5-diamino-1,2,4-triazole by subjecting solid hydrazine and dicyandiamide to a solid reaction under a solvent-free condition.
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WO/2022/155037A1 |
Disclosed are compounds for treating or preventing a disease or disorder responsive to antagonism of a P2Y14R receptor agonist in a mammal in need thereof, for example, compounds of formulas (I) and (II), wherein R1‑R8, X, Y, Z, X', Y'...
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WO/2022/143779A1 |
An alkenyl-containing compound represented by formula I or a pharmaceutically acceptable salt thereof.
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WO/2022/133551A1 |
The present application is directed towards compounds, pharmaceutically acceptable salts or prodrugs thereof, which are inhibitors of Histone Deacetylase (HDAC) binding or function. The compounds especially may have some selectivity for ...
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WO/2022/138606A1 |
A resin composition including a cyclic resin or a precursor thereof and a nitrogen-containing compound, in which the nitrogen-containing compound includes a nitrogen-containing heterocycle and an amino group in the same compound, one of ...
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WO/2022/126388A1 |
A method for synthesizing 5-bromo-1H-3-amino-1,2,4-triazole. The method has a route as (aa), in which a mixture of sodium bromate and sodium bromide is employed to serve as a brominated reagent; and a reaction route as (bb). The synthesi...
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WO/2022/126826A1 |
A preparation method for selinexor and an intermediate thereof. The present method has a short overall synthetic route and mild reaction conditions, no foul gas is generated in the reaction process, the safety is high, and the acceptable...
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WO/2022/129047A2 |
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...
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WO/2022/129041A1 |
The present invention is directed to novel prodrugs of modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurologi...
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WO/2022/129909A1 |
The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psyc...
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WO/2022/120353A1 |
The present invention provides compounds, compositions thereof, and methods of using the same.
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WO/2022/119864A1 |
Bis-amide inhibitors of SARS-CoV-2 (COVID) and methods of using them to treat a severe acute respiratory syndrome.
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WO/2022/119885A1 |
A thermoplastic polyurethane resin composition comprising: a thermoplastic polyurethane resin; an ultraviolet absorber package comprising a benzotriazole compound (UVA1), and a triazine compound (UVA2) wherein the mass ratio of UVA1 to U...
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WO/2022/111605A1 |
The present disclosure relates to an aryl or heteroaryl substituted 5-membered aromatic heterocyclic compound and the use thereof. In particular, provided is a compound as shown in formula I or a pharmaceutically acceptable salt thereof,...
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WO/2022/112855A1 |
A lipid compound of formula (I), including lipid nanoparticles thereof, and the manufacturing method and the use of pharmaceutical delivery are provided. The lipid compounds have formula (I): or a salt or an isomer thereof, wherein R1, R...
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WO/2022/107139A1 |
The present invention is directed to a process for the preparation of a hydrazine derivative by reaction of the corresponding oxirane with hydrazine, that uses as only solvent toluene. The process provides excellent yields and purities a...
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WO/2022/106588A1 |
The present invention provides novel compounds having the general formula: wherein R1 to R6 are as described herein, compositions including the compounds and methods of using the compounds.
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WO/2022/104599A1 |
An N-heterocyclic carbene catalyst. The structural general formula of the N-heterocyclic carbene catalyst is shown in formula I; and Ar1 and Ar2 in formula I are each independently selected from any one of aryl, substituted aryl, heteroa...
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WO/2022/103842A1 |
The present disclosure describes novel reagents and processes for preparing oligonucleotides, which have two or more nucleotides. In one embodiment, the reagent is represented by Formula I' or B.
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WO/2022/094244A1 |
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (I SR) and for treating related diseases, disorders, and conditions.
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WO/2022/091091A1 |
The present invention relates to polymers comprising bifunctional mono- or polycyclic heterocyclic or heteroaromatic repeating units having disinfecting activity, compositions thereof, and methods for disinfecting surfaces utilizing said...
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WO/2022/084362A1 |
The present invention relates to a method, a diagnostic system, a kit and the use thereof for efficiently detection of an analyte of interest by nanoESI mass spectrometry.
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WO/2022/081473A1 |
The present application generally relates to several processes for the preparation of (6R,10S)-10-{4-[5-chloro-2-(4-chloro-1H-1,2,3-triazol-1-yl)p
henyl]-6-oxo-1(6H)-pyrimidinyl}-1-(difluoromethyl)-6-methyl-
1,4,7,8,9,10-hexahydro-11,15-...
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WO/2022/078305A1 |
A compound represented by general formula (I) or a stereoisomer, tautomer, deuterated substance, solvate, prodrug, metabolite, pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, and a preparation method ther...
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WO/2022/070451A1 |
Provided is a composition for treating water that has excellent storage stability as a liquid and high sterilization performance, a water treatment method in which the composition for treating water is used, a method for manufacturing th...
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WO/2022/066933A1 |
Provided herein are compounds, compositions, and methods useful for inhibiting glycolate oxidase (GO) activity and for the treatment, prevention and amelioration of one or more symptoms of diseases or disorders related to GO enzymatic ac...
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WO/2022/064453A1 |
The present invention relates to novel N-linker heterocyclic fluoroalkenyl compounds of formula (I), Formula (I) wherein, R1, R2, R3, ring A and Y are as defined in the detailed description. The present invention further relates to their...
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WO/2022/063827A1 |
The present invention relates to an albidicin derivatives, in particular to amid bond isosteres compound according to general formula (1) and (2).
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WO/2022/065831A1 |
The present invention relates to a use of a triazole compound as a ghrelin receptor agonist, and more specifically, to a composition for preventing or treating diseases mediated by the ghrelin receptor, the composition being of a triazol...
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WO/2022/053453A1 |
The invention relates to novel compounds of formula (I), wherein A, V, R1 and R2 have the above mentioned meaning, and to their use for controlling animal pests, in particular arthropods and especially insects and arachnids.
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WO/2022/053000A1 |
Provided are a compound of general formula (I) or a stereoisomer, deuterium, solvate, prodrug, metabolite, and pharmaceutically acceptable salt or co-crystal thereof, an intermediate thereof, and a preparation method therefor, and an app...
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WO/2022/051984A1 |
The present invention relates to a process for synthesizing pirfenidone (1) by taking 5-methyl-3,4-dihydro-2-pyridone and halogenated benzene (chlorobenzene, bromobenzene or iodobenzene) as raw materials in the presence of a catalytic sy...
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WO/2022/051427A1 |
Described herein are compositions and methods for treating cancer in a subject. Using the compositions and methods of the disclosure, a subject may be administered (i) an inhibitor and/or an overrider and (ii) a chemotherapeutic.
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WO/2022/049376A1 |
The invention relates to compounds of formula (I): and related aspects.
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WO/2021/257723A9 |
The design, synthesis, and biological evaluation of a new family of highly effective conjugate compounds, including dendrimeric moieties and branched structures, are described. Pharmaceutical compositions including the subject dendrimeri...
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WO/2022/051565A1 |
The invention provides substituted 4-piperidinyl-quinazolines, 4-piperidinyl-pyrimidine-2-amines, and related compounds, pharmaceutical compositions, their use for inhibiting ERK5 activity, and their use in the treatment of medical disor...
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WO/2022/039120A1 |
Provided are: a polymerizable composition comprising a compound represented by formula (1), and an ultraviolet absorbing agent A in which a maximum absorption wavelength is present more on the shorter wavelength side than the compound re...
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WO/2022/030622A1 |
The present invention provides a method which can produce an intermediate of an azole derivative at lower cost than an existing production method. The method is for producing a compound represented by general formula (IV) and includes a ...
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WO/2022/026511A1 |
Disclosed are compounds of Formula 1 or Formula 1', including all geometric and stereoisomers, A-oxides, and salts thereof, wherein R1, R2, R3a, R3b, R3c, R3d, R4, Z and A, respectively, are as defined in the disclosure. Also disclosed a...
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WO/2022/026823A1 |
Provided herein are compounds or pharmaceutically acceptable salts thereof, having a structure of formula (I): wherein substituents are as described herein. Also provided is a pharmaceutical composition comprising a compound or pharmaceu...
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WO/2022/018121A1 |
The invention provides novel compounds having the general formula I wherein R1, R2 and R3 are as defined herein, compositions including the compounds and methods of using the compounds.
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WO/2022/013378A1 |
The present invention relates to compounds of general formula (I) inhibiting lysophosphatidic acid receptor 1 (LPA1), particularly the invention relates to compounds that are Ami do cyclohexane acid derivatives, methods of preparing such...
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WO/2022/008923A1 |
The present invention relates to the use of compounds of Formula (I) as herbicides, wherein Z, W, X1-X4, R1, F2, R3, R4, m and n are as defined herein. The invention further relates to agrochemical compositions comprising a compound of F...
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WO/2022/011338A2 |
The present invention relates to novel compounds that modulate the activity of one or more kinases, such as TYK2 or mutants thereof. The compounds, which may be kinase inhibitors or activators, are useful for treating autoimmune diseases...
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WO/2022/005414A1 |
The invention is related to new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (2a-j) and 7 new 1,2,4-triazole (3a-g) derivatives and synthesis of these compounds, in vitro anticancer activity studies and molecular docking and in silico ADME st...
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