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Matches 1 - 50 out of 8,670

Document Document Title
WO/2024/033293A1
The present invention relates to acylhydrazides obtained in situ by enzymatic hydrolysis of the parent prodrug 2-(difluoromethyl)- or 2-(trifluoromethyl)-1,3,4- oxadiazole, in histone deacetylase 6 (HDAC6).  
WO/2024/031192A1
Provided herein is the synthesis of a folate phosphoramidite of Formula I and the use of the folate phosphoramidite in the preparation of folate-siRNAs. Also provided are methods to silent expression of a target gene in a cell that expre...  
WO/2024/028363A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2024/028364A1
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of GPR84, and the treatment of GPR84-mediated disorders.  
WO/2024/028169A1
The present invention relates to novel thiophenolic compounds (I) which are useful in the treatment of proliferative and/or hyper-proliferative diseases. Preferably, the compounds of the present invention are endowed with inhibitory acti...  
WO/2024/030960A2
Methods and systems and compounds and agents for the induction or modulation of ferroptosis in a cell, a tissue, or a tumor in a subject are provided. Various agents and compounds are described. Various methods of administration are desc...  
WO/2024/030651A1
The present disclosure provides a compound of Formula (I'), or a pharmaceutically acceptable salt thereof and its use in, e.g. treating a condition, disease, or disorder in which inhibiting GPX4 in a subject is of therapeutic benefit, sp...  
WO/2024/025797A1
A composition includes at least one pH adjuster, at least one chelating agent, at least one anionic surfactant, at least one nitrogen containing heterocycle, at least one alkylamine compound, and an aqueous solvent, wherein the compositi...  
WO/2024/024866A1
[Problem] The present invention provides: a water-based coating composition containing an ultraviolet ray absorber, which has excellent transparency and satisfactorily blocks ultraviolet ray; and a method for producing the water-based co...  
WO/2024/025907A1
The present disclosure provides compounds of Formula (IA) and their pharmaceutical compositions: The compounds and compositions are useful for inhibiting the activity of plasma kallikrein, and they are useful in therapy and in methods of...  
WO/2024/019014A1
Provided as a precursor of a radioactive halogen-labeled compound is a compound represented by general formula (I) [in the formula, R1 represents a leaving group that can undergo nucleophilic substitution by a halide ion, R2 represents a...  
WO/2024/017150A1
Provided in the present application is a method for synthesizing deucravacitinib. The method comprises: subjecting the compound of formula (I) to chlorination and to electrophilic substitution with the compound of formula (VI) to synthes...  
WO/2023/280638A9
The application relates to vinyl thianthrenium compounds Vinyl- TT+X- of the Formula (I), a process for preparing the same and the use thereof for vinylating organic compounds.  
WO/2024/014430A1
The present invention addresses the problem of providing a method for producing an amino lipid compound that has improved yield in a carbonate esterification reaction and to provide an intermediate compound to be used in the abovemention...  
WO/2024/012537A1
The present invention relates to the technical field of new pesticide compounds, and disclosed are a compound containing a triazolinone structure, and the use thereof and an herbicide. The compound has the structure as represented by for...  
WO/2024/015861A1
Provided herein are methods of preparation of compound 101. Also provided are intermediate compounds useful in the preparation of compound 101, and methods of preparation of those intermediate compounds.  
WO/2024/014282A1
Provided is a method for producing a triazole derivative enantiomer (R). The method includes: a step for adding, in a solvent, a chiral molecule represented by general formula (IIa) or general formula (IIb) to a triazole derivative repre...  
WO/2024/010776A1
The present disclosure features agents that bind and stabilize transcription factors of interest.  
WO/2024/009691A1
The present invention provides: a nonaqueous electrolyte solution which comprises (I) at least one compound that is selected from the group consisting of compounds represented by general formula (1), compounds represented by general form...  
WO/2024/009283A1
Angiotensin AT2 receptor antagonists have been clinically validated for the treatment of chronic neuropathic pain. We discovered a series of lead compounds comprising a trisubstituted heterocyclic core that show high in vitro (sub-nanomo...  
WO/2023/247239A1
The present invention relates to a method for producing 2-[4-(4-chlorophenoxy)-2- (trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol in high purity and yield.  
WO/2023/250181A1
Provided is a compound having the structure of Formula (1) or a pharmaceutically acceptable salt, hydrate, solvate or isotope thereof, wherein A, B, Ri, R2, R3, R4, R5, R6, R7, m, 11, p, and y are as defined herein, for use in methods fo...  
WO/2023/247966A1
The present disclosure relates to copper-catalysed cycloaddition reactions. In particular, the use of copper-catalysed cycloaddition reactions in bioconjugation reactions, e.g. bioconjugation reactions involving the use of an ynamine as ...  
WO/2023/247712A1
The present invention relates to substituted 1,2,3-triazoles of formula (I) useful for the treatment of ocular diseases, in particular those related to retinal degeneration. The invention also relates to pharmaceutical compositions to tr...  
WO/2023/245156A2
The present invention relates to methods of treatment of a disease or pathology of the central nervous system, an eating disorder, or substance use disorder, drug dependence/abuse/addiction and withdrawal therefrom comprising administeri...  
WO/2023/241314A1
The present disclosure relates to a type of novel lipid compound and a use thereof, and specifically relates to a type of novel lipid compound and to a lipid nanodelivery carrier comprising the compound; the compound has improved biocomp...  
WO/2023/236824A1
The present application provides a dendron-like lipid compound, a liposome, a lipid complex, and a lipid nanoparticle and a use thereof. The dendron-like lipid compound is selected from any one of structures represented by formulas I-III...  
WO/2023/239909A1
Exemplary methods are directed to synthesizing an aryltriazole. An exemplary method may include mixing a weak acid with water to generate a first mixture; mixing an ortho-aryldiamine into the first mixture to generate a second mixture; h...  
WO/2023/232519A1
The present invention relates to a chemical compound according to general formula (1).  
WO/2023/235384A1
Disclosed herein are new aromatic compounds, compositions that include one or more aromatic compounds, and methods of synthesizing the same. Also disclosed herein are methods of enhancing readthrough of genes containing premature termina...  
WO/2023/226344A1
An ionic liquid composition and a preparation method therefor. The ionic liquid composition comprises the following components in percentages by weight: 80-90% of ionic liquid A, and 10-20% of ionic liquid B. By compounding the ionic liq...  
WO/2023/224981A1
Described herein are HSD17B13 inhibitors and pharmaceutical compositions comprising said inhibitors. The subject compounds and compositions are useful for the treatment of liver disease, metabolic disease, or cardiovascular disease, such...  
WO/2023/213785A1
The presently claimed invention is directed to a product, or a salt thereof obtainable by a process comprising at least the step of: a) reacting at least one compound of formula (I) wherein G* is selected from formula (A), or formula (B)...  
WO/2023/209191A1
The invention concerns a novel class of Prolyl oligopeptidase binding ligands, a pharmaceutical composition comprising same, the use of said ligands as medicaments, particularly, but not exclusively to promote autophagy and/or treat a di...  
WO/2023/210792A1
The present invention addresses the problem of providing a new herbicide which has both a high safety for crops and an excellent herbicidal activity on weeds. The herbicide is for overcoming a food crisis accompanying the expected increa...  
WO/2023/204967A1
NLRP3 selective inhibitors (NSIs) as anti-inflammatory agents are provided, as are methods of using NSIs to inhibit inflammation and prevent or treat diseases and conditions associated with inflammation, such as Alzheimer's disease, Park...  
WO/2023/205344A1
The present disclosure relates to 1,4,5 -substituted 1,2,3-triazoles useful as modulators of pregnane X receptor (PXR) and in the treatment of disorders associated with PXR dysfunction (e.g., disorders of uncontrolled cellular proliferat...  
WO/2023/198181A1
Carbobicyclic nucleoside compounds useful for the treatment of coronavirus disease 2019 (COVID-19), RSV and other viral infections are provided. The carbobicyclic nucleoside compound may be a compound as set forth herein. Pharmaceutical ...  
WO/2023/193341A1
Provided are a sphingolipid compound shown in formula (I), a liposome containing the sphingolipid compound, and an application. The sphingolipid compound is prepared by taking a long-chain alkyl group as a hydrophobic tail part, and bond...  
WO/2023/185752A1
Disclosed in the present invention are a triazolamide compound, a preparation method therefor, and a use thereof. Specifically, disclosed are a triazolamide compound as shown in formula I or a pharmaceutically acceptable salt thereof, an...  
WO/2023/190264A1
The present invention addresses the problem of providing: a novel triazole compound; a method for synthesizing the triazole compound; and a coupling agent. A triazole compound according to the present invention is represented by chemical...  
WO/2023/183463A1
Provided herein is a method of potentiating a cytotoxic effect of temozolomide against glioblastoma cells in a subject in need thereof, the method including administering to the subject a combination of: a therapeutically effective amoun...  
WO/2023/181075A1
The present application relates to amorphous solid dispersions of Deucravacitinib, process for the preparation of amorphous solid dispersion of Deucravacitinib, process for the preparation crystalline form of Deucravacitinib and process ...  
WO/2023/179758A1
Disclosed in the present application is a crystal of a fused tricyclic derivative or a pharmaceutically acceptable salt thereof; and specifically disclosed are a crystal of a compound of formula (I), a crystal of a pharmaceutically accep...  
WO/2023/177591A1
Described herein are a haloalkylpyridyl triazole MLL1-WDR5 protein-protein interaction inhibitors, pharmaceutical compositions and methods of use.  
WO/2023/170543A1
The present invention relates to fluorinated amphiphilic dendrimer structures (FJDs) capable of self-assembling into supramolecular systems of different size and shape. A further object is a supramolecular complex comprising at least one...  
WO/2023/166039A1
The present invention relates to compounds of formula (I) and the use thereof as inhibitors of P. aeruginosa virulence factor LasB. These compounds are useful in the treatment of bacterial infections, especially caused by P. aeruginosa.  
WO/2023/166303A1
The invention relates to compounds of formula (I): (I) and related aspects.  
WO/2023/165011A1
Disclosed in the present application are a cross-linking agent as well as a preparation method and the use thereof. The structure of the cross-linking agent contains triazolyl, and contains a double bond, amide acid or imide structure at...  
WO/2023/160035A1
A β-elemene vinylation coupled derivative, and a preparation method therefor and the use thereof in the preparation of an antitumor drug. Provided are a β-elemene vinylation coupled derivative having a structure as represented by formu...  

Matches 1 - 50 out of 8,670