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Matches 1 - 50 out of 1,054

Document Document Title
WO/2023/243686A1
The present invention provides a compound that exhibits a PLD-inhibitory activity. The present invention provides a compound having the following structural formula or the like, or a pharmaceutically acceptable salt thereof. (Each symb...  
WO/2023/237651A1
The present invention provides methods for the preparation of Compound (I) intermediate compounds and their use for the preparation of compound (I).  
WO/2023/236920A1
This disclosure provides compounds of Formula (1), compositions comprising the same, and methods of using the same, including uses in modulating SARM1 and treating various diseases and conditions, e.g., those caused by axonal degeneration.  
WO/2023/237656A1
This present invention relates to a crystalline form of (6S)-5-[4'-Fluoro-2- (trifluoromethyl)biphenyl-4-yl]-6-methyl-3,6-dihydro-2H-1,3, 4-oxadiazin-2-one which is the polymorph C, to processes for its preparation, to pharmaceutical com...  
WO/2023/220836A1
The present disclosure relates generally to new bifunctional linchpins that react selectively with cysteine residues to invoke cyclization while concurrently introducing a radiometal chelation ligand or silicon-based fluoride acceptor (S...  
WO/2023/217276A1
The present invention belongs to the technical field of pesticides, and specifically relates to a heterocyclic substituted aromatic compound, a preparation method therefor, a herbicidal composition and an application. The compound is as ...  
WO/2023/216910A1
Provided in the present invention is a new substituted bicyclic heteroaryl compound as represented by formula (A), or a pharmaceutically acceptable salt, an isotopic variant, a tautomer, a stereoisomer, a prodrug, a polymorph, a hydrate ...  
WO/2023/208706A1
A process for the preparation of a compound of formula (I) comprising the reaction of: R1-C(O)-NH-NH-C(O)-R2, with R3-CH2-CH2-O-CH2-CH2-R4, in the presence of an alcoholic solvent; wherein R1 and R2 are independently selected from straig...  
WO/2023/192328A1
The present disclosure features compounds (e.g., oxaziridine-based compounds), as well as related compositions and methods of use thereof, e.g., for selectively labeling a methionine residue in a target peptide or protein.  
WO/2023/169456A1
This disclosure relates to GLP-1 agonists, pharmaceutical compositions, and methods of use thereof.  
WO/2023/148735A1
The present disclosure relates to solid state forms of Indoxacarb or its solvate, processes for preparation thereof and agrochemical compositions thereof.  
WO/2023/131943A1
The present invention relates to novel di-imine, oxadiazepine and oxadiazine intermediates as key intermediates for preparation of oxadiazine insecticides, the processes of their preparation, purification and use in the preparation of fi...  
WO/2023/117380A1
The invention relates to dishwashing products that contain metal complexes of the general formula (I), (Aq+)p[Mn+Lm-](Xo-)r (I), wherein q is 1 or 2 and Aq+ represents a cation, selected from alkali metal cations with q = 1, alkaline ear...  
WO/2023/114615A1
A redox-based strategy for bioconjugation of tryptophan uses oxaziridine reagents that mimic oxidative cyclization reactions in indole-based alkaloid biosynthetic pathways to achieve highly selective and rapid tryptophan labeling.  
WO/2023/091464A1
The invention relates to compounds that inhibit DUBs, particularly USP9X. The invention also includes methods of inhibiting DUBs, including USP9X, and methods of treating cancers.  
WO/2023/083297A1
Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating disea...  
WO/2023/064343A1
Provided herein are compounds that modulate glucocerebrosidase (GCase), an enzyme whose activity is associated with neurological diseases and disorders (e.g., Gaucher's disease, Parkinson's disease). Also provided are pharmaceutical comp...  
WO/2023/046939A1
The present invention relates to certain macrocyclic compounds of the formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment or prevention of a disease associated with and/or caused by prot...  
WO/2023/286053A1
The present invention pertains to a process for preparing of methyl chloroformyl[4-(trifluoromethoxy)phenyl]carbamate of formula I as intermediate in the preparation of arthropodicidal indoxacarb, comprising reaction of compound of formu...  
WO/2023/278402A1
The present invention provides compounds, compositions thereof, and methods of using the same.  
WO/2022/213935A1
Provided is a compound as represented by formula (I) or a pharmaceutically acceptable salt thereof. The compound can be used in the preparation of a drug for treating 1-sphingosine phosphate receptor 1-related diseases, such as autoimmun...  
WO/2022/214053A1
A compound of formula (I) as a USP1 inhibitor or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, and the use thereof in the prevention or t...  
WO/2021/110968A9
The present disclosure provides macrocyclic compounds comprising a 4-amido- 2,4-pentadienoate (APD) moiety. The compounds exhibit toxicity that is selective to the hypoxic micro-environments often found in cancerous tissues. The disclose...  
WO/2022/127704A1
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. A method for preparing a compound of formula (II), comprising the steps of reacting a compound of formula (I) with a cyclization reagen...  
WO/2022/129909A1
The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psyc...  
WO/2022/125800A1
The present invention provides compounds, compositions thereof, and methods of using the same.  
WO/2022/123541A1
The present disclosure relates to a process for the preparation of pyrazole-oxadiazepine. The process of the present disclosure reduces solvent use, uses inexpensive and easily available reagents. The process is simple, efficient, enviro...  
WO/2022/109117A1
The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treat...  
WO/2022/103899A1
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.  
WO/2022/076563A1
The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.  
WO/2022/069563A1
The invention relates to a water-dispersible modified polyisocyanate and use thereof, especially as a crosslinking component in water-soluble or water-dispersible coating compositions. The water-dispersible modified polyisocyanate can be...  
WO/2022/071970A1
Compositions with supramolecular structures for use in agricultural methods include a source of micronutrients such as a fertilizer, a supramolecular host chemical or a supramolecular guest chemical configured to engage in host-guest che...  
WO/2022/048025A1
The present invention provides a method for synthesizing an atorvastatin calcium intermediate by using a multi-component one-pot method. Specifically, the present invention provides a one-pot synthesis method for 4-(4-fluorophenyl)-2-(2-...  
WO/2021/250240A1
The invention relates to a diaza-18-crown-6 derivative having formula (I): wherein: B is a moiety for a covalent bonding reaction; the two A are identical to each other and are a group of formula (II): where: n = 0 to 4; X1, X2, X3, X4 a...  
WO/2021/191035A1
The invention relates to compounds of formula (I), (I) and their use as herbicides. In said formula, R1 to R7 represent groups such as hydrogen, halo-gen or organic groups such as alkyl, alkenyl, alkynyl, or alkoxy; X is a bond or a diva...  
WO/2021/188620A1
Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sa...  
WO/2021/175225A1
Disclosed in the present invention are a series of tricyclic compounds, and particularly disclosed are a compound shown in formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2021/175223A1
Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.  
WO/2021/168567A1
A chelator having the general structure (I) for chelating radiometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radio...  
WO/2021/149767A1
Provided are: a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a therapeutic agent and/or a prophylactic agent for a disease in which the sodium channel (Nav) is involved and for various centr...  
WO/2021/123036A1
The present invention relates to use of a chelating compound (I) for chromatographic separation of rare earth elements, actinides, and/ or s-, p- and d-block metals, and to a method of chromatographic separation of chelates of rare earth...  
WO/2021/047308A1
Disclosed are a polyisocyanate composition and a method for preparing the composition. The composition is formed by polymerizing an aliphatic diisocyanate monomer at least including hexamethylene diisocyanate, and contains an isocyanurat...  
WO/2021/008908A1
The invention relates to a method for producing polyisocyanates having a low monomer content, said method comprising the following steps: (i) modifying at least one monomeric diisocyanate to obtain a mixture containing at least one polyi...  
WO/2021/005545A1
The present disclosure relates to a process for obtaining an enantiomeric mixture of Indoxacarb crystals having purity in the range of 95% to 99.5%, wherein the enantiomeric mixture comprises crystals of R-isomer and S-isomer. The S-isom...  
WO/2020/157188A1
The present invention provides dihydrooxydiazinone compounds of general formula (I) : (I), in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compound...  
WO/2020/160100A1
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.  
WO/2020/157201A1
The present invention includes name compounds of general formula (I) in which R1, Y, and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositio...  
WO/2020/109189A1
The present invention relates to a modified polyisocyanate and use thereof, in particular as a crosslinking component of water-soluble or water-dispersible coatings. The modified polyisocyanate is obtained by a reaction of a system compr...  
WO/2020/097950A1
Disclosed is a method for preparing polyisocyanate. A self-polymerization reaction of isocyanate is carried out using a fluorine-containing catalyst as a catalyst. After the reaction is completed, a fluorine-containing terminator is adde...  
WO/2020/014524A1
This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-...  

Matches 1 - 50 out of 1,054