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Matches 1 - 50 out of 1,026

Document Document Title
WO/2021/110968A9
The present disclosure provides macrocyclic compounds comprising a 4-amido- 2,4-pentadienoate (APD) moiety. The compounds exhibit toxicity that is selective to the hypoxic micro-environments often found in cancerous tissues. The disclose...  
WO/2022/127704A1
Disclosed are a method for preparing a carboxyl cyclic acid anhydride and a prepared product thereof. A method for preparing a compound of formula (II), comprising the steps of reacting a compound of formula (I) with a cyclization reagen...  
WO/2022/129909A1
The present invention relates to a group of novel compounds, methods for their manufacture and the use of these compounds as research tools and as pharmaceuticals. The novel compounds are analogues of cannabidiol (CBD). CBD is a non-psyc...  
WO/2022/125800A1
The present invention provides compounds, compositions thereof, and methods of using the same.  
WO/2022/123541A1
The present disclosure relates to a process for the preparation of pyrazole-oxadiazepine. The process of the present disclosure reduces solvent use, uses inexpensive and easily available reagents. The process is simple, efficient, enviro...  
WO/2022/109117A1
The present invention is directed to 3-amino pyrrolidine and piperidine macrocyclic compounds which are agonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treat...  
WO/2022/103899A1
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.  
WO/2022/076563A1
The instant invention describes macrocyclic compounds having antiproliferation activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders.  
WO/2022/069563A1
The invention relates to a water-dispersible modified polyisocyanate and use thereof, especially as a crosslinking component in water-soluble or water-dispersible coating compositions. The water-dispersible modified polyisocyanate can be...  
WO/2022/071970A1
Compositions with supramolecular structures for use in agricultural methods include a source of micronutrients such as a fertilizer, a supramolecular host chemical or a supramolecular guest chemical configured to engage in host-guest che...  
WO/2022/048025A1
The present invention provides a method for synthesizing an atorvastatin calcium intermediate by using a multi-component one-pot method. Specifically, the present invention provides a one-pot synthesis method for 4-(4-fluorophenyl)-2-(2-...  
WO/2021/250240A1
The invention relates to a diaza-18-crown-6 derivative having formula (I): wherein: B is a moiety for a covalent bonding reaction; the two A are identical to each other and are a group of formula (II): where: n = 0 to 4; X1, X2, X3, X4 a...  
WO/2021/191035A1
The invention relates to compounds of formula (I), (I) and their use as herbicides. In said formula, R1 to R7 represent groups such as hydrogen, halo-gen or organic groups such as alkyl, alkenyl, alkynyl, or alkoxy; X is a bond or a diva...  
WO/2021/188620A1
Peptidomimetic N5-methyl-N2-(nonanoyl-L-leucyl)-L-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds for use in methods of inhibiting the replication of noroviruses and coronaviruses in a biological sa...  
WO/2021/175225A1
Disclosed in the present invention are a series of tricyclic compounds, and particularly disclosed are a compound shown in formula (I) or a pharmaceutically acceptable salt thereof.  
WO/2021/175223A1
Disclosed are a series of benzo 2-azaspiro[4.4]nonane compounds, and specifically disclosed are a compound as represented by formula (P) or a pharmaceutically acceptable salt thereof.  
WO/2021/168567A1
A chelator having the general structure (I) for chelating radiometals such as 225Ac under mild conditions is provided. (I) The chelator can be coupled to a biological targeting moiety to facilitate targeted delivery of the chelated radio...  
WO/2021/149767A1
Provided are: a heterocyclic derivative and/or a pharmaceutically acceptable salt thereof that can serve as a therapeutic agent and/or a prophylactic agent for a disease in which the sodium channel (Nav) is involved and for various centr...  
WO/2021/123036A1
The present invention relates to use of a chelating compound (I) for chromatographic separation of rare earth elements, actinides, and/ or s-, p- and d-block metals, and to a method of chromatographic separation of chelates of rare earth...  
WO/2021/047308A1
Disclosed are a polyisocyanate composition and a method for preparing the composition. The composition is formed by polymerizing an aliphatic diisocyanate monomer at least including hexamethylene diisocyanate, and contains an isocyanurat...  
WO/2021/008908A1
The invention relates to a method for producing polyisocyanates having a low monomer content, said method comprising the following steps: (i) modifying at least one monomeric diisocyanate to obtain a mixture containing at least one polyi...  
WO/2021/005545A1
The present disclosure relates to a process for obtaining an enantiomeric mixture of Indoxacarb crystals having purity in the range of 95% to 99.5%, wherein the enantiomeric mixture comprises crystals of R-isomer and S-isomer. The S-isom...  
WO/2020/157188A1
The present invention provides dihydrooxydiazinone compounds of general formula (I) : (I), in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compound...  
WO/2020/160100A1
The present disclosure features compounds useful for the treatment of BAF complex-related disorders.  
WO/2020/157201A1
The present invention includes name compounds of general formula (I) in which R1, Y, and R3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositio...  
WO/2020/109189A1
The present invention relates to a modified polyisocyanate and use thereof, in particular as a crosslinking component of water-soluble or water-dispersible coatings. The modified polyisocyanate is obtained by a reaction of a system compr...  
WO/2020/097950A1
Disclosed is a method for preparing polyisocyanate. A self-polymerization reaction of isocyanate is carried out using a fluorine-containing catalyst as a catalyst. After the reaction is completed, a fluorine-containing terminator is adde...  
WO/2020/014524A1
This disclosure provides methods of using BAF complex modulating compounds as inhibitors of BAF-mediated transcription in target cells. The BAF complex modulating compounds include 12-membered macrolactam compounds that can target a BAF-...  
WO/2019/217449A1
The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R1, R2, R3, R4, L1, and L2 are as defined herein. The present invention also contemplates ...  
WO/2019/154288A1
Disclosed in the present invention are a cationic compound, a preparation method therefor and a use thereof. Provided by the present invention is a compound represented by formula I having a novel structure, or a pharmaceutically accepta...  
WO/2019/135604A1
The present invention relates to a method for producing a lactam compound from dioxazolone in the presence of a catalyst having a particular ligand, and to a lactam compound produced thereby, and can produce a lactam compound with excell...  
WO/2019/109402A1
The present invention pertains to the technical field of pesticides, and particularly relates to a dioxazine derivative, a preparation method therefor, an herbicidal composition containing the same, and an application thereof. The chemic...  
WO/2019/091975A1
The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.  
WO/2019/087087A1
The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programme...  
WO/2019/055657A1
The invention provided here creates a new paradigm for the treatment of a variety of conditions where modulation of a BAF complex is desired. The disclosure that follows outlines a strategy for modulating a BAF complex in a cell, and pro...  
WO/2019/052545A1
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of lipoprotein signal peptidase II (LspA), a key protein in b...  
WO/2019/034660A1
The invention relates to a method for producing polyisocyanates which comprise at least 10 mol% of iminooxadiazinedione groups based on the sum total of the iminooxadiazinedione and isocyanurate groups present in the polyisocyanate, by r...  
WO/2019/025562A1
The present invention provides dihydrooxydiazinone compounds of general formula (I) : in which R1, R2, R3, and R4, are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, ph...  
WO/2018/206635A1
The present disclosure relates to compounds of formula (I): RCG1-L-P (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an act...  
WO/2018/197523A1
The invention relates to novel compounds of formula (I) and their use in medicine, particularly in treating and /or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Additionally, the i...  
WO/2018/178982A1
It is an object of the present invention to provide a novel and advantageous process for commercially preparing of indoxacarb which is racemic or enantiomerically enriched at chiral center from its amide precursor using a new catalytic s...  
WO/2018/157813A1
The present invention relates to a series of tricyclic compounds and the use thereof as receptor agonists of sphingosine 1-phosphate subtype 1 (S1P1), and in particular relates to compounds as shown in formula (I) or pharmaceutically acc...  
WO/2018/137387A1
Provides a crystalline form of indoxacarb, the crystal preparation process, the analyses of the crystal through various analytical methods and using the crystal to prepare stable agrochemical formulation. Also provides the use of various...  
WO/2018/120093A1
Provided are a process for preparing an oxadiazacyclo compound and the use thereof. An N-alkoxycarbonyl hydrazine is cyclized with a disubstituted ether under the action of an alkali to give an N-alkoxycarbonyl oxadiazacyclo compound, an...  
WO/2018/093920A1
The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the natural...  
WO/2018/089951A1
Chemoselective conjugation is achieved through redox reactivity by reacting an N- transfer oxidant with a thioether substrate in a redox reaction in an aqueous environment to form a conjugation product. In embodiments, Redox-Activated Ch...  
WO/2018/039430A1
Radiofluorinated carboximidamides are disclosed as selective IDO enzyme radioligands and generate specific binding in accordance with IDO expression in vitro. MicroPET experiments indicate [18F]IDO49 specifically accumulate in IDO-expres...  
WO/2018/009417A1
Disclosed herein are small molecule calpain modulator compositions, pharmaceutical compositions, the use and preparation thereof. Some embodiments relate to macrocyclic α-keto amide derivatives and their use as therapeutic agents.  
WO/2017/202481A1
The invention relates to the use of l-(4,6-dipentyl-5,6- dihydro-2H-l,2,3-oxadiazin-2-yl)-3-hydroxypropan-l-one in treating and /or preventing infections caused by a bacterium, fungus or virus or in treating and/or preventing cancer. Add...  
WO/2017/194452A1
The present invention relates to seco (opened ring) macrolide compounds of formula (I), to the process for preparation thereof, to the use of said seco macrolide compounds as intermediates for preparation of macrolide based macrocycles, ...  

Matches 1 - 50 out of 1,026