| Document |
Document Title |
|
WO/2001/070682A2 |
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to Formula (I) whe...
|
|
WO/2001/070720A2 |
Disclosed are compounds which are inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular, the compounds have a structure according to the following F...
|
|
WO/2001/068599A2 |
A dosing form for at least one solid reagent for use in conventional organic and inorganic synthesis, in parallel synthesis, and in split and mix synthesis in combinatorial chemistry is provided as compressed tablets each containing the ...
|
|
WO/2001/066112A1 |
Urease inhibitors and drugs against Helicobacter pylori which contain, as the active ingredient, isothiazole derivatives represented by the following general formula (1) wherein R?1¿ represents hydrogen or amino; R?2¿ represents hydrog...
|
|
WO/2001/064644A1 |
Thiocarboxamides of the formula (I) in which Z represents a groupof formula (II) or (III) and R represents specified groups, are outstandingly active as microbicides in agriculture and horticulture, particularly as fungicides for the dir...
|
|
WO/2001/060819A1 |
Novel isoxazole and thiazole compounds of the general formula [1] and salts thereof; and use of both as excellent lysophosphatidic acid (LPA) receptor antagonists, wherein R1 and R2 are each optionally substituted alkyl or the like; R3 i...
|
|
WO/2001/056562A1 |
Emulsion compositions which contain compounds of the general formula (I), salts of the same, or prodrugs thereof and whose pHs are adjusted to ca. 6 or below are improved in the stability of the compounds, salts or prodrugs and exert exc...
|
|
WO/2001/055124A1 |
Novel isothiazolecarboxylic acid derivatives of the formula (I), in which A, Q, Z and k have the meanings mentioned in the specification, processes for the preparation of the new compounds and their use as microbicides.
|
|
WO/2001/055146A1 |
The present invention relates to a compound with aryl-amidines, particularly amidinoaryl-cyclopropanes, amidinoarylmethyl-pyrroles, amidinoaryl-benzenes, amidinoaryl-pyridines, or amindonoaryl-alanines, represented by formula (1), a phar...
|
|
WO/2001/046165A2 |
The invention relates to compounds of general formula (I), wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, X¿1?, X¿2?, X¿3? and Q have the significances given in claim 1, and optionally the enantiomers thereof. The active ingredients have ...
|
|
WO/2001/042201A1 |
The invention relates to novel compounds of formula (I), wherein A means -CH¿2?O- or -CH=N-; R¿1? is C¿1?-C¿4?-alkyl or cyclopropyl; R¿2? means C¿1?-C¿6?-alkyl, C¿2?-C¿6?-alkenyl, C¿2?-C¿6?-alkinyl or C¿1?-C¿6?-alkyl which i...
|
|
WO/2001/040206A1 |
Compounds of formula (I), wherein R¿1? is hydrogen or a specified substituent, R¿2? is hydrogen, C¿1?-C¿6?-alkyl, (C¿1?-C¿6?-alkylene)phenyl, pyridyl, COOR¿6?, CONR¿7?R¿8?, COR¿6?, allyl or CH¿2?-O-R¿6?; R¿3? is C¿1?-C¿6?-...
|
|
WO/2001/036375A1 |
This invention relates to new aminoalcohol derivatives or salts thereof represented by formula (I): wherein each symbol is as defined in the specification or salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pan...
|
|
WO/2001/034135A2 |
The therapeutic combinations of leukotriene (LTB¿4?) inhibitors and anti-cancer agents are disclosed. A method of treating cancer using leukotriene (LTB¿4?) inhibitors in conjunction with anti-cancer agents is also disclosed.
|
|
WO/2001/034580A1 |
The invention relates to novel heterocycle substituted diphenyl leukotriene B¿4? (LTB¿4?) antagonists, to compositions containing such compounds, and to methods of using such compounds for treatment of inflammatory diseases.
|
|
WO/2001/029014A1 |
Novel isothiazolecarboxylic esters of formula (I) wherein R?1¿ represents a hydrogen atom, methyl or ethyl, R?2¿ represents a hydrogen atom or C¿1-4? alkyl, R?3¿ represents a hydrogen atom, chloro, methoxy or nitro, and R?4¿ represe...
|
|
WO/2001/017982A1 |
The present invention includes benzophenone compounds (I) which are useful in the treatment of HIV infections.
|
|
WO/2001/015683A1 |
The invention relates to tramadol forms of administration whose action is delayed by means of a coating and which contain the active agent tramadol in the form of tramadol saccharinate and optionally, other adjuvants.
|
|
WO/2001/015682A1 |
The invention relates to pharmaceutical salts consisting of the active agent tramadol and at least one sugar substitute. The invention also relates to medicaments containing these salts, to the use of these salts for producing medicament...
|
|
WO/2001/015667A1 |
The invention relates to oral dosage forms with controlled total-release of an active substance. Said active substance is present in the form of at least two different salts that are present in the dosage form in a solid state of aggrega...
|
|
WO/2001/014339A2 |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X¿1?-X¿4?, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
|
|
WO/2001/007439A2 |
The present invention is directed to a process for the production of epothilone compounds, the improvement comprising preparing said compounds by cyclization of a compound produced from an intermediate of formula (II) wherein PG is a pro...
|
|
WO/2001/005774A1 |
Heteroaromatic ring compounds and pharmaceutically acceptable salts thereof, including the compound of formula (I) and exhibiting excellent physical properties and potent ameliorative effects against both immune disorders and chronic inf...
|
|
WO/2001/005775A1 |
A single-step process for the preparation of formula (I) benzisothiazoles from 2-acylphenylthiocyanates. Formula (I) benzisothiazoles are useful as key intermediates in the manufacture of herbicidally active compounds.
|
|
WO/2001/004116A2 |
This invention provides compounds having general structures (I), (II), (III). This invention also provides pharmaceutical compositions comprising same and methods of using these compositions to treat and prevent disorders characterized b...
|
|
WO/2001/002354A1 |
Heterocyclic amine derivatives represented by general formula (I) wherein R?1¿, R?2¿ and R?3¿ represent each H, optionally halogenated C¿3-6? cycloalkyl, etc.; Q represents an optionally substituted heterocycle containing O, S or N; ...
|
|
WO/2001/000229A1 |
The present invention provides combinations of a tumor necrosis factor antagonizing agent and a cyclooxygenase-2 inhibiting agent for treating inflammatory disease in a mammal.
|
|
WO/2001/000575A1 |
Heterocyclic dicarboxylic acid diamide derivatives represented by general formula (I): wherein R?1¿, R?2¿ and R?3¿ represent each H, optionally halogenated C¿3-6? cycloalkyl, etc.; Het represents a 5- or 6-membered heterocycle; X and...
|
|
WO/2000/073289A1 |
The invention relates to novel aryl-substituted S(O)¿m? cycles of formula (I), in which F?1¿, F?2¿, G, V, W, X, Y, Z and m have the meanings defined in the description. The invention further relates to methods for producing said cycle...
|
|
WO/2000/073290A1 |
Novel isothiazolecarboxamides of formula (I), in which X, Y, R?1¿, R?2¿, R?3¿ and R?4¿ have the meanings given in the specification, process for their preparation and their use as microbicides.
|
|
WO2000038716A9 |
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of radiation therapy and a cyclooxygenase-2 inhibitor.
|
|
WO/2000/071532A1 |
The present invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein Z, X, X?1¿, R?1¿, R?2¿ and R?3¿ are as defined herein as it relates to pharmaceutical composit...
|
|
WO/2000/069435A1 |
This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
|
|
WO/2000/068214A1 |
A process for the preparation of a compound of formula (I): wherein R is C¿1-6?alkyl; or an acid addition salt derived therefrom; the process comprising oxidising a compound of formula (II) with hydrogen peroxide with tert-butylmethylet...
|
|
WO/2000/068204A1 |
The invention relates to novel substituted benzoyl ketones of formula (I), wherein n represents 0, 1, 2 or 3; A represents a simple bond or alkanediyl (alkylene); R?1¿ represents hydrogen or optionally substituted alkyl or cycloalkyl; R...
|
|
WO/2000/068227A1 |
The invention relates to substituted benzoylisoxazoles of general formula (I), wherein R?1¿, R?2¿, R?3¿ and (R?4¿) represent hydrogen or certain substituents, a single bond or alkanediyl (alkylene) and an optionally substituted 4-12 ...
|
|
WO/2000/066574A1 |
A progesterone receptor antagonist of formula (1) wherein R¿1?, and R¿2? are each, independently, hydrogen, alkyl, substituted alkyl, hydroxy, alkoxy, substituted alkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl...
|
|
WO/2000/066163A1 |
This invention relates to cyclic combination therapies utilizing, in combination with a progestin, an estrogen, or both, progesterone receptor antagonists of general structure (1): wherein the substituents are as defined herein; or pharm...
|
|
WO/2000/059879A1 |
A method of preparing N,N-disubstituted-3,3'-dithiodipropionamide of formula (2) is provided. In the method, 3-mercaptopropionamide of formula (4) reacts with an aqueous solution of amine to prepare N-substituted-3-mercaptopropionamide o...
|
|
WO/2000/058306A1 |
The invention relates to novel substituted benzoylpyrazoles of the general formula (I), in which Z is a possibly substituted 4 to 12-membered, saturated or unsaturated, monocyclic or bicyclic heterocyclic grouping which contains between ...
|
|
WO/2000/056332A1 |
Biologically active sultams are disclosed which have the potent anti-HIV activity. Solution methods of syntheses, which use a new catalyst for the asymmetric reduction of a C=N intermediate, are described. Biological compositions and met...
|
|
WO/2000/053590A1 |
The invention relates to saccharin 5 carbonyl derivatives of formula (I), wherein the substituents have the following meaning: L represents C¿1?-C¿6?-alkyl, C¿1?-C¿6?-alkoxy; Z represents C¿1?-C¿6?-alkyl, C¿3?-C¿8?-cycloalkyl, CÂ...
|
|
WO/2000/049002A1 |
An improved process and intermediate compounds (N) for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-o
ne compounds having structural formula (I) and an improved process for the preparation of 6-(perfluoro...
|
|
WO/2000/049016A1 |
An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (I) from 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-o
ne compounds having structural formula (II).
|
|
WO/2000/049004A1 |
An improved process for the preparation of 6-(perfluoroalkyl) uracil compounds having structural formula (I) from urea compounds having structural formula (II).
|
|
WO/2000/049003A1 |
An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (I) from carbamate compounds having structural formula (II).
|
|
WO/2000/041697A1 |
The invention relates to the utilisation of compounds of formula (I) wherein the substituents have the meanings given in the description. The invention also relates to the salts thereof comprising pharmacologically compatible acids for p...
|
|
WO/2000/042029A1 |
1-Heterocycle substituted diarylamines, methods of making and using them, and compositions containing them.
|
|
WO/2000/040539A1 |
Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compos...
|
|
WO/2000/029398A1 |
Novel isothiazolecarboxylic acid derivatives of formula (I) in which X and Y have the meanings given in the specification, processes for the preparation of the new compounds and their use as biocides. New isothiazolecarboxylic acid chlor...
|
