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WO/2003/039543A1 |
Novel compounds of formula (I), wherein D, W, X, Y, T and R?1¿ have the meanings cited in Claim 1, are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatmen...
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WO/2003/040096A2 |
Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorder...
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WO/2003/037853A1 |
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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WO/2003/033484A1 |
The invention relates to substituted piperazine cyclohexane carboxylic acid amides of formula (I), methods for the production and use thereof in medicaments, especially for the prophylaxis and/or the treatment of cardiovascular diseases.
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WO/2003/031420A1 |
Novel isothiazole derivatives of the formula (I), wherein R and n have the meanings given in the specification, a process for the preparation of the new compounds and their use as microbicides. Novel intermediates of the formula (VII), w...
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WO/2003/029211A1 |
A difluoroalkene derivative which is sufficiently effective in controlling various pests even when used in a small dose and is highly safe for crops, natural enemies to the pests, and animals&semi and an intermediate for the derivative. ...
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WO/2003/029200A2 |
Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (Ia) and (Ib) where R¿1?, R¿2?, R¿3?, R¿4?, R¿5?, R¿6?, R¿8?, R¿9? and X aredefined herein. The compoundsare useful for treating autoi...
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WO/2003/016294A1 |
The preparation of sultams is disclosed. In one embodiment (e.g. scheme (I)), an alkanesulfonyl halide is reacted with a haloalkylamine to obtain the corresponding N-(haloalkyl)alkanesulfonamide which is then cyclized in the presence of ...
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WO/2003/010143A1 |
The present invention provides novel dialkylhydroxybenzoic acid derivatives containing metal chelating groups and the use of the novel compounds as therapeutics for treating and/or preventing various medical dysfunctions and diseases ari...
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WO/2003/008372A1 |
A bactericide which contains as the active ingredient a diamine derivative represented by the formula (1): (1) wherein R1 to R7 each represents a specific substituent, e.g., C1−6 alkyl&semi and R8 represents optionally substituted aryl...
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WO/2003/006454A2 |
Compounds of general formula (I), in which Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted i...
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WO/2003/006423A1 |
Disclosed are compounds of the formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the betasecretase enzyme that are useful in the treatment of Alzeheimer's disease and ot...
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WO/2003/004512A1 |
A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1$g(l)?6¿-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The...
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WO/2003/000181A2 |
Compounds having Formula (I), including pharmaceutically acceptable salts and prodrugs thereof are inhibitors of the dipeptidyl peptidase-IV enzyme (DP-IV), and are useful in the treatment of DP-IV mediated diseases and conditions, such ...
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WO/2002/096882A1 |
Substituted anilide derivatives represented by the general formula (&Verbar ), intermediates thereof, agricultural and horticultural chemicals, and their usage: (&Verbar ) wherein R1 is hydrogen, C1−6 alkyl, C1−6 haloalkyl, or the li...
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WO/2002/090332A2 |
There are provided novel compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together wit...
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WO/2002/081447A1 |
This invention relates to novel compounds of 3-cyclopentyloxy-4-methoxyphenyl-isothiazolinone derivatives having the activity to inhibit tumor necrosis factor-&agr (TNF-$g(a)) or cyclic AMP phosphodiesterase IV (PDE 4). In more detail, t...
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WO/2002/069901A2 |
This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bo...
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WO/2002/067916A2 |
The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance, particularly N,N-dimethylaminopropylphenol compounds or tradamol, and of at least one sugar substitute such as saccharin, cyclamate or acesulfa...
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WO/2002/067651A2 |
The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance and of at least one sugar substitute, to medicaments containing these salts, and to the use of these salts for producing medicaments
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WO/2002/068367A1 |
The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, b...
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WO/2002/066450A2 |
Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula (VI), and pharmaceutically acceptable salts thereof, wherein R¿0? is -CH¿2?-, -SO-, -O-, -SO¿2?-, or -S-; compositions com...
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WO/2002/066414A1 |
The invention relates to a method for isolating and purifying (1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-cycl
ohexanol as a saccharinate from a mixture of the diastereomers (1SR,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphe...
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WO/2002/062773A1 |
A compound of formula (I) wherein A and B are optionally substituted cyclohexenyl or phenyl groups, X is carbonyl or sulfonyl, and Y is 5-7 atoms-linker, is useful as histone deacetylase inhibitors, particularly for inhibiting cell proli...
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WO/2002/057242A2 |
Novel antagonists of &agr 4β1 integrin and/or &agr 4β7 integrin of the general Formula (I): wherein R1, R2, R5, L1, L2, Rb, W and Z are as defined in any one of claims 1 to 13, A represents -CH- or a nitrogen atom, and p is from 0 to 4.
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WO/2002/051822A2 |
Novel isothiazolecarboxamides of the formula (I) wherein R?1¿ represents a hydrogen atom or cyanomethyl, R?2¿ represents a hydrogen atom or methyl, and R?3¿ represents a hydrogen atom, C¿7-10? alkyl or methoxycarbonylphenoxymethyl, p...
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WO/2002/050045A1 |
This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammal...
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WO/2002/045750A1 |
Drugs which comprise a combination of an antiseptic (for example, a cycloalkene compound) with at least one chemical selected from the group consisting of antibacterial agents, antifungal agents, nonsteroidal anti-inflammatory agents, st...
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WO/2002/044158A1 |
The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of 3-(4-bromo-2.6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-b
utyl)-ureido]-isothiazole-4-carb...
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WO2001040223B1 |
The invention relates to compounds of formula (I) in which R1, R2, R3, X1, X2 and X3 are as defined in claim 1, and to any enantiomers thereof. The active substances have advantageous pesticidal properties. They are particularly suitable...
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WO/2002/042257A1 |
The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the uroge...
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WO/2002/036584A1 |
The present invention relates to compounds of formula (I) wherein U, A?1¿, A?2¿, A?3¿, A?4¿, V, X, Y, Z, Q, m and n are as defined in the description and claims and pharmaceutically acceptable salts and/or pharmaceutically acceptable...
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WO/2002/032887A1 |
A process for the preparation of a compound of formula (I) wherein R is C¿1-16?alkyl; or an acid addition salt derived therefrom; the process comprising oxidising a compound of formula (II) with hydrogen peroxide with a chlorinated alka...
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WO/2002/030356A2 |
The present invention relates to methods for use in producing epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing an aldol condensation of a first compound wit...
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WO/2002/028846A1 |
The present application describes novel cyclic sulfonyl derivatives of formula (I) particularly of formulae (II), (III), (IV) and (V) which are useful as metalloprotease inhibitors.
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WO/2002/020531A2 |
The invention relates to a method for producing anellated tetrahydro-[1H]-triazoles of formula I wherein the variables R?a¿, Z, Z?1¿, X, W, n and Q have the designations cited in patent claim 1, by cyclising compounds of general formul...
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WO/2002/017712A2 |
Compounds of formula (I): wherein A, B, D, and R are as defined herein and their agriculturally acceptable salts are disclosed as effective insecticides. In addition, compositions comprising an insecticidally effective amount of a compou...
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WO/2002/016305A1 |
The invention relates to a method for producing $g(b) ketoenol esters of the general formula (Ia) or (Ib), wherein Ar, R?a¿ and R?b¿ are defined as in claim 1. The inventive method is characterized by reacting an arylhalogenide of the ...
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WO/2002/014293A1 |
Preparation and characterisation of new ammonium salts of 1,2,benzisothiozolin-3-one, and their use for preparation of highly concentrated solutions with biocidal properties. Quaternary ammonium salts are prepared by reacting 1,2-benziso...
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WO/2002/006276A1 |
The present invention relates to a $g(b)¿3? adrenergic receptor agonist of formula (I) or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Typ...
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WO/2002/002529A1 |
Compounds of formula (I), wherein the ring with the increment (N-A) can be 5, 6 or 7-membered and can also contain an oxygen or sulfur atom or a C-C double bond, with the exception of the 1,4-benzoxazepine skeleton, A represents a carbon...
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WO/2001/097787A2 |
The invention relates to the use of inhibitors of the microsomal triglyceride transfer protein (MTP) for reducing the number of postprandial triglyceride-rich lipoprotein particles (ppTRL) or for reducing their decomposition products i.e...
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WO/2001/087838A1 |
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R?1¿, R?2¿, R?3¿, R?4¿, R?5¿,...
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WO/2001/087866A1 |
The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R?1¿, R?...
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WO/2001/087863A1 |
The invention relates to 3-arylisothiazoles of formula (I), wherein the variables X, Q, R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ have the meanings given in Claim 1. It also relates to their salts and to their use for controlling toxic plants.
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WO/2001/087830A2 |
The present application is directed to chemical compounds of formula (I-A) or formula (II-A) (in which the variables are as defined in the claims), compositions containing them and uses of the compositions for treating sleepiness, tiredn...
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WO/2001/076393A1 |
Salts of L-carnitine and lower alkanoyl L-carnitines with aspartame, cyclamic acid and saccharine are stable and non-hygroscopic and find utilization as sweeteners, particularly for coffee and tea.
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WO/2001/077090A2 |
Novel isothiazole derivatives of the formula (I) wherein A represents a group selected from (1), (2) and (3) in which R?1¿, R?2¿, R?3¿, R?4¿ and R?5¿ have the meanings given in the specification processes for the preparation of the ...
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WO/2001/072726A1 |
The invention relates to novel oxime derivatives of formula (I), in which A, R?1�, R?2�, R?3� and R?4� have the meanings as cited in the description. The invention also relates to a method for producing these novel substances and...
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WO/2001/070677A1 |
A class of compounds is disclosed, comprising sulphonamido-substituted bridged bicycloalkyl structures of formula (I) (where the variables are as defined in the claims). The compounds are inhibitors of $g(g)-secretase, and hence are usef...
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