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Matches 1 - 50 out of 15,612

Document Document Title
WO/2024/107308A1
Aminoalkyl piperazine (poly) pyrophosphates as effective flame retardants and thermoplastic polymer resins containing such flame retardants. These flame retarded resins are particularly useful in electrical and electronic components, suc...  
WO/2024/104411A1
The present application provides a memantine urea derivative, a preparation method therefor, and use thereof, which relate to the technical field of pharmaceutics. The memantine urea derivative provided by the present application has a t...  
WO/2024/107434A1
The present invention relates to compounds of formula (I) or a salt, stereoisomer, tautomer or N-oxide thereof. Furthermore, the present invention relates to compounds of formula (I), or a salt, stereoisomer, tautomer or N-oxide thereof,...  
WO/2024/105007A1
The present invention relates to compounds of formula (I) or a salt, stereoisomer, tautomer or N-oxide thereof. Furthermore, the present invention relates to compounds of formula (I), or a salt, stereoisomer tautomer or N-oxide thereof, ...  
WO/2023/018990A9
New lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells and tissue. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection ...  
WO/2024/094098A1
Provided in the present application are a compound for a delivery system and the use thereof, and an ionizable lipid having a hydrogen bond providing group.  
WO/2024/093816A1
Disclosed is a method for preparing hexamethylenediamine. The method comprises the following steps: (1) under an ammoniation reaction condition, optionally in the presence of a first solvent, subjecting hexanediol and ammonia to an ammon...  
WO/2024/087251A1
A cysteine-residue-specific chemical probe, which has similar reaction capacity and a higher reaction speed in comparison with existing IA chemical probes, and has certain differences in the types of labelled proteins because of a very s...  
WO/2024/092235A2
Provided herein are substituted phenylbenzenesulfonamide compounds and compositions thereof for modulating TRPML1. In some embodiments, the compounds and compositions are provided for treatment of neurodegenerative diseases.  
WO/2024/082629A1
Provided is a piperazine substituted phenol derivative having a structure as represented by formula (I). The compound has good salt forming properties and excellent water solubility, can meet the requirements of preparations, is low in m...  
WO/2024/084379A1
The present invention relates to a novel process for the preparation of amorphous solid dispersion of 1-{3-[3-(4-chlorophenyl) propoxy] propyl} piperidine, hydrochloride with Hydroxypropyl beta-Cyclodextrin (HPβCD) (1) The present inven...  
WO/2024/079351A1
The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof. The invention further relates to the use of the compounds of the invention as neuroprotective and/or neurore...  
WO/2024/079128A1
The invention relates to compounds and their therapeutic use, said compounds having the formula (I): wherein, for example,  Z is representing a (II)  X is representing a NR5R6 group wherein R5 and R6 are hydrogen,  R1 is represe...  
WO/2024/080321A1
The present invention provides: a compound which is capable of producing a polymer that has excellent alkali durability; a polymer which comprises this compound as a monomer; an electrolyte membrane which uses this polymer and has excell...  
WO/2024/078387A1
A substituted 3-fluorobenzenepropanoate compound represented by formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, a solvate (such as a hydrate) thereof, a clathrate thereof, a racemate thereof, a co-crys...  
WO/2024/077232A2
The present disclosure relates, in part, to immune cell targeted lipid nanoparticle (LNP) compositions, and methods of use thereof for ex vivo delivery of nucleic acid molecules and/or therapeutic agents to a target cell. In certain embo...  
WO/2024/074501A1
The present invention relates to a process for the fluorination and/or cyclization of an amino alkene or alkyne in a continuous-stream microreactor. The invention also relates to a facility for performing such a process.  
WO/2024/072908A1
Provided herein are compounds having one or more cleavable disulfide moieties and one or more hydrophobic tail moieties (HTM) for delivery of one or more therapeutic or diagnostic agents. In some embodiments, the one or more therapeutic ...  
WO/2024/068553A1
The present invention relates to tertiary amide compounds of formula (II), or a pharmaceutically acceptable salt thereof, wherein R7 comprises a group X which is -S(=O)2OH, -S(=O)OH or -P(=O)(OH)2- The compounds are capable of solubilizi...  
WO/2024/060641A1
The present invention provides a cyclotriarylphosphine ligand represented by general formula (I), and a method for preparing same. The present invention also provides a complex of palladium in coordination with the cyclotriarylphosphine ...  
WO/2024/059745A2
A series of novel substituted (hetero)arylmethanamines is described which bind to the N-methyl-D-aspartate receptor. Such compounds have value in various therapeutic indications including, but not limited to, pain, depression, tinnitus, ...  
WO/2024/052923A1
One or more ionizable lipid(s) and lipid nanoparticles comprising same are provided. Pharmaceutical compositions comprising the lipid nanoparticles encapsulating an active agent are also provided.  
WO/2024/054669A2
The present disclosure provides compounds according to Formula I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII, XIII, and XIV used as a component of lipid nanoparticle compositions for the delivery of a biological and/or therapeutic age...  
WO/2024/050352A2
The present disclosure provides modified immune cells or precursors thereof comprising chimeric antigen receptors and surface-bound, biologically inert molecules. Also included are methods of preparing said modified immune cells and meth...  
WO/2024/049979A2
Novel ionizable lipids and lipid nanoparticles that can be used in the delivery of therapeutic cargos are disclosed.  
WO/2024/050062A1
The present disclosure is concerned with substituted aminopiperazine compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of antimicrobial infections such a...  
WO/2024/043334A1
The present invention addresses the problem of providing a compound and pharmaceutical composition that possesses inhibitory activity against the drug efflux pumps of drug-resistant bacteria and, when used in combination with another dru...  
WO/2024/040496A1
Disclosed are an antiviral compound, and a preparation method therefor and a use thereof, particularly an anti-coronavirus compound capable of being used as a PLpro inhibitor, and a preparation method therefor and a use thereof. The comp...  
WO/2024/044147A1
Provided herein are methods for purifying an ionizable amino lipid (IAL) composition comprising impurities that may react with polynucleotides, such as mRNA. Methods for purifying IAL compositions comprise one or more scavenging-removal ...  
WO/2024/037422A1
The present disclosure relates to crystalline forms of (E) -N- ( (1R, 2R) -1- (3-chloro-4-cyclopropoxyphenyl) -1-hydroxy-3- (pyrrolidin-1-yl) propan-2-yl) -2- (6-chloronaphthalen-2-yl) -2- (hydroxyimino) acetamide, the method of preparin...  
WO/2024/035783A2
Lipid nanoparticle compositions (LNPs), methods for preparing the LNPs, methods of using the same, including, but not limited to, for treatment of certain diseases and disorders, including, but not limited to liver disorders, kits for th...  
WO/2024/033667A1
The present invention relates to visible light sensitive photoremovable protecting groups and their parent compounds X including a xanthene, xanthenium or related cores, represented by formula (Xa): (Xa) wherein the substituents are as d...  
WO/2024/027789A1
Disclosed are a cationic lipid compound as represented by formula (I) and composition for nucleic acid delivery, and a use. Also disclosed are a use of nano-lipid particles using said compound as a key component in the aspect of nucleic ...  
WO/2024/028808A1
The present disclosure relates to compounds of Formula (I) which modulate the activity of protein phosphatase 2A (PP2A). The compounds of the present disclosure are useful in treating, preventing, and/or ameliorating cancer, diabetes, au...  
WO/2024/031051A1
Provided herein are ionizable lipids, compositions comprising the ionizable lipids, and methods of making and using the same. The ionizable lipids provided herein can be formulated in lipid compositions for the delivery of macromolecules...  
WO/2024/026479A2
The present disclosure provides compounds, compositions thereof, and methods of using the same for the inhibition of CDK2, and the treatment of CDK2 related diseases and disorders.  
WO/2024/023287A1
The present invention relates to a compound of general formula (I). The invention further relates to the compounds of the invention as neuroprotective and/or neurorestorative agents, in particular for use in the treatment of neurological...  
WO/2024/026486A2
The present disclosure provides compounds, compositions thereof, and methods of using the same for the inhibition of CDK2, and the treatment of CDK2 related diseases and disorders.  
WO/2024/026481A2
The present disclosure provides compounds, compositions thereof, and methods of using the same for the inhibition of CDK2, and the treatment of CDK2 related diseases and disorders.  
WO/2024/026483A2
The present disclosure provides compounds, compositions thereof, and methods of using the same for the inhibition of CDK2, and the treatment of CDK2 related diseases and disorders.  
WO/2024/019936A1
The present disclosure describes compositions, preparations, nanoparticles (such as lipid nanoparticles), and/or nanomaterials and methods of their use.  
WO/2024/011414A1
Disclosed in the present invention is a reaction method for secondary amine and o-diiodobenzene, comprising: reacting secondary amine with o-diiodobenzene in the presence of an alkali metal hydride or a Grignard reagent to complete the r...  
WO/2024/012568A1
The invention relates to a key intermediate for preparing glucopyranosyl derivatives and preparation method thereof, the glucopyranosyl derivatives are sodium-dependent glucose transporter (SGLT) inhibitors. Specifically, the key interme...  
WO/2024/011415A1
Disclosed in the present invention is a method for preparing an o-iodophenyl compound, wherein an iodobenzene compound and an amide compound as raw materials are reacted in the presence of sodium hydride or n-butyllithium and a solvent t...  
WO/2023/280638A9
The application relates to vinyl thianthrenium compounds Vinyl- TT+X- of the Formula (I), a process for preparing the same and the use thereof for vinylating organic compounds.  
WO/2024/009324A1
The present invention provides the novel prodrugs of cannabidio-type phytocannabinoids having the general Formula A and its process thereof, where one or both the hydroxyl groups are attached to the other counter parts through ester bond...  
WO/2024/001995A1
The present invention relates to the technical field of drug synthesis, in particular to a lifitegrast morpholine salt, a method for preparing same, and use thereof. The lifitegrast morpholine salt provided by the present invention can b...  
WO/2024/001487A1
The present invention relates to the technical field of green, clean and efficient catalysis, and in particular, to a method for synthesizing a cyclic carbonate from carbon dioxide and an epoxy compound by means of a catalytic reaction a...  
WO/2023/250197A2
The disclosure relates to ionizable lipids and compositions comprising the ionizable lipids. Lipid-nanoparticle compositions comprised of an ionizable lipid, optionally in combination with other lipid components such as helper lipids, st...  
WO/2023/246218A1
Provided are an ionizable lipid for nucleic acid delivery and a composition thereof, which belong to the field of pharmaceutical chemistry. Provided are a compound represented by formula I and use of the compound as a nucleic acid delive...  

Matches 1 - 50 out of 15,612