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Matches 1 - 50 out of 15,188

Document Document Title
WO/2022/168884A1
The present invention provides a novel cationic lipid having excellent encapsulation and delivery stability of nucleic acid medicines. Provided is a compound represented by formula (I) or a pharmacologically acceptable salt thereof. (In ...  
WO/2022/166994A1
Provided in the present invention are a naphthyl urea compound, a preparation method therefor and the use thereof. A naphthyl urea parent nucleus group with a biological activity contained in the naphthyl urea compound is further chemica...  
WO/2022/163209A1
A carbon dioxide absorber which comprises an amine compound (A) having a heterocyclic structure (X) selected from among oxygen-containing heterocyclic structures and sulfur-containing heterocyclic structures and which has a content of th...  
WO/2022/160466A1
A 2-cyanoacrylate compound and use thereof for preventing and treating fungal diseases of crops, belonging to the field of fungicides. The 2-cyanoacrylate compound has good fungicidal activity, particularly has good fungicidal activity a...  
WO/2022/159445A1
The present disclosure is generally directed to activators of lipoprotein lipase useful in the treatment of diseases and disorders modulated by said enzyme and having the Formula (I), or a pharmaceutically acceptable salt, isomer, solvat...  
WO/2022/153306A1
The present invention is directed to compounds having anti quorum sensing activity, anti-inflammatory activity or both, compositions comprising same, and methods of using same, such for treating a subject afflicted with a disease.  
WO/2022/149618A1
The present invention provides a method for producing a compound having alkylated acidic functional groups. The method includes alkylating acidic functional groups by reacting, in a mixture containing a compound having two or more types ...  
WO/2022/149617A1
The present invention provides a library which comprises from 1 × 102 to 1 × 108 compounds; the compounds have a structure in which a first core block (first CB), a first linker (first L) and a second core block (second CB) are covalen...  
WO/2022/145923A1
The present invention relates to a pharmaceutical composition which is for preventing or treating viral infections and contains a piperlongumine-based compound as an active ingredient. Specifically, the piperlongumine-based compound acco...  
WO/2022/145707A1
The present invention provides a novel piperlongumine-based compound, and an immunomodulator and a health functional food for immunomodulation, which comprise the compound or a pharmaceutically acceptable salt or solvate thereof as an ac...  
WO/2022/144511A1
The invention relates to an ionic liquid comprising an anion of formula (I) and at least one onium cation, said ionic liquid having a colour of less than 115 Hazen units on the APHA scale. The invention also relates to a method for purif...  
WO/2022/133544A1
Cannabidiol (CBD) cannabinoids and CBD cannabinoid analogues with, inter alia, antimicrobial activity, synthetic methods for the preparation thereof and medical uses and formulations containing same.  
WO/2022/136641A1
The present invention generally relates to the field of ionizable (also termed cationic) lipids, and in particular provides a novel type of such lipids as represented by formula (I). The present invention further provides methods for mak...  
WO/2022/138931A1
Provided is a compound represented by general formula (B1). Also provided is a corrosion inhibitor (B) including one or more selected from compounds represented by general formula (B1). Further provided is a lubricant composition includi...  
WO/2022/130352A1
Present invention relates to compounds of general formula (I), their tautomeric forms, stereoisomers, pharmaceutically acceptable salts and pharmaceutical composition containing them. Invention also relates to process for the preparation...  
WO/2022/129933A1
Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ring A, Ring B, Ring C, R1, R2, R3, R4, R5, L, m, n, and p are as defined herein. The compounds are modulators of G-protein coupled rec...  
WO/2022/129047A2
The present invention is directed to novel modulators of the NMDA receptor. Separate aspects of the inventions are directed to pharmaceutical compositions comprising said compounds and uses of the compounds to treat neurological disorder...  
WO/2022/125636A1
Methods are provided for modulating MRGPRX2 generally, or for treating a MRGPRX2 dependent condition more specifically, by contacting the MRGPRX2 or administering to a subject in need thereof, respectively, an effective amount of a compo...  
WO/2022/115971A1
Disclosed are methods for separating, recovering, and purifying CBGA, CBDVA, THCVA, CBCVA, and CBCA from dewatered and desolventized crude complex extracts or mixtures of metabolites, cannabinoids, and cannabis phytochemicals. The method...  
WO/2022/120226A1
The present disclosure provides methods and related compositions that incorporate a molecularly targeted approach via the integrin subtype αvβ6 using Peptide Receptor Radionuclide Therapy (PRRT) and a theranostic approach.  
WO/2022/115973A1
Disclosed are methods for precipitation of CBDA-amine salts and THCA-amine salts from concentrated crude complex extracts. The crude complex extracts may be recovered from cannabis biomass or fermentation systems wherein microorganisms w...  
WO/2022/116714A1
Provided in the present application are a compound and the medical use thereof for novel coronavirus pneumonia, which belongs to the technical field of pharmaceuticals. The compound is a compound represented by formula I or formula II, o...  
WO/2022/115326A1
Described herein are methods of making the PPARδ agonist compound (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1- yl)phenyl)allyl)oxy)-2-methylphenoxy)acetic acid, including salt forms thereof.  
WO/2022/112855A1
A lipid compound of formula (I), including lipid nanoparticles thereof, and the manufacturing method and the use of pharmaceutical delivery are provided. The lipid compounds have formula (I): or a salt or an isomer thereof, wherein R1, R...  
WO/2022/115439A1
The invention relates to compounds of Formula I, and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds of the invention are effective in inhibiting KRAS protein with a G12C mutation and ar...  
WO/2022/107463A1
One objective of the present invention is to provide a novel method for producing a ketone derivative. Provided is a method for producing a ketone derivative (I) represented by formula (I), the method comprising a step for forming a keto...  
WO/2022/105046A1
Provided is a synthesis method of trans-4-[4-(3-methoxy-4-nitrophenyl)-1-piperazinyl]adamantan e-1-ol. The method comprises: taking 2-nitro-5-fluoroanisole as the starting raw material, and subjecting same to a three-step nucleophilic su...  
WO/2022/095461A1
Disclosed are a compound for specifically enhancing the spatial coupling degree of a TRPV4-KCa2.3 complex and the use thereof, which belong to the field of chemical medicines. The compound, which has a structure of general formula (I), m...  
WO/2022/093610A1
Crystalline 5-(dimethylamino)-N-(4-(morpholinomethyl)phenyl)naphthalene- 1-sulfonamide dihydrochloride dihydrate, methods of preparing the crystalline salt, pharmaceutical compositions containing the crystalline salt, and methods of trea...  
WO/2022/093780A1
Methods to activate or enhance phosphorylation of focal adhesion kinase (FAK) are provided herein. Methods to treat epithelial disorders in mammals, namely diseases of the gut, comprising the administration of one or more small molecules...  
WO/2022/084254A1
The present invention describes a mixture of isomeric aldimines of the formulae (Ia), (Ib) and (Ic) in which the ratio of the trans,trans isomer (Ia) to the sum of the cis,trans isomer (Ib) and the cis,cis isomer (Ic) is in the range of ...  
WO/2022/087008A1
Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating diseases. Specific diseases include those that are mediated by YAP/TAZ or those that are modulated by the interaction be...  
WO/2022/086894A1
The present disclosure encompasses solid state forms of Resmetirom, in embodiments crystalline polymorphs of Resmetirom, processes for preparation thereof, and pharmaceutical compositions thereof.  
WO/2022/078306A1
The present invention relates to the technical field of organic synthesis and chemical catalysis. Disclosed are a large steric hinderance palladium-nitrogen-heterocyclic carbene complex, a preparation method for same, applications of sam...  
WO/2022/072504A1
The present disclosure relates to antiviral composition and methods. Methods for using the antiviral compositions of the disclosure for inhibiting the growth of viruses and treatment of viral diseases are also described.  
WO/2022/059700A1
The present invention provides a triazine compound salt that has an aldosterone synthase inhibitory effect and is useful as a medicine, in particular, an agent for preventing or treating primary aldosteronism and the like, a crystal, and...  
WO/2022/056737A1
A synthetic method for a Venetoclax intermediate and analogues thereof. The reaction formula is as follows, where Y is a carbon atom or a nitrogen atom, R is a hydrogen atom or an organic substituent group, M is an alkali metal, alkaline...  
WO/2022/060459A1
Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein ...  
WO/2022/059684A1
Provided is a vitamin D derivative demonstrating excellent central nervous system migration, or a pharmaceutically acceptable salt or a solvate thereof. Specifically provided is a vitamin D derivative represented by formula (1), or a p...  
WO/2022/051862A1
The present application relates to the treatment of nematode infections. For example, the application relates to the use of compounds of Formula (I), Formula (II), Formula (III), Formula (IV), Formula (V) and/or Formula (VI) as defined h...  
WO/2022/052391A1
The present invention relates to a method for synthesizing vortioxetine or a pharmaceutically acceptable salt thereof. The process is accomplished by using a catalytic system consisting of a copper salt and an organic ligand. The catalyt...  
WO/2022/054755A1
The present invention relates to providing a new method for easily detecting tumor cells in tissue from a living body. The present invention includes a fluorescent dye containing a compound that exhibits solvatochromism for detecting tum...  
WO/2022/051804A1
Compounds of Formula (A) and methods for use as agricultural chemicals, including herbicides. Formula (A)  
WO/2022/051565A1
The invention provides substituted 4-piperidinyl-quinazolines, 4-piperidinyl-pyrimidine-2-amines, and related compounds, pharmaceutical compositions, their use for inhibiting ERK5 activity, and their use in the treatment of medical disor...  
WO/2022/045175A1
A purpose of the present invention is to provide a compound useful as a co-catalyst to be used in polymerization reactions of olefins, dienes, and acetylenes. According to the present invention, a fluorine-containing alkyl ammonium borat...  
WO/2022/042643A1
Disclosed are a pharmaceutically acceptable salt of cariprazine, a preparation method therefor, a pharmaceutical composition containing same, and the use thereof. The pharmaceutically acceptable salt of cariprazine is a salt formed from ...  
WO/2022/037465A1
The present invention relates to a lipid nanoparticle. The lipid nanoparticle is formed by a compound of the following structure (I) or pharmaceutically acceptable salt, tautomer or stereisomer thereof. The present invention also provide...  
WO/2022/040395A2
Compounds, compositions, and methods are provided for dual partial agonism of serotonin 5-HT7 and 5-HT1A receptors. The enantiomerically pure 5-phenyl-2-aminotetralin (5-PAT) compounds can be used to treat or prevent substance use disord...  
WO/2022/037590A1
The present invention relates to the field of medical chemistry and provides a quaternary ammonium salt compound for anesthesia, a preparation method therefor, and use thereof. The quaternary ammonium salt compound is a compound as repre...  
WO/2022/039079A1
A fluorine-containing ether compound represented by formula (1). (1) R1-O-R2-CH2-R3-CH2-R4-R5 (in which R3 is a perfluoropolyether chain, R1 is a C2–8 alkenyl group or a C3–8 alkynyl group, R2 and R4 are each independently a bivalent...  

Matches 1 - 50 out of 15,188