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Matches 1 - 50 out of 20,792

Document Document Title
WO/2021/068898A1
The present invention pertains to the field of medicinal chemistry, and relates to a novel KRAS G12C protein inhibitor, a preparation method therefor, and a use thereof. Specifically, a compound with a structure of formula (I) is provide...  
WO/2021/065382A1
Provided is a fluorine-containing ether compound represented by formula (1). The fluorine-containing ether compound is characteristically represented by formula (1) below. (1): R1-R2-CH2-R3-CH2-R4 (R3 is a perfluoropolyether chain; R1 is...  
WO/2021/065893A1
The purpose of the present invention is to provide a novel low-molecular-weight compound that exhibits agonistic activity on an orexin receptor and is expected to be useful as a prophylactic or therapeutic agent for narcolepsy and the li...  
WO/2021/062559A1
This disclosure relates to carmabinoid derivatives of Formula (1) wherein R4 or R7 is a carboxamide group, pharmaceutical compositions comprising these compounds and methods of using the carmabinoid derivatives. These compounds are poten...  
WO/2021/063373A1
The present invention relates to a compound represented by formula I and a stereoisomer, tautomer, solvate, polymorph thereof or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing same, a preparation meth...  
WO/2021/056646A1
A method for catalyzing anti-markovnikov hydroamination reaction of olefin and amine, relating to the field of green catalysis. Under the catalytic action of a catalyst, olefin and amine are subjected to hydroamination reaction in a solv...  
WO/2021/057882A1
A compound of formula I, a method for using these compounds as an EGFR inhibitor, and a pharmaceutical composition comprising these compounds. The compound is used in the treatment, prevention or amelioration of diseases or conditions su...  
WO/2021/058018A1
Disclosed herein are compounds that inhibit KRas G12C, pharmaceutical compositions, methods of preparation and uses thereof.  
WO/2021/052817A1
An aqueous composition comprising (a) metal ions comprising or consisting of tin ions and silver ions and (b) at least one complexing agent of formula (C11): RC12-XC11-RC11 and their salts, wherein XC11 is selected from (a) a divalent 5 ...  
WO/2021/055725A1
Described herein is the use of a PPAR-delta agonist in the treatment of kidney diseases, wherein: the kidney disease is Alport syndrome, Goodpasture syndrome, thin basement membrane nephropathy (TBMN), focal segmental glomerulosclerosis ...  
WO/2021/052353A1
The present invention relates to the technical field of enzyme inhibitors, and relates in particular to a hydroxamic acid derivative, a preparation method therefor and an application thereof. The hydroxamic acid group in the hydroxamic a...  
WO/2021/049563A1
A photobase generator that comprises a compound including a first skeleton, which is represented by general formula (a), and a second skeleton, which includes a nitrogen atom that has been bonded to the combining site of the first skelet...  
WO/2021/049564A1
This photobase generator comprises a compound having: first skeletons represented by general formula (a); and a second skeleton having nitrogen atoms that are bonded to bonding positions of the first skeletons to form amide groups, where...  
WO/2021/048809A1
The present invention relates to novel heterocyclic compounds of general formula (I) their tautomers, stereoisomers, enantiomers, pharmaceutically acceptable salts and pharmaceutical composition. The compounds of general formula (I) belo...  
WO/2021/041320A1
Provided are novel prodrugs of treprostinil, as well as methods of making and methods of using these prodrugs.  
WO/2021/038490A1
Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula I as follows: Formula I wherein R1, R2, R3 ...  
WO/2021/037090A1
In view of the lack of targeted anticancer drugs in the prior art, provided is a naphthylamine compound and a biologically acceptable salt thereof, a preparation method therefor, and an application thereof. The naphthylamine compound and...  
WO/2021/037018A1
The present invention relates to a dihydroquinazoline or tetrahydroquinazoline compound as shown in formula (I), and racemates, enantiomers, diastereomers, pharmaceutically acceptable salts or solvates thereof, and further discloses inte...  
WO/2021/033504A1
A method for producing a carbonyl compound by means of a flow reaction, wherein: a triphosgene solution is introduced into a flow path (I); the triphosgene solution comes into contact with a solid catalyst, which is affixed to at least a...  
WO/2021/033505A1
A method for producing a carbonyl compound by means of a flow reaction, wherein: a triphosgene solution, a tertiary amine solution and an active hydrogen-containing compound solution are introduced into different flow paths and are cause...  
WO/2021/032958A1
In one aspect, the invention relates to a process for preparing a compound of formula (XII), wherein PG is a protecting group, or a compound of formula (XI), comprising the steps of: (i) treating a compound of formula XIII, wherein PG is...  
WO/2021/023634A1
Disclosed is a process for the synthesis of pitolisant HCl of formula (I), from piperidine and 1-bromo-3-chloropropane. The process according to the invention is economically efficient and easily industrially scalable.  
WO/2021/022890A1
The present invention belongs to the technical field of biomedicine, and specifically relates to a cyclohexanamine D3/D2 receptor partial agonist and a pharmaceutically acceptable salt thereof, and a synthetic method therefor and use the...  
WO/2021/026179A1
The present invention is directed to compounds of the formula (I) wherein all substituents are defined herein, as well as pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositio...  
WO/2021/022761A1
The present invention relates to a preparation method for a halogen substituted compound. A piperazine derivative represented as formula I reacts with a halogenated acetyl halide derivative represented as formula VI to generate the halog...  
WO/2021/019523A1
A process for the preparation of cariprazine hydrochloride (Formula I) by reacting trans-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclo hexanamine (Formula II) or it's salt with N,N-dimethylcarbamoyl chloride (Formula III) in a b...  
WO/2021/021634A1
Compositions for delivering nucleic acids to cells or tissue microenvironments are provided. In one embodiment, the compositions are lipid nanoparticle compositions formulated to have reduced splenic and hepatic clearance. It has been di...  
WO/2021/018834A1
The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, m, n and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use fo...  
WO/2021/020429A1
The present invention provides a compound represented by formula (I) or a pharmaceutically acceptable salt thereof which has the effect of antagonizing the LPA1 receptor.  
WO/2021/017645A1
The present invention relates to the field of medicine synthesis, relates to a racemic preparation method for preparing a chiral β-amino acid and a derivative thereof, and particularly relates to a racemization method for a sitagliptin ...  
WO/2021/018833A1
The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4x, R4y, k and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for c...  
WO/2021/018135A1
Provided are heterocyclyl alkyl substituted dichlorobenzoyl compounds and applications thereof. Specifically, provided are compounds represented by formula (I) and preparation methods therefor, compositions containing these compounds and...  
WO/2021/009568A1
Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and f...  
WO/2021/007663A1
This disclosure relates to cannabinoid derivatives of formula (I), pharmaceutical compositions comprising them, and methods of using the cannabinoid derivatives in treating or preventing a diseases associated with a cannabinoid receptor ...  
WO/2021/007478A1
Provided herein are sulfone compounds, for example, a compound of Formula A, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, a mixture of two or more tautomers, or an isotopic variant there...  
WO/2021/004947A1
The invention discloses a method for preparation of acetoacetate ester compounds with amino alcohol catalysts which are themselves diketenized in the course of the diketenization reaction; and subsequent polymerization of these acetoacet...  
WO/2021/000687A1
The present invention provides a preparation method for a crystal form of PAC-1 . The crystal form A of PAC-1 provided in the present invention, by using CuKα radiation and an X-ray powder diffractogram represented with 2θ diffraction ...  
WO/2020/262648A1
The present invention provides a compound that has an excellent pest-controlling effect and that is represented by formula (I) [in the formula, L represents an oxygen atom or CH2, E represents a C2-C10 chain hydrocarbon group or the like...  
WO/2020/258972A1
The present invention provides a brand-new hydrazone amide derivative and an application thereof in preparation of medicaments for preventing and treating alopecia. The structural formula of the hydrazone amide derivative is as shown for...  
WO/2020/264176A1
Heteroaryl and aliphatic analogs of diarylurea-based cannabinoid 1 receptor (CB1 R) allosteric modulators of formula (I) are described. Exemplary analogs can provide improved potencies and pharmacokinetic properties. Methods of using the...  
WO/2019/234567A9
The present patent application relates to compounds of formula (1) wherein Y and Z are independently O, N, P; R, R1, R2, R3, where present, are independently H, optionally substituted C1-C12 alkyl, O, or R and R1 and/or R2 and R3 form, t...  
WO/2020/258971A1
Provided are a new class of hydrazone amide derivatives and the use thereof in the preparation of anti-osteoporosis drugs, wherein the structural formula of the hydrazone amide derivative is as shown in formula (I), and same are a new cl...  
WO/2020/262134A1
The present invention addresses the problem of providing a purification method for an actinic ray-sensitive or radiation-sensitive resin composition which can be used to form a pattern in which defects are inhibited. The present inventio...  
WO/2020/252589A1
The present document describes compounds, or pharmaceutically acceptable salt thereof, of a core formula (I) where R1 features an amine group, particularly useful in the formulation of lipid particles including nucleic acid therapeutic a...  
WO/2020/257299A1
A method for preparing isotopologues and/or stereoisotopomers of cyclic and heterocyclic alkenes and dienes is described. The method provides regio- and/or stereospecific addition of hydrogen, deuterium, tritium and a variety of other su...  
WO/2020/257549A2
Compounds are provided that are useful as immunomodulators. The compounds have the Formula (I) including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1a, R1b, R1c, R1d, R2a, R2b, R3, R3a, R4, R5, R6, R7, R8 and t...  
WO/2020/248076A1
Disclosed are methods for separating, recovering, and purifying cannabidiolic acid (CBDA) salts from an organic solvent solution comprising a mixture of cannabinoids. The methods comprise solubilizing the mixture of cannabinoids in C5-C7...  
WO/2020/251012A1
Provided is are an agricultural and horticultural agent, in particular a compound which is useful as the active ingredient of an agricultural and horticultural pest control agent, a mite control agent, a nematode control agent or a disea...  
WO/2020/248075A1
The current application relates to pyronaridine or 6-chloro-2-methoxyacridine analogs having binding affinity for the ERCC1-XPF hetero-dimerization interface. The compounds can be used for targeting DNA repair in tumor cells via ERCC1-XP...  
WO/2020/250234A1
This invention is directed to a method of treating a human patient afflicted with Huntington disease and/or symptoms thereof, comprising administering to the patient a pharmaceutical composition comprising pridopidine or a pharmaceutical...  

Matches 1 - 50 out of 20,792