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JPWO2005095356A1 |
A heat-generating agent and singlet oxygen generation that are effective as a new cancer therapeutic agent that kills cancer cells by the action of heat and / or singlet oxygen, which is different from alkylating agents such as MMC, and ...
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JP2008505108A |
Paclitaxel is separated from a mixture containing cephalomannin by column chromatography on silica gel using a solvent mixture containing methyl isobutyl ketone and a less polar solvent as the mobile phase. The less polar solvent can be ...
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JP2008505111A |
Paclitaxel is isolated by a process including normal phase chromatography using a polyamide stationary phase and a mixture containing a dialkyl ketone and a less polar solvent as a mobile phase. Suitable dialkyl ketones include acetone o...
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JP2007537271A |
A process for synthesizing a C-7 protected baccatin III compound represented by formula (A), which comprises reacting a 10-deacetylbaccatin III compound represented by formula (B) with a protecting agent and an acylating agent in the pre...
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JP4023097B2 |
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JP2007533608A |
A process for the preparation of alkylene oxide, which process involves mixing fresh feed containing organic hydroperoxide and alkene with a recycle stream to obtain a reaction mixture containing of from 5 to 80% wt of alcohol, based on ...
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JP4003264B2 |
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JP2007530520A |
The present invention relates to a method for the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human which is optionally being treated with ionising radiation, particular...
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JP4001384B2 |
The invention pertains to a coating composition comprising a first compound comprising at least one bicyclo- or spiro-orthoester group and as a second compound an amino resin. The invention also comprises a process for curing the present...
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JP2007277148A |
To provide a trisoxetane ether compound that can be made into a polymer, and an optical waveguide. The compound is represented by formula (7) and is prepared by forming a cesium phenolate moiety from a trisoxetane ether compound and a ph...
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JPWO2005080322A1 |
The present invention relates to a novel fluorene derivative or a salt thereof, which is characterized by a structure in which a functional group such as a guanidino group is bonded to a fluorene skeleton via a carbonyl group. The compou...
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JP3990060B2 |
Storage stabilization of compounds with an oxetane ring or oxetane rings, which are useful as ring opening polymerizable monomers, is improved by addition of basic compounds thereto. The basic compound is preferably an alkali metal hydro...
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JP2007527713A |
The invention is directed to a method for the production of taxanes by culturing suspension cells of Taxus sp. in a nutrient medium that comprises an indanoyl amino acid. The indanoyl amino acid may be added in batch mode or in a feed st...
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JP2007527432A |
A taxane having the formula: wherein X3 is furyl, X5 is t-butoxycarbonyl, Bz is benzoyl, and Ac is acetyl.
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JP3976778B2 |
An object of the present invention is to provide a curable composition which: is excellent in reactivity, in particular, cationic polymerizability with respect to light and heat; and has good heat resistance. The object is carried out by...
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JP2007230968A |
To provide a liquid-crystalline composition excellent in orientation property and exhibiting little disarrangement of the orientation after fixing the orientation of the liquid-crystal material, and a compound providing the liquid-crysta...
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JP3974938B2 |
Combinations of (a) taxol, taxotere, or their derivatives, with (b) a therapeutic substance are used in the treatment of neoplastic disorders. Pref., (b) is an alkylating agent, (esp. cyclophosphamide, ifosamide, melphalan, hexamethyl me...
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JP2007525408A |
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders c...
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JP3969785B2 |
To obtain a synthetic product useful for preservating and storing interal organs prior to the transplantation to patients who need the transplantation by containing a specific compound and calcium in a physiologically acceptable preserva...
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JP2007524587A |
N-alkylglycine trimers with the capacity to arrest the cell cycle in human cancer cells and to induce apoptosis useful for the therapy of cancer. Combination of said N-alkylglycine trimers with taxol.
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JP3965789B2 |
To obtain a curing composition with excellent curability and storage stability, useful e.g. as a coating material by including metal oxide particles and a hydrolyzable group-bearing oxetane compound. This curing composition is obtained b...
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JP2007210942A |
To provide a method for effectively and environmentally safely isolating analog of taxanes. The method comprises use of a preparative high-performance liquid chromatography in an industrial scale. The method uses a "Load and Lock Axial C...
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JP2007210946A |
To provide a new compound having self-polyaddition reactivity, to provide a new polymer obtained by self-polyaddition reaction, and to provide a method for producing the polymer. A compound having an oxetanyl group, an amide bond and a c...
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JP2007523131A |
The invention relates to substituted ß-lactones (oxetanones) of general formula (I), in which R
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JP3959976B2 |
To obtain a new oxetane ring-containing α,ω-(dimethylol) perfluoroalkane derivative and to provide a method for producing the same. This oxetane ring-containing α,ω-(dimethylol)perfluoroalkane derivative is represented by formula (1)...
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JP3953428B2 |
To provide a method for purifying Taxotere (R). The method for purifying the Taxotere (R) comprises subjecting the Taxotere obtained by partial synthesis of 10-deacetylbaccatine III to centrifugal partition chromatography between two par...
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JP3953106B2 |
New taxoids of general formula (I): (I) wherein Z represents a hydrogen atom or a radical of general formula: (II) in which R1 represents an optionally substituted benzoyl radical, a thenoyl or furoyl radical or a radical R2-O-CO- in whi...
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JP2007191432A |
To provide a new bisoxetane ether compound preparing a polymer having excellent thick membrane-forming properties, curability, heat resistance, etc., to provide a method for producing the compound and to provide an optical waveguide usin...
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JP2007191431A |
To provide a new bisoxetane ether compound preparing a polymer having excellent thick membrane-forming properties, curability, heat resistance, etc., to provide a method for producing the compound and to provide an optical waveguide usin...
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JP3950993B2 |
This invention relates to a pharmaceutical composition comprising as active principle, docetaxel or a taxoid derived from docetaxel, one or more unsaturated phospholipids and a small amount of one or more negative phospholipids, allow th...
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JP2007504273T5 |
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JP3942197B2 |
This invention relates to a taxane derivative represented by the following formula (1): wherein at least one of X and Y represents a group -CO-A-B in which A represents a single bond, an alkylenecarbonyl group or the like and B represent...
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JP2007169172A |
To provide a method for purifying an epoxy resin obtaining an epoxy compound used as an adhesive for an optical member having an extremely high non-coloring property and maintaining high transparency, an adhesive for an optical member an...
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JP3940392B2 |
To provide new taxanes which have utility as anti leukemia and antitumor agents. The taxane derivatives having C7 substitutents wherein the substituents are independently selected from a group comprising H or an acloxy group, are valuabl...
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JP2007516168A |
The present invention relates to a process for preparing a compound of the formula I or a pharmaceutically acceptable salt, prodrug, hydrate or solvate thereof, wherein R1, R2, R3 and R4 are as defined herein. The compound of formula I i...
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JP3933196B2 |
Taxane derivatives having an alkyl substituted C13 side-chain.
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JP3933322B2 |
To obtain a hardenable composition capable of providing a new reaction use of an oxetane compound, hardly causing volumetric shrinkage at the hardening time, excellent in dimensional stability and further excellent in thermal stability b...
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JP3931448B2 |
To obtain the subject compound useful as a monomer capable of industrially favorable ring-opening polymerization from an easily treatable material by reacting a 3-halogenomethyl-3-alkyloxetane in a specified condition. A bis (3-alkyloxet...
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JP2007137898A |
To provide new derivatives of 10-deacetylbaccatine III and 10-deacetyl 14β-hydroxybaccatine III having cytotoxicity and antitumor activity.The derivatives are prepared starting from the so-called syntons or from other taxanes of natural...
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JP3921252B2 |
PURPOSE: To obtain a new taxol derivative useful as an antitumor agent and having improved effectiveness against the cancer of digestive tracts, especially colon cancer. CONSTITUTION: This ether derivative (salt) is expressed by formula ...
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JP3919268B2 |
To obtain the subject new complex comprising a specific ruthenium- iodine-optically active phosphine complex and useful as a catalyst for various organic synthetic reactions having a high catalyst activity and high asymmetric yield and u...
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JP3917173B2 |
Taxane derivatives substituted on the C10 position with novel substituents are disclosed. The novel compounds have utility as antileukemia and antitumor agents.
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JP2007112788A |
To provide a new oxetane compound useful as a polymerizable component of a curable composition.The new oxetane compound is represented by the general formula(I) ( wherein, R1 and R4 are each an alkyl, cycloalkyl or aryl; R3 is an alkylen...
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JP2007091749A |
To provide a specific antibody selective for TRAIL receptor DR5, which, both in vivo and in vitro, not only can be bound to a cell surface receptor but also can potently induce apoptosis of various types of abnormal cells (including tumo...
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JP2007507405A |
This invention provides a device for promoting crystallization of integral membrane proteins using a surface of alkylketene dimers doped with a nucleating compound. A coating that enhances crystallization of integral membrane proteins in...
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JP2007070328A |
To provide a new trisoxetane ether compound capable of producing a polymer excellent in thick membrane-forming property, curing property, heat resistance, etc., a method for producing the same and an optical waveguide using the same.This...
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JP2007070324A |
To provide a new oxetane ether compound capable of producing a polymer excellent in thick membrane-forming property, curing property, heat resistance, etc., a method for producing the same and an optical waveguide using the same.This bis...
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JP2007070319A |
To provide a method for synthesizing an oxetane compound, without accompanying complex operations, and capable of producing the oxetane compound capable of producing a polymer excellent in heat resistance, mechanical characteristics, a l...
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JP2007070323A |
To provide a new oxetane ether compound capable of producing a polymer excellent in thick membrane-forming property, curing property, heat resistance, etc., a method for producing the same and an optical waveguide using the same.This tet...
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JP2007070326A |
To provide a new compound capable of producing a polymer excellent in thick membrane-forming property, curing property, heat resistance, etc., a method for producing the same and an optical waveguide using the same.This bis(hydroxyphenyl...
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