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JP2001278874A |
To provide a method for producing an oxetane derivative used as an intermediate for various kinds of fluorine functional materials and having a fluorine substituent group in the side chain. This method for producing the compound represen...
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JP2001278875A |
To obtain a 3-fluoroalkoxymethyl-3-alkyloxetane and to provide a method for producing the same, to obtain especially a compound having a fluoroalkyl ether bond having difluoromethylene group or fluoromethylene group at the α-position of...
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JP3217155B2 |
PURPOSE: To obtain a new compound useful as antileucemia, antitumor agent. CONSTITUTION: The compound expressed by formula I [R1 is phenyl; R3 is CH3O-, CH3 CH2O-; Z is -OT1, -COT2 (T1 is H, a hydroxyl protecting group; T2 is H, a 1-6C a...
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JP3217156B2 |
PURPOSE: To obtain a new compd. of to derivative useful as an anti-leukemia and anti-tumor agent. CONSTITUTION: The novel substd. taxane is a compd. of formula I [wherein R1 is 2-furyl or 2-thienyl; Z is -OT1 or -COT2 (T1 is H or a hydro...
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JP2001517225A |
Processes for preparing compounds of the formula (I) are described: P1OOC-CH(OH)-CHR1-CONH-Z wherein P1 is hydrogen or a protecting group, Z is a group -CHR2COOP2 or -CHR2CONR3R4 wherein P2 is hydrogen or a protecting group and R1-R4 are...
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JP3208517B2 |
PURPOSE: To obtain a novel compound having a low toxicity and an anti-tumor activity. CONSTITUTION: This novel compound is expressed by formula I [wherein R1 is -COR2 (wherein R2 is t-butyloxy, 1-6C alkyl or the like); R2 is 1-6C alkyl, ...
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JP2001513778A |
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
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JP2001226365A |
To provide an oxetane compound for cationic polymerization having high polymerizing property and improved heat resistance, a method of preparing the compound and further a cationically polymerizable composition containing the compound.An...
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JP2001220387A |
To provide a method for the enantio-selective synthesis of a δ-lactone useful as a precursor for orlistat.The objective method for the production of a δ-lactone (I) comprises the treatment of an acyl halide (II) with a ketene acetal (I...
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JP2001511139A |
A compound of formula (I), wherein W is -NHOH or -OH, R1 is either free or protected hydroxymethyl or mercaptomethyl or derivatives thereof, R2 is free or protected hydroxy, R3 and R4 is an organic group, R5 is hydrogen or methyl, or R4 ...
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JP2001199974A |
To provide a structurally new taxol derivative having an anti-tumor activity. This 7, 8-cyclopropataxane having the anti-tumor activity is a compound of the following formula I [wherein, R1 is CORZ (wherein RZ is t-butyloxy, a 1-6C alkyl...
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JP3189140B2 |
PURPOSE: To provide a new compound usuful as antitumor agents, which has high solubility in water. CONSTITUTION: The compound of formula I (T is taxane part which has a substituted 3-amino-hydroxypropanoiloxy group upon C13; (m) is 0-6; ...
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JP2001509150A |
The present invention is directed to novel taxoids possessing strong reversing activities for drug-resistance associated with anti-cancer agents, the preparation of these reversal agents and pharmaceutical compositions thereof. The new t...
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JP3184350B2 |
PURPOSE: To efficiently enzymatically resolve the subject compound useful as a raw material, etc., for medicines by bringing an enantiomeric mixture of specific azetidinone derivatives into contact with an enzyme or a mlcroorganism capab...
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JP3182231B2 |
PURPOSE: To obtain a novel substituted taxane useful as an antileukemic agent or an anticancer agent. CONSTITUTION: This novel compound of formula I {wherein R1 and R3 are each phenyl, naphthyl, -CHCHC6H5 or formula II [wherein Q is CH3,...
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JP2001507029A |
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
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JP3165141B2 |
Heteroatom containing perfluoroalkyl terminated neopentyl glycols of the formulas HO[-CH2C(CH2X-E-Rf)2CH2O]1-3-H or HO[-CH2C(CH2X-Rf)2CH2O]1-3-H are prepared from halogenated neopentyl glycols or oxetanes and thiols of the formula Rf-E-S...
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JP2001505527A |
PCT No. PCT/EP97/00440 Sec. 371 Date Jul. 30, 1998 Sec. 102(e) Date Jul. 30, 1998 PCT Filed Jan. 31, 1997 PCT Pub. No. WO97/28156 PCT Pub. Date Aug. 7, 1997The invention relates to pharmacologically active compounds that have the ability...
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JP3157165B2 |
The present invention is directed to novel taxanes useful as chemotherapeutic agents or their precursors. Processes for preparing the novel taxanes include coupling reactions, in the presence of a base, of baccatin of formula (III) or (I...
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JP2001504864A |
A process is described for converting the C(7) hydroxy group of a 10-acyloxy-7-hydroxytaxane to an acetal or ketal, the process comprising treating the 10-acyloxy-7-hydroxytaxane with a ketalizing agent in the presence of an acid catalys...
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JP3148243B2 |
Patients with elevated blood levels of low-density lipoprotein (LDL) and total cholesterol are treated by administering beta -hydroxy- beta -methylbutyric acid (HMB) to reduce the patient's blood level of LDL and total cholesterol. HMB c...
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JP3145993B2 |
To obtain a new antitumor compound having strong antitumor activity against human breast cancer cell, non-small cell lung cancer cell, ovarian cancer cell and colon carcinoma cell. This compound is shown by formula I (R1 is an alkyl, an ...
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JP3145821B2 |
PURPOSE: To obtain a partially novel compd. in one-step process in good yield and selectivity by reacting cyclic hydroxyether, a material substance easily available and 1,3-butadine with a catalyst obtained by combining a Pd catalyst and...
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JP2001039961A |
To provide an economically advantageous method for producing an oxetane compound having chloromethyl group at the 3-position by which a phase-transfer catalyst used is recovered and reutilized. A reactional liquid after a reaction is sep...
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JP2001501613A |
A method for producing paclitaxel is accomplished by first esterifying C-7-CBZ baccatin III with a C3'-N-CBZ-C2'-O-protected (2R, 3S)-3-phenylisoserine side chain to form a first intermediate. Next, the carbobenzyloxy groups at C-7 and a...
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JP2001031664A |
To obtain a new naphthalene derivative which has specific oxetane rings and is useful for obtaining photocurable resins or thermosetting resins capable of being extremely quickly cured with light or heat to produce the cured products hav...
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JP2001501578A |
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process incudes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs with...
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JP2000336133A |
To produce a new compound capable of carrying out a photocationic polymerization and a thermal polymerization using an acidic catalyst and providing a resin useful for varnishes, etc.This compound is represented by the formula (R' is H o...
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JP2000327672A |
To provide a method by which an oxetane compound useful as a material for cationic curable resins can stably be preserved at room temperature over a long period. This method for preserving an oxetane compound in the presence of a basic c...
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JP2000514458A |
A method of acylating 10-deacetylbaccatin III at the C-10 position over the C-7 hydroxy position thereof to produce baccatin III is accomplished first by dissolving 10-deacetylbaccatin III in an anhydrous ether solvent, such as tetrahydr...
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JP2000514082A |
PCT No. PCT/FR97/01201 Sec. 371 Date May 5, 1999 Sec. 102(e) Date May 5, 1999 PCT Filed Jul. 4, 1997 PCT Pub. No. WO98/01435 PCT Pub. Date Jan. 15, 1998A process for selective monoacylation of 10-deacetylbaccatin III, or a derivative the...
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JP2000273093A |
To provide a method for conveniently producing a high purity hydroxyalkyloxetane, not requiring an additional purifying process for removing secondary products and especially not containing secondary products such as acrolein having a ba...
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JP2000264963A |
To obtain the subject high-molecular weight copolymer having reactive groups on the side chain without using a conventional phosgene method by polyaddition reaction between a bisoxetane compound and a bischloroformate compound using a sp...
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JP2000511905A |
The present invention concerns novel paclitaxel derivatives, their use as antitumor agents, and pharmaceutical formulations.
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JP3085710B2 |
Process for the preparation of a taxane derivative of general formula (I) and use of the product obtained as a preparation of taxane derivatives of general formula (II). In the general formula (I), R1 represents an acetyl radical or a pr...
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JP2000510832A |
The invention is an oxazolidine ester of silylated baccatin III of formula (VII)which is a useful intermediate to produce pharmaceutically useful anti-cancer compounds.
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JP2000510470A |
1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
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JP2000510148A |
The present invention concerns the novel compound 7-O-methoxymethyl paclitaxel, its use as an antitumor agent and pharmaceutical compositions containing the novel compound.
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JP2000219630A |
To obtain a new derivative having an oxetane ring on a side chain, and having excellent pharmacological activity as an osteogenesis stimulating agent, a bone resorption suppressing agent or the like. A derivative of formula I [R1 and R2 ...
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JP3074086B2 |
Novel 3-substituted oxetane monomers for photoinitiated cationic polymerization, compositions for polymerization containing these oxetanes, processes for polymerizing the monomers, and polymers produced thereby are disclosed. A class of ...
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JP2000204090A |
To simply and inexpensively isolate and purify the subject texanes including paclitaxel of high purity in high yield and are useful for treatment or the like of ovarian cancer or the like by covering the interactive absorbing medium with...
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JP3066873B2 |
The present invention relates to a method for mass production of taxol with a high yield, which comprises the step of inoculating Taxus genus plant cells in a medium containing AgNO3 and incubating it.
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JP3064419B2 |
PCT No. PCT/FR93/00965 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07876 PCT Pub. Date Apr. 14, 1994This invention relates to a method of preparing esters of baccatine III or 10-deace...
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JP3062986B2 |
The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
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JP3062349B2 |
A method for extracting taxanes such as taxol, comprising the use of supercritical fluids.
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JP3059149B2 |
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JP3057097B2 |
PCT No. PCT/FR91/00132 Sec. 371 Date Aug. 21, 1992 Sec. 102(e) Date Aug. 21, 1992 PCT Filed Feb. 20, 1991 PCT Pub. No. WO91/13053 PCT Pub. Date Sep. 5, 1991.New beta -phenylisoserine derivative of formula (I), its preparation and its use...
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JP2000159757A |
To produce the subject compound as an anti-tumor compound simply by removing 7-position hydroxyl group in a taxol derivative to introduce a 6,7-olefine type compound, and then treating the same in a solvent, in the presence of a metal ca...
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JP2000506898A |
A method of producing docetaxel comprises the esterification of C7, C10 di-CBZ 10-deacetyl baccatin III and an N-CBZ C2'-protected 3-phenyl isoserine side chain wherein C2' is protected by a hydrogenatable benyl-type protecting group. Th...
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JP3048175B2 |
The present invention is a method that uses an absorption column for the cleavage and recovery of taxanes, which are not normally detected as free taxanes. The method processes a first solution that contains standard detectable taxanes a...
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