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JP2004515497A |
A process for the preparation of paclitaxel starting from 10-deacetylbaccatine III.
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JP2004149486A |
To provide a method for producing an oxetane derivative in high yield by which the treatment of a raw material is facilitated.The method for producing the oxetane derivative involves reacting a hydroxy group or mercapto group of an oxeta...
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JP2004143136A |
To provide an oxetane compound having excellent ink curability and substrate adhesiveness independent of the environmental humidity even under a light source of low lighting intensity and giving a high-quality image free from bleeding de...
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JP2004143135A |
To provide a new oxetane compound having excellent stability, an actinic energy ray curable composition having good ink stability and ink ejection stability, giving a recorded image having excellent curability, scratch resistance and adh...
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JP2004143137A |
To provide an oxetane compound capable of recording a high-precision image having excellent letter quality and free from the generation of color mixing defect, an actinic energy curable composition containing the oxetane compound, an ink...
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JP2004115526A |
To provide a method for synthesizing taxol or its derivative having a tumor suppression effect.An intermediate for the taxol expressed by formula (11) (R1 is H, hydroxy, a protected hydroxy or -OCOR30, or forms carbonate together with R2...
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JP2004511453A |
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders c...
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JP3519084B2 |
A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal or an ammonium alkoxide is reacted with a beta-lactam.
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JP2004510785A |
New photopolymerizable liquid crystalline dioxetane compounds are provided having the general formula I:wherein R1 and R2 are independently selected from straight or branched C1-C4 alkyl and hydrogen; X and X' are independently selected ...
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JP2004509919A |
Compounds according to formula I:wherein T1 is a taxoid group, preferably of Formula II:wherein R1 is C6H5; R2 is O; L is a linking group; and T2 is a substituent selected from the group consisting of epipodophyllotoxin, amsacrine, ellip...
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JP2004091347A |
To provide a structurally new oxetane compound and to provide an active energy ray curing type ink comprising the structurally new oxetane compound and having good letter quality and excellent adhesion to recording media.The oxetane comp...
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JP3508502B2 |
To obtain a new compound useful as a coating material or the like by using a readily available raw material. This compound is represented by the formula (R is H or a 1-6C alkyl), e.g. 3,3'-[4,4'-bitolylenediyl-bis(oxymethylene)]bis(3-eth...
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JP3502657B2 |
PURPOSE: To obtain the subject compound useful e.g. for the treatment of cardiac disease and lipid metabolism diseases from waste materials by acylating a precursor of D-(+)-carnitine or the like, lactonizing after acid hydrolysis, treat...
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JP3502649B2 |
PURPOSE: To manufacture L-(-)-carnitine useful as pharmaceuticals, in high yield without need of conversion of the waste-product into an achiral intermediate, from a (D)-(+)-carnitine derivative. CONSTITUTION: This compound is manufactur...
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JP2004059527A |
To provide a bis(1,1,1,3,3,3-hexafluoro-2-hydroxypropyl)benzene derivative having an oxetane ring and synthesized from a readily available raw material and to provide a method for producing the derivative.The bis(1,1,1,3,3,3-hexafluoro-2...
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JP2004051556A |
To provide a method for industrially safely producing an oxetane derivative in a high yield.This method comprises reacting an oxirane compound with the hydroxy or mercapto group of an oxetane compound having such a group in an aqueous so...
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JP3498146B2 |
PCT No. PCT/FR94/00880 Sec. 371 Date Jan. 16, 1996 Sec. 102(e) Date Jan. 16, 1996 PCT Filed Jul. 13, 1994 PCT Pub. No. WO95/02576 PCT Pub. Date Jan. 26, 1995A process for the preparation of N-carbonylarylimine of the general formula I: I...
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JP3497165B2 |
Chiral catalysts for enantioselectively epoxidizing a prochiral olefin and for enantioselectively oxidizing a prochiral sulfide are disclosed, together with methods of using such catalysts. In accordance with one aspect of the invention,...
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JP2004043439A |
To obtain a new β-lactam useful for production of an N-substituted isoserine.This β-lactam is represented by the formula (wherein R1 is OR6, SR7 or NR8R9; R2 is hydrogen, an alkyl, an alkenyl, an alkynyl, an aryl or a heteroaryl; R3 is...
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JP2004035412A |
To provide a method for producing an oxetane derivative with which an industrially readily available and easily handleable raw material is used and the efficiency is good.The method for producing the oxetane derivative comprises nucleoph...
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JP3492367B2 |
Taxol (I) is a complex diterpene which is currently considered the most exciting lead in cancer chemotherapy. Taxol possesses high cytotoxicity and strong antitumor activity against different cancers which have not been effectively treat...
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JP3492690B2 |
Novel methods for the preparation of sidechain-bearing taxanes, comprising the preparation of an oxazoline compound, coupling the oxazoline compound with a taxane having a hydroxyl group directly bonded at C-13 thereof to form an oxazoli...
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JP2004501143A |
The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or release...
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JP3482316B2 |
To obtain a releasing agent composition for mold improved in the productivity with excellent releasing property without causing trouble such as the spotting and excellent in storing stability at low temp. by containing alkyl or alkenyl k...
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JP3478341B2 |
Method and apparatus are described for isolating taxoids from taxoid containing source materials. The method and apparatus isolate taxoids from waxes and other constituents of the ornamental yew tree needle with the use of critical or ne...
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JP2003340287A |
To obtain a catalyst for enanthio selective epoxidation of a polychiralolefin and enanthio selective oxidation of a polychiralsulfide, and to provide a method using this catalyst. A catalyst consisting of a salene derivative having a gen...
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JP2003535874A |
The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and antimicrotubule agents...
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JP2003535854A |
A chemical compound comprising an isotopically labeled analog of a standard taxane molecule, wherein said isotopically labeled analog is synthetically formed to have incorporated therein at a selected position a stable isotope of an elem...
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JP2003335764A |
To provide an industrially advantageous method for producing an oxetane compound by dehydrohalogenating cyclization of 3-halo-1-propanols (or 3-chloro-1-propanol as one of them) of the formula (1) in high yield without the need of a two-...
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JP2003335765A |
To provide a resin composition high in curing rate and giving a resin coating film of low refractive index, low water absorption and high hardness, therefore suitable for the clad layer for optical fibers, and to provide a cured product ...
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JP3469237B2 |
Prepn. of a substd. isoserine ester (I) comprises reacting a beta-lactam of (II) with a metal alkoxide MOCE1E2E3 (III). In the formulae, R1 = OR6, SR7, or NR8R9; R2 = H, 1-15C alkyl, 2-15C alkenyl, 2-15C alkynyl, 6-15C aryl, or heteroary...
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JP3470721B2 |
4-acetoxy-2alpha-benzoyloxy-5beta, 20-epoxy-1beta, 7beta, 10beta-trihydroxy-9-oxo-11-taxen-13alpha-y1(2R,3S)-3-t-butox
ycarbonylamino-3-phenyl-2-hydroxypropionate trihydrate obtained by a process of centrifugal partition chromatography.
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JP2003327688A |
To obtain a monomer for forming a resist highly transparent to radiation and satisfying a fundamental function, a polymer for a resist material and an acid dissociable group-containing resin used in a chemical amplification type resist.T...
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JP2003531826A |
Compounds of the formula ofare disclosed as well as a method of preparation.
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JP2003530391A |
The present invention relates to a compound named Percyquinnin which is obtainable by cultivation of the fungus ST 001837 (DSM 13303), and to its pharmaceutically acceptable salts. The present invention further relates to a process for t...
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JP3452928B2 |
Taxane derivatives having alternative C2 substituent which is -OCOR31 wherein R31 is substituted phenyl and the substituent is selected from the group consisting of alkanoxy, protected hydroxy, halogen, alkyl, aryl, alkenyl, acyl, acylox...
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JP2003267961A |
To provide an industrially advantageous method for producing an oxetane ether compound, comprising the hydrogen halide-removing etherification reaction of a halogen compound with an alcohol compound, by which the oxetane ether compound c...
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JP2003528091A |
The present invention concerns novel 7-deoxy taxane derivatives their use as antitumor agents, and pharmaceutical formulations.
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JP2003527380A |
A process for producing 10-deacetyl baccatin III from an acidic solution containing a spectrum of taxanes, comprising contacting the acidic solution containing the spectrum of taxanes with a hydrazine hydrate, thereby to convert into 10-...
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JP3445973B2 |
The semisynthesis of paclitaxel and its analogs using new intermediates which are derivatives of 10-deacetyl-baccatin III, as well as to a method for preparing these derivatives. These novel derivatives have alkyl carbonate or alkyl carb...
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JP2003526665A |
N-deacetyl-thiocolchicine and 10-deacetyl-baccatin III derivatives of formula (I) wherein R and n have the meanings specified in the disclosure, are valuable antitumoral drugs.
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JP3445209B2 |
To provide a method for purifying lipstatin in high yield and high purity from crude lipstatin. This method comprises (a) a liquid-liquid extracting step of lipstatin from a nonpolar solvent selected from an aliphatic or an aromatic hydr...
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JP2003525934A |
A process for obtaining paclitaxel and other taxanes from a source containing taxanes. The process involves extracting taxane compounds from the source into an organic solvent and passing this composition through a distribution chromatog...
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JP3441458B2 |
This invention provides 7-deoxy-taxol analogs of Formula I: The compounds of Formula I (including II and III) are useful for the same cancers for which taxol has been shown active, including human ovarian cancer, breast cancer, and malig...
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JP2003524685A |
This invention relates to novel oxetanone derivative compounds and processes for producing such derivatives that are useful as lipase inhibitors. Further the invention relates to processes for producing salts and for producing pharmaceut...
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JP2003524684A |
This invention is directed to mono- and bis-substituted oxetane monomers having fluorinated alkoxymethylene side chains, hydroxy-terminated prepolymers derived from these mono- and bis-substituted oxetane monomers and tetrahydrofuran (TH...
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JP3437623B2 |
PURPOSE: To obtain a ruthenium-iodo-optically active phosphine complex having high catalytic activity and useful for catalysts, etc., for producing an optically active 4-methyl-2-oxetanone which is an intermediate for polymers, medicines...
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JP2003523971A |
The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations.The invention claims compounds of formula I and the use of compounds of formula I or pharmaceutical salts thereof as ...
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JP3431155B2 |
A process for abstracting a C10 hydroxy, acyloxy or sulfonyloxy substituent from a taxane in which the C10 hydroxy, acyloxy or sulfonyloxy substituted taxane is reacted with samarium diiodide.
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JP2003522168A |
Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
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