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JP3335427B2 |
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JP2002534422A |
A method of isolating paclitaxel from pactitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueou...
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JP3331204B2 |
The present invention relates to a method for mass production of taxol with a high yield, which comprises the step of inoculating Taxus genus plant cells in a medium containing AgNO3 and incubating it.
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JP2002284772A |
To provide a new taxol derivative and further to provide a method for screening a protein by using the derivative.This new taxol derivative is represented by formula 1. The immobilized product is obtained by bonding the derivative with f...
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JP3328286B2 |
Taxane derivatives of the formula (* CHEMICAL STRUCTURE *) (3) wherein R1 is phenyl or p-nitrophenyl, R3 is furyl or thienyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or mono...
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JP3320416B2 |
A metal alkoxide having the following formula: (1) wherein T1 is hydrogen or a hydroxy protecting group, Z is -OT2, or -OCOCH3, T2 is hydrogen or a hydroxy protecting group, and M is selected from the group comprising Group IA, IIA and t...
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JP2002526424A |
The present invention provides novel paclitaxel formulations which may be terminally sterilized and show long term stability in water containing admixtures.
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JP2002226399A |
To obtain a composition and to provide a method suitable for treatment or prophylaxis of inflammatory diseases, and to provide significant advantages compared with present procedures while treating problems accompanied with the present p...
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JP2002525405A |
The present invention relates to macromonomers containing ethylene glycol repeat units, to chemically inert polymers prepared therefrom and to the use of such polymers in solid phase biochemical assays. A macromonomer of polyethylene gly...
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JP2002524454A |
4-Methyl-4-(4-mlthylpent-3-en-1-yl)-2-oxetanone of formula (1):or its oligomer is an intermediate product for the preparation of a series of geranic acid derivatives, which are important synthetic building blocks in the preparation of pe...
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JP2002523407A |
The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1=C(O)CH2CH(OH)COOX, R2=H, C(O)CH2CH(OH)COOX, X=H, Li, Na or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical ...
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JP2002523364A |
The present invention relates a new use of taxoid derivatives. It relates more precisely to a method for treating abnormal cell proliferation of different resistant cell lines expressing multidrug resistance P-glycoprotein. This type of ...
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JP2002523034A |
A process useful for the preparation of intermediates in synthesis or semi-synthesis of paclitaxel analogs wherein a starting taxane such as 10-deacetylbaccatin III is deacetylated at the C-4 position using a microorganism or an enzyme d...
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JP3310056B2 |
PURPOSE: To easily obtain the subject compound in high optical purity at a low cost by the asymmetric hydrogenation of 4-methylene-2-oxetanone in the presence of a ruthenium-optically active phosphine complex as a catalyst. CONSTITUTION:...
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JP3310084B2 |
PURPOSE: To provide a producing method being economically excellent and also industrially advantageous and capable of efficiently obtaining an optically active 4-methyl-2-oxetanone useful as an intermediate in an organic synthetic chemic...
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JP3307260B2 |
To obtain the subject new compound comprising a specific structure having oxetanyl, capable of rapidly being hardened by a short time irradiation if light when being used as a ultraviolet-hardenable resin and providing a hardened materia...
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JP3304088B2 |
10-Desacetoxytaxol and its derivs. of formula (I) are new, where R2 = H or opt. protected OH; R3, R4 = H, opt. protected OH, Me, -SH, -NH2 or -NR8R9; R5 = R10 or -OR10; R6, R7 = H, alkyl or aryl; R8, R9 = H, alkyl, alkenyl, alkynyl or ar...
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JP2002193960A |
To provide a method for producing ethers having oxetane ring in good yield and in low cost.A method for producing ethers having an oxetane ring of this invention is characterized by continuously or non-continuously supplying an alkali to...
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JP3299754B2 |
This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction and selective crystallization starting with a methanolic extract of the vegetable matter.
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JP3299753B2 |
This invention relates to a process for obtaining 10-deacetylbaccatin III from various parts of yew (Taxus sp.) by extraction with a suitable organic solvent of the aqueous solution obtained after treating the appropriate part of yew wit...
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JP3294280B2 |
PCT No. PCT/KR97/00157 Sec. 371 Date Feb. 23, 1999 Sec. 102(e) Date Feb. 23, 1999 PCT Filed Aug. 25, 1997 PCT Pub. No. WO98/08832 PCT Pub. Date Mar. 5, 1998The present invention elates to a process for preparing paclitaxel represented by...
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JP3295879B2 |
This invention relates to a method for preparing taxane derivatives of general formula (I)by esterification at a temperature between -10 and 60° C. of a derivative of baccatine III or 10-deacetyl baccatine III of general formula (II)by ...
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JP3292457B2 |
To obtain the subject new compound which is an agonist for OFQ receptor and/or an antagonist useful for treating mental disturbance, nervous disturbance and physiological disorder. This compound is shown by formula I (R1 and R2 are each ...
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JP3287852B2 |
The present invention provides methods for treating or preventing inflammatory diseases such as psoriasis or multiple sclerosis, comprising the step of delivering to the site of inflammation an anti-microtubule agent, or analogue or deri...
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JP2002515481A |
A method of modifying or altering the structure of a 1alpha-hydroxylated vitamin D compound to increase its biological activity by altering the conformational equilibrium of the A-ring to favor a chair conformation that presents the 1alp...
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JP2002513786A |
The present invention relates to a method of producing paclitaxel or a paclitaxel analog comprising the esterification of C-7, C-10 di-CBZ 10-deacetylbaccatin III with an N-carbamate protected, C-2-protected 3-phenyl isoserine side chain...
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JP3281125B2 |
PURPOSE: To provide a catalyst system improved in selectivity and reaction speed at the time of carbonylation of epoxides by reaction with carbon monoxide. CONSTITUTION: Carbon monoxide and an epoxide are allowed to react with each other...
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JP3278768B2 |
PCT No. PCT/FR93/00224 Sec. 371 Date Sep. 26, 1994 Sec. 102(e) Date Sep. 26, 1994 PCT Filed Mar. 8, 1993 PCT Pub. No. WO93/17997 PCT Pub. Date Sep. 16, 1993This invention relates to a method for preparing beta -phenylisoserine and analog...
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JP2002511457A |
An antitumor compound of formula (5) and also provided by the present invention is a method of preparing a compound of formula (5) whereby diesterification of the alcohol groups located at the 2' and 7 positions of paclitaxel is followed...
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JP2002509142A |
Disclosed are crystalline complexes of baccatin III with imidazole, 2-methylimidazole or isopropanol, which are useful for isolating baccatin III from plant tissue cell culture and plant extracts containing baccatin Ill.
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JP3261550B2 |
PURPOSE: To obtain novel compounds having an anti-tumor activity effective against taxol-resistant cancer cell HCT-116/VM46. CONSTITUTION: These compounds expressed by formula I {wherein R1 is -COR2 [wherein R2 is RO- or R (wherein R is ...
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JP3261548B2 |
PURPOSE: To obtain new taxol derivs. useful as anti-tumor agents. CONSTITUTION: The taxol derivs. are compds. of formula I [where Rj is -CORz; Rz is -butyloxy, a 1-6C alkyl, phenyl or the like; Ry is a 1-6C alkyl, 2-6C alkenyl, 3-6C cycl...
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JP2002505326A |
Process for synthesizing paclitaxel by treating baccatin III with a strong base in a solvent, adding an electrophile to the solution to form a 7-O-protected baccatin III derivative, reacting the 7-O-protected baccatin III derivative with...
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JP2002504079A |
(57) [Summary] The present invention provides novel paclitaxel analogs that exhibit strong paclitaxel-like activity in vitro and in vivo against a variety of tumors, especially 2 ", 3" side chain halogenated cepharomannin.
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JP2002502376A |
Methods and compositions for transporting drugs and macromolecules across biological membranes are disclosed. In one embodiment, the invention pertains to a method for enhancing transport of a selected compound across a biological membra...
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JP2002501060A |
A method of acylating 10-deacetylbaccatin III at the C-10 position over the C-7 hydroxy position thereof to produce baccatin IIII is accomplished first by dissolving 10-deacetylbaccatin III in an acceptable ether solvent therefor, such a...
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JP2002501043A |
The present invention relates to new naphthyl- and anilide-substituted sulphonamides of the general formula (I)in which the substituents A, D, E, G, R1, R2, R3, R4 and X have the meanings indicated,and to processes for their preparation ...
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JP2002501042A |
The invention relates to novel naphthyl substituted and heterocyclic substituted sulfonamides of general formula (I) in which A, D, E, R<1> and R<2> have the meanings given in the description. The invention also relates to a method for t...
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JP2002501043A5 |
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JP2001526626A |
C7, C10 di-CBZ 10-deacetyl baccatin III of the formula: provides an intermediate for the production of docetaxel. A method of producing this C7, C10 di-CBZ 10-deacetyl Baccatin III is provided. Here, 10-deacetyl Baccatin III is acylated ...
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JP2001525799A |
PCT No. PCT/EP98/02448 Sec. 371 Date Nov. 2, 1999 Sec. 102(e) Date Nov. 2, 1999 PCT Filed Apr. 24, 1998 PCT Pub. No. WO98/50377 PCT Pub. Date Nov. 12, 19982-Benzoylcyclohexane-1,3-diones of the formula I: where: R1 and R2 are each hydrog...
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JP2001523674A |
The present invention provides new methods isolating taxanes and other metabolites from taxane-producing plant materials.
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JP2001524118A |
PCT No. PCT/EP98/02622 Sec. 371 Date Nov. 2, 1999 Sec. 102(e) Date Nov. 2, 1999 PCT Filed May 4, 1998 PCT Pub. No. WO98/50379 PCT Pub. Date Nov. 12, 19984-Benzoylpyrazoles of the formula I where: A is a group of the formula IIIa, IIIb or...
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JP2001524067A |
(57) [Summary] The present invention provides a method for producing and using taxanes containing an electrophilic radiation sensitizing functional group, a pharmaceutical preparation thereof, and a radiation sensitizing agent for this n...
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JP3233632B2 |
(2R,3S)- beta -Phenylisoserine, its salts and its preparation by the action of ammonia on (2R,3R)- beta -phenylglycidic acid, and its use for the preparation of taxane derivatives of general formula: (R = H, COCH3; R1 = C6H5, (CH3)3C-O-).t
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JP3228592B2 |
PURPOSE: To provide a method for inducing callus cells from explant tissue and the application of the callus cells in a suspension cell culture of taxanes. CONSTITUTION: This method for inducing callus cells from explant tissue consists ...
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JP2001521493A |
The present invention concerns novel taxane derivatives, their use as antitumor agents, and pharmaceutical formulations.
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JP3222466B2 |
Methods of obtaining renewable sources of taxanes including taxol are provided. Compositions comprising taxanes which are useful as source materials for the further purification of taxanes are also disclosed. Specifically, a method of dr...
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JP2001519366A |
The invention relates to the use of arsenic trioxide to treat a solid tumor selected from the group consisting of breast, colon, ovarian, renal, bladder, prostate and lung cancer.
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JP2001293302A |
To provide an extraction method for highly separating/purifying only an aimed component from an extract containing the component to be extracted by a supercritical fluid and a compound resembling the component as a mixture with regard to...
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