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JP2000506158A |
PCT No. PCT/FR97/00386 Sec. 371 Date Aug. 4, 1998 Sec. 102(e) Date Aug. 4, 1998 PCT Filed Mar. 5, 1997 PCT Pub. No. WO97/32869 PCT Pub. Date Sep. 12, 1997Novel taxoids of general formula (I), the preparation thereof and pharmaceutical co...
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JP3043411B2 |
Prodn. of taxane derivs. of formula (I) comprises (a) condensing oxazolidine deriv. (II) with taxane (III) to form cpd. (IV); (b) treating this with acid (under conditions which do not affect R1' and R2) to give cpd. (V); (c) reacting (V...
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JP3038496B2 |
Heteroatom containing perfluoroalkyl terminated oxetanes of the formula are prepared from 3,3-dihalogenated oxetanes and thiols of the formula Rf-E-SH, amines of the formula Rf-E-NH-R, alcohols of the formula Rf-E-OH or perfluoro-amides,...
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JP2000106893A |
To provide a method for producing a taxane-type diterpene such as taxol or the like, which can cope with increase in quantity demanded, can be carried out at a low cost and can preserve the environment.A taxane-type diterpene is took out...
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JP3030088B2 |
Taxane derivatives and a method of preparing taxane derivatives of formula (I): are disclosed. In general formula (I), Ar represents an aryl radical; R represents a phenyl radical or a radical R5-O- in which R5 represents an alkyl, alken...
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JP3031715B2 |
An efficient protocol for the synthesis of taxol, taxol analogs, and their intermediates is described. The process includes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs wi...
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JP3020277B2 |
The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having lymphomas and breast cancer using the microtubule agent, Taxol. The present method of administration, ser...
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JP2000502989A |
Dioxetanes that can be triggered by bases are provided which can be used to detect bases in organic solvents, aqueous preparations and detect gaseous bases in the atmosphere. The dioxetanes can be used to detect the release of bases from...
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JP3019528B2 |
PURPOSE: To obtain a macrocyclic ketone or a β-lactone suitable as its intermediate, useful as antitumor agent, antimicrobial agent, perfume, etc., in high efficiency and economically. CONSTITUTION: An acid halide of a dibasic acid of f...
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JP2000502670A |
PCT No. PCT/FR96/02030 Sec. 371 Date Jun. 10, 1998 Sec. 102(e) Date Jun. 10, 1998 PCT Filed Dec. 19, 1996 PCT Pub. No. WO97/23472 PCT Pub. Date Jul. 3, 1997Novel taxoids of general formula (I), the preparation thereof, and pharmaceutical...
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JP2000063371A |
To produce the subject compound useful as a coating material, an adhesive or the like at a low cost in high yield and purity by subjecting a (meth)acrylate lower alkyl ester to transesterification reaction with a specific oxetane ring-co...
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JP3014760B2 |
PCT No. PCT/FR93/00967 Sec. 371 Date May 3, 1995 Sec. 102(e) Date May 3, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07877 PCT Pub. Date Apr. 14, 1994This invention relates to a method of preparing taxane derivatives of general formula...
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JP3014762B2 |
PCT No. PCT/FR93/00969 Sec. 371 Date Apr. 5, 1995 Sec. 102(e) Date Apr. 5, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07879 PCT Pub. Date Apr. 14, 1994This invention relates to a method of preparing taxane derivatives of formula (I) b...
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JP3014761B2 |
PCT No. PCT/FR93/00968 Sec. 371 Date Apr. 4, 1995 Sec. 102(e) Date Apr. 4, 1995 PCT Filed Oct. 4, 1993 PCT Pub. No. WO94/07878 PCT Pub. Date Apr. 14, 1994Method of preparing taxane derivatives of general formula (I) by esterification of ...
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JP2000053668A |
To provide a purifying method in which purifying procedure is simplified and the loss of taxane compound on purifying is reduced for the purpose of efficiently obtaining a taxane compound-including ingredient and to provide a convenient ...
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JP3012002B2 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...
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JP3012325B2 |
PCT No. PCT/FR91/00133 Sec. 371 Date Aug. 21, 1992 Sec. 102(e) Date Aug. 21, 1992 PCT Filed Feb. 20, 1991 PCT Pub. No. WO91/13066 PCT Pub. Date Sep. 5, 1991.A method for preparing beta -phenylglycidic-(2R, 3R) acid optionally in the form...
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JP3012370B2 |
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JP2000044523A |
To inexpensively obtain a taxane-type compound while maintaining an environment by carrying out extraction, isolation and purification using the needle leaf part of Taxus cuspidata Sieb et Zucc. A needle leaf part of Taxus cuspidata Sieb...
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JP3007470B2 |
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JP3007188B2 |
Prepn. of benzyl ketone derivs. of formula (I) comprises: (a) reaction of a benzyl chloride deriv. of formula (II) with an excess of Zn powder in a diluent, at 30-200 deg.C., under a protective gas; (b) removal of excess Zn powder; and (...
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JP2000500759A |
PCT No. PCT/GB96/02820 Sec. 371 Date May 14, 1998 Sec. 102(e) Date May 14, 1998 PCT Filed Nov. 18, 1996 PCT Pub. No. WO97/19050 PCT Pub. Date May 29, 1997Compounds of formula (I) wherein R1, R2, R3, R4, X are as defined in the specificat...
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JP2000500437A |
The present invention generally relates to at least one precursor compound and derivatives thereof, a process for preparing a taxane, and a baccatin derivative.
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JPH11514965A |
The synthesis of paclitaxel obtained from the semi-synthesis of taxol using a protected baccatin III backbone which is esterified with a suitably protected side chain acid, thereby producing an intermediate which may be acylated and depr...
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JPH11335362A |
To obtain oxetanone in a high yield by oxidatively subjecting a dialkylpropanediol and/or a dialkylhydroxypropionaldehyde to ring formation in the presence of a solid catalyst and oxygen. A 2,2-dialkyl-1,3-propanediol of the formula (R a...
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JP2986550B2 |
The present invention relates to novel derivatives obtained by oxidation and the stereospecific reduction of 10-deacetylbaccatine III, and successive esterification with a variously substituted isoserine chain to prepare taxol analogues....
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JPH11513978A |
An efficient protocol for the synthesis of taxol, taxol analogs and their intermediates is described. The process includes the attachment of the taxol A-ring side chain to baccatin III and for the synthesis of taxol and taxol analogs wit...
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JPH11322735A |
To obtain a new compound polymerizable by UV exposure in a short time, polymerizable without requiring elimination of oxygen, readily preparable from easily obtainable starting substances. This compound is shown by the formula RCHO [R1 i...
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JPH11322736A |
To obtain a β-lactone derivative useful as a polymer raw material, an intermediate in an organic synthetic chemical industry, a raw material for medicines, etc., by reacting a specific aldehyde compound with a ketene in the presence of ...
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JPH11322734A |
To obtain a new complex having a high catalytic activity, and useful as a catalyst capable of providing a high asymmetric yield in an asymmetric reaction, i.e., capable of providing a product having a high optical purity. This new comple...
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JP2980475B2 |
Long-chain ketene dimers are prepared in a process in which in the absence of an organic solvent carboxylic acid chloride is fed, with intensive mixing, into a recipient of triethyl amine at a rate of not more than 3 moles/hour per mole ...
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JP2969617B2 |
PURPOSE: To obtain the new subject derivative useful as a synthetic intermediate for a taxol derivative having antitumor action, etc., by performing condensation reaction of a baccatin compound with an epoxypropionic acid and subsequentl...
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JP2963910B2 |
A retroviral protease inhibiting compound of the formula A - X - B or a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group; A is (1) substituted amino, (2) substituted carbonyl, (3) functionalized im...
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JP2964475B2 |
To obtain a new baccatin derivative having low toxicity and high water-soluble property and stability, excellent in antitumor activity and useful for treating a wide range of tumors such as breast cancer, ovarian cancer, lung cancer, mal...
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JP2964474B2 |
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JP2958119B2 |
A process for the preparation of a compound of formula (I) comprising contacting a mixture containing at least one taxane compound having an ester linkage at the C-13 position with at least one borohydride reducing salt in a reaction sol...
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JPH11263772A |
To obtain the subject compound useful for producing the precursor of paclitaxel side chain by reaction of a specific acyl chloride with a reaction product of a specific amine and a specific aldehyde in the presence of triethylamine follo...
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JPH11255759A |
To obtain the subject compound useful as a raw material for synthesizing polymers or medicines, or an intermediate for e.g. liquid crystal materials, by reaction between an aldehyde and a ketene in the presence of a specific bis-sulfonam...
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JPH11246540A |
To obtain the subject new derivative having extremely enriched reactivity and extremely excellent as a raw material of a functional material while maintaining heat resistance intrinsically possessed by calix[4]resorcin arene. This deriva...
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JPH11246541A |
To obtain a new multi-functional oxetane compound giving a light- curing or a thermosetting resin having excellent heat resistance, mechanical properties and adhesiveness, by reacting a respective specific oxetane with a multifunctional ...
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JP2945479B2 |
A method of processing a feed liquid in the form of an extraction solution containing taxane solutes that is an extraction product of a biomass utilizes at least one semipermeable membrane to remove at least one taxane solute from the so...
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JPH11236382A |
To obtain the subject compound of high optical purity through reduced process steps by using the enantiomer of the subject compound readily obtainable from unnecessary by-product through a specific process. (S)-3-Hydroxy-4-butyrolactone ...
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JP2941951B2 |
New taxoids of general formula (I):their preparation and pharmaceutical compositions containing them.The new products of general formula (I) in which Z represents a radical of general formula (II):display noteworthy antitumour and antile...
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JPH11228558A |
To provide the new compound maintaining the original heat resistance of calixarene, having extremely rich reactivity and useful as a raw material for functional materials. A compound of formula I [R1 and R2 are each H or an alkyl which m...
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JPH11228559A |
To easily obtain a trans-oxazoli(di)ne compound useful as an intermediate for synthesizing baccatine derivatives having antitumor activities, such as taxol, by isomerizing a specific cis-oxazoli(di)ne compound. This method for producing ...
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JPH11508567A |
PCT No. PCT/EP96/02573 Sec. 371 Date Jun. 1, 1998 Sec. 102(e) Date Jun. 1, 1998 PCT Filed Jun. 14, 1996 PCT Pub. No. WO97/02236 PCT Pub. Date Jan. 23, 1997Disclosed is a process for producing beta -amino- alpha -hydroxycarboxylic acid de...
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JPH11171881A |
To obtain the subject new compound useful as a cysteine protease inhibitor excellent in oral absorbability, tissue migration properties, cell wall permeability, etc. This compound is represented by formula I [R1 is a (substituted) 6-14C ...
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JP2912463B2 |
The invention relates to a novel process for producing a compound having the formula I wherein R1, R2 and X are described herein, via corresponding beta -keto- and beta -hydroxy- delta -lactones, as well as novel intermediates which occu...
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JP2902269B2 |
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JPH11140071A |
To obtain the subject new compound having excellent antitumor activities, and expected to be applied for the treatment for a wide-ranging tumors such as breast cancer, ovarian carcinoma, lung cancer and malignant melanomas. This new comp...
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