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WO/2005/090326A1 |
A microorganism belonging to filamentous fungi, capable of producing antibiotic FKI-1778A and/or FKI-1778B and/or FKI-1778C and/or FKI-1778D is cultured in a culture medium to thereby accumulate the antibiotic FKI-1778A and/or FKI-1778B ...
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WO/2005/087700A2 |
The present invention discloses bisphenyl compounds of the formula (1): wherein R1, R2, R3, R4, R5, R6, X, Y, W are defined herein after. These compounds are useful as pharmaceuticals.
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WO/2005/087215A1 |
The invention relates to acetyl 2-hydroxy-1,3-diaminospirocyclohexanes and derivatives thereof that are useful in treating at least one disease, disorder, and condition associated with amyloidosis. Amyloidosis refers to a collection of d...
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WO/2005/084349A2 |
Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.
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WO/2005/085170A1 |
Compounds that may have anti-inflammatory activity are of general formula (I); wherein X1, is H or COR1, and X2 is H or COR2 but X1, and X2 are not both H; R1 and R2 are the same or different and are each C1-4 alkyl substituted with R3, ...
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WO/2005/082878A1 |
The invention relates to the novel antibiotic HKI10311129 which has a molecular weight of 1113 and the summation formula C56H75NO22. The invention also relates to a method for producing said antibiotic using the microorganism Streptomyce...
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WO/2005/080318A1 |
The invention provides a process permitting easy production in high yield of &agr -aminooxyketones, which are equivalents for the synthesis of monosaccharides or pentoses and equivalents of &agr -hydroxyketones serving as intermediates i...
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WO/2005/080475A2 |
The invention relates to the use of core-shell particles whose shell forms a matrix and whose core is essentially solid, is essentially comprised of an inorganic material, has an essentially monodisperse size distribution, and is joined ...
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WO/2005/080322A1 |
A novel fluorene characterized by having a fluorene skeleton to which a functional group such as a guanidino group is attached via a carbonyl group, or its salt. This compound has such an advantage as showing a high affinity particularly...
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WO/2005/080317A2 |
The present invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt or solvate thereof, wherein: A and B independently represent CH2 or O, with the proviso that A and B are not simultaneously O; Cy repres...
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WO/2005/079378A2 |
Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.
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WO/2005/077928A1 |
Disclosed herein is an industrially feasible process for producing HMG-CoA reductase inhibitor, simvastatin, via an improved acylation process using lovastatin ammonium salt as a starting material. The process comprising treating lovasta...
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WO/2005/075491A1 |
The present invention relates to a determination of a stereochemistry, a synthesis and dauer effect of 6R-(3,6-dideoxy-L-arabino-hexopyranosyloxy) heptanoic acid as a pheromone isolated from the Caenorhabditis elegance related to suppres...
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WO/2005/073165A1 |
The invention aims at providing highly effective insecticides. Compounds represented by the general formula (1); insecticides containing the same as the active ingredient; and a process for the production thereof: (1) wherein A1, A2, A3 ...
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WO/2005/073211A1 |
The invention relates to pyranone derivatives of general formula (I), wherein X is chlorine, bromine or iodine and R1 and R2 is independently a hydrogen atom, an alkyl, cycloalkyl or alkylene, linear or branched group containing 1-20 car...
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WO/2005/070877A1 |
The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these...
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WO/2005/070911A1 |
The invention relates to the resolution of racemic mixtures, and in particular to the separation of enantiomers of chiral alcohols utilising recyclable chiral auxiliaries. The present invention also relates to a process for preparing the...
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WO/2005/069741A2 |
This invention relates to an industrially feasible process for producing HMG-CoA reductase inhibitor, simvastatin via novel intermediates, wherein the process comprises treating lovastatin [2] or lovastatin ammonium salt [2’] with hydr...
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WO/2005/068415A1 |
Disclosed is a phenylalanine derivative having excellent VLA-4 inhibitory activity which is represented by the following general formula (1) or a salt thereof. (1) (In the formula, R1 represents an aromatic hydrocarbon group having 6-10 ...
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WO/2005/068418A1 |
The invention encompasses novel sulfide and disulfide compounds, compositions comprising sulfide and disulfide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose...
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WO/2005/068420A1 |
The present invention relates to novel urea and thiourea compounds, compositions comprising urea or thiourea compounds, and methods useful for treating and preventing aging, Alzheimer’s Disease, cancer, cardiovascular disease, diabetic...
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WO/2005/068410A1 |
The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders com...
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WO/2005/068412A1 |
The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders c...
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WO/2005/066159A1 |
The present invention relates to a novel class of compounds mainly, leucinamide-amino-carboxylate derivatives of formula (I) wherein Y is CR1R2, O, S, -SO2, C=0 or NR9; Z is CR1R2, O, S, -SO2, C=O or NR9 and each G is independently a CR1...
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WO/2005/066150A1 |
A process for manufacturing simvastatin is provided using novel intermediates. Thus, for example, lovastatin is reacted with methoxyethylamine, alpha methylated 2-methylbutyryl side chain of the amide formed, hydrolyzed and lactonized to...
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WO/2005/063705A1 |
Compounds represented by the general formula (1) or (100) have excellent inhibitory activities against cell adhesion and cell infiltration and are useful as therapeutic or preventive agents for various inflammatory and autoimmune disease...
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WO/2005/063729A1 |
The present invention provides a novel compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof having a superior GPR40 receptor function modulating action, whic...
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WO/2005/063728A2 |
Provided is a process for reduction of statin ketoesters and purification of diol esters of the statins through selective crystallization.
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WO/2005/063222A1 |
An Hsp90 family protein inhibitor which contains as an active ingredient a benzene derivative represented by the following general formula (I), a prodrug thereof, or a pharmacologically acceptable salt of either.
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WO/2005/062748A2 |
Bicyclic carbohydrates for the treatment of infections caused by herpseviridae, and in particular cytomegalovirus. The invention consists of the novel bicyclic carbohydrates the generic structure of which is formula I: wherein R1 is eith...
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WO/2005/061448A1 |
The present invention provides methods for treating vascular diseases such an aneurysm (particularly abdominal aortic aneurysm) and neointimal hyperplasia. The methods include use of known compounds such as amiloride and oxamflatin, and ...
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WO/2005/061479A1 |
A process for producing tetrahydropyran-4-one, which is represented by the formula (1), characterized by reacting at least one of dihydropyran-4-one and pyran-4-one, which are represented by the formula (2): (2) (wherein (A) indicates a ...
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WO/2005/061443A2 |
The invention relates to benzoyl-substituted phenylalanine amides of formula (I), wherein the variables R1 to R15 have the meanings indicated in the description, the agriculturally useful salts thereof, methods and intermediate products ...
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WO/2005/061478A1 |
A process for producing a 4-alkoxycarbonyltetrahydropyran or tetrahydropyranyl-4-carboxylic acid represented by the formula (1): (1) (wherein R3 represents hydrogen or alkyl), characterized by reacting a 4-acyl-4-alkoxycarbonyltetrahydro...
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WO/2005/058812A2 |
A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituen...
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WO/2005/058861A1 |
The present invention relates to a process for preparing simvastatin, comprising the steps of reacting a diol lactone of formula 4 with a di-substituted silyl dichloride (dichlorosilane) to produce a diol lactone dimer of formula 5, subs...
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WO/2005/058859A1 |
A process for producing an alkyl 3-(4-tetrahydropyranyl)-3-oxopropionate compound represented by the formula (1): (1) (wherein R<1> and R<2> may be the same or different and each represents a group not participating in the reaction, prov...
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WO/2005/058860A1 |
A process for producing a 4-(un)substituted tetrahydropyran-4-carboxylic acid compound or an ester compound thereof which are represented by the formula (1): (1) (wherein R1 represents hydrogen or a hydrocarbon group; R2 represents hydro...
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WO/2005/056519A1 |
The present invention provides a compound represented by the formula (I): (INSERT CHEMICAL FORMULA) (wherein R1 is a lower alkyl substituted by a lower alkoxy or a heterocyclic group, or a heterocyclic group; R2 is a lower alkyl optional...
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WO/2005/053631A1 |
The invention provides a process for producing microcapsules with UV filter activity, wherein at least one type of crosslinkable chromophore with UV-A and/or UV-B and/or UV-C filter activity and optionally at least one type of crosslinka...
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WO/2005/054267A1 |
The present invention relates to compounds of formula (1) and salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 is a glycosyl moiety, hydroxyl-protected acetate derivatives thereof or ami...
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WO/2005/049599A1 |
It is intended to provide a method of efficiently producing Ascopyrone P from 1,5-D-anhydrofructose. A method of producing Ascopyrone P which comprises heating a solution of 1,5-D-anhydrofructose to 100°C or above at pH 10 or lower.
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WO/2005/047223A1 |
The invention relates to protected alcohol with formula (R1 - O-)mPG, wherein R1 represents a linear, straight-chain alkyl group having 26-30 C-atoms, m is 1 or 2, and PG, forming an ether group in combination with the -O- of the former ...
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WO/2005/047276A2 |
The invention relates to a method for the production of a statin. Said method comprises the following steps: a) a compound of formula (II) is produced, wherein S1 represents a hydrogen atom or a hydroxyl protective group, S2 and S3 indep...
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WO/2005/047236A1 |
The present invention relates to sulfoxide and bis-sulfoxide compounds of formula (I), formula (II), or formula (III), compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiova...
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WO2005012220A9 |
The present invention relates to novel compounds with a variety of therapeutic uses, more particularly novel substituted cyclic alkylidene compounds that are particularly useful for selective estrogen receptor modulation. Formula (I) inc...
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WO/2005/044795A1 |
The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3- &lcub [3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]c
arbonyl&rcub cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro- 2H-pyran-4-yl...
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WO/2005/044796A1 |
The invention relates to the novel 2-halogen-6-alkyl-phenyl substituted spirocyclic tetramic acid derivatives of formula (I), wherein A, B, G, X, Y and Z are defined as above. The invention also relates to several methods and intermediat...
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WO/2005/042521A2 |
This invention is directed generally to proteinase (also known as “protease”) inhibitors, and, more particularly, to piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids that, inter alia, inhibit matrix metalloproteinase (als...
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WO/2005/040087A1 |
The invention relates to a method for the production of 6,6,6-trihalo-3,5-dioxohexanic acid esters of formula (I) in addition to the enols thereof and E and Z isomers, wherein X independently represents fluorine, chlorine or bromine and ...
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