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Patent Searching and Data


Matches 251 - 300 out of 458

Document Document Title
WO/1992/020662A1
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are useful as angiotensin II antagonists.  
WO/1992/018490A1
Bicyclic derivatives of general formula (I), wherein X1 is -S- or -SO-; X2 is -CO- or -CS-; R1 is hydrogen, halogen or lower alkyl optionally substituted by halogen or lower alkoxy; R2 and R3 are each independently hydrogen, lower alkyl,...  
WO/1992/005164A1
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.  
WO1991019475A1
This invention relates to certain quinolinyl-benzoheterobicyclic compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or as mediator release inhibitors usef...  
WO/1991/017156A1
5-(1-Hydroxy-2-piperidinopropyl)-2(1H,3H)-indolone derivatives and analogs; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.  
WO/1990/003969A1
Selected indazoles have been found effective in the control of nonagronomic arthropods and are used for that purpose in compositions comprising appropriate carriers.  
WO/1984/004303A1
Compounds of the formula (I), wherein C1 and N4 are in trans configuration to each other, Y is OH, R1COO, R2R3NCOO- or R4O whereby R1 is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-h...  
JP2024512646A
It is a compound of the formula: where the variable substituents are defined herein.  
JP7448961B2
This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardi...  
JP7407196B2
Compounds of formula (I):as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related disea...  
JP7311720B2
Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related disea...  
JP2023516494A
The present invention relates generally to new compounds for therapeutic use. In particular, the disclosed series of compounds with immunomodulatory activity are useful in the treatment of immune system dysfunction and various cancers. P...  
JP2023040072A
To provide bifunctional compounds which find utility to degrade and inhibit Androgen Receptor.There is provided a compound represented by following formula (example 1).SELECTED DRAWING: Figure 1  
JP2023038270A
To provide compounds for use in methods for regulating Kelch-like ECH associated protein 1 (KEAP1)-erythroid factor 2-related factor 2 (Nrf2) interaction.The present invention provides a compound selected from a group set forth in Claim ...  
JP7212763B2
Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as...  
JP2023500611A
Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that can cause degradation of various proteins, such as IKZF2 (Helios). . Also disclosed are pharmaceutical ...  
JP2022552132A
The present invention provides compounds of formula (I) [Chemical 1] [wherein Ar represents a phenyl or 6-membered heteroaryl group, R1 and R2 independently represent a hydrogen atom or a deuterium atom, R3 represents a (1) -COR4 group, ...  
JP7073405B2
The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof,wherein the variables of compound of formula X are as defined in the claims and the description.  
JP6893030B2
This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardi...  
JP2020502136A
The present invention relates to bisarylamide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to the bisaryl heterocycle of formula (I). [Chemical 1]  
JP2020502152A
The present invention relates to ether-bound triazole compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to compounds of formul...  
JP2020502123A
The present invention relates to bisaryl heterocyclic compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to the bisaryl heteroc...  
JP2020500918A
The present invention relates to N-arylpyrazole compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of the present invention include compounds o...  
JP6630671B2
The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.  
JP6615876B2
The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosur...  
JP6273250B2
The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.  
JP6262228B2
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of makin...  
JP2017523213A
The present invention is in the field of medicinal chemistry and relates to compounds that inhibit bacterial gyllase and pharmaceutical compositions thereof. The compound is useful as an inhibitor of bacterial gilase activity and bacteri...  
JP6182592B2
The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the prepar...  
JP6111276B2
The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I ar...  
JP2016515100A
The present invention relates to the formula (I) [in the formula, A, X.1~ X3, Y1~ Y5Represents various substituents] to provide 3-{phenyl [(heterocyclylmethoxy) imino] methyl} -heterocyclyl derivatives. [Chemical 1]  
JP5802136B2
Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JA...  
JP5685181B2
The present invention discloses novel cyclohexane derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), or a pharmaceutically acceptable salt or...  
JP5566255B2
The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment o...  
JP5539868B2
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defi...  
JPWO2012102255A1
The present invention is EP1General formula (I) of the present invention having a receptor antagonistic effect [Chemical][In the formula, A is a benzene ring, a pyridine ring, etc., and Y1Is C1-6It is an alkylene group, etc., and Y2Is a ...  
JP5412370B2
The present invention provides novel compounds represented by formula I or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.  
JP2013537216A
Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compounds (I) and their enantiomers and diastereoisomers, and addition salts with an acid or a base, are new. Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compoun...  
JP5209760B2
The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.  
JP5161233B2
The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.  
JP2013028648A
To provide new methods and compositions for administering homoharrigtonine.The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is ...  
JP5027802B2
The present invention relates to compounds of the formula I, in which R1; R2; R3; V; G1 and G2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a stro...  
JP5008242B2
The invention relates to a novel process for preparing known asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives.  
JP4955646B2
There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such th...  
JP2012512141A
4-Amino-1,2,3-benzoxathiazine compounds (I) and their salts, are new. 4-Amino-1,2,3-benzoxathiazine compounds of formula (I) and their salts are new. R1-R4 : H, halo, carbamoyl, thiocarbamoyl, nitro, cyano, hydroxy, SF 5 , 1-6C-alkyl, 2-...  
JP2011256198A
To provide methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases.There is disclosed the 2,4-pyrimidin...  
JP4834557B2
The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.  
JPWO2009154190A1
To provide a useful compound which can be used as a medicine, particularly a therapeutic agent for peripheral arterial occlusion. As a result of diligent studies on EP4 receptor agonists, the inventors have found that the 1-position of t...  
JP4808380B2
Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.  
JP4789934B2
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods...  

Matches 251 - 300 out of 458