Heterocyclic Compounds

Matches 251 - 300 out of 456	< 1 2 3 4 5 6 7 8 9 10 >

Document	Document Title
WO/1992/005164A1	NOVEL AMINOBENZOSULTAM DERIVATIVES AS LIPOXYGENASE INHIBITORS Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.
WO1991019475A1	QUINOLINYL-BENZOHETEROBICYCLIC DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 This invention relates to certain quinolinyl-benzoheterobicyclic compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or as mediator release inhibitors usef...
WO/1991/017156A1	NEUROPROTECTIVE INDOLONE AND RELATED DERIVATIVES 5-(1-Hydroxy-2-piperidinopropyl)-2(1H,3H)-indolone derivatives and analogs; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.
WO/1990/003969A1	SUBSTITUTED INDAZOLES AS ARTHROPODICIDES Selected indazoles have been found effective in the control of nonagronomic arthropods and are used for that purpose in compositions comprising appropriate carriers.
WO/1984/004303A1	NEW OCTAHYDROBENZO (f) QUINOLINE DERIVATIVES Compounds of the formula (I), wherein C1 and N4 are in trans configuration to each other, Y is OH, R1COO, R2R3NCOO- or R4O whereby R1 is an aliphatic hydrocarbon residue having 1-17 carbon atoms, a phenyl, 2,6-dimethylphenyl or 3- or 4-h...
JP2024512646A	KHK inhibitor It is a compound of the formula: where the variable substituents are defined herein.
JP7448961B2	Mixed disulfide bonds of thienopyridine compounds and their use This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardi...
JP7407196B2	KIF18A inhibitor Compounds of formula (I):as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related disea...
JP7311720B2	IL4I1 inhibitor and method of use Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related disea...
JP2023516494A	Compounds with immunomodulatory activity and their therapeutic use The present invention relates generally to new compounds for therapeutic use. In particular, the disclosed series of compounds with immunomodulatory activity are useful in the treatment of immune system dysfunction and various cancers. P...
JP2023040072A	COMPOUNDS AND METHODS FOR TARGETED DEGRADATION OF THE ANDROGEN RECEPTOR To provide bifunctional compounds which find utility to degrade and inhibit Androgen Receptor.There is provided a compound represented by following formula (example 1).SELECTED DRAWING: Figure 1
JP2023038270A	INHIBITORS OF KEAP1-Nrf2 PROTEIN-PROTEIN INTERACTION To provide compounds for use in methods for regulating Kelch-like ECH associated protein 1 (KEAP1)-erythroid factor 2-related factor 2 (Nrf2) interaction.The present invention provides a compound selected from a group set forth in Claim ...
JP7212763B2	Inhibitor of KEAP1-Nrf2 protein-protein interaction Sultam compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with the KEAP1-Nrf2 interaction, such as...
JP2023500611A	Helios low-molecular-weight degradation inducer and method of use Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, or tautomers thereof that can cause degradation of various proteins, such as IKZF2 (Helios). . Also disclosed are pharmaceutical ...
JP2022552132A	Novel substituted 6,7-dihydro-5H-benzo[7]annulene compounds, methods for their preparation and their therapeutic use The present invention provides compounds of formula (I) [Chemical 1] [wherein Ar represents a phenyl or 6-membered heteroaryl group, R1 and R2 independently represent a hydrogen atom or a deuterium atom, R3 represents a (1) -COR4 group, ...
JP7073405B2	Method for Producing Chiral 2,3-Dihydrothiazolo [3,2-A] Pyrimidine-4-Ium Compound The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof,wherein the variables of compound of formula X are as defined in the claims and the description.
JP6893030B2	Mixed disulfide bonds of thienopyridine compounds and their use This invention is in the field of medicinal chemistry. In particular, the invention relates to mixed disulfide conjugates of thienopyridine compounds, and their use as therapeutics for the treatment, amelioration, and prevention of cardi...
JP2020502136A	Bisarylamide as an NRF2 regulator The present invention relates to bisarylamide analogs, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to the bisaryl heterocycle of formula (I). [Chemical 1]
JP2020502152A	Ether-bound triazole as an NRF2 activator The present invention relates to ether-bound triazole compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to compounds of formul...
JP2020502123A	Bisaryl heterocycle as NRF2 activator The present invention relates to bisaryl heterocyclic compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 activators. In particular, the present invention relates to the bisaryl heteroc...
JP2020500918A	N-arylpyrazole as an NRF2 regulator The present invention relates to N-arylpyrazole compounds, methods of producing them, pharmaceutical compositions containing them and their use as NRF2 regulators. In particular, the compounds of the present invention include compounds o...
JP6630671B2	Nrf2 regulator The present invention relates to bis aryl analogs, pharmaceutical compositions containing them and their use as Nrf2 regulators.
JP6615876B2	Enzyme interacting drug The present disclosure relates generally, but not exclusively, to compounds and their use as enzyme interacting agents, in particular, agents which interact with one or more enzymes in the sphingolipid biosynthesis pathway. The disclosur...
JP6273250B2	The condensation heterocyclic compound as an ion channel modulator The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes.
JP6262228B2	The Arylsultam derivative as a RORc modulator Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of makin...
JP2017523213A	Quinolone derivative as an antibacterial agent The present invention is in the field of medicinal chemistry and relates to compounds that inhibit bacterial gyllase and pharmaceutical compositions thereof. The compound is useful as an inhibitor of bacterial gilase activity and bacteri...
JP6182592B2	Amino indri roux substitution imidazolyl pyrimidine and its use as medicine The invention relates to new amino-indole-substituted imidazolyl-pyrimidines of formula 1 wherein R1, R2, R3, R4 and R5 are defined as in claim 1 and pharmaceutically acceptable salts thereof and the use of these compounds for the prepar...
JP6111276B2	The macro ring compound by which conformation restrictions were carried out and by which total synthesis was carried out The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A, conformation Modulator B and Bridge C. Macrocycles described by this ring system I ar...
JP2016515100A	Bactericidal 3-{Phenyl [(heterocyclylmethoxy) imino] methyl} -heterocyclic derivative The present invention relates to the formula (I) [in the formula, A, X.1~ X3, Y1~ Y5Represents various substituents] to provide 3-{phenyl [(heterocyclylmethoxy) imino] methyl} -heterocyclyl derivatives. [Chemical 1]
JP5802136B2	Compositions and Methods for Inhibition of the JAK Pathway Disclosed are compounds of formula I, compositions containing them, and methods of use for the compounds and compositions in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JA...
JP5685181B2	Cyclohexane derivative with NPYY5 receptor antagonistic activity The present invention discloses novel cyclohexane derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), or a pharmaceutically acceptable salt or...
JP5566255B2	Prevention and treatment of 1,2,3-trisubstituted aryl derivatives and 1,2,3-trisubstituted heteroaryl derivatives as metabolic modulators and disorders such as diabetes and hyperglycemia associated with these derivatives The present invention relates to certain 1,2,3-trisubstituted aryl and heteroaryl derivatives of Formula (Ia) that are modulators of metabolism. Accordingly, compounds of the present invention are useful in the prophylaxis or treatment o...
JP5539868B2	Sulfonamides as TRPM8 modulators Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defi...
JPWO2012102255A1	Indole derivative, or pharmacologically acceptable salt thereof The present invention is EP1General formula (I) of the present invention having a receptor antagonistic effect [Chemical][In the formula, A is a benzene ring, a pyridine ring, etc., and Y1Is C1-6It is an alkylene group, etc., and Y2Is a ...
JP5412370B2	Compounds and methods for the treatment or prevention of FLAVIVIRUS infection The present invention provides novel compounds represented by formula I or pharmaceutically acceptable salts thereof useful for treating flaviviridae viral infection.
JP2013537216A	Dihydrobenzoxatiazepine derivatives, their preparation, pharmaceutical compositions and use as AMPA receptor modulators Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compounds (I) and their enantiomers and diastereoisomers, and addition salts with an acid or a base, are new. Phenoxy-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepine-dioxide compoun...
JP5209760B2	1-N-Phenylamino-1H-imidazole derivative and pharmaceutical composition containing it The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
JP5161233B2	2,4-Pyrimidineamine derivatives as inhibitors of JAK kinase for the treatment of autoimmune diseases The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases are therapeutically useful.
JP2013028648A	FORMULATION AND METHOD OF ADMINISTRATION OF CEPHALOTAXINE, INCLUDING HOMOHARRINGTONINE To provide new methods and compositions for administering homoharrigtonine.The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is ...
JP5027802B2	Heteroaryl-carboxylic acid (sulfamoylalkyl) amide-derivative as a factor Xa inhibitor The present invention relates to compounds of the formula I, in which R1; R2; R3; V; G1 and G2 have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a stro...
JP5008242B2	Method for Producing Asymmetric 4,6-Bis (aryloxy) Pyrimidine Derivatives The invention relates to a novel process for preparing known asymmetrical 4,6-bis(aryloxy)pyrimidine derivatives.
JP4955646B2	Sith-2,4,5-triaryl-imidazoline and their use as anti-cancer drugs There are presented compounds of the formula or pharmaceutically acceptable salts thereof, wherein Y1, Y2, X1, X2, X3 and R are as described in this application. These compounds are believed to inhibit MDM2-p53 interaction and as such th...
JP2012512141A	4-Amino-1,2,3-benzoxathiazine derivative as a pesticide 4-Amino-1,2,3-benzoxathiazine compounds (I) and their salts, are new. 4-Amino-1,2,3-benzoxathiazine compounds of formula (I) and their salts are new. R1-R4 : H, halo, carbamoyl, thiocarbamoyl, nitro, cyano, hydroxy, SF 5 , 1-6C-alkyl, 2-...
JP2011256198A	METHOD OF TREATING OR PREVENTING AUTOIMMUNE DISEASE WITH 2,4-PYRIMIDINEDIAMINE COMPOUND To provide methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases.There is disclosed the 2,4-pyrimidin...
JP4834557B2	1-N-Phenylamino-1H-imidazole derivative and pharmaceutical composition containing it The invention relates to the compounds of formula (I): in which R1, R2, R3, R4, Q and Z are as defined in the specification. The invention also relates to the pharmaceutical compositions containing these compounds.
JPWO2009154190A1	Pyridone compound To provide a useful compound which can be used as a medicine, particularly a therapeutic agent for peripheral arterial occlusion. As a result of diligent studies on EP4 receptor agonists, the inventors have found that the 1-position of t...
JP4808380B2	Carbamic acid ester as an HIV protease inhibitor Compounds useful for inhibiting HIV protease are disclosed. Methods of making the compounds, and their use as therapeutic agents, for example, in treating wild-type HIV and of multidrug-resistant strains of HIV, also are disclosed.
JP4789934B2	Inhibitor of type 1 11-beta-hydroxysteroid dehydrogenase The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods...
JP4695588B2	Amino heteroaryl compound as a protein kinase inhibitor Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided. Preferred compounds of formula 1 have activity as protein kinase inhibitors, including as inhibitors...
JP4682315B2	Substituted azole compounds, their production, and their use The invention relates to fungicide and insecticide, especifically to the substituted azole compounds and its preparation method and use thereof. The azole compounds of the invention having general formula (I): The compounds of present in...

Matches 251 - 300 out of 456	< 1 2 3 4 5 6 7 8 9 10 >