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JP3743520B2 |
Thienyl-, furyl- and pyrrolyl-sulfonamides, formulations of pharmaceutically acceptable salts thereof and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(isoxazolyl)thi...
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JP3741441B2 |
Processes for preparing endothelin antagonists of formula (I) and pharmaceutically acceptable salts thereof and processes for preparing intermediates thereof.
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JP2006017737A |
To develop a therapeutic compound to regulate selectively an immune response, and to treat a T-cell mediated disease.The present invention relates to the discovery that a certain adverse inflammatory response, an allergic disease, an und...
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JP2006501199A |
The present invention is directed to compositions and methods for the treatment of patients with cephalotaxines, for example, homoharringtonine. The invention is also directed to improvements in the purity, manufacturing process, formula...
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JPWO2004026292A1 |
Equation (I)(A indicates an alkoxycarbonylalkyl group, etc., R indicates a hydroxyl group which may be protected, or A and R together form a 6- or 7-membered ring containing an oxygen atom, and B indicates a carbonyl. Indicates a group o...
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JP3704055B2 |
To obtain a new intermediate useful for a method for diastereoselective synthesis for preparing optically active cis-nucleosides, nucleoside analogs and derivatives. This intermediate is represented by the formula (I), wherein, W and X a...
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JP3665335B2 |
PCT No. PCT/EP94/02784 Sec. 371 Date Jan. 25, 1996 Sec. 102(e) Date Jan. 25, 1996 PCT Filed Aug. 24, 1994 PCT Pub. No. WO95/05739 PCT Pub. Date Mar. 2, 1995Use of 3-aryl-5,6-dihydro-1,4,2-oxathiazines and their oxides having the formula ...
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JP2005505506A |
The present invention is macrocycles of the formula (X): for treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme for the treatment of Alzheimer's disease and other dise...
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JP3570744B2 |
Novel compounds of the formula I in which R<1>, X and Y have the meanings given in Patent Claim 1, and their salts inhibit the binding of fibrinogen to the fibrinogen receptor and can be used for the treatment of thromboses, apoplexy, ca...
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JP2004143134A |
To obtain a novel medicine having a JNK (C-Jun N-terminal Kinase) inhibiting action.The subject inhibitor comprises a compound having an isoquinoline skeleton, e.g., a compound represented by the formula [wherein the ring A and the ring ...
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JP2004123732A |
To obtain a new five-membered heterocyclic compound having excellent adipose tissue weight reducing action, hypoglycemic action, and hypolipidemic action, and useful as a prophylactic and therapeutic agent for obesity, diabetes, hyperlip...
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JP2004505916A |
The invention relates to substituted and unsubstituted 3H-benzo[1,2,3]oxathiazole 2,2-dioxides, 1,3-dihydrobenzo[1,2,5]thiadiazole 2,2-dioxides and 1,3-dihydro-benzo[c]isothiazole 2,2-dioxides, to their preparation and to their use in me...
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JP3483893B2 |
Modified aminoacids of formula RC(=O)ZC(R11)((C=O)m(CH2)nR2)C(=X)ANR3R4 (I), their tautomers, diastereomers, enantiomers, mixtures and salts are new. R = 1-7C n-alkyl (optionally ~w-substituted), 1-6C n-alkylamino (optionally N-substitut...
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JP3465215B2 |
To provide a new compound having strong angiotensin II antagonistic action, hypotensive action and central nervous action and useful for the treatment of circulatory diseases such as hypertension, cardiac diseases, cerebral apoplexy, nep...
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JP2003300959A |
To provide a new modified amino acid, a method for producing the same and uses thereof.The modified amino acid is represented by general formula (I) (wherein, A, Z, X, n, m, R, R2, R3, R4 and R11 are each as defined in claim 1), its taut...
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JP2003528081A |
Heterocyclic acylsulfimides, processes for their preparation, compositions comprising them and their use as pesticides Acylsulfimides of the formula (I) where the symbols and indices are as defined in the description, are suitable for co...
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JP3437462B2 |
To obtain an insecticide capable of exhibiting accurate controlling effect on injurious insects without giving phytotoxicity to culturing plants by including a specific heterocyclic compound as an active ingredient. This insecticide is o...
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JP2003212846A |
To provide a therapeutic agent and prophylactic agent for hepatitis C, having HCV polymerase antagonism and so realizing anti-HCV action.The condensed ring compound represented by general formula [I] (wherein, each symbol is defined in t...
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JP3420549B2 |
To obtain an anticancer compound in a high yield useful for treating a highly proliferative disorder such as cancer in mammals by using a specific synthetic intermediate. (A) A compound of formula I [R1 and R2 are each a 1-10C alkyl, a 1...
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JP2003028858A |
To treat a disease transmitted by a T cell.The treatment is related to a treatment by which an undesirable immune response including a little troublesome inflammation response, an allergeric disease, a transplant negativism disease and a...
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JP3352082B2 |
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JP2002316986A |
To provide a new heterocyclic compound, a method for producing the same and the use of the compound as an insecticide.The heterocyclic compound is expressed by formula (I) [the group of formula (II) is the group of formula (III) (Z1 is O...
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JP2002308875A |
To solve the problem that, since endothelin is related to specific disease states and to many physiological effects, a compound which can hinder or strengthen the endothelin-receptor mutual action and endothelin-related activities such a...
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JP3330972B2 |
The present invention relates to highly diastereoselective processes for production of cis-nucleosides and nucleoside analogues and derivatives in high optical purity and intermediates useful in those processes.
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JP2002531423A |
The invention provides a preservative composition comprising, in synergistic proportions, an oxathiazine compound plus one or more of a quaternary ammonium compound and a triazole compound as well as methods of treating wood and other ma...
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JP2002525373A |
Disclosed are compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein: A is (un)substituted alkylene; R1 and R2 are the same or different and represent hydrogen, halogen, alkyl, alkoxy, alkylthio, hydroxy, (un)subs...
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JP3290657B2 |
Novel substituted triazolinone, triazolinethione, and triazolinimine compounds of the formula I are useful as angiotensin II antagonists. (* CHEMICAL STRUCTURE *) (I)
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JP2002513792A |
The invention relates to novel methoximinomethyloxathiazines, to two processes for their preparation and to their use as pesticides.
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JP2002508352A5 |
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JP2002508352A |
Novel amines of formulas 1D and 1Eare disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological di...
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JP2002508361A |
Novel amines of formulas (1A) and (1B) are disclosed and are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathologic...
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JP2002508362A |
Novel amines of formulas 1, 1C, 1F, 1G and 1H or a pharmaceutical acceptable salt thereof wherein n is an integer of from 0 to 2; m is an integer of from 0 to 3; R is sulfonamide, amide, heterocycle, sulfonic acid, or hydroxamic acid; A'...
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JP3263241B2 |
PURPOSE: To obtain a benzene derivative having calcium overload inhibiting action in addition to vasohypotonic action and lipid peroxide inhibiting action and useful as an agent for preventing and treating ischemic diseases and as a hypo...
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JP2002504883A |
(57) [Summary] 7-Azabicyclo [2.2.1] -heptane and -heptene derivatives have been disclosed that can be administered to mammals, including humans, to treat diseases associated with decreased or increased cholinergic activity.
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JP2002504081A |
A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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JP2001524949A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP2001316378A |
To provide a compound exhibiting strong and long-lasting activities for inhibiting cell adhesion by oral administration, and useful as an antithrombic agent.This benzamide derivative is a compound represented by the formula [wherein, A i...
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JP3229013B2 |
PURPOSE: To obtain optically active cis-nucleoside and a compd. analogous to the nucleoside by glycosylating purine or pyrimidine bases with a specified intermediate in the presence of a specified Lewis acid. CONSTITUTION: Desired purine...
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JP2001512416A |
Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formulawhereinR1a and R1b independently represent (C1-C6) alkyl; R2 represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the subs...
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JP2001163779A |
To provide a method for treating erection dysfunction or erection impotence in a human male patient.This method for treating erection dysfunction or erection impotence comprises administration of a prostaglandin receptor agonist of formu...
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JP2001502677A |
The invention relates to novel oxime derivatives of formula (I), in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (in...
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JP2001500517A |
Substituted carbamoyltriazoles of the formula I as defined in the specification and the agriculturally useful salts thereof, processes for their preparation and their use as herbicides.
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JP3112980B2 |
The invention concerns a heterocyclene derivative of the formula I, or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a heterocyclene derivative of the formula I, or a pharmaceuti...
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JP2000509718A |
(57) [Summary] Compounds represented by formula (I), as well as their N-oxides and agriculturally suitable salts, are disclosed which are useful in controlling unwanted vegetation. In equation (I) above, Q is (Q-1), (Q-2) or (Q-3); and A...
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JP3048558B2 |
To provide a new compound especially useful as pharmaceuticals for the treatment or prevention of amyloidosis. This compound is expressed by formula II or formula II [R is SH, benzyl or phenyl; R1 is H or a halogen; X is (CH2)n or the li...
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JP2000504727A |
A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
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JP2000502050A |
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...
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JP3012002B2 |
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...
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JP3012086B2 |
Benzodiazepine analogs of the formula: are disclosed which are antagonists of gastrin and cholecystokinin (CCK).
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JP2961516B2 |
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