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Matches 351 - 400 out of 428

Document Document Title
JP2002504883A
(57) In order to treat the disease relevant to a fall or rise of summary Kolin activity, the 7* アザビ cyclo 2.2. 1 * heptane and * heptene derivative with which the mammals including humans can be medicated are indicated.  
JP2002504081A
A compound of formula (I), or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.  
JP2001524949A
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
JP2001316378A
To provide a compound exhibiting strong and long-lasting activities for inhibiting cell adhesion by oral administration, and useful as an antithrombic agent.This benzamide derivative is a compound represented by the formula [wherein, A i...  
JP3229013B2
PURPOSE: To obtain optically active cis-nucleoside and a compd. analogous to the nucleoside by glycosylating purine or pyrimidine bases with a specified intermediate in the presence of a specified Lewis acid. CONSTITUTION: Desired purine...  
JP2001512416A
Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formulawhereinR1a and R1b independently represent (C1-C6) alkyl; R2 represents (C1-C10) alkyl or substituted (C1-C10) alkyl wherein the subs...  
JP2001163779A
To provide a method for treating erection dysfunction or erection impotence in a human male patient.This method for treating erection dysfunction or erection impotence comprises administration of a prostaglandin receptor agonist of formu...  
JP2001502677A
The invention relates to novel oxime derivatives of formula (I), in which A stands for alkadiyl, Ar for optionally substituted aryls or heteroaryls respectively, G for a single bond, optionally an alkandiyl interrupted by heteroatoms (in...  
JP2001500517A
Substituted carbamoyltriazoles of the formula I as defined in the specification and the agriculturally useful salts thereof, processes for their preparation and their use as herbicides.  
JP3112980B2
The invention concerns a heterocyclene derivative of the formula I, or a pharmaceutically-acceptable salt thereof. The invention also concerns processes for the manufacture of a heterocyclene derivative of the formula I, or a pharmaceuti...  
JP2000509718A
(-- 57) summary -- the compounds shown in controlling the vegetation which is not desirable by useful formula (I), those N* オキシド, and agriculturally suitable salt are indicated. In the above-mentioned formula (I), Q is (Q*1), (Q*...  
JP3048558B2
To provide a new compound especially useful as pharmaceuticals for the treatment or prevention of amyloidosis. This compound is expressed by formula II or formula II [R is SH, benzyl or phenyl; R1 is H or a halogen; X is (CH2)n or the li...  
JP2000504727A
A compound of formula (I) or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.  
JP2000502050A
This invention relates to macrocyclic molecules which inhibit metalloproteinases, including aggrecanase, and the production of tumor necrosis factor (TNF). In particular, the compounds are inhibitors of metalloproteinases involved in tis...  
JP3012002B2
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors, of formula (I). In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specif...  
JP3012086B2
Benzodiazepine analogs of the formula: are disclosed which are antagonists of gastrin and cholecystokinin (CCK).  
JP2961516B2  
JPH11263777A
To obtain a new compound useful as an agrochemical for controlling Arthropoda, esp. insects, plant nematodes, helminth, or protozoan and the like, all being harmful organisms on farm products or the like. This new compound is shown by fo...  
JPH11509531A
1-Amino-3-benzyluracils I(X=oxygen, sulfur;R1=C1-C4-haloalkyl;R2=H, halogen; R3, R7=H, CN, SCN, halogen, C1-C4-haloalkyl, C1-C4-haloalkoxy, C1-C4-haloalkylthio;R4=H, CN, SCN, halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-hal...  
JP2927551B2
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one o...  
JP2875557B2
Heterocyclically substituted alkoxycoumarins of the formula in which R<1> and R<2> are, independently of one another, hydrogen, C1- to C5-alkyl, trifluoromethyl, phenyl, halogen or together are a C3- to C5-alkylene chain; furthermore R<3...  
JP2847969B2  
JPH11500717A
The application relates to novel heterocycloalkenes, to a number of processes for their preparation and to their use as fungicide.  
JPH10509140A
Pyrazole derivatives represented by formula (I) and physiologically acceptable salts thereof can suppress the production of both of prostaglandins and leukotrienes simultaneously, and, therefore, exhibit anti-inflammatory and analgesic e...  
JPH10508030A
Antihyperglycemic compounds selected from the group consisting of C-substituted pentacycloazoles and N-alkyl-substituted pentacycloazoles.  
JP2766421B2
The present invention relates to a novel antibacterial compound of formula (I) from the genus Alteromonas and which shares structural similarity with the pseudomonic acids. i  
JP2764784B2
PURPOSE: To provide the subject compound having wide range of vermin controlling effect without giving chemical damage to a cultivated plant and useful as insecticide. CONSTITUTION: The compound is expressed by formula I [A is a 5-member...  
JP2761441B2
The present invention provides certain 3-aryl-5,6-dihydro-1,4,2-ocathiazines and their oxides, useful for the long-term preservation of wood and composite wood materials against wood damaging and wood destroying materials. The present in...  
JPH10504275A
Compounds having the formulawhere R2 is a heteroaryl group linked to the remainder of the molecule via a carbon atom adjacent a nitrogen atom and R4 and R5 are both hydrogen atoms or together represent -SO- or -SO2- and A is C2-C4 alkyle...  
JPH1072444A
To obtain the subject new compound useful as a medicine having a pharmacological activity such as a growth hormone accelerating activity. A benzene condensed lactam derivative expressed by formula I [R1 is a lower alkyl; R3 is H or a low...  
JP2695132B2
PURPOSE: To obtain a new inhibitor which inhibits DNA gyrase activity in bacteria, has antibiotic properties, especially antibacterial activity against microorganisms and is useful for treatment or prophylaxis of infectious diseases. CON...  
JPH09511215A
Heteroarylpiperidines, pyrrolidines, and piperazines of the formula wherein X is -O-, -S-, -NH-, or -N(R 2 )- R 2 is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, alkoxycarbonyl a...  
JPH09221481A
To obtain a medicine comprising a new specific aromatic compound, containing thiazolidine-2,4-dion-5-ylmethyl group, etc., and useful as a therapeutic agent, a preventing agent, etc., for insulin-resistance diseases, hyperglycemia, hyper...  
JP2645962B2
Compounds shown by the above formula or salt thereof show a strong angiotensin II antagonistic activity and hypotensive action and CNS activity, and are useful as therapeutic agents of circulatory diseases such as hypertensive diseases a...  
JP2614981B2
PURPOSE: To provide new compds. having low toxicity, useful for agonist of 5-HT1 like acceptor, such as antimigraine medicine, etc. CONSTITUTION: The compds. have formula I (where R1 is H, halogen, 1-6C alkyl, 1-6C alkoxy, cyano or the l...  
JP2609122B2  
JP2610988B2
Novel heterocyclic compounds of the formula (I) wherein A, R<1>, E, Z, X and Y have the meanings as defined in the patent application and the use of the new compounds as insecticides.  
JPH0881463A
To obtain a novel compound that has activity against microorganisms, particularly Gram-positive bacteria, mycobacteria, anaerobic microorganisms and the like with low toxicity and is useful for prevention and treatment of systemic infect...  
JPH07121941B2
This invention relates to certain quinolinyl-benzoheterobicyclic compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists and/or as mediator release inhibitors usef...  
JPH07113021B2
Compounds of formula I: in which R1, R2, R3, R4, R5, R6, R7, X, and n are defined in the description, their optical isomers and their addition salts with a pharmaceutically acceptable base or acid. Medicinal products.  
JPH0791280B2
Aminobenzosultam derivatives as inhibitors of lipoxygenase and useful in the treatment or alleviation of allergic and inflammatory diseases.  
JPH07242664A
PURPOSE: To obtain the subject novel compound having an antagonism against angiotensin II, useful for treatment of hypertension, aldosterone excessiveness, cardiac insufficiency, central nervous system diseases, or the like. CONSTITUTION...  
JPH0780998B2
Electrically conducting homo- and/or copolymers and/or tripolymers can be produced from novel monomers, such as a 3-substituted 2,5-di(2-thienyl)pyrrole. The polymers exhibit unexpectedly high stability and conductivities, and can be fun...  
JPH07173142A
PURPOSE: To obtain the subject novel inhibitor which inhibits the angiotensinogen-cleaving action of a natural proteolytic enzyme, renin, and is useful in treating or preventing renin-associated hypertension, hyperaldosteronism, glaucoma...  
JPH0751564B2
Spirocyclic compounds of the formula: are oxytocin and vasopressin antagonists useful in the treatment of pre-term labor, dysmenorrhea and for the stoppage of labor preparatory to cesarean delivery, timing of parturition, uterine hyperac...  
JPH0699423B2
PCT No. PCT/US91/01470 Sec. 371 Date Nov. 6, 1992 Sec. 102(e) Date Nov. 6, 1992 PCT Filed Mar. 4, 1991 PCT Pub. No. WO91/17156 PCT Pub. Date Nov. 14, 1991.5-(1-Hydroxy-2-piperidinopropyl)-2(1H,3H)-indolone derivatives and analogs; pharma...  
JPH06329637A
PURPOSE: To provide novel compounds useful as active compounds in medicaments, particularly as hypotensor and anti-artherosclerosis agents. CONSTITUTION: A compound of formula I [wherein A represents alkyl, alkenyl, or cycloalkyl; B repr...  
JPH0678339B2  
JPH06237790A
PURPOSE: To obtain an enantiomer of a heterodicyclic alcohol by stereoselectively resolving from its corresponding racemic body through a specific process having no need of an optically active reagent, while converting another enantiomer...  
JPH06507418A
Substituted 1-(2H)-isoquinolinones of the structural formula: (I) are angiotensin II antagonists which are useful in the treatment of hypertension and congestive heart failure.  

Matches 351 - 400 out of 428