Sugars, Derivatives Thereof, Nucleosides, Nucleotides, Nucleic Acids

Matches 451 - 500 out of 9,648	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >

Document	Document Title
WO/2020/158687A1	METHOD OF PRODUCING PHOTOREACTIVE NUCLEOTIDE ANALOG In the present invention, a method for producing a compound of formula I comprises a step for causing a compound of formula III to undergo a Pechmann condensation reaction with respect to a compound of formula II in the presence of an or...
WO/2020/154455A1	NON-IMMUNOSUPPRESSIVE FK506 ANALOGS AND USE THEREOF The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods...
WO/2020/151295A1	COMPOUND HAVING DINUCLEOTIDE STRUCTURE Provided is a novel compound having a dinucleotide structure. Also provided are the method for preparing such compound having a dinucleotide structure, and the uses thereof in preparing a drug for treating virus infection, especially hep...
WO/2020/154656A1	COMPOSITIONS AND METHODS FOR TREATING, PREVENTING OR REVERSING AGE-ASSOCIATED INFLAMMATION AND DISORDERS Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).
WO/2020/154546A1	HIGH INTENSITY LABELED REACTANT COMPOSITIONS AND METHODS FOR SEQUENCING Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules...
WO/2020/154512A1	Methods of Identifying Adenosine-to-Inosine Edited RNA This disclosure relates to improved methods of identifying A-to-I RNA edits in a sample. In certain embodiments, this disclosure relates to methods of purifying RNA containing an inosine base comprising the steps of: exposing an RNA samp...
WO/2020/142825A1	REAGENTS BASED ON A TERTIARY AMINE BACKBONE TO INTRODUCE CHEMICAL FUNCTIONALITY IN NUCLEIC ACIDS AND SEQUENCE-CONTROLLED POLYMERS It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthes...
WO/2020/143800A1	LIVER-SPECIFIC AMPK AGONIST, PREPARATION METHOD THEREFOR AND USES THEREOF The present invention provides a liver-specific AMPK agonist, a preparation method therefor and the uses thereof. Specifically, the present invention provides a compound of formula (I) and the uses thereof for treating non-alcoholic fatt...
WO/2020/146397A1	NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
WO/2020/143740A1	CYCLIC DINUCLEOTIDE PRODRUG MOLECULE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Disclosed are a cyclic dinucleotide prodrug molecule, a preparation method therefor and an application thereof relating to the field of pharmaceuticals. The cyclic dinucleotide prodrug molecule has a structure shown in formula I, II, or ...
WO/2020/140559A1	5-DEOXY-D-RIBOSE DERIVATIVE Provided is a 5-deoxy-D-ribose derivative (III), when the derivative (III) is used for preparing capecitabine, the stereoselectivity is good and the yield is high. Further provided is a preparation method of the derivative, wherein the p...
WO/2020/135715A1	COMPOUND FOR TUMOR IMMUNITY AND APPLICATION THEREOF Disclosed is a compound represented by Formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, and an application of the compound as a STING agonist. (I)
WO/2020/136170A2	NUCLEOSIDES AND NUCLEOTIDES WITH 3'-HYDROXY BLOCKING GROUPS Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or thiocarbamate 3ʹ-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses o...
WO/2020/139871A1	HIGHLY ACCURATE DE NOVO POLYNUCLEOTIDE SYNTHESIS Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or...
WO/2020/139962A1	HETEROBIFUNCTIONAL INHIBITORS OF E-SELECTIN AND GALECTIN-3 Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For examp...
WO/2020/139960A1	GALECTIN-3 INHIBITING C-GLYCOSIDES Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described an...
WO/2020/131578A2	NICOTINYL RIBOSIDE COMPOUNDS AND THEIR USES The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have ...
WO/2020/131649A1	NOVEL CRYSTALLINE FORMS OF AN NRTTI COMPOUND The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4'- Ethynyl-2-fluoro-2'-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the...
WO/2020/127461A1	AMORPHOUS FORM OF 5-BROMOPYRIDIN-3-YL 3-DEOXY-3-[4-(3,4,5-TRIFLUOROPHENYL)-1H-1,2,3-TRIAZOL-1-YL]-1-THIO-ALPHA-D-GALAC TOPYRANOSIDE The present invention relates to a stabilized amorphous form of a compound of formula (I) as well as compositions for oral administration comprising the compound of formula (I) in a therapeutically effective amount.
WO/2020/128469A1	SYNTHESIS OF 8-CHLOROADENOSINE DERIVATIVES INCLUDING NUC-9701 The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chl...
WO/2020/131759A1	3' PROTECTED NUCLEOTIDES The present disclosure provides 3' protected nucleotides, including those 3' protected nucleotides having a detectable tag. Systems and methods of sequencing nucleic acids using the 3' protected nucleotides are also disclosed, such as th...
WO/2020/123772A1	SOLID FORMS OF A CD73 INHIBITOR AND THE USE THEREOF Solid forms of Compound I, which modulates the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compound and methods for preparing the solid forms, are described herein. The use of such solid form ...
WO/2020/123488A1	CRYSTALLINE FORMS OF NICOTINOYL RIBOSIDES AND DERIVATIVES THEREOF, AND METHODS OF PREPARATION THEREOF The present disclosure provides crystalline Form II of nicotinic acid riboside, crystalline Form II of nicotinic acid riboside triacetate, and methods of preparation thereof. In an embodiment, the present disclosure relates to crystallin...
WO/2020/122547A1	NICOTINAMIDE RIBOSIDE DERIVATIVE CONJUGATED TO FATTY ALCOHOL The present invention relates to a nicotinamide riboside derivative conjugated to a fatty alcohol, and a wrinkle reducing or anti-aging composition comprising same. A nicotinamide riboside derivative conjugated to a fatty alcohol accordi...
WO/2020/117623A1	CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...
WO/2020/117625A1	CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...
WO/2020/118139A1	A1 ADENOSINE RECEPTOR AGONISTS AND METHODS OF USE THEREOF Disclosed are compounds of the formulas (I), (II), and (II): which are A1 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein Y, R1‑R6, R10‑R15, and R20�...
WO/2020/117624A1	CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...
WO/2020/108343A1	ORAL PHARMACEUTICAL COMPOSITION USING 4'-THIONUCLEOSIDE COMPOUND AS ACTIVE INGREDIENT, PREPARATION METHOD THEREFOR AND USE THEREOF (I) An oral pharmaceutical composition containing a 4'-thionucleoside compound of formula (I), a capsule and a product containing same, and a preparation method therefor and the use thereof. The oral pharmaceutical composition has a good...
WO/2020/104335A1	ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal...
WO/2020/103929A1	OLIGONUCLEOTIDE AND PRODRUG THEREOF Disclosed is an oligonucleotide and a prodrug thereof, and in particular, disclosed are: a compound shown by formula I, a tautomer thereof, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method, a pharmaceuti...
WO/2020/103916A1	SEPARATION AND PURIFICATION METHOD FOR URIDINE TRIPHOSPHATE Provided is a separation and purification method for uridine triphosphate. The separation and purification method comprises the following steps: 1) loading: filtering crude uridine triphosphate and then loading same into a chromatography...
WO/2020/104492A1	PYRIDINIUM SALTS AS ACTIVATORS IN THE SYNTHESIS OF STEREODEFINED OLIGONUCLEOTIDES The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling act...
WO/2020/107013A1	ORALLY ACTIVE PRODRUG OF GEMCITABINE The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.
WO/2020/102980A1	PREPARATION METHOD FOR NUCLEOTIDE FOR SEQUENCING Proposed is a preparation method for a nucleotide for sequencing, i.e. a preparation method for a compound represented by formula (I), comprising (1) performing a first nucleophilic substitution reaction on a compound represented by form...
WO/2020/100826A1	CROSSLINKED ARTIFICIAL NUCLEIC ACID ALNA The present invention provides a novel crosslinked artificial nucleic acid and an oligomer that includes the same as a monomer. More specifically, the present invention provides a compound represented by general formula (I) (the symbols ...
WO/2020/102326A1	METHODS FOR DETERMINING AND INCREASING NAD LEVELS The present application provides methods for determining the level of NAD in a patient, including a whole blood sample from a patient. In addition, methods of increasing NAD levels in combination with determining the NAD level in a patie...
WO/2020/085720A1	PROCESS FOR PREPARING LACTIC ACID BACTERIA NUCLEOTIDE INCLUDING LOW-MOLECULAR WEIGHT FUNCTIONAL BIOMATERIAL, AND CUBOSOME PREPARED THEREBY The present invention relates to a process for simultaneously preparing a lactic acid bacteria nucleotide and a low-molecular weight functional biomaterial having utility in industries related to skincare and cosmetics, and more specific...
WO/2020/086366A1	METHODS FOR SEPARATING LARGE NUCLEIC ACIDS UNDER DENATURED CONDITIONS The present disclosure provides methods for separating nucleic acids in a sample based on the length of the nucleic acids using a capillary electrophoresis device with formamide as a denaturing agent and a non-aqueous separation matrix c...
WO/2020/086834A1	NUCLEOTIDE ANALOGUES Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.
WO/2020/078807A1	PRODRUG OF GALACTOSIDE INHIBITORS OF GALECTINS The present invention relates to a prodrug compound of the general formula I or II. The prodrug compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3...
WO/2020/078808A1	GALACTOSIDE INHIBITOR OF GALECTINS The present invention relates to a compound of the general formula I or II. The compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in ...
WO/2020/081690A1	6-MERCAPTOPURINE NUCLEOSIDE ANALOGUES A compound has the following formula (I) or formula (II), an isomer thereof, a tautomer thereof, a pharmaceutical acceptable solvate thereof, or a pharmaceutical acceptable prodrug thereof.
WO/2020/078000A1	CARBOHYDRATE-DERIVED AZACYCLOCARBENE, PRECURSOR IMIDAZOLE SALT THEREOF, AZACYCLOCARBENE-COORDINATED TRANSITION METAL COMPLEX, PREPARATION METHOD THEREFOR, AND USE IN CATALYTIC REACTION 1,3-disubstituted-2H-imidazolyl-2-carbene is a common type of azacyclocarbene, which may be used in a plurality of fields, comprising catalyzing organic reactions, acting as a transition metal ligand, and acting as a supporting ligand in...
WO/2020/073274A1	METHOD FOR SEQUENCING POLYNUCLEOTIDE Provided is a method for determining the sequence of a target single-chain polynucleotide, which method comprises monitoring the successive incorporation of nucleotides complementary to the target single-chain polynucleotide, wherein the...
WO/2020/074004A1	CYCLIC DINUCLEOTIDE COMPOUND AND USES THEREOF Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compoung acting as a STING agonist.
WO/2020/072497A1	METHYL AND ETHYL NICOTINATE-RIBOSIDE-5-PHOSPHATES, PREPARATION THEREOF AND METHODS OF USE THEREOF The invention provides a compound of formula (I): (I) wherein R is methyl or ethyl. The invention also provides a process for the preparation of the compound. The invention further provides a method for increasing cell NAD+ production or...
WO/2020/073026A1	4-THIORIBOSE NAD ANALOGUES AND METHODS OF SYNTHESIZING AND USING THE SAME This disclosure provides a method of synthesis of 4'-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4'-thioribose NAD+ an...
WO/2020/068657A1	2'-HALOGENATED-4'-THIO-2'-DEOXY-5-AZACYTIDINE ANALOGS AND USE THEREOF Halogenated analogs of 5-aza-2'-deoxycytidine, such as halogenated analogs of 5-aza-4'-thio-2'-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated an...
WO/2020/069424A1	DISULFIDE-LINKED REVERSIBLE TERMINATORS The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety compris...

Matches 451 - 500 out of 9,648	< 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 >