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Matches 301 - 350 out of 9,399

Document Document Title
WO/2020/158910A1
Disclosed are a 5'-modified nucleoside and a nucleotide using the same. The nucleoside according to the present invention is represented by formula (I). The 5'-modified nucleoside according to the present invention is usable as a substit...  
WO/2020/158687A1
In the present invention, a method for producing a compound of formula I comprises a step for causing a compound of formula III to undergo a Pechmann condensation reaction with respect to a compound of formula II in the presence of an or...  
WO/2020/154455A1
The present invention provides a new class of non-immunosupressive FK506 analogs which are FKBP-selective, small-molecule BMP agonists with modest potency therepeutics for tissue repair and regeneration. Also disclosed herein are methods...  
WO/2020/151295A1
Provided is a novel compound having a dinucleotide structure. Also provided are the method for preparing such compound having a dinucleotide structure, and the uses thereof in preparing a drug for treating virus infection, especially hep...  
WO/2020/154656A1
Disclosed is a method for preventing, delaying or reversing age-associated inflammation, by administering to a patient in need thereof a therapeutically effective amount of at least one reverse transcriptase inhibitor (RTI).  
WO/2020/154546A1
Compositions useful for the detection of single molecules in a sample are provided. In some aspects, the disclosure provides a nucleotide connected to a nucleic acid comprising a FRET label comprising at least three luminescent molecules...  
WO/2020/154512A1
This disclosure relates to improved methods of identifying A-to-I RNA edits in a sample. In certain embodiments, this disclosure relates to methods of purifying RNA containing an inosine base comprising the steps of: exposing an RNA samp...  
WO/2020/142825A1
It is provided an achiral, non-nucleosidic backbone for phosphoramidites that can be inserted with high yields in nucleic acid strands and sequence-controlled oligo(phosphodiester)s through solid phase synthesis (SPS) using a DNA synthes...  
WO/2020/143800A1
The present invention provides a liver-specific AMPK agonist, a preparation method therefor and the uses thereof. Specifically, the present invention provides a compound of formula (I) and the uses thereof for treating non-alcoholic fatt...  
WO/2020/146397A1
Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.  
WO/2020/143740A1
Disclosed are a cyclic dinucleotide prodrug molecule, a preparation method therefor and an application thereof relating to the field of pharmaceuticals. The cyclic dinucleotide prodrug molecule has a structure shown in formula I, II, or ...  
WO/2020/140559A1
Provided is a 5-deoxy-D-ribose derivative (III), when the derivative (III) is used for preparing capecitabine, the stereoselectivity is good and the yield is high. Further provided is a preparation method of the derivative, wherein the p...  
WO/2020/135715A1
Disclosed is a compound represented by Formula (I), optical isomers thereof, pharmaceutically acceptable salts thereof, and an application of the compound as a STING agonist. (I)  
WO/2020/136170A2
Embodiments of the present disclosure relate to nucleotide and nucleoside molecules with acetal or thiocarbamate 3ʹ-OH blocking groups. Also provided herein are methods to prepare such nucleotide and nucleoside molecules, and the uses o...  
WO/2020/139871A1
Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or...  
WO/2020/139962A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands are disclosed. For examp...  
WO/2020/139960A1
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of galectin-3 to ligands are disclosed. For example, inhibitors of galectin-3 are described an...  
WO/2020/131578A2
The disclosure provides nicotinamide riboside (NR), the reduced form of NR (NRH), nicotinic acid riboside (NAR), the reduced form of NAR (NARH), derivatives thereof, compositions thereof and uses thereof. The NR and NAR derivatives have ...  
WO/2020/131649A1
The present disclosure provides novel anhydrate crystalline Forms 1 and 4 of 4'- Ethynyl-2-fluoro-2'-deoxyadenosine and pharmaceutical compositions thereof, each of which may be useful for the inhibition of HIV reverse transcriptase, the...  
WO/2020/127461A1
The present invention relates to a stabilized amorphous form of a compound of formula (I) as well as compositions for oral administration comprising the compound of formula (I) in a therapeutically effective amount.  
WO/2020/128469A1
The present invention generally relates to a novel process for the preparation of 8-chloroadenosine derivatives, and particularly NUC-9701(8-chloroadenosine-5'-O- [naphthyl(benzyloxy-L-alaninyl)] phosphate) an anticancer ProTide of 8-chl...  
WO/2020/131759A1
The present disclosure provides 3' protected nucleotides, including those 3' protected nucleotides having a detectable tag. Systems and methods of sequencing nucleic acids using the 3' protected nucleotides are also disclosed, such as th...  
WO/2020/123772A1
Solid forms of Compound I, which modulates the conversion of AMP to adenosine by 5'-nucleotidase, ecto, and compositions containing the compound and methods for preparing the solid forms, are described herein. The use of such solid form ...  
WO/2020/123488A1
The present disclosure provides crystalline Form II of nicotinic acid riboside, crystalline Form II of nicotinic acid riboside triacetate, and methods of preparation thereof. In an embodiment, the present disclosure relates to crystallin...  
WO/2020/122547A1
The present invention relates to a nicotinamide riboside derivative conjugated to a fatty alcohol, and a wrinkle reducing or anti-aging composition comprising same. A nicotinamide riboside derivative conjugated to a fatty alcohol accordi...  
WO/2020/117623A1
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...  
WO/2020/117625A1
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...  
WO/2020/118139A1
Disclosed are compounds of the formulas (I), (II), and (II): which are A1 adenosine receptor agonists, pharmaceutical compositions comprising such compounds, and a method of use of these compounds, wherein Y, R1‑R6, R10‑R15, and R20...  
WO/2020/117624A1
A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3a, R4, R5, R5a, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as indu...  
WO/2020/108343A1
(I) An oral pharmaceutical composition containing a 4'-thionucleoside compound of formula (I), a capsule and a product containing same, and a preparation method therefor and the use thereof. The oral pharmaceutical composition has a good...  
WO/2020/104335A1
The present invention relates to a compound of the general formula (1). The compound of formula (1) is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in a mammal...  
WO/2020/103929A1
Disclosed is an oligonucleotide and a prodrug thereof, and in particular, disclosed are: a compound shown by formula I, a tautomer thereof, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method, a pharmaceuti...  
WO/2020/103916A1
Provided is a separation and purification method for uridine triphosphate. The separation and purification method comprises the following steps: 1) loading: filtering crude uridine triphosphate and then loading same into a chromatography...  
WO/2020/104492A1
The present invention relates to a method for preparing stereodefined phosphorothioate oligonucleotides, especially locked stereodefined phosphorothioate oligonucleotides with a high yield, using pyridinium acidic salts as a coupling act...  
WO/2020/107013A1
The disclosure includes compounds of Formula (I): wherein R1, R2, and R3, are defined herein. Also disclosed is a method for treating a neoplastic disease with these compounds.  
WO/2020/102980A1
Proposed is a preparation method for a nucleotide for sequencing, i.e. a preparation method for a compound represented by formula (I), comprising (1) performing a first nucleophilic substitution reaction on a compound represented by form...  
WO/2020/100826A1
The present invention provides a novel crosslinked artificial nucleic acid and an oligomer that includes the same as a monomer. More specifically, the present invention provides a compound represented by general formula (I) (the symbols ...  
WO/2020/102326A1
The present application provides methods for determining the level of NAD in a patient, including a whole blood sample from a patient. In addition, methods of increasing NAD levels in combination with determining the NAD level in a patie...  
WO/2020/085720A1
The present invention relates to a process for simultaneously preparing a lactic acid bacteria nucleotide and a low-molecular weight functional biomaterial having utility in industries related to skincare and cosmetics, and more specific...  
WO/2020/086366A1
The present disclosure provides methods for separating nucleic acids in a sample based on the length of the nucleic acids using a capillary electrophoresis device with formamide as a denaturing agent and a non-aqueous separation matrix c...  
WO/2020/086834A1
Disclosed herein, inter alia, are compounds, compositions, and methods of using the same for the sequencing of a nucleic acid.  
WO/2020/078807A1
The present invention relates to a prodrug compound of the general formula I or II. The prodrug compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3...  
WO/2020/078808A1
The present invention relates to a compound of the general formula I or II. The compound of formula I or II is suitable for use in a method for treating a disorder relating to the binding of a galectin, such as galectin-3 to a ligand in ...  
WO/2020/081690A1
A compound has the following formula (I) or formula (II), an isomer thereof, a tautomer thereof, a pharmaceutical acceptable solvate thereof, or a pharmaceutical acceptable prodrug thereof.  
WO/2020/078000A1
1,3-disubstituted-2H-imidazolyl-2-carbene is a common type of azacyclocarbene, which may be used in a plurality of fields, comprising catalyzing organic reactions, acting as a transition metal ligand, and acting as a supporting ligand in...  
WO/2020/073274A1
Provided is a method for determining the sequence of a target single-chain polynucleotide, which method comprises monitoring the successive incorporation of nucleotides complementary to the target single-chain polynucleotide, wherein the...  
WO/2020/074004A1
Provided are a compound of formula (I), an optical isomer thereof, a pharmaceutically acceptable salt thereof, uses of said compoung acting as a STING agonist.  
WO/2020/072497A1
The invention provides a compound of formula (I): (I) wherein R is methyl or ethyl. The invention also provides a process for the preparation of the compound. The invention further provides a method for increasing cell NAD+ production or...  
WO/2020/073026A1
This disclosure provides a method of synthesis of 4'-thioribose NAD+ and analogues thereof, using an efficient chemoenzymatic approach. Also provided are methods of inhibiting the CD38 enzyme and compounds including 4'-thioribose NAD+ an...  
WO/2020/068657A1
Halogenated analogs of 5-aza-2'-deoxycytidine, such as halogenated analogs of 5-aza-4'-thio-2'-deoxycytidine (5-aza-T-dCyd) are described. Pharmaceutical compositions including a halogenated analog and methods of using the halogenated an...  

Matches 301 - 350 out of 9,399