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WO/2023/277630A1 |
A galactoside derivative according to the present invention has the effect of inhibiting galectin-3 by having a structure in which a spiro ring is fused to C1, and appropriate substituents at other carbon positions. Therefore, the galact...
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WO/2022/271540A1 |
This document provides ((benzoimidazolyl)ethyl)cyclobutyl-containing compounds useful in treating cancer such as cholangiocarcinoma.
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WO/2022/271878A1 |
The invention provides substituted 4-ethynyl-3-hydroxy-tetrahydrofuranyl-adenine phosphoramidates and related compounds, pharmaceutical compositions, their use for inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptas...
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WO/2022/265964A1 |
Described herein are orally-bioavailable nucleoside analogs and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of coronavirus infections, including SARS-CoV-2 in...
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WO/2022/262845A1 |
The present disclosure relates to ester derivatives of N 4-hydroxycytidine (NHC), to pharmaceutical compositions thereof, and to the use and method of the ester derivatives of N 4-hydroxycytidine to treat viral infections.
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WO/2022/263489A1 |
Disclosed herein are base-modified nucleoside-5 '-oligophosphates (bm-N5OP) that include a positively charged moiety at least at one position of the base, compositions comprising the same, compositions made from the same, methods of maki...
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WO/2022/266237A1 |
Deoxynucleotide prodrugs and methods of their use for treatment of diseases characterized by unbalanced nucleotide pools such as MPV17 and deoxyguanosine kinase deficiency are provided herein.
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WO/2022/265054A1 |
To provide a hair growth stimulant that is a topical agent exhibiting effects such as promoting hair shaft growth in hairs such as scalp hair, beard hair, eyebrows and/or eyelashes, accelerating gene expression contributing to hair growt...
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WO/2021/209425A9 |
The present disclosure is directed toward alkynyl nucleoside analogs, compositions comprising these compounds, and their use for treating hepatitis E infections.
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WO/2022/266316A1 |
Embodiments of the present application relate to N-acetylgalactosamine-conjugated nucleosides. In particular, the N-acetylgalactosamine is installed on the nucleobase of the nucleosides through a wide variety of linkers. Methods of makin...
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WO/2022/266322A1 |
The disclosure relates to in vivo and ex vivo uses of dihydronicotinamide riboside (NRH), dihydronicotinic acid riboside (NARH) and reduced derivatives thereof to treat immune-related disorders (e.g., systemic inflammatory response syndr...
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WO/2022/258043A1 |
The present invention provides gemcitabine anticancer derivatives of formula (III) and the anticancer pharmaceutical use, which have the potential to be developed into AKR1C3-activated anticancer drugs.
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WO/2022/260535A1 |
Compounds of the Formula (I), pharmaceutical compositions comprising compounds of the Formula (I), and their use for treating or preventing an infection caused by Human Cytomegalovirus (HCMV), Epstein-Barr virus (EBV), or Human Immunodef...
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WO/2022/260336A2 |
The present invention relates to a nucleoside derivative, which can be used for the prevention or treatment of cancer by inhibiting a kinase, and a pharmaceutical composition comprising same, wherein the nucleoside derivative has inhibit...
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WO/2022/254376A1 |
The present disclosure provides neoDegraders and neoDegraders conjugated to binding moieties. Also provided are compositions comprising the conjugates. The compounds and compositions are useful for treating a disease or condition, e.g., ...
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WO/2022/254457A1 |
The present invention relates to an improved process for the preparation of (4R)-1-[(2R, 4R, 5R)-3,3-difluoro-4-hydroxy-5- (hydroxymethyl) oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one compound of formula-1 and its intermediate compounds. [F...
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WO/2022/251032A1 |
A method for purifying nucleotides is provided, that includes preparing a solution comprising (a) 3'-blocked nucleotides, (b) 3'-OH nucleotides, (c) a polishing polymerase, and (d) a template. The polishing polymerase and the template ar...
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WO/2022/248960A1 |
The present invention relates to solid forms of molnupiravir, including its co-crystals, solvates, hydrates and/or polymorphs, processes for their preparation, pharmaceutical compositions containing the same.
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WO/2022/251594A1 |
The present invention relates to methods for treating a patient infected with hepatitis B virus (HBV) with a therapeutically effective amount of a a phosphoramidate prodrug of clevudine either alone or in combination with a second antivi...
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WO/2022/245814A1 |
The invention provides methods and compositions for treating medical disorders, such as cancer, and inhibiting LINE1 reverse transcriptase and/or HERV-K reverse transcriptase using a substituted 4-fluoro-2,5-dihydrofuranyl phosphonic aci...
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WO/2022/242540A1 |
Disclosed are a tri-coordinated phosphorus derivative, an intermediate, and a preparation method. The structural formula is as follows: R2 is a phenol group, a pentafluorophenol group, and a C1-4 alkoxy group, and the alkoxy group is opt...
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WO/2022/245584A1 |
Provided herein are phosphoramidate and cyclophosphate prodrug compounds of unnatural configuration nucleotide, their preparation, and their uses, such as treating liver diseases or nonliver diseases via intervening in the molecular path...
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WO/2022/238568A1 |
The invention relates to a prodrug formed from a compound comprising a pharmaceutically active antioxidant molecule which is covalently coupled, via a bond comprising at least one carboxylic ester group, to a nucleoside devoid of free hy...
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WO/2022/240952A1 |
Oligonucleotide conjugates are provided herein that inhibit or reduce expression of target genes in the neurons of the central nervous system. Also provided are compositions including the same and uses thereof, particularly uses relating...
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WO/2022/237747A1 |
Disclosed is a compound of formula (I), and a stereoisomer, a pharmaceutically acceptable salt, a solvate, a co-crystal or a deuterated product thereof, or a pharmaceutical composition containing same, and the use thereof as a CD73 antag...
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WO/2022/238816A1 |
Bicyclic heterocyclic compounds and derivatives thereof that have antiviral properties are disclosed. Pharmaceutical compositions and pharmaceutical formulations in unit dosage form suitable for the delivery of the compounds to a subject...
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WO/2022/234598A1 |
This invention provides a process for the preparation of orthogonally protected ribose derivative. Which are further used as donor for the synthesis of N4-hydroxy cytidine and its derivatives by using commercially available materials und...
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WO/2022/235838A1 |
Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising N4- acetylcytidine and/or 5-hydroxymethyluridine, and polyribonucleotides comprising the same. Also provided herein are compositions comprising a polyribonu...
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WO/2022/233923A1 |
The present invention discloses synthesis of nicotinamide riboside chloride (NRCl). More particularly, the present invention describes cost effective and industrially scalable process for the synthesis of NRCl in amorphous form.
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WO/2022/227117A1 |
Disclosed are a method for synthesizing vidarabine monophosphate and the use thereof, which belong to the field of drug synthesis. The synthesis method comprises subjecting 5-iodo-2-((phosphonooxy)methyl)-4-(tosyloxy)tetrahydrofuran-
3-y...
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WO/2022/232622A1 |
Alkylsulfenyl thiocarbonates capable of releasing hydropersulfides (RSSH) and carbonyl sulfide (COS) under physiological conditions and their use for treating or preventing disorders, diseases, or conditions associated with oxidative str...
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WO/2022/227873A1 |
The present invention relates to the technical field of new medicines, and provides a selenium-containing ribose compound having KGA inhibitory activity and a synthesis method therefor and an application thereof. The present invention de...
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WO/2022/225827A1 |
Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-14-(6-ami
no-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfi
dooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11,2,10]penta
oxadiphospha-cyclotetradecin-7-yl]-1,9-...
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WO/2022/220019A1 |
The purpose of the present invention is to provide a method for synthesizing a long-chain nucleic acid (particularly DNA) with high accuracy. The present invention provides a method for synthesizing a long-chain nucleic acid, the method ...
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WO/2022/218274A1 |
The present invention relates to a nucleoside analog as shown in the following formula and a use thereof. Specifically, the present invention relates to a nucleoside analog as shown in the following formula, or a pharmaceutically accepta...
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WO/2022/218943A1 |
This specification discloses novel phosphate compounds of formula (I) useful for labelling RNA in-cellulo. The phosphates are spontaneously taken up by cells and may be used as substrates for RNA synthesis once across the cell membrane. ...
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WO/2022/214692A1 |
A novel pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates are provided. The pseudo solid phase protecting group is represented by formula II wherein: * indicates the poin...
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WO/2022/216577A1 |
Novel forms of 2-amino-9-[(2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-14-(6-ami
no-9H-purin-9-yl)-15,16-difluoro-2,10-dihydroxy-2,10-disulfi
dooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11,2,10]penta
oxa-diphosphacyclotetradecin-7-yl]-1,9-...
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WO/2022/212442A1 |
Provided herein are methods of making trinucleotides and tetranucleotides for use as 5' mRNA caps. The methods utilize a novel "top-down" strategy and provide for synthesis of oligonucleotides with higher yields and increased efficiency ...
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WO/2022/204777A1 |
The present invention relates to antiviral compounds selected from cytokinins, their nucleosides and nucleotide analogs, and their prodrugs as inhibitors of viral RNA synthesis, or their salts, solvates, derivatives, or even combinations...
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WO/2022/206922A1 |
The present invention relates to the field of nucleic acid sequencing. Specifically, provided in the present invention is a nucleotide analogue for sequencing. The nucleotide analogue carries a linker on the base or the ribose ring 3'-OH...
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WO/2022/208508A1 |
The present invention provides a scalable two-step synthesis of molnupiravir. The reaction sequence involves the use of commercially easily available cytidine (1), and molnupiravir is formed through direct hydroxy amination of the cytidi...
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WO/2022/211627A1 |
This invention relates to compounds that are useful as inhibitors, in particular as inhibitors of Nicotinamide N-methyltransferase (NNMT), and formulations composing such compounds. The compounds and formulations may be used as a medicam...
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WO/2022/212230A1 |
The present invention relates to efficient processes useful in the preparation of fluorinated cyclic dinucleosides, such as [P(R)]-2'-deoxy-2'-fluoro-5'-O-[(R)-hydroxymercaptophosphiny
l]-P-thio-β-D-arabino-adenylyl-(3'→5')-3'-deoxy-3...
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WO/2022/204770A1 |
The present invention relates to antiviral compounds selected from cytokinins, their nucleosides and nucleotide analogs, and their prodrugs as inhibitors of viral RNA synthesis, or their salts, solvates, derivatives, or even combinations...
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WO/2022/203427A1 |
The present invention relates to: an adenosine derivative capable of acting as an antagonist on A2A and A3 adenosine receptors through the introduction of substituents into carbons at the 2nd and 8th positions and 6th and/or 9th amine(s)...
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WO/2022/194924A1 |
This invention relates to compounds of Formula (I) useful as synthons for a general synthetic method for making chiral phosphorothioates, to their preparation and to their use in a robust large scale process for making P-chiral phosphoro...
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WO/2022/189846A1 |
The present invention relates to medicine, and in particular to the treatment of viral infections, more particularly to inhibitors of viral mRNA cap methyltransf erases (MTases). Even more particularly, the invention relates to adenosylm...
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WO/2022/190915A1 |
Provided are: a novel compound having improved in-vivo efficacy and antitumor activity of a curcumin derivative, or a salt thereof; and an antitumor activator containing the same as an active ingredient. The present invention is a compou...
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WO/2022/189459A2 |
The present invention relates to beta D-galactopyranose compound of formula (I). Wherein the pyranose ring is β-D-galactopyranose, and these compounds are high affinity galectin-3 inhibitors for use in treatment of inflammation; fibrosi...
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