Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 251 - 300 out of 1,066

Document Document Title
WO/2003/047499A2
An amphiphilic compound is provided capable of forming vesicles or liposomes, said amphiphilic compound having at least one headgroup containing a selectively cleavable group or moiety such as a residue of a choline or phenylalanine deri...  
WO/2003/045967A1
This invention is directed to compounds of formula (1) and their pharmaceutically acceptable salts, wherein R?1¿, R?2¿, and R?3¿ are as defined herein; intermediates for the synthesis of such compounds; and methods of using such compo...  
WO/2003/035661A1
The invention relates to compounds having the following formula (I), in which: R¿a? represents a sugar moiety, an arylamino group, or an alkyl group comprising at least one amino group, R¿b? represents an halogen atom, an halogenoalkyl...  
WO2003000709A9
the invention relates to Siglec inhibitors that have an increased affinity for the receptor molecule. The Siglec inhibitors provided by the invention are preferably selective of a given Siglec molecule. The invention further relates to m...  
WO/2003/022860A1
Preparation of synthetic monosaccharides, disaccharides, trisaccharides, tetrasaccharides and pentasaccharides for use in the preparation of synthetic heparinoids.  
WO/2003/018598A2
Monosaccharide (pyranoside) conjugates of the formula have been found to be useful as enhancers and/or inhibitors of heparin binding to FGF. The compounds have the potential to be useful in regenerative medicine or for treatment of patho...  
WO/2003/011881A2
Glucoside and glucuronide derivatives ofhydromorphone, dihydromorphine, and dihydroisomorphine and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising a glucoside or glucuronide derivative ofhydromorphone, d...  
WO/2003/002127A1
The present invention relates to the use of a glycosidase inhibitor for the manufacture of a medicament for the treatment of a disease, wherein glycosidase enzymes hydrolyze glycoconjugates of a patient to reveal neutral glycan receptors...  
WO/2002/090359A1
The quaternary ammonium N-glucuronide adduct of 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethox y)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine is cleavable by glucuronidase enzymes in the body and can thereby act as a...  
WO2001056563A9
The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advance...  
WO/2002/086116A1
An enzyme which decomposes a sulfated fucoglucuronomannan and is useful in the field of glycotechnology; a process for producing the enzyme; a fucoidan fraction reduced in the number of the kinds of molecules and useful as a reagent in g...  
WO/2002/083066A2
Crystalline complexes are obtained from a 1:1 or 2:1 mixtures of either the (D) or (L) enantiomer of natural amino acids and compounds of formula (I) wherein R¿1?, R¿2? and R¿2a? are independently hydrogen, OH, OR¿5?, alkyl, -OCHF?2...  
WO/2002/072593A2
The present invention relates to alkylated C-sugars which are now carbohydrate derivatives based on the 'C-Sugar' platform. These alkylated C-sugars are converted from hydrophilic, hydrogen-bonded saccharide derivatives and are very stab...  
WO/2002/072779A2
Nucleic acid labeling compounds are disclosed. The compounds are synthesized by condensing a heterocyclic derivative with a cyclic group (e.g. a ribofuranose derivative). The labeling compounds are suitable for enzymatic attachment to a ...  
WO/2002/064605A2
This invention provides $g(b)-D-Glucuronidase substrates of formula (I) wherein R¿1?, R¿2?, and R¿7? - R¿12? are independently selected from the group consisting of: hydrogen, fluorine, chlorine, bromine, iodine, alkyl, hydroxyl, alk...  
WO/2002/062810A2
Disclosed herein is a class of linkable tetrasaccharide compounds that includes the amino phenyl glycoside of sialyl Lewis X (SLe?X¿) and related analogs. These compounds have conjugatable nucleophilic groups, making them useful in prep...  
WO/2002/053159A1
Tacrolimus derivatives having high levels of neurotrophic activity and low levels of immunosuppresive activity. These compounds are useful as neurotrophic agents, particularly, for preventing or treating neuronal injury/dysfunction.  
WO/2002/051828A2
The invention concerns novel C-glycoside derivatives, their synthesis methods and compositions containing them. The invention also concerns the use, in a physiologically acceptable medium, in a cosmetic composition or for preparing a pha...  
WO/2002/051803A2
The invention concerns novel C-glycoside derivatives, cosmetic, hygienic or pharmaceutical compositions containing them and their use as amphiphilic agents and in particular as emulsifiers and/or surfactants. The invention also concerns ...  
WO/2002/048197A1
Primary hydroxyl groups in a substrate having both primary and secondary hydroxyl groups can be selectively oxidised to carbaldehyde and/or carboxyl groups by contacting the substrate with a cyclic nitroxyl compound in the presence of a ...  
WO/2002/040060A2
The invention provides radiopharmaceuticals for diagnostic and therapeutic applications, conjugates of antioxidants with metal chelating ligands, intermediate compounds, methods of making such radiopharmaceuticals, ligands, and intermedi...  
WO/2002/036600A2
In a composition comprising a therapeutic agent and a compound which is a trisaccharide or higher polysaccharide, that compound has the formula X[-Y-Z]¿n? wherein X and Z are each saccharide molecules in which none, some or all OH group...  
WO/2002/032963A1
This invention relates to compounds of general formula I, in which S is a carbohydrate core matrix; a is a pharmaceutically active moiety; L is a linker a covalent bond; n is an integer of 2 to 19; and R' is hydrogen, thioalkyl or X-Z in...  
WO/2002/032913A1
A method for the oxidation of substrates comprising treating an aqueous, basic solution of a substrate having an oxidizable functionality using an elemental halogen as terminal oxidant in the presence of an oxoammonium catalyst/halide co...  
WO/2002/030940A2
The invention relates to novel amidines and quanidines, the production and use thereof and the use thereof as trypsine-type serine protease competitive inhibitors, especially thrombine and compliment proteases Cls and Clr. The invention ...  
WO/2002/024832A1
The invention aims at providing a method for protecting unsaturated compounds from chemical changes due to radical reactions by inhibiting the conversion of unsaturated compounds into radicals. This aim is attained by an aggregate-formin...  
WO/2002/018449A1
The present invention provides a new class of compounds presenting a high compatibility with tissues and organic fluids. Such new compounds are polysaccharides essentially formed of units of uronic acid and/or hexosamine, containing nitr...  
WO/2002/010130A1
Processes for the preparation of pyrrolidones (7 and 8) and pyrrolidines (9 and 10) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to dr...  
WO/2002/008240A1
Compounds represented by the general formula (1) wherein R?1¿ is a carboxyl-protecting group; and R?2¿, R?3¿ and R ?4¿ are each independently a hydroxyl-protecting group, or alternatively R?2¿ and R?3¿ or R?3¿ and R?4¿ together r...  
WO/2002/008239A1
The invention relates to novel disaccharides of formula (I), wherein R?1¿ is selected from the group consisting of hydrogen, linear or branched (C¿1?-C¿4?) alkyl, phenylalkyl with less than ten carbon atoms and -COCH¿3?; R?2¿ is sel...  
WO/2002/004471A1
Hyaluronic acid oligosaccharides consisting of 4 to 60 saccharides; fractions characterized by containing these hyaluronic acid oligosaccharides and having specific physicochemical properties; and drugs containing the same. These hyaluro...  
WO/2002/002583A1
An amine salt of a lignan compound, i.e., [1-O-[4-(3,4-dimethoxyphenyl)-2-(3-ethylpentanoyl)-5,6,7-tri methoxy-3-(methoxycarbonyl)naphthalen-1-yl]-$g(b)-D-glucopyr anoside]uronic acid. The salt is useful as a medicine. Also provided is a...  
WO/2001/079244A1
Hydrophilic transportable N-linked glycosyl dopaminergic prodrug compounds according to FORMULA (V), wherein, Ring 1 comprises a cyclic or heterocyclic ring, or aryl or heteroaryl ring, all of said rings comprising 4 to 8 carbon atoms, a...  
WO/2001/074776A1
A process for the preparation of 1,5-dideoxy-1,5-imino hexitols of a hexose sugars from novel hydroxyl protected oxime intermediates. The process includes formation of a lactam which is reduced to the hexitol. The hexitols are useful as ...  
WO/2001/044220A2
The present invention provides fluorescent nucleoside analogs which comprise a fluorescent cyclic compound joined to a carbon of a sugar molecule such as pentose, hexose, ribose or deoxyribose or analogs thereof in either an $g(a) or $g(...  
WO/2001/044264A2
The invention relates to compounds of formula (I), which are suitable for the production of medicaments for the treatment and prophylaxis of diseases, in which an increased activity of matrix-degrading enzymes, in particular, stromelysin...  
WO/2001/034657A1
In a new process for oxidising a primary and/or secondary alcohol, an oxidising agent is used in the presence of a di-tertiary-alkyl nitroxyl, in an aqueous reaction medium at a pH of below 7. The di-tertiary-alkyl nitroxyl is especially...  
WO/2001/027128A1
SGLT2 inhibiting compounds are provided having formula (I) where R?1¿, R?2¿, and R?2a¿ are independently hydrogen, OH, OR?5¿, lower alkyl, CF¿3?, OCHF¿2?, OCF¿3?, SR?5i¿ or halogen, or two of R?1¿, R?2¿ and R?2a¿ together with...  
WO/2001/025246A2
The current invention relates to the design, synthesis, and biochemical evaluation of chromogenic substrate compounds for sialidases of bacterial, viral, protozoa, and vertebrate (including human) origin. In particular, this invention pr...  
WO/2001/022971A1
Sebum production inhibitors which contain as the active ingredient compounds having glucuronic acid derivatives and glucosamine derivatives in the structure as represented by general formula (1) or pharmacologically acceptable salts ther...  
WO/2001/019960A1
Chimeric carbohydrates produced by recombinant microorganism carrying exogenous glycosyl transferases act with or without exogenous enzymes required for synthesis or nucleotide synthesis precursors. These recombinant microorganism can be...  
WO1999061647A9
A process for purifying and concentrating a gluconic acid derivative, such as 2-keto-L-gulonic acid, comprising introducing a non-viable and/or acidified fermentation medium or an in-vitro reactor medium comprising at least the gluconic ...  
WO/2001/009152A1
The present invention relates to a process for the purification of 2-keto-L-gulonic acid by continuous liquid chromatography using a weakly basic ion exchange resin.  
WO/2001/000217A1
Medicinal compositions for preventing or treating diarrhea which contain, as the active ingredient, siastain B or its derivatives having a $g(b)-glucuronidase inhibitory activity and are useful as preventives or remedies for diarrhea whe...  
WO/2000/074674A1
What is disclosed is a meso-tetraarylporphyrin compound suitable for photodynamic therapy Forumula 1 or derivatives thereof, wherein two or three of R, R', R'', R''' represent cationic groups and the remaining R, R', R'', or R''' groups ...  
WO/2000/066601A1
The invention concerns a method for preparing aloin which consists in extracting from a substance containing aloe, in particular the yellow sap of aloe or a derived product, in the presence of an aliphatic diol or triol with low molecula...  
WO/2000/061568A2
The invention relates to substituted 1,4-benzothiazepine-1,1-dioxide derivatives and to the acid addition salts thereof. The invention discloses 1,4-benzothiazepine-1,1-dioxide derivatives of formula (I), wherein R?1¿, R?2¿, R?3¿ and ...  
WO/2000/061640A1
Crosslinked compounds of hyaluronic acid and the derivatives thereof, prepared by the technique of precipitation induced by supercritical antisolvent (SAS), can be used to advantage for the preparation of biomaterials for use in the fiel...  
WO/2000/060719A1
The invention concerns a generator for a windmill. The generator is of the kind being directly coupled to the main shaft of the wind rotor of the windmill. The generator is a stator consisting of a number of stator modules that are indiv...  
WO/2000/056734A1
The invention relates to compounds of formula (I), their tautomers, their salts and their water addition products, the radicals and symbols A, D, E, G and L having the meanings given in claim no. 1 and for example A = N, CR; D = C or N, ...  

Matches 251 - 300 out of 1,066