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Matches 251 - 300 out of 864

Document Document Title
JP6749644B2
To provide: a method of chemically synthesizing α(1→4) glycoside cyclic trimers and tetramers; and α(1→4) glycoside cyclic trimers and tetramers that have not been synthesized before.The present invention provides α(1→4) glycosi...  
JP2020514373A
Manufacturing the synthetic pathway which manufactures the false 3 sugar amino glycoside compound denoted by formula I or Ia defined by this specification, and the compound concerned is provided with a useful donor compound and a recepto...  
JP2020059728A
To provide new methods for efficient synthesis of halichondrin B analogs, particularly eribulin, useful as anticancer agents.A method of preparing an intermediate in synthesis of eribulin comprises performing a macrocyclization reaction ...  
JP2020055786A
To provide a compound for endo-β-N-acetylglucosaminidase activity detection.The present invention provides a compound expressed by a formula I in which a combination of a fluorescent group and an extinction group causing fluorescence re...  
JP2019534313A
The present invention is aimed at a useful diazaspiro [4.5] Deccan intermediate and its salt to prepare tryptophan hydroxylase (TPH) and the spiro loop compound which is especially inhibitor of isoform 1 (TPH1). The method of preparing a...  
JPWO2018143140A1
General formula (1A):The inside of [type and Y are carbonyl group, sulfonyl group, substitution, or unsubstituted Al Killen machine;R.1And R2same in Is or differing -- hydrogen atom or hydroxyl group;R3Is a hydrogen atom, substitution, a...  
JP2019520342A
The present invention describes the new conjugate of formula (I) of a medicine combinable with the glucose perception protein which enables reversible discharge of a medicine according to glucose concentration, and a portion.  
JP6455857B2  
JP2018203621A
To provide novel amide compounds modified with N-linked sugar chain.The amide compound modified with N-linked sugar chain of the invention is represented by Formula (1). The cyclic structure Ain Formula (1) is a sugar or sugar derivative...  
JP2018199706A
To provide a novel oligosaccharide or polysaccharide containing a 1,2-cis form of amino sugar.The present invention provides a sugar chain compound described in (g), the sugar chain compound containing a 1,2-cis form of sugar residue. (g...  
JP2018535237A
The present invention is a glucopyranosyl derivative as sodium dependency glucose cotransporter (SGLT) inhibitor, and a complex of L-pyroglutamic acid, And it is related with those use in manufacture of the medical supplies for treating ...  
JP2018534312A
The present invention is the following formula,Inside of a formula, R1And R2It Is and becomes independent and they are H and C.1~C6It can be Alkyl , for example, methyl, ethyl, propyl, butyl, Aryl , for example, phenyl, and Para - methox...  
JP2018145108A
To provide: a method of chemically synthesizing α(1→4) glycoside cyclic trimers and tetramers; and α(1→4) glycoside cyclic trimers and tetramers that have not been synthesized before.The present invention provides α(1→4) glycosi...  
JPWO2017034004A1
[Subject] Provide a new gelling agent containing a sugar derivative. [Means for Solution] A gelling agent which consists of a compound denoted by following formula (1) or a formula (2). [Formula 1]Inside of [type, R1Straight chain shape ...  
JP6370490B2
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing ...  
JPWO2017047816A1
The present invention provides the intermediate compound for the manufacturing method of guanidine bridge construction type artificial nucleic acid (it abbreviates to GuNA hereafter), and its manufacture. Specifically, the present invent...  
JP6347742B2
There is provided a novel gelator containing a sugar derivative. A gelator comprising a compound of Formula (1) or Formula (2): wherein each of R 1 and R 3 is independently a linear or branched alkyl group having a carbon atom number of ...  
JP6342968B2  
JP6334676B2
Processes for the preparation of 4-amino-1-((1S,4R,5S)-2-fluoro-4,5-dihydroxy-3-hydroxymethyl -cyclopent-2-enyl)-1H-pyrimidin-2-one ( 13 , RX-3117) and its intermediates are described.  
JP2018021001A
To provide novel sugar derivative production methods which can prepare novel sugar derivatives simply and securely, and to provide novel sugar derivatives which can be produced by the production methods.The present invention provides a s...  
JP2017222590A
To provide a novel compound that can be used for the detection of endo-β-N-acetylglucosaminidase (ENGase) activity and a screening method useful for the development of ENGase activity inhibitors.A compound represented by the following f...  
JP2017530107A
One hydrate and crystal of L-proline compound of sodium glucose cotransporter 2 prevention medicine and L-proline compound are provided. concrete -- 1 and 6-drying-ized-1-C-{4-chloro 3- [(3-full Oro - 4-ethoxy phenyl) methyl] phenyl}-5-C...  
JP6193513B2
Compounds of Formula (A) are described herein and the uses thereof for the treatment of diseases, conditions and/or disorders mediated by pharmaceutical compositions and the uses thereof as asialoglycoprotein receptor (ASGPR) targeting a...  
JP6175138B2
The present invention relates to a thiophene derivative of the following general formula I or an enantiomer, diastereoisomer, hydrate, solvate, tautomer, racemic mixture or pharmaceutically acceptable salt thereof or to its use as a drug...  
JP2017516838A
Formula I: [The inside of a formula, R1 Is , *OC (eta) (X) (CH)2)nIt is C (=O) OH and is R.2 Is , *OH, *N3Or *nu (eta) C (=O) CH3Come out, and it is or is R.1And R2It becomes together with the carbon atom which Is and they have combined,...  
JP6147737B2
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also prov...  
JPWO2016047428A1
[Subject] Let it be a subject, and to be quantity yield , to excel in solid selectivity moreover, and to provide the manufacturing method of the annular hemiacetal compound which can be manufactured extensive on mild conditions. [Means f...  
JP2016028038A5  
JPWO2014125967A1
A subject of the present invention is providing a pyranose donor which uses alpha*O * pyranoside for a method for manufacturing simple at a high selection rate, and the method, even if flexibility is high and does not set up strict react...  
JPWO2014132468A1
(a) Or provide the sugar chain compound which is a sugar chain compound of a statement and contains a 1 and 2* Sis type Saccharide residue machine in (b) : (a) Many sugar or oligosaccharide which the sugar unit shown by formula (I) or (I...  
JP6054900B2  
JP2016537349A
The present invention relates to a 2 sugar intermediate and a synthesizing method for the same, belongs to the chemicals medicine manufacture field, and, more specifically, relates to the preparing method of the 2 sugar fragmentation whi...  
JP6027119B2
Disclosed herein is 10-α/β-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable N salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R″ are as defined herein in the specification...  
JP5972867B2  
JP5965407B2
The invention is directed to compounds for selectively inhibiting glycosidases, uses of the compounds and pharmaceutical compositions including the compounds, and methods of treating diseases and disorders related to deficiency or overex...  
JP5893738B2
Novel compounds of formula (I) wherein R1 to R4 and X have the meaning according to the claims, are glucosidase inhibitors, and can be employed, inter alia, for the treatment of Alzheimer's disease.  
JP2016028038A
To provide a method for preparing enantiomerically enriched (1 S,4R)-2-oxa-3-azabicyclo[2.2.1]hept-5-ene.There is provided a method for producing an azabicyclo derivative including: reacting cyclopentadiene with protected 1-C-nitroso-β-...  
JP2016008183A
To provide an efficient production method of an α-hydroxycarboxylic acid in a mild condition, and to provide a production method of a biodegradable plastic from a raw material containing the α-hydroxycarboxylic acid.In a synthesis meth...  
JPWO2013172239A
The present invention is an acid diffusion control agent which consists of at least one sort of compounds chosen from a group which consists of a compound denoted by compound denoted by a following formula (1), and a following formula (2...  
JPWO2013172239A1
The present invention is an acid diffusion control agent which consists of at least one sort of compounds chosen from the group which consists of a compound denoted by the compound denoted by a following formula (1), and a following form...  
JP5803907B2  
JP5800729B2  
JP2015180682A
To provide processes and intermediates for preparation of compounds having antiviral activity.Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,2-f][1,2,4]triazinyl ...  
JP2015166325A
To provide a novel alkoxyamine compound which can be easily manufactured and applied suitably as an alcohol oxidation catalyst capable of exerting sufficiently high catalytic activity in oxidation of primary and secondary alcohols.There ...  
JP2015526416A
[Subject] Offer of a チオフェン derivative useful for diabetic medical treatment. [Means for Solution] The present invention is following general formula I [-izing 1].It is related with a の チオフェン derivative or its エナ...  
JP5771237B2
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods...  
JP5767643B2
Provided are processes and intermediates for the syntheses of nucleosides of pyrrolo[1,2-f][1,2,4]triazinyl and imidazo[1,24][1,2,4]triazinyl heterocycles of Formula I.  
JP5766334B2  
JP2014524911A5  
JP5764174B2
Methods of synthesizing sodium glucose co-transporter 2 inhibitors, as well as compounds useful therein, are disclosed. Particular inhibitors are compounds of formula I:  

Matches 251 - 300 out of 864