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JP2010285446A |
To provide processes for producing alkylamino glucosaminide phosphate compounds and disaccharide compounds functioning as immunoeffectors or adjuvants intended for vaccines and the like comprising various novel intermediates and intermed...
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JP4599295B2 |
An ±-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a monosaccharide or a reducing end of an oligosacch...
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JP4577478B2 |
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JP2010189410A |
To provide a new aminobenzophenone derivative which has excellent physicochemical properties, especially has improved bioavailability, and is pharmacologically active.The new aminobenzophenone derivative is represented by general formula...
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JP4504018B2 |
The invention provides a compound of the formula : wherein R 1 is -H, -SPh, -Ph, -allyl or -benzyl; R 2 is -H, -Et, -allyl, -Me or benzyl; R 3 is -H, -Et, -Me, -allyl or -benzyl; and R 4 and R 5 together form a ring and are -OCH(Ph)O- ; ...
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JP2010070462A |
To provide an industrially more advantageous method for producing 2,2'-anhydroarabinosylthymine which is a suitable intermediate for producing a nucleic acid derivative such as L-thymidine.A 2,2'-anhydro-5,6-dihydrouridine-5-alkoxymethyl...
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JP2010065038A |
To provide conjugates of fatty alcohols and pharmaceutical agents useful in treating cancer, viral deseases, psychiatric disorders.Compositions (1) are expressed by chemical formula (1). In the formula, R is an 8-26C fat group of a fatty...
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JP4435305B2 |
The present invention provides a topiramate immunoassay and reagents for use in the immunoassay. In particular, topiramate is derivatized at the sulfamate moiety or the 9-carbon or 10-carbon methyl group of topiramate to add a label boun...
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JP4393863B2 |
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JP4347488B2 |
A process for the addition of an azide function to an organic compound in which process a mixture is prepared by adding an epoxide-derivative of the organic compound and an alkali metal azide salt to a solvent is described. The mixture i...
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JP4294317B2 |
A chemically amplified photoresist composition comprising, (a) a compound which cures upon the action of an acid or a compound whose solubility is increased upon the action of an acid; and (b) as photosensitive acid donor, at least one c...
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JP4251410B2 |
Anticonvulsant derivatives useful in treating psoriasis are disclosed. 00000
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JP2008545650A |
The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.
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JP4182218B2 |
A novel glucose derivative inducing apoptosis. The glucose derivative is represented by the following general formula (I) wherein X, Y and Z are the same or different and each is hydrogen, halogenoalkyl, hydroxy, or alkoxy, provided that...
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JP4162491B2 |
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of formula (1) in which Z 1 and Z 2 are moieties derived from sugar. The invention also provides methods for preparing such comp...
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JP4153057B2 |
Trehalose is oxidized to give oxidized trehalose which then is hydrolyzed to produce D-glucuronolactone which is thereafter recovered to realize high-yield and low-cost production of D-glucuronolactone.
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JP4097294B2 |
The present invention describes a method for treating neuropathic pain comprising administering to a mammal afflicted with such condition a therapeutically effective amount for treating such condition of a compound of formula (I), wherei...
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JP2007530700A |
Compounds and methods useful in the control, treatment, and prevention of fungal activity, of the following formula: where R1-3 are independently H, alkyl, methyl, acyl, halogen, phenyl, R4 is H, alkyl, methyl, acyl, alkoxy, halogen, phe...
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JP3992510B2 |
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JP2007527520A |
Methods are disclosed for providing a library of composite or novel composition samples on a support. The method involves depositing one or more components as concentration gradients on the surface of the support. The concentration gradi...
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JP3942414B2 |
To provide a new efficient synthesis method for industrially producing an L-type nucleic acid derivative as a medicine. A method by which the L-type nucleic acid derivative can industrially be produced from L-arabinose, one of few indust...
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JP2006232861A |
To provide a novel efficient synthetic method for industrially producing an L-nucleic acid derivative as a medicine.Provided is the method industrially producing the L-nucleic acid derivative in a short process by using L-arabinose which...
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JP2006518759A |
It is taught here that enkephalin peptides which are glycosylated with a disaccharide will be transported across the blood brain barrier and deliver analgesic effects superior to morphine when introduced into the bloodstream. Glycosylate...
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JP3789951B2 |
PURPOSE: To obtain a new compound capable of producing hydantocidin in high yield without forming stereoisomers. CONSTITUTION: This sugar derivative is a compound of formula I [R1 and R2 each is H or together form a (substituted) alkylid...
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JP2006514071A |
The invention relates to novel pharmaceutically acceptable salts of anticonvulsant derivatives, processes for preparation of and pharmaceutical compositions containing said salts, useful in the treatment of epilepsy.
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JP2006052182A |
To provide a method for producing a fluorinated purine nucleoside derivative, by which the 3-position (preferably the α-position) is economically and efficiently fluorinated and which is suitable for industrial production.This method fo...
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JP2006502103A |
The invention relates to a novel palatinose condensation product which is obtained by condensing the disaccharide palatinose in a molten mass of palatinose, water and an organic acid.
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JP3725233B2 |
To obtain a trehalose derivative excellent in surface-active ability and safety to skin and useful as a surfactant, etc., capable of using for cosmetics, medicines, foods, etc., by reacting trehalose with an acetal compound in the presen...
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JP2005536493A |
This invention relates to processes for production of alkylamino glucosaminide phosphate compounds, and of disaccharide compounds, including various novel intermediates and intermediate processes. In one aspect, glycosyl halides are prod...
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JP2005289964A |
To provide an efficient production method of a 2-deoxy-L-ribose compound and its protection compound.This production method comprises reacting an aldehyde compound represented by formula (1) (wherein R1 and R2 are each independently or i...
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JP3706875B2 |
To provide tea leaves with reduced caffeine content, capable of being taken by a large amount for a long time as an antiallergic beverage or food. A method for producing tea leaves is provided by immersing any of raw leaves of "Benifuuki...
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JP2005530808A |
This invention relates to a new pharmaceutically useful compound which is a stoichiometrically 1:1 adduct of tramadol hydrochloride and topiramate, to the manufacture and use thereof.
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JP2005526852A |
The present invention is directed to novel compounds of the formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as described in the specification, processes for the preparation of and pharmaceutical compositions comprising said derivati...
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JP3662954B2 |
PURPOSE: To obtain the subject compound, useful for a raw material, etc., for liquid crystals, medicines, agrochemicals, etc., by optically resolving a recemic 1-benzyloxy-6,6,6-trifluoro-4-hexyn-3-ol, then carrying out the reduction of ...
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JPWO2003072587A1 |
The present application discloses a novel method for producing a non-volatile thiazolidine compound, which comprises holding cysteine and / and cystenylglycine or cystine and a reducing sugar in an aqueous solvent under heating. Accordin...
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JP2005514352A |
The present invention is directed to a method for treating autoimmune diseases comprising administering a therapeutically effective amount of a compound of the following formula (I) wherein X, R1, R2, R3, R4, R5 and R6 are as herein defi...
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JP3621097B2 |
The present invention relates to a method of preparing BCH-189 and various analogues of BCH-189 from inexpensive precursors with the option of introducing functionality as needed. This synthetic route allows the stereoselective preparati...
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JP2005503358A |
The present invention includes compounds and compositions of beta-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
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JP3602050B2 |
A composition comprises 12,13-(Pyranosyl)-indolo(2,3-a)pyrrolo(3,4-c)carbazole and 12,13-(pyranosyl)-furo(3,4-c)indolo(2,3-a)carbazole derivatives (I), or their isomers, salts with acids or bases, are new A composition comprises 12,13-(P...
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JP2004262911A |
To provide a method for producing effectively an optically active α-aminoketone.A method for producing an optically active α-aminoketone shown by general formula (2) comprises allowing a new chiral alkoxide originating from glucose, wh...
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JP2004523478A |
The present invention relates to novel N12, N13-bridged sugar derivatives of indolylopyrrolocarbazoles and pharmaceutical formulations thereof which exhibit topoisomerase-I activity and are useful in inhibiting the proliferation of tumor...
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JP2004518803A |
Avilamycin derivatives, gene technology biosynthesis processes for their production, medications containing these compounds, as well as the use of these compounds for the production of a active agent against infectious diseases, as well ...
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JP2004175792A |
To provide a method for simply producing a 2,2'-anhydro-1-(β-D-arabinofuranosyl)uracil compound at a low cost.This method for producing the 2,2'-anhydro-1-(β-D-arabinofuranosyl)uracil compound comprises heating a 3',5'-O-sulfinylxylour...
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JP2004517932A |
The present invention provides stable compounds prepared from boronic acid and lyophilized compounds thereof of formula (1) in which Z 1 and Z 2 are moieties derived from sugar. The invention also provides methods for preparing such comp...
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JP2004123605A |
To provide a method for highly selectively, efficiently and safely advancing the fluorination reaction of a desired substrate.This fluorination method comprises reacting a specific fluorine compound such as N, N-diethyl-α, α-difluoro-(...
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JP3516959B2 |
Methods and compositions are provided which increase the cellular uptake of bioactive materials by covalently bonding such compounds to carbohydrate moieties through chemical linkers using other than glycosidic bonds. Numerous carbohydra...
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JP2003530300A |
Anticonvulsant derivatives useful in maintaining weight loss.
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JP2003527324A |
Heterocyclic aromatic amides (HAA) according to Formula (I) wherein X1-X4, M, Z, and A are herein defined. The invention also encompasses hydrates, salts and complexes thereof. These compounds are useful as antifungal agents.
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JP3430318B2 |
PURPOSE: To provide halistatin 1 which is useful as a material for anticancer drugs. CONSTITUTION: Halistatin 1 is shown by the formula. This compound is obtained from the sponge Phkellia-carteri gathered in the west Indian Ocean by extr...
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JP3430317B2 |
PURPOSE: To provide halistatin 2 which exerts, as an anti-tumor agent, a particularly excellent activity against leukemia, small cell carcinoma of lung, large bowel cancer, CNS cancer and melanoma. CONSTITUTION: The halistatin 2 is shown...
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