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JP3430318B2 |
PURPOSE: To provide halistatin 1 which is useful as a material for anticancer drugs. CONSTITUTION: Halistatin 1 is shown by the formula. This compound is obtained from the sponge Phkellia-carteri gathered in the west Indian Ocean by extr...
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JP3430317B2 |
PURPOSE: To provide halistatin 2 which exerts, as an anti-tumor agent, a particularly excellent activity against leukemia, small cell carcinoma of lung, large bowel cancer, CNS cancer and melanoma. CONSTITUTION: The halistatin 2 is shown...
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JP2003176250A |
To provide a method of synthesizing phosphine oxide being a synthon for ring A used for preparing 19-nor-vitamin D compound and provide a new synthetic intermediate that is formed on the way of the synthetic route.In this new synthetic p...
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JP3411280B2 |
A method for vacuum distillation includes separation of a liquid product delivered to a reservoir under vacuum into a vapour-gaseous phase and at least one liquid fraction, withdrawal of the vapour-gaseous phase from the reservoir using ...
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JP3403218B2 |
PURPOSE: To provide a new compound useful as an antiliphemic and for treating liver disorders with cholestasis with no side-effects, which has activity to decrease the cholesterol level in the serum and has high affinity for transport sy...
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JP2003055394A |
To provide a synthetic compound which is useful for obtaining an oligo saccharide specifically bound to a target nucleic acid in the specific sequence of a gene, and to enable the enhancement in the effect of an anti-gene method. This di...
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JP2003505465A |
Anticonvulsant compounds of the general formula I:where X, R1, R2, R3, R4, R5, and R6 are as herein defined; are useful in treating acute ischemia-induced neurodegeneration, such as occurs during and after stroke, head trauma, spinal inj...
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JP2003502325A |
The invention relates to a method for the enantiomer separation of cis-8-benzyl-7,9-dioxo-2,8-diazabicy-clo[4.3.0]nonane (also described below as cis-6-benzyl-5,7-dioxooctahydropyrrolo[3,4-b]pyridine or dioxopyrrolopiperidine). The inven...
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JP2002544135A |
Synthetic methods for convenient large scale preparation of D-erythro sphingosines and ceramides of high isomeric purity are described.
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JP2002543214A |
Provided are L-ribo bicyclic nucleotide compounds as well as syntheses of such compounds. The nucleoside compounds of the invention are useful in forming oligonucleotides that can produce nucleobase specific duplexes with complementary s...
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JP3356324B2 |
Compounds of the general formula (I): wherein R1, R2, R3, R4, R5, R6, n and p are as herein defined; exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Compounds of this class are also us...
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JP2002537264A |
The present invention relates to benzaldehyde derivatives which are useful as anticancer agents. Some of the compounds of this invention are novel per se.
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JP2002537263A |
The present invention relates to benzaldehyde derivatives which are useful as anticancer agents. Some of the compounds of this invention are novel per se.
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JP2002536328A |
Anticonvulsant derivatives useful in treating autism.
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JP2002535270A |
Anticonvulsant derivatives useful in treating cluster headaches are disclosed.
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JP2002534529A |
The present application relates to a group of novel substituted pentose and hexose monosaccharide derivatives, not previously disclosed, which exhibit potent anti-cell adhesion and anti-inflammatory activities. Methods of preparation, ph...
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JP2002534530A |
This invention relates generally to compounds and processes for synthesizing derivatives of 2-3-O-isopropylidene-alpha-L-xylo-2-hexulofuranosonic acid. The compounds of this invention are useful, inter-alia, for the inhibition and preven...
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JP2002293792A |
To provide a low-cost, safe and industrially excellent method for producing a nucleoside or sugar derivative in which a secondary hydroxy group is substituted with fluorine, in which the fluorination can be carried out by one process.A n...
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JP2002533468A |
The application relates to the design and synthesis of novel hexasaccharides of general formula (I), wherein: each R is independently selected from hydrogen, an alkyl or substituted alkyl group, an acyl or substituted acyl group, a phosp...
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JP2002235096A |
To provide a method for using a cyclic sugar ketone as a catalyst for a peroxo compound.A method for using a cyclic sugar ketone of formula (1) (wherein, R1 and R2 are each H, a 1-22C alkyl, a 2-22C alkenyl or phenyl; R3 is a 1-4C alkoxy...
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JP2002517504A |
The invention provides a novel method for synthesizing Morphine-6-Glucuronide comprising the step of reacting 3-O-pivaloyloxymorphine and methyl 1alpha,2-ethylorthopivalate-3,4-di-O-pivaloylglucouronate.
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JP2002511456A |
A method for kinetically resolving a stereoisomer mixture of compounds using asymmetric epoxidation is provided. Compounds contain an olefin moiety providing one stereoisomer to be epoxidized at a higher rate than the other stereoisomer ...
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JP2002506868A |
Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have general formula (I) or (II) wherein are independently R or Z as defined below, or in combination F and F' is Ar1 as defi...
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JP3259191B2 |
PURPOSE: To obtain a compound simply and in high yield useful as an antiviral agent by reacting a specific arabinoaminooxazoline with an α- bromomethylacrylic ester and subjecting the reaction product to ring closure reaction with potas...
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JP2002504548A |
The present invention relates to cyclic pro-perfumes comprising a moiety derived from a fragrance raw material alcohol. Such cyclic perfumes may contain dioxolane and glucosyl orthesters that are suitable for use in delivering enhanced f...
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JP2002501546A |
C-nucleosides are synthesized by a method in which a sugar is derivatized in a single step to provide a heterocycle at the C1 position, and then the heterocycle is aromatized in another single step. In one class of preferred embodiments ...
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JP3217059B2 |
This invention relates to a method of producing peracetyloxazolines from peracetyl saccharides. The method involves reacting the starting material, a peracetyl saccharide, with a reagent combination, to directly produce the peracetyl oxa...
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JP3209796B2 |
PURPOSE: To provide an efficient process for continuous production of a sucrose 6-ester without requiring the addition or removal of an acid. CONSTITUTION: A soln. of sucrose and trimethyl orthoacetate in dimethylformamide is passed thro...
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JP2001192395A |
To obtain an oligonucleotide having largely excessive diastereomers and containing an optically isomerically pure phosphorothioate bond, a phosphorus-bonded oligonucleotide containing substantially whole Rp bonds or whole Sp bonds, a res...
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JP2001158788A |
To obtain a chiral compound suitable for producing a chloesteric liquid crystal composition.This composition uses a compound expressed by general formula I. The cholesteric liquid crystal composition is usable as cosmetics for protecting...
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JP3174410B2 |
PURPOSE: To obtain a sulfamate showing antispasmodic activity and useful for the treatment for symptoms such as epilepsy from an easily available source material under safe conditions. CONSTITUTION: A compd. expressed by RCH2OH (R is for...
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JP3170280B2 |
A solvent-free method for synthesizing an ethereally-substituted, blocked monosaccharide comprising the steps of: 1) mixing, in the absence of solvent, a partially blocked monosaccharide unblocked at one position, an alkyl halide or a su...
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JP3160105B2 |
PURPOSE: To provide the subject compound useful as a key production intermediate for hydantocidin known as an excellent herbicidal substance. CONSTITUTION: The compound of formula I (R1 to R4 are H or hydroxyl- protecting group; X is hyd...
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JP2001502316A |
A compound and method for producing an enantiomerically enriched epoxide from an olefin using a chiral ketone and an oxidizing agent is disclosed.
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JP2001501580A |
This invention pertains to nucleoside analogs that have antiviral activity and improved metabolic stability, compositions comprising them, and methods of antiviral treatment employing them. More particularly, this invention pertains to i...
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JP2000514425A |
A method for treating obesity comprising administering a therapeutically effective amount of a compound of the formula: is disclosed.
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JP2000514426A |
Disclosed herein is a method of treating amyotrophic lateral sclerosis with topiramate and related compounds.
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JP3080973B2 |
This invention provides novel cyclic acetals useful as delayed release flavorants and odorants. These compounds possess no detectable flavor or odor themselves at normal temperatures and atmospheric conditions but release an aldehyde fla...
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JP2000509364A |
The present invention relates to compositions and methods for inhibiting the aging of amino-containing amino acid, peptides, proteins and biomolecules. Accordingly, a composition is disclosed which comprises an agent or compound capable ...
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JP3046359B2 |
The present invention relates to D-pentofuranose derivatives represented by the following formulas (1) through (4): (wherein A represents a chlorobenzoyl group; R<1> represents a hydrogen atom, an aliphatic lower acyl group, a substitute...
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JP3044175B2 |
PURPOSE: To remove an allyl group, etc., in high selectivity and high yield without exercising bad influence on other functional group by reacting a specific compound containing an allyl group, etc., with a sulfinic acid compound in the ...
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JP3012924B2 |
2-Methyl-{4-O-(2-amino-2-deoxy-beta-glucopyranosyl)-1,2-dide
oxy-alpha-glucopyrano}(2,1-d)-2-oxazoline of the following formula or an acid addition salt thereofA 50% deacetylated chitin having a repeating structure represented by the fol...
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JPH11511480A |
Methods and intermediates for the preparation of oligomers containing diastereomerically enriched phosphorothioate linkages are disclosed.
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JP2938193B2 |
The present invention relates to an efficient new route for the preparation of (+)-nojirimycin and (+)-1-deoxynojirimycin which involves the steroselective reductive amination of 1,2-O-isopropylidene-5-oxo- alpha -D-glucuronolactone. The...
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JP2930983B2 |
A trehalose derivative of the formula: wherein one, two, three or four of R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> are independently selected from the group consisting of C1-40 aliphatic acyl groups and all the rest of them are ...
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JPH11508549A |
PCT No. PCT/FR96/00991 Sec. 371 Date Jan. 29, 1999 Sec. 102(e) Date Jan. 29, 1997 PCT Filed Jun. 25, 1996 PCT Pub. No. WO97/01343 PCT Pub. Date Jan. 16, 1997This invention relates to a new use of a sophorolipidic compound, of pharmaceuti...
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JPH11504623A |
Esters of hydroxyl-containing indolocarbazoles and acids containing selected solubilizing groups are provided. Compositions including the indolocarbazole esters and methods for the use of the indolocarbazole esters are also provided.
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JP2843592B2 |
A process of preparing l -biopterin is disclosed which comprises the steps of: Subjecting to selective Grignard reaction D-ribose having the hydroxyl groups in the 2- and 3-positions protected by an acetal group to give 6-deoxy-3,4-O-alk...
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JP2787344B2 |
5-Amino-5-deoxy-1,2-O-isopropylidene- alpha -D-glucofuranose is conveniently prepared by a hydride reduction of 5-azido-5-deoxy-1,2-O-isopropylidene- alpha -D-glucuronolactone and can readily be converted to nojirimycin, deoxynojirimycin...
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JP2770892B2 |
PURPOSE: To provide the subject new derivative enabling accurate and efficient determination of α-amylase activity and useful as a reagent for the determination of α-amylase activity. CONSTITUTION: The derivative of formula I (X1 is me...
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