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WO/2020/224580A1 |
Disclosed in the present invention is a refining method for vasopressin. The refining method comprises the following steps: sequentially performing reverse phase enrichment, reverse phase salt conversion, and reverse phase purification o...
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WO/2020/223761A1 |
The present invention provides methods for the fractionation of low molecular weight proteins from mixed protein populations, and proteins obtained by said methods. The methods described herein may find application in, but are not limite...
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WO/2020/227588A1 |
Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention a...
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WO/2020/227144A1 |
The present disclosure provides purification platforms comprising a depth filter step and/or a hydrophobic interaction chromatography (HIC) step. Also disclosed herein are methods of using the purification platforms described herein and ...
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WO/2020/221970A1 |
A process for synthesizing peptides or proteins or peptidomimetics by successive elongation, with units, of the second end (primary or secondary amine function, hydroxyl function or thiol function) of a peptide or protein or peptidomimet...
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WO/2020/223445A1 |
Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
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WO/2020/222100A1 |
Method for purifying at least one lipoglycopeptide antibiotic comprising the steps of: i) dissolving said at least one lipoglycopeptide antibiotic in an aqueous solution to form a mixture, ii) loading said mixture into a chromatographic ...
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WO/2020/221781A1 |
The invention discloses a method for separation of antibodies or antibody fragments, comprising the steps of: a) providing a feed comprising antibodies or antibody fragments having a VH3 region and being devoid of an Fc region capable of...
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WO/2020/219395A1 |
Provided herein, inter alia, are compositions and methods for the isolation and/or purification of granulocyte colony-stimulating factor (G-CSF) from inclusion bodies (IBs). Some embodiments of the disclosure relate to a method for prepa...
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WO/2020/217895A1 |
A purpose of the present invention is to form a more calm electrical field region by using a property, whereby electromagnetic waves are easily concentrated at a tapered section on a light-receiving surface side, to evenly disperse said ...
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WO/2020/219684A1 |
This tool utilizes orthogonality concepts used for analytical chromatography and apply them to chromatography for downstream processing applications utilizing a small set of product-agnostic, optimally orthogonal resins with which most s...
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WO/2020/219927A1 |
Disclosed herein are methods for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.
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WO/2020/218497A1 |
A method for producing a peptide, comprising the following steps (1), (A), (2) and (B). (1) The step of producing an N-protected C-protected peptide in which each of the N-terminal amino group and the C-terminal is protected by a protect...
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WO/2020/218412A1 |
The present invention addresses the problem of providing a method for highly efficiently producing a peptide. This method for producing a peptide comprises the following step (1): (1) A step in which a silylated amino acid or peptide, ...
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WO/2020/210965A1 |
Provided are a method for extracting a hirudin mutant, HV2-Lys47, from a fermentation broth of the hirudin mutant HV2-Lys47 produced by the fermentation of Escherichia coli, and purifying same, the use of the hirudin mutant HV2-Lys47 in ...
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WO/2020/214679A1 |
Disclosed herein are amantadine binding polypeptides, fusion proteins thereof, and uses of such polypeptides and fusion proteins.
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WO/2020/213568A1 |
Disclosed is a method for producing a polymerized polypeptide aggregate, said method comprising a step for reacting a polypeptide, which has a tag on the N-terminal side and/or C-terminal side, with a polymerase to give a reaction liquid...
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WO/2020/213928A1 |
The present invention pertains to a method for purifying botulinum toxin, the method comprising the steps of: (a) precipitating a culture medium containing botulinum toxin; (b) microfiltering sulfuric acid-precipitated botulinum toxin; (...
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WO/2020/212477A1 |
A method and apparatus for the manufacture of disulfide bonded peptides is provided, wherein a solution of an oxidizing agent and a solution of a peptide comprising at least two sulfhydryl groups are added simultaneously into a reaction ...
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WO/2020/210907A1 |
The present disclosure relates to processes for recovering valuable products from Fabaceae family plant fractions, in particular from Medicago sativa ssp. The processes disclosed herein include processes for obtaining macrofibers, microf...
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WO/2020/213929A1 |
The present invention relates to a method for purifying botulinum toxin, comprising the steps of: (a) pretreating a culture medium containing botulinum toxin; (b) purifying the pretreated botulinum toxin using cation exchange chromatogra...
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WO/2020/209318A1 |
In the present invention, an affinity purified resin having sufficient binding affinity for a modified Fc region having reduced bindability with protein A was found. Specifically, immunoglobulin containing a modified Fc region having red...
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WO/2020/209267A1 |
This method is for producing a polyamide medium for purifying a protein-containing solution and comprises a step for treating, with an acidic or alkaline aqueous solution, a polyamide medium yet to be treated with said acidic or alkaline...
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WO/2020/210596A1 |
Disclosed herein are polypeptide molecules having Prostate apoptosis response-4 (Par-4) pro-apoptotic activity in cancer cells and enhanced biological half-life, and related methods. Specifically, the disclosure provides a composition co...
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WO/2020/210448A1 |
The present invention relates to a composition for stimulating muscle growth, repair and maintenance and the method of using the same. The present invention generally relates to compositions and methods for supporting muscle anabolism. T...
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WO/2020/208409A1 |
The present application relates to improved processes for the preparation of peptide intermediates/modifier compounds of Formula (I) and their use in the synthesis of peptide derivatives. The present application further provides the comp...
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WO/2020/210161A1 |
A method for making a caffeoylquinic composition from a botanical source is disclosed. The method may include chromatographing an extract of biomass on an ion exchange stationary phase and obtaining an eluent comprising a caffeoylquinic ...
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WO/2020/201228A1 |
The present invention provides method of removing particles from a feed fluid, the method comprising: passing the fluid through a first filtration medium having a thickness of from 5 to 20 μm, wherein passing the feed fluid through the ...
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WO/2020/205465A1 |
The present invention generally relates to a composition matter useful for diagnosis and treatment of Alzheimer's disease comprising A-L-F or a pharmaceutically acceptable salt thereof, wherein A is beta-amyloid peptide or a fragment the...
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WO/2020/201816A1 |
Disclosed are compounds and methods for highly effective chemoselective peptide cyclization and bicyclization directly on unprotected peptides and other compounds as well as the compounds produced by the methods, which have a novel struc...
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WO/2020/203718A1 |
A method for purifying a protein-containing solution that contains a target protein, said method comprising: (α1) a step for contacting the protein-containing solution with a porous medium containing a polyketone; and (α2) a step for p...
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WO/2020/201450A1 |
This invention relates to the chemoenzymatic production of modified peptides, including macrocycles, by providing a peptide covalently linked to a solid support by a benzyl linker, such as a hydroxymethylbenzoic acid (HMBA) linker, cleav...
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WO/2020/202726A1 |
The present invention solves the problem of providing a technique allowing a novel radiolabeled compound to be produced. The present invention is a radio-labeled compound production method comprising: a step of irradiating a radiation be...
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WO/2020/200980A1 |
The present invention relates to new methods for the purification of immunoglobulins from cell culture harvest. These methods are characterized by cleaning steps preceding an initial capture chromatography step. Preferably, the initial c...
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WO/2020/205928A1 |
The present disclosure relates to methods and systems for the continuous production of recombinant proteins. In particular embodiments, the disclosure relates to methods and systems using capture chromatography, post-capture chromatograp...
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WO/2020/199461A1 |
Disclosed is a method for synthesizing a polypeptide-derived compound, comprising the following steps: step 1: attaching Fmoc-Gly-OH to a resin to obtain a Fmoc-Gly resin; step 2: in accordance with a sequence of a peptide-derived compou...
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WO/2020/206138A1 |
Provided herein are methods and compositions for purifying antibodies. Purification is achieved by increasing the binding capacity of protein A chromatography by covalent attachment of a protein A domain (E, D, A, B, C), or domain Z, or ...
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WO/2020/201519A1 |
The present invention is directed to a novel process for purifying a recombinant polypeptide from a solution comprising one or more impurities, wherein the process is a chromatography process which uses saccharin. The present invention a...
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WO/2020/205467A1 |
The present disclosure provides compounds represented by Formulae I and IV: wherein R1a, R1b, R2a, R2b, A, E, QD, and QE are as defined in the specification, and the salts and solvates thereof. Compounds of Formula I are degraders of STA...
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WO/2020/205469A1 |
In certain embodiments, the present invention provides a method of measuring the level of hydrophobicity of a chromatographic resin. In certain embodiments, the present invention provides a method of selecting a chromatographic resin con...
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WO/2020/196475A1 |
A novel anti-HER2 antibody-pyrrolobenzodiazepine (PBD) derivative conjugate; a medicine using the antibody-drug conjugate that has a therapeutic effect on a tumor; and a method for treating a tumor using the antibody-drug conjugate or th...
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WO/2020/198665A1 |
The present invention relates, in part, to agents, chimeric proteins and protein complexes that bind fibroblast activation protein (FAP) and their use as diagnostic and therapeutic agents. The present invention further relates to pharmac...
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WO/2020/195514A1 |
A purpose of the present invention is to provide a method for efficiently supporting a thiol group-including compound on an insoluble substrate. This method for supporting a thiol group-including compound on an insoluble substrate is cha...
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WO/2020/197934A1 |
The present disclosure provides a method for chemoselective modification of a target molecule. A subject method includes contacting a target molecule comprising a thiol moiety with a biomolecule comprising a reactive moiety, wherein the ...
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WO/2020/192174A1 |
A method for identifying individual female sea cucumbers having ovaries in development for Holothuria scabra, comprising: extracting pseudocoelom fluid of a Holothuria scabra; performing centrifugal separation to separate out vitellin; p...
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WO/2020/197492A1 |
The present invention provides improved processes for purifying liraglutide.Liraglutide is purified via two sequential RP-HPLC purifications followed by a salt-exchangestep, where a pH is kept constant in the first and second purificatio...
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WO/2020/192496A1 |
Disclosed is a method for co-production of yeast glucan, mannose protein and yeast extract using beta-1,6-glucanase. The method comprises the following steps: taking yeast cells as a raw material, subjecting the yeast cells to a high-tem...
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WO/2020/195303A1 |
This peptide complex contains a peptide, and a cell membrane permeability-imparting group that is introduced into the peptide, wherein the cell membrane permeability-imparting group has a dendritic structure having four or more branches,...
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WO/2020/193485A1 |
The invention discloses a method for sanitization of a bioprocess chromatography column, comprising the steps of: a) providing a bioprocess chromatography column with a packed bed of separation resin particles and a movable adapter; b) w...
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WO/2020/197436A1 |
The invention relates to the field of bioengineering, specifically to a method for producing a Cas-family recombinant nuclease preparation for a CRISPR/Cas system in cells of the Escherichia coli strain Rosetta-gami В (DE3), to a Cas-fa...
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