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WO/2021/005857A1 |
Provided are: a novel anti-Aβ antibody capable of detecting an Aβ-related peptide; and a method and a kit for measuring an Aβ-related peptide in a biological sample by immunochemically using said novel anti-Aβ antibody. This monoclon...
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WO/2021/007147A1 |
The present invention provides compositions and methods for wound debridement and healing. The debridement compositions preferably comprise a metalloprotease enzyme such as a choriolytic enzyme.
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WO/2021/000543A1 |
The present invention relates to the field of polypeptide synthesis, and provides a method for synthesizing Etelcalcetide. The method uses β-S(Trt)-D-Arg(Boc)3-OH as a raw material, replaces alanine in a peptide sequence with cysteine, ...
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WO/2021/001814A1 |
The present invention is directed to a polynucleotide molecule including a first polynucleotide sequence encoding a labelling sequence that is operably linked to a second polynucleotide sequence encoding a protein of interest with a link...
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WO/2021/001741A1 |
The invention relates to a Protein A chromatography step of a purification process for a therapeutic protein, wherein a load solution including the therapeutic protein is applied onto a Protein A chromatography medium. According to the i...
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WO/2020/247738A9 |
Aspects of the disclosure relate to methods of purifying complexes comprising a protein (e.g., antibody) covalently linked to an oligonucleotide. In some embodiments, complexes comprising a protein covalently linked to an oligonucleotide...
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WO/2021/002408A1 |
The present invention provides a peptide having a fluoroalkyl group as a side chain. The present invention is a method for manufacturing a fluoroalkyl-group-containing peptide in which a compound represented by general formula (6-2) or (...
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WO/2021/002257A1 |
The purpose of the present invention is to provide a method whereby a virus or a virus-like particle can be easily purified. The method according to the present invention for purifying a virus or a virus-like particle is characterized by...
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WO/2020/259714A1 |
A method for preparing degarelix. Introducing a dipeptide fragment Fmoc-Pro-D-Ala-OH and using morpholine/DMF deprotection reagent can effectively control hydantoin impurities [4Aph(D/L-Hydantoinacetyl)5]Degarelix and [D-Pro 9]Deagarelix...
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WO/2020/264441A1 |
The present technology provides an approach to designing libraries of peptide sequences for discovery and testing of significantly more motifs than would be otherwise available in a given fixed library format. The technology includes a p...
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WO/2020/258704A1 |
Provided is a seamless continuous flow chromatographic method. At least three chromatography devices are used in the method, wherein at least two of the chromatography devices constitute a first type of chromatography device, and at leas...
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WO/2020/261245A1 |
Embodiments herein are directed to methods for preparing and compositions containing microalgae biomass. Described herein are, for example, methods of preparing a microalgal flour that involve culturing microalgae, concentrating the micr...
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WO/2020/262259A1 |
A method for peptide compound production which includes a step in which a compound represented by formula (1) is used; a reagent for protective-group formation which includes the compound; and the compound. At least one of R1 to R8 and Y...
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WO/2020/260436A1 |
The present invention relates to methods of protein purification, in particular using ion exchange chromatography. Modified proteins and peptide tags suitable for use in purification by ion exchange chromatography are provided, as are re...
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WO/2020/264513A1 |
A diagnostic system detects and/or measures hemoglobin and/or hemoglobin variants in blood of subject to determine hemoglobin levels, hemoglobin variants, and/or anemia in the subject.
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WO/2020/264139A1 |
The present disclosure relates to a heterologous recombinant baculovirus (rBV) expression system for the production of foreign heterologous proteins in insect cells. This system comprises a recombinant baculovirus backbone within a genom...
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WO/2020/262590A1 |
The objective of the invention is to provide a cyclic peptide production method whereby multimerized impurity by-products that are generated during a cyclization reaction are eliminated effectively, the purity of the obtained cyclic pept...
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WO/2020/263717A1 |
A method that uses Protein A chromatography to separate antigen-binding polypeptide monomers comprising one or more immunoglobulin single variable domains (ISVDs) from aggregates of said monomers is disclosed.
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WO/2020/262258A1 |
A method for producing a peptide compound including a step that uses a condensed polycyclic aromatic hydrocarbon compound represented by formula (1), a reagent for forming a protecting group that includes the compound, and the compound. ...
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WO/2020/255906A1 |
The present invention provides a linked body for fluorescent labeling agents, said linked body suppresses noises caused by specific adsorption during quantitative determination and localization analysis of a target substance. The prese...
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WO/2020/254683A2 |
The present invention relates to a SorCS2 crystal structure, the atomic coordinates obtained by X-ray crystallography of same, and their use in molecular modelling. The invention further relates to methods of growing crystals of SorCS2. ...
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WO/2020/254540A1 |
The present invention relates to means and methods for conjugating/ attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) ...
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WO/2020/254176A1 |
The present disclosure is directed to method (100) for separating a biomolecule from a fluid (2), wherein the biomolecule is produced by biological cells in a perfusion bioreactor (3), the method comprising: forwarding (110) a product fl...
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WO/2020/254539A1 |
The present invention relates to means and methods for conjugating/attaching target molecules such as proteins to a label and/or carrier. Specifically, the present invention provides a complex comprising a metal cation coordinating (i) a...
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WO/2020/250102A1 |
The present invention relates to a process for the preparation of Plecanatide, which comprises preparation of three fragments such as Fragment A (7 amino acids), Fragment B (3 amino acids), Fragment D (6 amino acids) and coupling the fra...
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WO/2020/252260A1 |
High resolution affinity chromatography combining affinity resolving and affinity capture processes using a single chromatography matrix results in improved resolution between closely related molecular species and significantly enhances ...
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WO/2020/248947A1 |
A walnut oligopeptide powder, a manufacturing method therefor, and use thereof. The peptide content of the oligopeptide powder is 80 wt% or above, and the molecular weight of 95% or more of the walnut peptide is 1500 Dalton or below. The...
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WO/2020/248360A1 |
Provided is a preparation method of verakatide, comprising the following steps: 1) preparing the fully protected verakatide main chain-solid phase synthetic resin by solid-phase synthesis; 2) cracking to remove the side chain protecting ...
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WO/2020/249546A1 |
The present invention relates to a method for recovering a protein of interest from a fermentation broth by adding a salt of a divalent cation and increasing the pH.
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WO/2020/248372A1 |
Provided is a method for synthesizing desmopressin, the method comprising the following steps: 1) selection of a solid carrier resin; 2) synthesis of a main chain peptide resin; 3) cracking same and removing the resin and a protecting gr...
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WO/2020/247574A1 |
The present invention relates to the field of antibody formulations. In particular, the present invention relates to specific methods of preparing masked antibodies with reduced aggregation. In some embodiments, the masked antibodies com...
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WO/2020/244224A1 |
Disclosed are a tripeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, a preparation method therefor and an application thereof. The structure of the tripeptide ethylene oxide derivative is as represented by...
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WO/2020/247634A1 |
The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating ion exchange chromatography columns for reuse in the large-sca...
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WO/2020/244351A1 |
Disclosed is a proteolytic peptide for casein in goat milk that regulates the activity of B lymphocytes, wherein the sequence of the proteolytic peptide for casein in goat milk is as shown in SEQ ID NO: 1. The method for preparing the pr...
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WO/2020/241769A1 |
[Problem] To provide a structural protein microbody which can act as a core for forming a protein nanofiber. [Solution] A structural protein microbody which comprises a structural protein and satisfies at least two of the following requi...
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WO/2020/243226A1 |
The present disclosure relates to peptoids for inhibiting O-GlcNAcylated proteins, and in particular, the c-Rel peptide of NF-kappaB. The compounds can be used in the prevention or treatment of diseases of conditions having elevated leve...
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WO/2020/242765A1 |
Provided herein engineered peptides that comprise a combination of spatially-associated topological constraints, wherein at least one constraint is derived from a reference target, and methods of selecting said engineered peptides. Furth...
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WO/2020/237709A1 |
Disclosed is a long-acting exenatide derivative. A double amount of exenatide is conjugated with a single amount of fatty acid chains to obtain an exenatide derivative having a longer pharmacological action time. Also disclosed are a pre...
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WO/2020/237132A1 |
The disclosure relates to a diazirine precursor mass tag compound represented by structural formula (I). Also disclosed is a method for detecting analytes in a sample, comprising derivatizing the analytes with the compound of formula (I)...
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WO/2020/236150A1 |
Ready-to-use liquid bivalirudin compositions, methods of using the ready-to-use bivalirudin compositions, and methods of preparing the ready-to-use liquid bivalirudin compositions are provided herein. The liquid ready-to-use bivalirudin ...
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WO/2020/234578A1 |
The present invention relates to a method of acylating lysine residues on antibodies using a thioester as the acylating reagent, wherein the thioester first reacts with a cysteine residue of the antibody, before the acyl moiety is transf...
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WO/2020/234742A1 |
The instant invention is related to protein purification for removal of process and product related impurities. In particular, the invention relates to purification of recombinant human granulocyte colony stimulating factor (rh-GCSF) usi...
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WO/2020/237095A1 |
Methods for detecting and/or discriminating between variants of a contaminating protein or multiple contaminating proteins in a sample by a physical parameter, in which the method includes: separating protein components of a sample by mo...
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WO/2020/229145A1 |
The invention concerns a process for the preparation of fish proteases from fish viscera, preferably from cod (Gadus genus) viscera. The fish proteases produced according to the invention have high specific enzymatic activity and are use...
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WO/2020/229964A1 |
This application relates to methods for the production of polysaccharide antigen-carrier protein conjugates, in particular conjugates of Group B Streptococcus (GBS) capsular polysaccharide and a carrier protein, in particular CRM197. The...
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WO/2020/206399A9 |
This application relates generally to the processing of egg protein isolates for use in various food, sports nutrition and nutraceutical applications, methods of making egg protein isolates, and apparatus for making egg protein isolates....
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WO/2020/228097A1 |
Provided are a cyclic peptide compound simulating a natural product structure, and a method for preparation thereof. The preparation method is: the compound of formula I, a divalent palladium catalyst, and a silver salt undergoing an int...
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WO/2020/229381A1 |
The present invention relates to a method for purification of plasma proteins. More closely, the invention relates to a method using magnetic beads for separation of different plasma proteins from a plasma fraction, such as a cryoprecipi...
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WO/2020/227814A1 |
Proteinaceous cellulose microparticles are provided. These microparticles comprise cellulose nanocrystals and one or more peptide, one or more protein, or a mixture thereof, wherein the nanocrystals and the peptide(s) and/or protein(s) a...
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WO/2020/231337A1 |
The present invention relates to stapled analogues of relaxin-3 (R3) B-chain or R3 B1-22R having binding and antagonist potency for RXFP3 receptor. Specifically, a hydrocarbon staple was introduced at i(14), i+4(18) positions or i(14), i...
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