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WO/2020/252266A9 |
The present disclosure provides coupling methods and systems for producing peptides or proteins using semi-continuous or continuous manufacturing techniques to enable rapid production of peptides and proteins using solid phase peptide sy...
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WO/2021/037109A1 |
Provided herein are thiosuccinyl-crosslinked hemoglobin analogs useful as blood replacement agents, pharmaceutical compositions comprising the same and the methods of use and preparation thereof.
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WO/2021/036057A1 |
Disclosed is a method for preparing nesiritide, comprising the following steps: 1) synthesizing an intermediate 1 by means of a solid phase synthesis method; 2) synthesizing an intermediate 2 by means of a solid phase synthesis method; a...
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WO/2021/041199A1 |
Embodiments of the invention include systems and methods that enable the identification of candidate proteins that have desired features of a target protein. An example method comprises receiving first and second input proteins. The meth...
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WO/2021/040703A1 |
The present disclosure relates to atypical split N- and C-inteins and variants thereof. This disclosure also relates to complexes comprising the split N- or C-inteins of this disclosure and a compound of interest and compositions compris...
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WO/2021/041904A1 |
Described are methods for producing recombinant Arginase, such as PEGylated, cobalt-substituted recombinant human Arginase 1. Also described are pharmaceutical compositions comprising such recombinant Arginase, as well as methods of trea...
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WO/2021/036063A1 |
The present invention relates to a cyclic peptide from a novel bone morphogenetic protein 2 (BMP2), a preparation method therefor and an application thereof. The cyclic peptide from the novel BMP2 is selected from one of the following cy...
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WO/2021/039681A1 |
The purposes of the present invention are to provide a method for fractionating soybean proteins, to provide a method for analyzing protein composition in soybeans, and to provide a method for evaluating a soybean species, etc. by determ...
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WO/2021/039901A1 |
The present invention addresses the problem of providing a method for highly efficiently producing a peptide. The present invention provides a method for producing a peptide, said method comprising steps (1) and (2): (1) a step for rem...
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WO/2021/035184A1 |
Provided herein are methods of improving solubilization, extraction, and isolation of recombinant spider silk proteins with a salt and alcohol buffer. Provided herein are methods of solubilizing a recombinant spider silk protein from a h...
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WO/2020/013696A9 |
The present invention pertains to novel thiocycloheptyne derivatives of general formula (I) : and in particular to thiacycloalkynesulfoimine derivatives and their synthesis. The invention also relates to the use of the novel thiocyclohep...
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WO/2021/033176A1 |
A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ...
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WO/2021/031471A1 |
Provided is a method for preparing carbetocin, comprising the following steps: sequentially coupling Gly, Leu, Pro, Cys(CH2CH2CH2CO2R1), Asn(R2), Gln(R3), Ile, and Tyr(Me) to an amino resin to obtain an Fmoc-fully-protected peptide resin...
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WO/2021/034727A1 |
Described herein are cholix-IL-10 fusion proteins, and methods of use thereof, which can be characterized by a distinct response in an individual when administered. This distinct response can comprise changes in levels of one or more mar...
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WO/2021/026800A1 |
Disclosed is a method for synthesizing Degarelix acetate. The method comprises: S1, carrying out a condensation reaction with the first six amino acids of Degarelix in sequence by using a Rink Amide MBHA resin as a carrier so as to obtai...
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WO/2021/030427A2 |
The present invention provides a protein separation microgel having a first plate having a first opening; a second plate; a gel substrate formed between the first plate and the second plate; and a plurality of wells positioned at a first...
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WO/2021/028658A1 |
A process for purifying a liquid feedstock comprising a monoclonal antibody and impurities, the process comprising passing the liquid feedstock through an apparatus comprising at least two processing units, each such unit producing a pro...
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WO/2021/027251A1 |
Provided are a material for detecting an anti-MOG autoantibody in a human body fluid, a preparation method therefor and the use thereof. An MOG antigen is coated on an NC membrane to prepare a material for detecting an anti-MOG receptor;...
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WO/2021/030096A1 |
The present invention relates to a glycosaminoglycan impregnated biopolymer-based scaffold implant for repairing and regeneration of damaged and diseased human menisci. The biopolymer can be any suitable natural or genetically engineered...
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WO/2021/027250A1 |
Provided are a detection material, a preparation method and an application of an anti-NMDAR autoantibody in human body fluid, NMDAR antigen is coated on a carrier film to prepare an anti-NMDAR receptor detection material, a specific NMDA...
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WO/2021/029740A2 |
The present invention relates to a botulinum toxin preparation method capable of obtaining botulinum toxin in a high yield through a simplified process that does not include animal-derived ingredients. The botulinum toxin preparation met...
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WO/2021/027762A1 |
Provided are an oral hypoglycemic peptide, and a fatty acid derivative and use thereof. The sequence of the polypeptide is as shown in SEQ ID NO.1. The polypeptide or fatty acid derivative thereof may be used to prepare drugs or pharmace...
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WO/2021/028660A1 |
A process for purifying a composition comprising water, a target substance, impurities and optionally cells, the process comprising the steps (A) and (B): (A) preparing a liquid feedstock by performing step (Ai) and/or (Aii) on the compo...
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WO/2021/028663A1 |
Apparatus for purifying a liquid comprising a target substance comprising at least two units arranged in series such that the feed stream of the second and any subsequent units comprises the product stream from a downstream unit, wherein...
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WO/2021/024622A1 |
Provided is a method that enables production of, easily at an industrial scale, a highly pure glycomacropeptide containing less phenylalanine. Specifically, the method for producing glycomacropeptide comprises: (A) bringing a whey protei...
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WO/2021/023619A1 |
The invention relates to the field of manufacturing recombinant antibody molecules. In particular, methods of purifying such recombinant antibody molecules are provided wherein imidazole or an imidazole-analogue is added during the eluti...
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WO/2021/023892A1 |
The present invention relates to a method for modifying and purifying peptides comprising an immobilizing step, a modification step and a releasing step. In the immobilizing step, a crude linker-tagged peptide L-P is coupled to a solid s...
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WO/2021/022377A1 |
The present disclosure provides methods of preparing perivascular tissue lysates and methods of preparing mesenchymal stem cell (e.g., perivascular stem cell) lysates and total protein products from cultured cells (e.g., cultured perivas...
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WO/2021/025126A1 |
This method for producing a protein crystal includes: a step (a) for adding, to a protein synthesis system, a nucleic acid that encodes crystalline protein; and a step (b) for incubating the protein synthesis system during the predetermi...
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WO/2021/021260A1 |
Embodiments of the present disclosure are directed to systems and methods for modulating pH in a mixture containing a polypeptide. The pH may be modulated for any suitable purpose, e.g., inactivating virus in the mixture. Methods may inc...
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WO/2021/017789A1 |
Provided are an Aβ42 aggregation-induced luminescence fusion as well as a construction method therefor and an application thereof. The Aβ42 aggregation-induced luminescence fusion is EPB-Aβ424F, the phenylalanine at position 4 in the ...
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WO/2021/017793A1 |
A method for preparing a chemically synthesized acidic polypeptide, which mainly solves the disadvantages of difficult impurity purification and low yield of an acidic polypeptide compound. The method is high performance liquid chromatog...
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WO/2021/020474A1 |
The purpose of the present invention is to provide: a method for purifying an antibody in non-adsorption mode using an inorganic compound that contains silicon dioxide and aluminum oxide, as a method for producing an antibody at a lower ...
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WO/2021/017790A1 |
The present invention belongs to the fields of biotechnology and chemical engineering. Provided are an αSN aggregation induced luminescence fusion EPB-αSN4F and EPB-αSN39Y. The two are respectively obtained by means of the biological ...
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WO/2021/019167A1 |
The invention relates to a method for purifying a target substance starting from a fluid to be treated which comprises at least one impurity, said method comprising the following steps: – provision of a stream of the fluid to be treate...
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WO/2021/015704A2 |
The invention, is related to the collagen nanoparticles obtained from the waste scaly skins from the fish by using micro fluid technique; to the method for obtaining said collagen nanoparticles and their field of use.
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WO/2021/016421A1 |
The present disclosure provides methods for analyzing proteins and protein interactions in a biological sample, including complex samples, such as cells or tissues, comprising of a plurality of proteins. The methods allow detection of a ...
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WO/2021/011636A1 |
The present invention relates to epigenetic therapies for the treatment of cancer. In particular embodiments, the present invention relates to CAPERα (Coactivator of AP1 and Estrogen Receptor) RRM3 domain-derived cell penetrating peptid...
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WO/2021/010316A1 |
The present invention addresses the problem of providing an N-substituted amino acid-containing peptide and a method for producing a protein binding factor using the peptide. More specifically, the present invention pertains to a peptide...
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WO/2021/010638A1 |
The present invention relates to a method for purifying a diglycosylated interferon-beta protein and, more specifically, to a method for purifying a diglycosylated interferon-beta protein, wherein a culture containing interferon-beta exp...
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WO/2021/007701A1 |
Provided is a method for preparing Liraglutide via a solid phase peptide synthesis.
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WO/2021/007703A1 |
Provided is a method for preparing liraglutide via a solid phase peptide synthesis, wherein the method uses a Fmoc-Gly-resin with a Fmoc protective group as a carrier for the solid phase peptide synthesis, and after the completion of a d...
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WO/2021/009568A1 |
Provided herein are benzenesulfonamide derivatives having Formula (III), pharmaceutical compositions comprising said compounds, and method for using said compounds for disrupting proteins/polypeptides, protein/polypeptide function, and f...
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WO/2021/010221A1 |
This preparation method for a sample to be analyzed comprises bringing the sample into contact with an amidation reaction solution that has a pH of 7.7 or more and that contains an alkalizing agent and at least one first compound which i...
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WO/2021/007243A1 |
Provided herein, inter alia, are compositions, systems, and methods for the purification of granulocyte colony- stimulating factor (GCSF). Also provided are GCSF obtained by the disclosed methods and systems, pharmaceutical compositions ...
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WO/2021/007484A1 |
Processes for preparing and purifying protein from plant material, and compositions and uses comprising the same, are provided.
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WO/2021/007504A2 |
The present disclosure pertains to compositions with reduced presence of host cell proteins and methods of making such compositions. In particular, it pertains to compositions methods of making compositions with reduced presence of host ...
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WO/2021/004463A1 |
A method for preparing an antioxidative peptide from a peanut meal by employing a high pressure-assisted enzymatic hydrolysis method, comprising the extraction of heat denatured protein in the peanut meal, high-pressure preprocessing, en...
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WO/2021/006419A1 |
The present invention relates to a method for refining an ophthalmic protein pharmaceutical with an isoelectric point in a particular range by applying cation exchange chromatography or anion exchange chromatography. According to the pre...
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WO/2021/007127A1 |
Disclosed herein are methods for the selective substitution of a hydrogen bonded to a carbon atom (e.g., a hydrogen of an aliphatic methylene group) of a compound, which comprise contacting the compound with a substituent in the presence...
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