Peptides

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Document	Document Title
WO/2021/011283A1	INSULIN LIKE GROWTH FACTOR BINDING PROTEIN BIOACTIVE PEPTIDE FRAGMENTS Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.
WO/2020/264389A1	NOVEL THETA DEFENSIN ANALOGS Novel peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating infection and/or sepsis. These analogs are active at concentrations below those needed to provide a bactericidal or bacteriostatic effe...
WO/2020/264328A1	COMPOSITIONS AND METHODS FOR TREATMENT OF FUNGAL INFECTIONS Novel peptide analogs of a θ-defensin have been developed that provide a biphasic effect in treating disseminated fungal disease and/or associated septic shock. These analogs are active at concentrations below those needed to provide a ...
WO/2020/232048A1	Thiostrepton Analogs and Methods of Making and Using Same Provided herein are thiostrepton analogues, such as but not limited to compounds of Formula I, with improved aqueous solubility and antibacterial properties against antibiotic-resistant bacterial strains. The methods of the invention fur...
WO/2020/173926A1	USE OF DESTRUXIN-TYPE FUNGAL CYCLIC PEPTIDES AS ANTIBACTERIAL AGENTS ACTIVE AGAINST CLOSTRIDIUM PERFRINGENS The invention relates to the use of a destruxin or derivatives thereof for preventing or combating Clostridium perfringens in human or veterinary therapy or in animal nutrition.
WO/2020/152043A1	ORGANIC MOLECULES FOR OPTOELECTRONIC DEVICES The invention relates to an organic molecule, in particular for the application in optoelectronic devices. According to the invention, the organic molecule has a structure of formula (I) R1 and R2 are independently selected from the grou...
WO/2020/149258A1	IMMUNE CHECKPOINT INHIBITOR Provided is a new immune checkpoint inhibitor. The present invention provides an immune checkpoint inhibitor having as an active ingredient one or more selected from a peptide fragment of the N-end region of caveolin 1, a peptide fragmen...
WO/2020/144166A1	DEFENSIN FRAGMENTS FOR USE IN THERAPY OR PROPHYLAXIS The present invention relates to new peptides derived from HD-5 or HNP-4 having antimicrobial activity for use in modulating the microbiome of intestines, the lungs, the skin, the mouth, the eye, the ear, the vagina or other bodily surfa...
WO/2020/122182A1	AMINO ACID HAVING FUNCTIONAL GROUP CAPABLE OF INTERMOLECULAR HYDROGEN BONDING, PEPTIDE COMPOUND CONTAINING SAME AND METHOD FOR PRODUCTION THEREOF The present inventor found that the membrane permeability of a peptide compound can be improved by employing at least one amino acid which has a side chain capable of forming an intermolecular hydrogen bond, as one of the amino acids con...
WO/2020/117429A1	NOVEL ANTIBACTERIAL CELL-PENETRATING PEPTIDES The present disclosure relates to novel antibacterial cell-penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating pept...
WO/2019/133179A3	SOLUTION-PHASE AFFINITY SELECTION OF INHIBITORS FROM COMBINATORIAL PEPTIDE LIBRARIES The present invention provides novel peptides (e.g., peptides, macrocyclic peptides, mini-proteins) that modulate protein-protein interactions or salts thereof, and methods of making and using the inventive peptides. In some embodiments,...
WO/2019/227240A1	METHODS FOR TREATING CANCER WITH ACYLDEPSIPEPTIDE ANALOGS Methods and uses for treating cancer in a subject are provided. In particular, the present disclosure provides methods and uses relating to treating a subject with cancer by activating human mitochondrial ClpP (HsClpP). The present discl...
WO/2019/217116A1	METHOD FOR SOLUTION-PHASE PEPTIDE SYNTHESIS The present disclosure relates in general to the field of peptide synthesis. In general, the system provides for solution-phase peptide synthesis methods in organic solvents, some of which are immiscible with aqueous solutions, alkane so...
WO/2019/191527A1	CDP PROTEIN SECRETION INHIBITORS rovided herein are compounds that inhibit protein secretion, e.g., via inhibition of Sec61. Also provided are compositions of the inhibitor compounds, and methods of using these inhibitors. The compounds disclosed herein can be used, e.g...
WO/2019/157293A1	APRATOXIN ANALOGS Disclosed herein are apratoxin analogs.
WO/2019/151439A1	CREATION OF PEPTIDE-BASED ANTI-TUMOR AGENT The purpose of the present invention is to provide an echinomycin derivative having anti-cancer activity equal to or greater than that of echinomycin, and a production method therefor based on a chemical procedure. Provided are an echino...
WO/2019/119302A1	CMKLR1 ANTAGONIST POLYPEPTIDES AND DERIVATIVES AND APPLICATIONS THEREOF Disclosed in the present invention are CMKLR1 antagonist polypeptides (SEQ ID No: 1-17) and derivatives and applications thereof. The derivatives of the polypeptides are products obtained by conventional modification on amino acid side c...
WO/2019/119303A1	CMKLR1 ANTAGONISTIC POLYPEPTIDE, AND DERIVATIVE AND APPLICATION THEREOF Disclosed in the present invention are a CMKLR1 antagonistic polypeptide (the sequences being SEQ ID No: 1-24), and a derivative and application thereof. The derivative of the polypeptide is a product obtained by conventionally modifying...
WO/2019/115765A1	BACTERIAL SIDEROPHORE GRAMIBACTIN The invention relates to a peptide siderophore, comprising one or more N-nitroso-hydroxylamine ligands. In a preferred embodiment, the peptide siderophore comprises two side chains, each with a N-nitroso-hydroxylamine ligand, and a furth...
WO/2019/108591A1	ENDOPARASITIC DEPSIPEPTIDES The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof (1) wherein each of R1, R2, R3, R4, L1, and L2, are as defined herein. The present invention also contempl...
WO/2019/091975A1	METHOD FOR THE SYNTHESIS OF CYCLIC DEPSIPEPTIDES The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.
WO/2019/040589A1	METHODS FOR PRODUCTION OF EMODEPSIDE FROM PF1022A DERIVATIVES Provided is a method of producing a PF1022A derivative, said method comprising the steps of: reacting a compound of Formula II: wherein R1 and R2 are independently selected from hydrogen, halo and triflate, subject to the proviso that at...
WO/2019/040585A1	METHODS FOR PRODUCTION OF PF1022A DERIVATIVES AND FLOW PLATFORMS USEFUL FOR THE SAME Provided herein are improved methods of producing a derivative of PF1022A, for example a compound of Formula I: Formula I wherein R1 and R2 are each independently hydrogen or nitro, and at least one of R1 and R2 is nitro. In some embodim...
WO/2019/013148A1	SUBSTRATE COVERED WITH POLYMERS FOR SELECTIVE SEPARATION OF CELLS OR FOR CELL CULTURING A liganded substrate having at least part of the surface thereof covered by a polymer (P1) containing a structural unit represented by formula (1a) and (1b), a raw material of said liganded substrate, and a production method thereof are ...
WO/2018/232152A1	METHODS FOR TREATING DRUG RESISTANT CANCERS Provided are methods for determining whether a glioblastoma (GBM) tumor or GBM cancer cell will be sensitive to a treatment targeting the integrin avb3 (alpha.v.beta.3.) pathway, comprising determining whether the GBM tumor or the GBM ca...
WO/2018/225851A1	METHOD FOR SYNTHESIZING PEPTIDE CONTAINING N-SUBSTITUTED AMINO ACID A method for producing a peptide containing an N-substituted amino acid or an N-substituted amino acid analogue according to the present invention includes the steps of: preparing an Fmoc-protected amino acid, an Fmoc-protected amino aci...
WO/2018/214463A1	NOVEL ANTIBIOTIC AND PREPARATION METHOD, USE, AND APPLICATION THEREOF A compound represented by formula I or a stereoisomer, tautomer, oxynitride, hydrate, solvate, metabolite, or pharmaceutically acceptable salt or prodrug of the compound represented by formula I.
WO/2018/187173A1	NOVEL DEPSIPEPTIDES AND USES THEREOF The present invention relates generally to novel depsipeptides, to methods for the preparation of the novel depsipeptides, to pharmaceutical compositions comprising the novel depsipeptides; and to methods of using the novel depsipeptides...
WO/2018/166899A1	METHODS FOR PRODUCTION OF PF1022A DERIVATIVES Provided are processes for the production of PF1022A derivative compounds, including incubating a microorganism strain capable of producing such compounds in a culture medium to produce a resulting culture, said culture medium containing...
WO/2018/151839A1	ANTIMICROBIAL AGENTS AND COMPOSITIONS COMPRISING THE SAME The present invention is directed to antimicrobial agents and compositions including the same. The antimicrobial agent can include a polypeptide or a peptidomimetic of the polypeptide. The polypeptide can have a net positive charge of at...
WO/2018/106545A1	COMPOSITIONS AND METHODS FOR ENHANCED PRODUCTION OF ENDURACIDIN IN A GENETICALLY ENGINEERED STRAIN OF STREPTOMYCES FUNGICIDICUS This disclosure describes compositions and methods for enhanced production of enduracidin in genetically engineered strains of Streptomyces fungicidicus. In particular, the present disclosure describes the genetic manipulation of regulat...
WO/2018/103905A1	MODIFIED STREPTOMYCES FUNGICIDICUS ISOLATES AND THEIR USE The present invention is drawn to modified Streptomyces fungicidicus isolates, to compositions comprising these isolates, and methods of using such isolates and compositions to biologically synthesize enduracidin (enramycin). In addition...
WO/2018/093920A1	ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS The present invention provides cyclic depsipeptide compounds of formula (I) wherein the stereochemical configuration of at least one carbon atom bearing the groups Cy1, Cy2, R1, R2, R3, R4, Ra and Rb is inverted compared with the natural...
WO/2018/081898A1	IMPROVEMENTS IN CD47 BLOCKADE THERAPY BY HDAC INHIBITORS CD47+ disease cells such as cancer cells are treated using a combination of CD47 blockade drug and a histone deacetylase (HDAC) inhibitor. The anti-cancer effect of one drug enhances the anti-cancer effect of the other. Specific combinat...
WO/2018/045313A1	SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical...
WO/2018/045245A1	CYCLIC PEPTIDE ANALOGS AND CONJUGATES THEREOF Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.
WO/2018/031521A1	AUREOBASIDIUM DERIVATIVES AND METHODS OF SYNTHESIS In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable c...
WO/2017/201278A1	THIOESTER PRODRUGS OF MACROCYCLES AS INHIBITORS OF HISTONE DEACETYLASES The present invention provides a novel macrocyclic prodrug compound of general Formula (I), a pharmaceutical composition comprising a compound of Formula (I), and a method for treating diseases mediated by HDAC enzymes by administering a...
WO/2017/166812A1	RAKICIDIN COMPOUNDS AND APPLICATIONS THEREOF IN TREATING DISEASES CAUSED BY PATHOGENIC ANAEROBES Disclosed is a Rakicidin compound, Rakicidin B1. Also disclosed are applications of Rakicidins A, B, and B1 in preparing drugs for treating anaerobic infections.
WO/2017/142040A1	CYCLIC DEPSIPEPTIDE COMPOUND A cyclic depsipeptide compound represented by general formula (I) or (II), or a salt thereof. (In formulas (I) and (II), A1, A2, and A3 each independently represent an amino acid structure represented by any of formulas (A-1) to (A-3), A...
WO/2017/125933A1	FORMATION OF FUNCTIONALIZED NANOPARTICLES BY SUPRAMOLECULAR CO-ASSEMBLY The present invention provides nanoparticle conjugates incorporating the self- assembling module diphenylalanine (FF) dipeptide into a bioactive moiety. The conjugate self-assembles to form distinct nanometric structures such as nanosphe...
WO/2017/100645A3	INHIBITORS OF BACTERIAL RNA POLYMERASE: ARYLPROPANOYL, ARYLPROPENOYL, AND ARYLCYCLOPROPANECARBOXYL PHLOROGLUCINOLS The invention provides compounds that are inhibitors of bacterial RNA polymerase. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention ha...
WO/2017/116702A1	ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals, including humans. The compounds and compositions may be used fo...
WO/2017/096304A1	SLC45A2 PEPTIDES FOR IMMUNOTHERAPY Provided are SLC45A2 peptides that bind to MHC I (HLA-A2) on melanoma cells or other antigen-presenting cells and are recognized by T-cell receptors on T cells. The SLC45 A2 peptides may be therapeutically used to treat a cancer, such as...
WO/2017/068596A1	AN IMPROVED PROCESS FOR THE PREPARATION OF (1S, 4S, 7Z, 10S, 16E, 21R)- 7-ETHYLIDENE-4,21-BIS(1-METHYLETHYL)-2-OXA-12,13-DITHIA-5, 8, 20, 23- TETRAAZABICYCLO[8.7.6]TRICOS-16-ENE-3, 6, 9, 19, 22-PENTONE The present invention is relates to an improved process for the preparation (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(1-methylethyl)- 2-oxa-12,13-dithia-5,8,20,23-tetraazabi-cyclo[8.7.6]tricos-1 6-ene-3,6,9,19,22-pentone of formula I.
WO/2017/058114A1	BUTELASE-MEDIATED PEPTIDE LIGATION The present invention relates to a method of forming a peptide of Formula (I) (P1-Xaa1-Xaa2-P2) by ligating a first peptide of Formula (II) (P1-Xaa1-X-R, wherein X is O or S) to a second peptide of Formula (II I) (Xaa1-Xaa2-P2) by enzyma...
WO/2016/187534A1	ANTHELMINTIC DEPSIPEPTIDE COMPOUNDS The present invention provides cyclic depsipeptide compounds of formula (I) and compositions comprising the compounds that are effective against parasites that harm animals. The compounds and compositions may be used for combating parasi...
WO/2016/172795A1	MODULATING URACIL-DNA GLYCOSYLASE AND USES THEREOF The present invention concerns a method for the prevention and/or treatment of an activation-induced deaminase (AID)-associated disease in a subject in need thereof, said method comprising administering an effective amount of an uracil-D...
WO/2016/144259A1	SELF-ASSEMBLING ULTRASHORT ALIPHATIC DEPSIPEPTIDES FOR BIOMEDICAL APPLICATIONS The present invention relates to ultrashort depsipeptides which are capable of self-assembling into hydrogels. One preferred embodiment is of Ac-ILVaGK-NH2, where a represents lactic acid. The invention also relates to the use of these d...
WO/2016/141230A1	CYCLIC PEPTIDE ANALOGS AND CONJUGATES THEREOF Provided are cyclic peptide analogs, conjugates comprising such compounds, and pharmaceutical compositions comprising such compounds and conjugates, and methods of treating cancer with such compounds and conjugates.

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