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WO/2001/030804A2 |
The present invention is directed to the sodium salt of formula (5) which may be useful in the treatment of prostate cancer and benign prostatic hyperplasia. Also described are lyophilized formulations that comprise the sodium salt 5 or ...
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WO2000032823A9 |
The invention provides methods for covalently tagging proteins with their encoding DNA sequences as shown in the Figure. These DNA-protein fusions may be used in molecular evolution and recognition techniques.
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WO/2001/014395A2 |
The present invention provides novel n-alkenyl glycosides and glycoconjugates, n-alkyl glycoamino acids, and methods for the synthesis thereof. In another aspect, the present invention provides novel clustered glycopeptides and methods f...
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WO/2001/002018A2 |
The invention relates to a compound of the general formula (I) X(B)¿m?, wherein X is a unit of the value m and the members B are the same or different and represent K-R, wherein K represents a bond or A?1¿-(A?2¿-A?3¿)¿k?-sp, wherein...
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WO/2000/078956A1 |
Modifications of the peptide pyrrhocoricin permit the production of a variety of anti-bacterial or anti-fungal peptides having general formula R?1¿-Asp-Lys-Gly-X-Y-Leu-Pro-Arg-Pro-Thr-Pro-Pro-Arg-Pro-Il
e-Tyr-X'-Y'-R?2¿[SEQ ID NO:1] or...
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WO/2000/077028A1 |
Retro-inverso peptides derived from interleukin-3 (IL-3) having between 12 and about 40 amino acids and including the sequence shown in SEQ ID NO: 1. These peptides have the same activity as native IL-3 and also have neurotrophic activit...
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WO/2000/069892A1 |
A glycopeptide of the formula A¿1?-A¿2?-A¿3?-A¿4?-A¿5?-A¿6?-A¿7?, in which each dash represents a covalent bond; wherein A¿1? comprises a modified or unmodified $g(a)-amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, ara...
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WO/2000/069893A1 |
The present invention relates to vancomycin analogs in which the vancosamine residue is substituted with a lipid-like substituent that includes a first aryl moiety and a second aryl moiety joined together by a flexible linker moiety, tha...
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WO/2000/068257A1 |
Provided are neoglycopeptides comprising a peptide of 1 to 15 amino acid residues in which at least one amino group or internal amide nitrogen bears a saccharide either attached directly or via a group of the formula (CH¿2?CH¿2?)G?1¿ ...
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WO/2000/059528A1 |
Compounds that are analogs of glycopeptide antibiotics are disclosed. The compounds have the formula A¿1?-A¿2?-A¿3?-A¿4?-A¿5?-A¿6?-A¿7? wherein each of the groups A¿2? to A¿7? is a modified or unmodified $g(a)-amino acid residue...
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WO/2000/053614A1 |
The invention relates to a method for producing glyco-conjugates of 20(S)-camptothecin in which a 3-O-methylated $g(b)-L-fucose building block is linked to the 20 hydroxyl group of a camptothecin derivative via thiourea-modified peptide ...
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WO/2000/052035A1 |
The invention provides a direct method for monitoring bacterial transglycosylase activity using labeled substrates produced by chemo-enzymatic synthesis wherein the labels are selected to permit the detection of both polymeric and non-po...
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WO/2000/052037A1 |
A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex...
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WO2000018904A9 |
The invention concerns cDNA molecules encoding TANGO 180, TANGO 181, TANGO 182, TANGO 183, TANGO 184, TANGO 185, TANGO 186, TANGO 187, TANGO 188, TANGO 189, and TANGO 215, all of which are either secreted or transmembrane proteins. The n...
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WO/2000/047605A2 |
The invention refers to 20 enterocyte growth factors - EGFs with enhanced effectiveness as to their influence on the speed of morphogenesis, 9 of them stimulate cell growth and 11 ones inhibit cell growth. The method is in isolating them...
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WO/2000/044335A2 |
The present invention relates to dihydro derivatives of the uridyl peptide antibiotics mureidomycin, pacidimycin and napsamycin which have antibiotic activity against a number of bacterial strains including strains resistant to current t...
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WO/2000/042067A1 |
A compound which comprises: (i) a saccharide compound having transglycosylase inhibitory activity; and (ii) a second compound that is capable of binding a protein or enzyme involved in cell wall biosynthesis, a precursor used in cell wal...
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WO/2000/042052A1 |
A disaccharide compound having formula (I); wherein R¿2?Y¿2?Y¿1? is bounded to a ring carbon atom adjacent to the alpha glycosidic linkage; W¿1?, W¿2?, W¿3? and W¿4? are independently O, NH or S; R¿8? is hydrogen, hydroxyl or a h...
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WO/2000/039156A1 |
Disclosed are derivatives of glycopeptide compounds having at least one substituent of the formula: -R?a¿-Y-R?b¿-(Z)¿x? where R?a¿, R?b¿, Y, Z and x are as defined, and pharmaceutical compositions containing such glycopeptide deriva...
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WO/2000/035887A2 |
The present invention describes novel compounds of the formula: (Q)¿d?-L¿n?-C¿h?, useful for the diagnosis and treatment of cancer, methods of imaging tumors in a patient, and methods of treating cancer in a patient. The present inven...
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WO/2000/017226A1 |
The invention provides methods and compositions useful for making synthetic peptide conjugates. In one embodiment, the invention provides compositions comprising structure (I) wherein R is selected from lower substitute or unsubstitute a...
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WO/2000/009546A1 |
A process for easily preparing regular glycopeptides useful as materials of scientific studies, medical care, food and so on, which comprises coupling a fluorinated glycoside of a mono- or oligo-saccharide as represented by general formu...
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WO/2000/004044A1 |
A glycopeptide of the formula A¿1?-A¿2?-A¿3?-A¿4?-A¿5?-A¿6?-A¿7?, in which each dash represents a covalent bond; wherein A¿1? comprises a modified or unmodified -amino acid residue, alkyl, aryl, aralkyl, alkanoyl, aroyl, aralkano...
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WO/1999/065934A1 |
The present invention relates to compounds of formula (I), wherein R?1¿ is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl, chromanyl or the camphor group, which gro...
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WO/1999/064378A2 |
A combinatorial library comprising a predetermined collection of nucleoside peptide molecules for inhibiting the transfer of a sugar from a selected sugar nucleotide donor to a selected acceptor by a carbohydrate processing enzyme. The n...
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WO/1999/062919A1 |
Novel bipyridyl-osmium complex conjugates, their preparation, and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used...
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WO/1999/062918A1 |
Novel imidazole-osmium complex conjugates, their preparation, and their use in electrochemical assays are described. The redox reversible-osmium complexes can be prepared to exhibit unique reversible redox potentials and can thus be used...
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WO/1999/063346A1 |
A method and device for detection and quantification of biologically significant analytes in a liquid sample is described. The method includes contacting a volume of a liquid sample with predetermined amounts of at least a first and seco...
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WO1999048515A9 |
The present invention provides novel alpha -O-linked glycoconjugates such as alpha -O-linked glycopeptides, as well as convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the muci...
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WO/1999/056760A1 |
The present invention is directed to N?1¿-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.
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WO/1999/042476A1 |
Novel antibacterial agents that act as multibinding agents are disclosed. The compounds of the invention comprise from 2-10 ligands covalently connected, each of said ligands being capable of binding to a transglycosylase enzyme substrat...
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WO/1999/017793A1 |
Hydrochlorides of vancomycin antibiotics prepared by firstly freezing an aqueous solution of a vancomycin antibiotic hydrochloride at - 1 to - 20 °C, then secondarily freezing the same at - 25 to - 80 °C, and vacuum-drying the resultan...
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WO/1999/012959A1 |
The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural an...
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WO/1999/011654A1 |
Randomly generated glycopeptide combinatorial libraries are generated by randomly glycosylating a peptide having at least one glycosylation site with at least one glycosyl donor, optionally blocking unreacted glycosylation sites on the g...
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WO/1999/010006A1 |
The present invention is directed to methods for treating infections caused by Staphylococcus aureus with reduced glycopeptide sensitivity. The invention is preferably practiced with strains of Staphylococcus aureus which are methicillin...
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WO/1998/057657A1 |
The present invention teaches the use of antibodies raised against the Group A mucopeptide for the treatment of septic shock and Rheumatoid Arthritis, and the identification of specific peptides that can be used in such treatments. The i...
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WO/1998/052589A1 |
The present invention is directed to N?1�-alkylated derivatives of desleucyl A82846B. These derivatives are useful as antibacterials and also as starting materials from which further antibacterial compounds are prepared.
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WO/1998/052592A1 |
The present invention is directed to N?LEU�-carbamoyl and thiocarbamoyl derivatives of A82846B and N?DISACC� variations thereof. These derivatives are useful as antibacterials and also as starting materials from which further antibac...
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WO/1998/052596A1 |
The present invention is directed to glycopeptides and more particularly to derivatives of the glycopeptide A82846B. In these derivatives, the leucyl has been removed to create 'hexapeptides' of A82846B and its N?DISACC� variations. Th...
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WO/1998/051703A1 |
The invention relates to 20(S) camptothecin glycoconjugates, wherein a 3-O-methylated $g(b)-L-fucose element is bonded to the 20-hydroxyl group of a camptothecin derivative by means of a thiourea-modified peptide spacer. The invention al...
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WO/1998/046642A1 |
A modified human TNF$g(a) molecule capable of raising neutralizing antibodies towards wild-type human TNF$g(a) following administration of said modified TNF$g(a) molecule to a human host, wherein at least one peptide fragment of the huma...
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WO/1998/046580A1 |
The present invention is directed to deacyl teicoplanin, and to a process for preparing deacyl teicoplanin by reacting teicoplanin with ECB deacylase. Deacyl teicoplanin can be alkylated to produce compounds useful for their antibacteria...
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WO/1998/046579A1 |
The present invention is directed to teicoplanin derivatives of general formula (I). These derivatives are useful as antibiotics for the control of gram-positive bacteria.
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WO/1998/046246A1 |
The present invention provides novel $g(a)-O-linked glycoconjugates such as $g(a)-O-linked glycopeptides, as well as convergent methods for synthesis thereof. The general preparative approach is exemplified by the synthesis of the mucin ...
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WO/1998/043677A1 |
A carbohydrate peptide conjugate comprising: a carrier comprising a dendrimeric poly-Lysine enabling multiple epitopes to be covalently attached thereto, at least one peptide comprising one T epitope or several identical or different T e...
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WO/1998/042354A1 |
The present invention relates to therapeutic compositions and methods for treating and preventing infection by an immunodeficiency virus, particularly HIV infection, using chemokine proteins, nucleic acids and/or derivatives or analogues...
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WO/1998/033929A2 |
The invention concerns the use of a polypeptide comprising at least 6 continuous amino acids of the sequence as shown in the sequence identifiers 1 to 5 as cell receptor and/or co-receptor of adenoviruses. It also concerns the use of a c...
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WO/1998/027107A1 |
A novel method of covalently coupling polysaccharides to other biopolymers is provided, using an amino-thiol linker represented by formula (1): H�2?N-[(CH�2?)�m?-CHR?1�-CR?2�R?3�-A]�q?-CHR?4
�-(CHR?5�)�p?-CHR?6�-S-R...
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WO/1998/026085A1 |
Decoloring processes appropriate for the economical production of vancomycin on an industrial scale whereby a favorable decoloring effect and a high yield can be both established, characterized by bringing vancomycin into contact with ad...
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WO/1998/021952A1 |
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics, the improvement residing in employing pyridine-borane as reducing agent.
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