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WO/2024/086578A2 |
The present disclosure provides methods, kits, and therapeutic molecules for evaluating and treating patients with IPF and subtypes of IFF. Specifically, the present disclosure provides a method for diagnosing a patient with IFF and subt...
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WO/2024/085251A1 |
The purpose of the present invention is to provide a method for evaluating the quality of a retinal implant without actually performing retinal implanting.　The present invention relates to a method for evaluating the quality of a retin...
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WO/2024/084197A1 |
The invention relates to methods for reducing the level of xenobiotic in an environment by contacting the environment with a composition comprising one or more bacterial strains. The invention also relates to bacterial strains for use in...
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WO/2024/083866A1 |
A polypeptide, a nucleic acid molecule, a T-cell receptor or a T-cell displaying the T-cell receptor for use in the prevention or treatment of mesothelioma in a subject is provided. A polypeptide, a nucleic acid, a T-cell receptor or a T...
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WO/2024/085495A1 |
The present specification provides a biomarker composition for diagnosing or predicting the prognosis of colon cancer and use thereof. A composition, a kit, and a method according to an embodiment enable diagnosis of colon cancer with hi...
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WO/2024/086770A2 |
This disclosure relates generally to compositions and methods for assessing neuroinflammation based on the presence of absence of somatic mutations. The compositions and methods provided herein are useful for predicting a subject's risk ...
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WO/2024/082728A1 |
Provided are an RSB11 superior allelic variant RSB11-R and an application thereof in improving rice sheath blight resistance. Also provided is a DNA molecule (an RSB11 superior allelic variant RSB11-R promoter), the nucleotide sequence t...
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WO/2024/080363A1 |
A device according to the present disclosure is provided with: a base part that holds a sample and that includes a flow path structure formed therein; and an accumulation part having an accumulation space that communicates with the flow ...
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WO/2024/080451A1 |
The present invention relates to a method for preparing a high purity DNA fragment mixture using isopropanol and magnesium chloride, wherein impurities such as moisture, blood, and fat are effectively removed and the purity of the DNA fr...
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WO/2024/080731A1 |
The present invention relates to a methylated marker gene for the diagnosis of pancreatic cancer and a use thereof. As an alternative to the challenging early diagnosis of pancreatic cancer, the present invention aims to enhance the sens...
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WO/2024/080414A1 |
The present invention relates to a method for predicting the response of cancer patients to an immune cell therapeutic agent by measuring the expression levels of CD68, CD163 and CD14 genes in cancer tissue. According to the present inve...
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WO/2024/080776A1 |
The present invention relates to a sulfur-containing probe for colorimetric detection, and a method for accelerating enzymatic activity through sulfur introduction into nucleic acids. Particularly, the present invention relates to: a sul...
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WO/2024/078585A1 |
A method for generating probes on a carrier and a method for detecting a target substance in a sample. The first method comprises the following steps: hybridizing a probe template with oligonucleotides immobilized on a carrier, and exten...
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WO/2024/081810A2 |
Cell-stored barcoded viral protein libraries with are described. The libraries can be used to map resistance mutations to therapeutic treatments. The libraries include features that allow efficient collection and assessment of informativ...
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WO/2024/081868A1 |
The disclosure provides the methods of detecting an anti-lysosomal enzyme antibody in a human subject (e.g., in the presence of a circulating lysosomal enzyme) and the methods of improving an efficacy of an anti-lysosomal enzyme antibody...
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WO/2024/081563A1 |
In some examples, novel photochemically-reversible hydrogels and nanogel particles are described comprising copolymer chains including at least one reactive alkene or reactive 1,4-diene end group capable of [2+2] or [2+2+2+2] photodimeri...
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WO/2024/081884A1 |
The present disclosure provides methods and compositions for the treatment of glycogen storage diseases (e.g., GSD IX). In some aspects, the present disclosure provides splice-switching oligonucleotides that correct splicing defects and ...
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WO/2024/080818A1 |
The present invention relates to a composition for detecting target nucleic acids, comprising two probes having different Tm values and capable of hybridizing adjacently on the target nucleic acid, and to a method for detecting n target ...
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WO/2024/081914A1 |
Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays. For example, the compounds may be u...
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WO/2024/081869A1 |
The present disclosure relates in some aspects to methods and compositions for quality control (e.g., assessing the level of fixation of a biological sample) and/or optimization of analyte detection in fixed samples. In some embodiments,...
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WO/2024/080847A1 |
The present invention discloses the identification of microbial groups that significantly increase or decrease in the saliva of patients with oral cancer, compared to a control group, and relates to a composition for diagnosing oral canc...
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WO/2024/081592A2 |
Polynucleotides, expression constructs, compositions, kits and method relating to genetic disorders are disclosed. Some embodiments provided herein encompass variants of a protein that relate to a genetic disorder. Also contemplated are ...
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WO/2024/081156A1 |
The present disclosure relates to compositions of matter and assay methods used to detect one or more non-nucleic acid targets of interest in a sample. The compositions and methods provide signal boost upon detection of non-nucleic acid ...
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WO/2024/081796A1 |
The present disclosure is directed to methods for detecting a prostate cancer, methods for determining whether a prostate cancer is stable or progressive, low or high Gleason grade, methods for determining the completeness of surgery, an...
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WO/2024/079022A1 |
An in-vitro diagnostic (IVD) analyzer (200) comprising at least one sensor (212) located in a flow-through sensor path (211) of detecting unit and requiring at least one oxygenated calibration fluid (221', 222') for calibration is herein...
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WO/2024/081421A1 |
Provided herein are methods and compositions for an epigenetic clock comprising differentiation-independent methylation sites to asses biological age of a human subject.
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WO/2024/078420A1 |
An isothermal nucleic acid amplification RAA primer probe combination for detecting Candida auris, and the use thereof. The primer probe combination has a high amplification efficiency, a strong specificity, and no obvious false positive...
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WO/2024/081769A2 |
Methods for detecting disease in a subject are described. In some instances, the methods may comprise: receiving sequence read data for a plurality of sequence reads derived from a sample; determining a methylation fraction value for a p...
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WO/2024/079706A1 |
The invention relates to methods of identifying and characterizing a Cannabis spp. plant with respect to a flowering time trait comprising genotyping the plant for a quantitative trait locus (QTL) associated with a flowering time trait, ...
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WO/2024/081805A1 |
Described herein are systems, apparatus, methods, and/or computer program product embodiments, and/or combinations and sub-combinations thereof which enables automated determination of index sequence(s) during DNA sequencing data analysi...
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WO/2024/079146A1 |
The invention relates to a DNA origami biosensor capable of detecting at least two different target oligonucleotides at the same time, said biosensor comprising at least one DNA origami hinge and at least two detection sites, wherein eac...
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WO/2024/081212A1 |
Provided herein are methods, compositions, and kits for in vitro transcription of spatially captured target nucleic acids on an array.
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WO/2024/079056A1 |
The invention relates to a method for hepatocellular carcinoma (HCC) risk stratification in patients, in particular with advanced chronic liver disease or cirrhosis using combinations of single nucleotide polymorphisms (SNPs), alone or w...
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WO/2024/081622A1 |
The present invention provides modified oligo(dT) primers containing at least one deliberate mismatch within the dT span of the primer which provides improved stability and replicability of the resulting cDNA molecules. In the context of...
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WO/2024/081853A2 |
Described herein is an amperometric biosensor, e.g., chronoamperometric biosensor for the measurement of the concentration of amine-comprising substates, including dopamine, octopamine, tyramine, norepinephrine, tryptamine, 5-methoxytryp...
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WO/2024/077439A1 |
The present application discloses a method for constructing a single-cell transcriptome and chromatin accessibility dual-omics single-cell sequencing library. The method comprises: a) preparing a single-cell suspension; b) obtaining an o...
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WO/2024/081689A1 |
The invention provides methods to noninvasively profile the tumor or the tumor microenvironment using a body fluid sample such as a blood draw. Methods of the disclosure use a liquid biopsy analysis to profile immune cell abundance and d...
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WO/2024/080650A1 |
The present invention relates to a composition and method for predicting sulfonylurea dependency in diabetic patients by identifying the mRNA levels of gastric inhibitory polypeptide receptor (GIPR); the levels or activity of GIPR protei...
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WO/2024/079341A1 |
The present invention relates to a method for obtaining one or more fluorescent images of one or more cells, the method comprising the steps of incubating the one or more cells with a first probe for fluorescence imaging of nuclear DNA a...
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WO/2024/080483A1 |
The present invention relates to a CRISPR-Cas-based composition for detection of Listeria monocytogenes and a Listeria monocytogenes detection method using same and, more specifically, to a composition for detection of Listeria monocytog...
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WO/2024/077410A1 |
The present application relates to the technical field of metal ion chemistry, and provides a method for reducing an azide methoxy group, a sequencing method, and a kit. The method for reducing an azide methoxy group provided by the pres...
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WO/2024/081776A1 |
Disclosed are compositions and methods for performing nucleic-acid-based assays to determine the presence or absence of a target nucleic acid in a biological sample. The disclosed methods include the use of one or more oligomers that spe...
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WO/2024/081570A1 |
Aspects of the present disclosure relate to creating a graph, such as a directed-acyclic-graph (DAG), which represents the causal links in a biological process. In aspects, a researcher can establish the graph to incorporate the complexi...
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WO/2023/034602A9 |
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WO/2024/081040A1 |
Materials and methods for the diagnosis of traumatic brain injury using miRNA biomarkers are disclosed. Amplification nucleotide chains amplify a detectable signal indicating the expression and/or upregulation of the biomarkers. Detectio...
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WO/2024/080651A1 |
The present invention relates to a composition and a method, which can predict sulfonylurea dependence of diabetes patients by identifying: a first variant selected from the group consisting of a variant at base 43801878 (A allele), a va...
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WO/2024/077963A1 |
Disclosed in the present application is a primer-probe combination used for detecting influenza A viruses and influenza B viruses by means of recombinase polymerase amplification (RPA). The primer-probe combination comprises a probe and ...
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WO/2024/077984A1 |
The present invention belongs to the technical field of molecular breeding in maize. Provided are a maize dwarfing-related molecular marker having semi-dominance and the use thereof. The maize dwarfing-related molecular marker is caused ...
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WO/2024/077357A1 |
The present disclosure relates to methods for assessing the risk of a human subject for developing melanoma. Also provided are polymorphisms associated with the risk of a human subject for developing melanoma.
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WO/2024/081851A2 |
A method of synthesizing a polynucleotide composition includes performing a synthesis of the polynucleotide composition via phosphoramidite chemistry, solid-phase supported synthesis, to create polynucleotide chain. During at least one c...
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