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WO/2024/043048A1 |
The present invention can provide a microfluidic device comprising a function part such as a reaction part in a flow path, wherein a flow of a fluid can be generated near the surface of the function part. The microfluidic device is obtai...
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WO/2024/043160A1 |
The objective of the present invention is to make it possible to provide a fluid device which is provided with a branched flow passage and in which backflow and stagnation of fluid does not occur. The fluid device comprises a main flow p...
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WO/2022/183102A9 |
Disclosed are compositions, systems, kits, and methods for detecting an analyte or target molecule in a sample by regulated in vitro transcription. The compositions, systems, kits, and methods typically comprise and/or utilize one or mor...
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WO/2024/044578A1 |
The present invention relates to the field of Premenstrual dysphoric disorder (PMDD) and perimenopausal depression (PMD). More specifically, the present invention relates to the use of biomarkers to diagnose PMDD, PMD or predict a risk t...
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WO/2024/040739A1 |
A test device (100), comprising a light separator (1), a light diffuser (2), and a printed circuit board (3) which are arranged from top to bottom. The light separator (1) is provided with two sample inlets (11) and two observation windo...
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WO/2024/041748A1 |
A connector (100, 102) is provided for generating a biological structure (400, 500, 600, 700) comprising: a protein backbone (106); a first reactive interactor (108) arranged towards a first end of the protein backbone (106) and configur...
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WO/2024/042680A1 |
The variant production device according to one embodiment includes: a mutation induction treatment unit that irradiates an organism from which a variant is to be produced, with radiation or electromagnetic energy, or introduces a chemica...
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WO/2024/042217A1 |
Disclosed herein are methods of modifying 5-methylcytosine (5-mC), 5- hydroxymethylcytosine (5-hmC), or 5-formlcytosine (5-fC) in a polynucleotide. The method may include oxidizing the 5-mC, 5-hmC, or 5-fC to 5-carboxylcytosine (5-caC); ...
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WO/2023/007019A9 |
The present invention is inter alia concerned with (A) a compound of formula (I) as defined herein or a salt, stereoisomer, tautomer or deuterated version thereof, (B) a cap analog comprising a 5' terminal acyclonucleoside, wherein the a...
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WO/2024/042557A1 |
Method to prepare a crude biological sample to supply viral RNA suitable to be detected by means of nucleic acid hybridization and amplification techniques, wherein the method comprises: - supplying a crude biological sample in liquid fo...
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WO/2024/044703A1 |
The present disclosure relates generally to compositions, methods, and systems for the characterization of antigen-binding molecules (e.g., antibodies) in biological samples. This characterization permits the identification of the ABM th...
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WO/2024/040871A1 |
A gene sequencer and a method for using same. The gene sequencer comprises an excitation module and a sequencing module. The excitation module comprises a light source, a diaphragm, and an even-order aspheric reflector. The sequencing mo...
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WO/2024/044749A1 |
In some embodiments, a computer-implemented method of enhancing sequence read data from a cell-free DNA (cfDNA) sample from a subject for predicting a pregnancy-related condition is provided. A computing system determines a coverage prof...
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WO/2024/040428A1 |
The present application provides a detection device and a method for extracting nucleic acids and belongs to the technical field of reagent detection. The detection device comprises: a main body cavity, wherein the main body cavity compr...
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WO/2024/043830A1 |
The present invention relates to methods for the detection of the presence and/or amount of target nucleic acids in a sample, wherein said target nucleic acids are those of two or more fungal species involved in fungal sepsis. The method...
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WO/2024/044619A2 |
Methods for detecting, stimulating, and/or monitoring communication within a cell or between cells are provided, and methods of treating a subject having a disease, disorder or condition by causing communication within a cell or between ...
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WO/2024/041348A1 |
The provided are biomarkers combination and characterization methods for the diagnosisof Kawasaki disease (KD) in a clinical setting. In particular, provide is the use of the combination of RNA/DNA molecular biomarkers and theircopy numb...
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WO/2023/212315A9 |
The disclosure relates to method and kits for highly specific detection and quantification of extracellular vesicles (EVs) by targeting at least two EV surface markers using binding reagents. The binding reagents contain hybridisation se...
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WO/2023/288275A9 |
The present application provides compounds and methods for identifying a modulator of a protein of interest using TR-FRET donor attached to the protein of interest and a tracer containing TR-FRET acceptor. Disclosed assay platforms utili...
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WO/2024/042493A1 |
The present application provides a method for non-invasive preimplantation genetic testing of embryos, comprising the following steps: (a) preparation of the embryo specimen to be tested for NIPGT analysis, a non-invasive preimplantation...
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WO/2024/044352A1 |
Provided herein are methods and compositions for the diagnosis, prognosis, and treatment of dilated cardiomyopathy (DCM) and heart failure (HF). In particular, provided are methods and compositions for detecting a loss-of-function mutati...
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WO/2024/043238A1 |
The inventors discovered that it is possible to improve the chasmogamy of wheat by suppressing the Sof1 gene function, and that the chasmogamy of wheat can be evaluated using suppression of the Sof1 gene function as the index.
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WO/2024/041517A1 |
The present invention relates to the field of medical instruments. Disclosed are an all-in-one machine for sample detection and a control method therefor. According to the all-in-one machine for sample detection and the control method th...
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WO/2024/044228A1 |
Provided herein are compositions and methods for identifying COVID-19 subjects at risk for cerebrovascular events.
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WO/2024/040957A1 |
Provided are an amplification-free method for the preimplantation genetic testing (PGT) of in-vitro fertilization (IVF) embryos, an amplification-free method of generating a library for the PGT, and a method of identifying the genetic ba...
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WO/2024/041749A1 |
A sequencing scaffold for attachment of target nucleic acid strands (204) comprises at least one nucleic acid backbone (100, 102, 104, 200a, 200b) with a plurality of attachment regions (118, 119) at predetermined positions, each attachm...
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WO/2024/044789A2 |
Proper functioning of the human body relies on the organization of cells in 3D space. A cell's function and fate are determined by its biomolecule composition and 3D environment. The spatial identification of proteins, RNAs, DNAs, and ot...
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WO/2024/044764A2 |
Various aspects disclosed relate to a centrifugal microfluidic device to perform dynamic solid phase sodium bisulfate conversion. The device includes a reaction assembly. The reaction assembly includes a plurality of individual chambers,...
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WO/2024/044168A2 |
A method for treating a V-ATPase malfunction may include identifying a malfunction of at least apportion of a V-ATPase protein, where the malfunction occurs in a transmembrane portion of the V-ATPase protein. Further, the method may incl...
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WO/2024/043522A1 |
The present invention relates to a method for selecting highly potent stem cells for the treatment of neurological diseases using TIMP-1, MCP-1, GROα, and IL-6, and a pharmaceutical composition for the prevention or treatment of neurolo...
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WO/2024/044304A1 |
A CRISPR-Cas9 system for treating a disease, disorder, or condition associated with one or more somatic mutations in a subject in need of treatment thereof is disclosed. The system comprises a sgRNA-guided Cas9, wherein the sgRNA targets...
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WO/2024/041574A1 |
Provided herein are uses of conjugates of anti-CLDN18.2 antibodies or antigen-binding fragments thereof with radionuclides in imaging, patient screening, treatment process monitoring and efficacy evaluation.
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WO/2024/044398A1 |
A composition is orally or topically administered to a patient susceptible to infection by an orthopoxvirus such as monkeypox (mpox). The composition includes inhibitors configured to bind to orthopoxvirus envelope proteins, e.g., MPXV A...
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WO/2024/042042A1 |
Methods for the rapid detection of the presence or absence of Monkeypox Virus (MPXV) in a biological or non-biological sample are described. The methods can include performing an amplifying step, a hybridizing step, and a detecting step....
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WO/2024/044668A2 |
A method of isolating ultrashort single-stranded cell-free DNA (uscfDNA) is described as well as methods of using the uscfDNA for detecting biomarkers and diagnosing diseases and disorders.
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WO/2024/044739A2 |
The present invention describes compositions for use in a proximity assay for detecting glycosylated molecules in a sample, and methods of use of the compositions for a proximity assay for detecting glycosylated molecules.
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WO/2024/043743A1 |
The present invention relates to a composition for amplifying a FLT3 gene, and uses thereof, and, more particularly, to a composition comprising a primer set capable of simultaneously amplifying an ITD detection region and a TKD mutation...
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WO/2024/038435A1 |
The present invention discloses a method for producing a modified peanut plant with at least one improved phenotypic trait. The method comprises steps of genetically modifying at least one regulatory gene involved in allergen synthesis a...
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WO/2024/039196A1 |
The present invention relates to a method for predicting metastasis or prognosis of cancer or predicting a patient's responsiveness to a drug, by confirming the mRNA level or protein expression level of LRRFIP2 isoform 2 or 3 formed by a...
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WO/2024/037252A1 |
Provided are a PCR primer for sex identification of young pigeons, use thereof, and a method for sex identification of young pigeons. The primer is designed for a specific EE0.6 sequence fragment on the W chromosome of female pigeons. Du...
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WO/2024/038918A1 |
The present invention pertains to: an aptamer which contains an oligonucleotide (for example, an oligonucleotide containing a base sequence which has at least 90% of the sequence identity of the base sequence represented by SEQ ID NO 14 ...
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WO/2024/040040A2 |
A nucleic acid probe composition for enriching, extracting, and/or detecting a variant target nucleic acid in a sample comprising the variant and a reference target nucleic acid is provided. The variant and reference each comprise a nucl...
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WO/2024/036363A1 |
A system for nucleotide chain sequencing, the system including an apparatus with: at least one electrode for measuring a collective electromagnetic signal from a portion of a nucleotide chain, the portion including a plurality of nucleot...
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WO/2024/038203A1 |
Provided is a method for multiplexed fluorescence microscopy comprising contacting a fixed sample with a set of binding agent-T-oligonucleotide conjugates to allow the binding agents to bind to any binding partners present in the sample,...
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WO/2024/040246A2 |
Method and device for detecting SARS-CoV-2 specific T-Cell interferon-gamma activation is described. By using a microfluidic chip to allow ELISpot interferon gamma release assays (IGRA) be performed using a small amount of fingerstick wh...
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WO/2024/037449A1 |
The present disclosure relates to a method for constructing a sequencing library, a gene probe combination and a kit. The library construction method of the present disclosure can achieve ultra-multiple digital gene expression detection ...
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WO/2024/036445A1 |
Provided are a method for preparing a sequencing library and a kit for preparing a sequencing library. The preparation method comprises the following steps: (i) obtaining a nucleic acid fragment to be tested; (ii) adding a linker element...
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WO/2024/039230A1 |
The present invention relates to a novel biomarker VISTA for the diagnosis or prognosis of patients having idiopathic pulmonary fibrosis, which allows a simple diagnosis or prognosis of idiopathic pulmonary fibrosis by analyzing the VIST...
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WO/2024/039692A1 |
The disclosure further provides diagnostic, prognostic, and therapeutic methods, which are based, at least in part, on determination of the identity of a genotype of interest identified herein.
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WO/2024/036787A1 |
Disclosed is use of brain-refreshing marker genes nr1d4a and nr1d4b in screening a brain-refreshing medicament, relating to the technical field of medicament screening. Particularly, disclosed is a method for screening a brain-refreshing...
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